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NeuroEE SIGNED

Delineation of a brain circuit regulating energy expenditure to impact body weight

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NeuroEE project word cloud

Explore the words cloud of the NeuroEE project. It provides you a very rough idea of what is the project "NeuroEE" about.

pallidus    sympathetic    linking    epidemic    beige    optimal    rigorously    axis    heisler    regulating    clarify    curie    discovered    hypothesize    environment    international    hydroxytryptamine    circuit    vmh    rowett    contribution    genetic    obesity    health    white    broaden    neurotransmitter    tone    drive    interests    hypothesis    tissue    neural    leader    data    prof    deleterious    supervision    critical    found    utilized    brain    fellowship    global    brown    opportunity    plays    generation    laboratory    expertise    marie    msc    weight    university    platform    bat    aberdeen    me    thermogenic    thermoregulation    underpinnings    hypothalamus    node    construct    metabolism    region    browning    trained    ventromedial    ee    energy    rpa    ht    inducing    expenditure    neurochemical    definitively    adipose    sklodowska    body    nutrition    input    indicate    2014    cell    career    century    engineered    raphe    diabetes    preliminary    supply    perform    nicotine    arguably    network    human    wat    decrease    transferable    estrogen    lora    communicator    receiving    form    transmitting    2012   

Project "NeuroEE" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN 

Organization address
address: KING'S COLLEGE REGENT WALK
city: ABERDEEN
postcode: AB24 3FX
website: http://www.abdn.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.abdn.ac.uk/rowett/research/index.php
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2018-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN UK (ABERDEEN) coordinator 195˙454.00

Map

 Project objective

Obesity is now a global epidemic with a significant and deleterious impact on human health. My career aim is to clarify the neural underpinnings of energy expenditure (EE) given that this makes a significant contribution to body weight. During my early career, I discovered a circuit linking the ventromedial hypothalamus (VMH) to brown adipose tissue (BAT) and inducing thermogenic beige (browning) white adipose tissue (WAT), regulating EE. Moreover, I found that the VMH-BAT axis is utilized by estrogen (Cell Metabolism, 2014) and nicotine (Diabetes, 2012) to increase EE and decrease body weight. My preliminary data indicate that a critical node between the VMH and BAT is the raphe pallidus (RPa), a brain region known to drive sympathetic tone to BAT. My immediate career aim is to clarify the neurochemical communicator receiving the VMH-EE related input and transmitting to BAT and browning. Given that the RPa is rich in the neurotransmitter 5-hydroxytryptamine (5-HT) which plays a role in thermoregulation, I hypothesize that 5-HT is a crucial component of my circuit. I propose to perform a Marie Sklodowska-Curie Fellowship (MSC) under Prof Lora Heisler’s supervision, arguably the global leader in 5-HT obesity research. Her laboratory is in the Rowett Institute of Nutrition and Health, University of Aberdeen, an Institute with more than a century of focused state-of-the-art obesity and nutrition research. This will supply an optimal environment for a MSC providing me with the opportunity to broaden my research interests, and allowing me to construct an international network of obesity researchers. A MSC will also provide the opportunity for me to be trained in transferable next generation engineered genetic technology that will allow me to rigorously and definitively test my current research hypothesis and to provide state-of-the-art expertise that will form a platform for my future career. 5-HT, brown adipose tissue, browning, raphe pallidus, ventromedial hypothalamus

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The information about "NEUROEE" are provided by the European Opendata Portal: CORDIS opendata.

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