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NeuroEE SIGNED

Delineation of a brain circuit regulating energy expenditure to impact body weight

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NeuroEE project word cloud

Explore the words cloud of the NeuroEE project. It provides you a very rough idea of what is the project "NeuroEE" about.

ventromedial    bat    tone    transmitting    definitively    vmh    regulating    platform    form    career    drive    fellowship    perform    sympathetic    beige    international    transferable    metabolism    browning    input    pallidus    tissue    weight    rpa    estrogen    neurotransmitter    diabetes    inducing    health    rowett    thermoregulation    human    construct    curie    university    ht    heisler    laboratory    trained    arguably    network    deleterious    genetic    wat    hypothesis    opportunity    clarify    raphe    circuit    nicotine    epidemic    data    neural    prof    supervision    linking    contribution    2012    hydroxytryptamine    optimal    brown    neurochemical    node    cell    ee    marie    plays    indicate    brain    discovered    communicator    adipose    supply    global    hypothesize    thermogenic    aberdeen    century    environment    axis    generation    hypothalamus    utilized    preliminary    region    interests    body    white    receiving    broaden    found    lora    me    engineered    nutrition    2014    expertise    critical    decrease    msc    underpinnings    rigorously    sklodowska    energy    expenditure    obesity    leader   

Project "NeuroEE" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN 

Organization address
address: KING'S COLLEGE REGENT WALK
city: ABERDEEN
postcode: AB24 3FX
website: http://www.abdn.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.abdn.ac.uk/rowett/research/index.php
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2018-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN UK (ABERDEEN) coordinator 195˙454.00

Map

 Project objective

Obesity is now a global epidemic with a significant and deleterious impact on human health. My career aim is to clarify the neural underpinnings of energy expenditure (EE) given that this makes a significant contribution to body weight. During my early career, I discovered a circuit linking the ventromedial hypothalamus (VMH) to brown adipose tissue (BAT) and inducing thermogenic beige (browning) white adipose tissue (WAT), regulating EE. Moreover, I found that the VMH-BAT axis is utilized by estrogen (Cell Metabolism, 2014) and nicotine (Diabetes, 2012) to increase EE and decrease body weight. My preliminary data indicate that a critical node between the VMH and BAT is the raphe pallidus (RPa), a brain region known to drive sympathetic tone to BAT. My immediate career aim is to clarify the neurochemical communicator receiving the VMH-EE related input and transmitting to BAT and browning. Given that the RPa is rich in the neurotransmitter 5-hydroxytryptamine (5-HT) which plays a role in thermoregulation, I hypothesize that 5-HT is a crucial component of my circuit. I propose to perform a Marie Sklodowska-Curie Fellowship (MSC) under Prof Lora Heisler’s supervision, arguably the global leader in 5-HT obesity research. Her laboratory is in the Rowett Institute of Nutrition and Health, University of Aberdeen, an Institute with more than a century of focused state-of-the-art obesity and nutrition research. This will supply an optimal environment for a MSC providing me with the opportunity to broaden my research interests, and allowing me to construct an international network of obesity researchers. A MSC will also provide the opportunity for me to be trained in transferable next generation engineered genetic technology that will allow me to rigorously and definitively test my current research hypothesis and to provide state-of-the-art expertise that will form a platform for my future career. 5-HT, brown adipose tissue, browning, raphe pallidus, ventromedial hypothalamus

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The information about "NEUROEE" are provided by the European Opendata Portal: CORDIS opendata.

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