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NeuroEE SIGNED

Delineation of a brain circuit regulating energy expenditure to impact body weight

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NeuroEE project word cloud

Explore the words cloud of the NeuroEE project. It provides you a very rough idea of what is the project "NeuroEE" about.

career    metabolism    wat    underpinnings    msc    clarify    epidemic    university    cell    transferable    contribution    interests    pallidus    receiving    adipose    broaden    thermoregulation    neurochemical    construct    weight    critical    arguably    opportunity    communicator    beige    tissue    aberdeen    century    energy    transmitting    2014    preliminary    estrogen    optimal    generation    vmh    hydroxytryptamine    form    network    tone    decrease    nicotine    regulating    curie    circuit    environment    expertise    marie    engineered    nutrition    node    definitively    body    bat    expenditure    discovered    lora    trained    health    diabetes    neurotransmitter    input    perform    prof    axis    utilized    thermogenic    sympathetic    data    2012    hypothesize    ventromedial    brown    rpa    global    hypothesis    human    inducing    indicate    platform    drive    fellowship    linking    obesity    browning    me    neural    brain    laboratory    international    rowett    heisler    region    found    hypothalamus    plays    supply    rigorously    deleterious    leader    genetic    supervision    ht    sklodowska    ee    white    raphe   

Project "NeuroEE" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN 

Organization address
address: KING'S COLLEGE REGENT WALK
city: ABERDEEN
postcode: AB24 3FX
website: http://www.abdn.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.abdn.ac.uk/rowett/research/index.php
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2018-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN UK (ABERDEEN) coordinator 195˙454.00

Map

 Project objective

Obesity is now a global epidemic with a significant and deleterious impact on human health. My career aim is to clarify the neural underpinnings of energy expenditure (EE) given that this makes a significant contribution to body weight. During my early career, I discovered a circuit linking the ventromedial hypothalamus (VMH) to brown adipose tissue (BAT) and inducing thermogenic beige (browning) white adipose tissue (WAT), regulating EE. Moreover, I found that the VMH-BAT axis is utilized by estrogen (Cell Metabolism, 2014) and nicotine (Diabetes, 2012) to increase EE and decrease body weight. My preliminary data indicate that a critical node between the VMH and BAT is the raphe pallidus (RPa), a brain region known to drive sympathetic tone to BAT. My immediate career aim is to clarify the neurochemical communicator receiving the VMH-EE related input and transmitting to BAT and browning. Given that the RPa is rich in the neurotransmitter 5-hydroxytryptamine (5-HT) which plays a role in thermoregulation, I hypothesize that 5-HT is a crucial component of my circuit. I propose to perform a Marie Sklodowska-Curie Fellowship (MSC) under Prof Lora Heisler’s supervision, arguably the global leader in 5-HT obesity research. Her laboratory is in the Rowett Institute of Nutrition and Health, University of Aberdeen, an Institute with more than a century of focused state-of-the-art obesity and nutrition research. This will supply an optimal environment for a MSC providing me with the opportunity to broaden my research interests, and allowing me to construct an international network of obesity researchers. A MSC will also provide the opportunity for me to be trained in transferable next generation engineered genetic technology that will allow me to rigorously and definitively test my current research hypothesis and to provide state-of-the-art expertise that will form a platform for my future career. 5-HT, brown adipose tissue, browning, raphe pallidus, ventromedial hypothalamus

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