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NeuroEE SIGNED

Delineation of a brain circuit regulating energy expenditure to impact body weight

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Outcomes and results

 NeuroEE project word cloud

Explore the words cloud of the NeuroEE project. It provides you a very rough idea of what is the project "NeuroEE" about.

university    white    circuit    hypothesize    heisler    clarify    plays    transmitting    2014    arguably    rigorously    weight    found    nutrition    ventromedial    critical    broaden    form    leader    msc    lora    environment    estrogen    marie    fellowship    browning    deleterious    wat    decrease    optimal    hypothalamus    thermoregulation    nicotine    generation    neural    brown    engineered    construct    curie    career    pallidus    supply    aberdeen    genetic    utilized    input    interests    network    metabolism    beige    cell    rpa    health    brain    adipose    2012    obesity    bat    sklodowska    expertise    ht    region    drive    tone    international    contribution    platform    discovered    trained    diabetes    node    vmh    thermogenic    epidemic    regulating    body    data    linking    neurotransmitter    expenditure    energy    human    indicate    opportunity    prof    underpinnings    laboratory    communicator    perform    rowett    hypothesis    supervision    me    sympathetic    ee    transferable    hydroxytryptamine    global    tissue    axis    century    raphe    inducing    receiving    neurochemical    definitively    preliminary   

Project "NeuroEE" data sheet

The following table provides information about the project.

Coordinator		 THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN 

Organization address
address: KING'S COLLEGE REGENT WALK
city: ABERDEEN
postcode: AB24 3FX
website: http://www.abdn.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Project website https://www.abdn.ac.uk/rowett/research/index.php
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2018-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN UK (ABERDEEN) coordinator 195˙454.00

Map

 Project objective

Obesity is now a global epidemic with a significant and deleterious impact on human health. My career aim is to clarify the neural underpinnings of energy expenditure (EE) given that this makes a significant contribution to body weight. During my early career, I discovered a circuit linking the ventromedial hypothalamus (VMH) to brown adipose tissue (BAT) and inducing thermogenic beige (browning) white adipose tissue (WAT), regulating EE. Moreover, I found that the VMH-BAT axis is utilized by estrogen (Cell Metabolism, 2014) and nicotine (Diabetes, 2012) to increase EE and decrease body weight. My preliminary data indicate that a critical node between the VMH and BAT is the raphe pallidus (RPa), a brain region known to drive sympathetic tone to BAT. My immediate career aim is to clarify the neurochemical communicator receiving the VMH-EE related input and transmitting to BAT and browning. Given that the RPa is rich in the neurotransmitter 5-hydroxytryptamine (5-HT) which plays a role in thermoregulation, I hypothesize that 5-HT is a crucial component of my circuit. I propose to perform a Marie Sklodowska-Curie Fellowship (MSC) under Prof Lora Heisler’s supervision, arguably the global leader in 5-HT obesity research. Her laboratory is in the Rowett Institute of Nutrition and Health, University of Aberdeen, an Institute with more than a century of focused state-of-the-art obesity and nutrition research. This will supply an optimal environment for a MSC providing me with the opportunity to broaden my research interests, and allowing me to construct an international network of obesity researchers. A MSC will also provide the opportunity for me to be trained in transferable next generation engineered genetic technology that will allow me to rigorously and definitively test my current research hypothesis and to provide state-of-the-art expertise that will form a platform for my future career. 5-HT, brown adipose tissue, browning, raphe pallidus, ventromedial hypothalamus

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The information about "NEUROEE" are provided by the European Opendata Portal: CORDIS opendata.

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