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NeuroEE SIGNED

Delineation of a brain circuit regulating energy expenditure to impact body weight

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NeuroEE project word cloud

Explore the words cloud of the NeuroEE project. It provides you a very rough idea of what is the project "NeuroEE" about.

neurochemical    platform    communicator    university    regulating    career    arguably    node    brown    supervision    thermogenic    nutrition    laboratory    curie    bat    perform    brain    pallidus    expenditure    decrease    rigorously    critical    axis    vmh    environment    broaden    ht    international    rpa    sklodowska    clarify    inducing    browning    wat    lora    beige    energy    2014    contribution    utilized    ee    global    hypothesis    transferable    century    body    weight    underpinnings    trained    data    hydroxytryptamine    aberdeen    cell    plays    definitively    drive    heisler    neural    network    human    diabetes    thermoregulation    generation    nicotine    tone    deleterious    health    expertise    linking    hypothalamus    optimal    indicate    ventromedial    discovered    me    supply    estrogen    engineered    fellowship    receiving    white    2012    metabolism    form    tissue    marie    epidemic    transmitting    region    raphe    neurotransmitter    sympathetic    interests    genetic    msc    prof    circuit    opportunity    hypothesize    adipose    obesity    leader    rowett    input    found    construct    preliminary   

Project "NeuroEE" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN 

Organization address
address: KING'S COLLEGE REGENT WALK
city: ABERDEEN
postcode: AB24 3FX
website: http://www.abdn.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.abdn.ac.uk/rowett/research/index.php
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2018-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN UK (ABERDEEN) coordinator 195˙454.00

Map

 Project objective

Obesity is now a global epidemic with a significant and deleterious impact on human health. My career aim is to clarify the neural underpinnings of energy expenditure (EE) given that this makes a significant contribution to body weight. During my early career, I discovered a circuit linking the ventromedial hypothalamus (VMH) to brown adipose tissue (BAT) and inducing thermogenic beige (browning) white adipose tissue (WAT), regulating EE. Moreover, I found that the VMH-BAT axis is utilized by estrogen (Cell Metabolism, 2014) and nicotine (Diabetes, 2012) to increase EE and decrease body weight. My preliminary data indicate that a critical node between the VMH and BAT is the raphe pallidus (RPa), a brain region known to drive sympathetic tone to BAT. My immediate career aim is to clarify the neurochemical communicator receiving the VMH-EE related input and transmitting to BAT and browning. Given that the RPa is rich in the neurotransmitter 5-hydroxytryptamine (5-HT) which plays a role in thermoregulation, I hypothesize that 5-HT is a crucial component of my circuit. I propose to perform a Marie Sklodowska-Curie Fellowship (MSC) under Prof Lora Heisler’s supervision, arguably the global leader in 5-HT obesity research. Her laboratory is in the Rowett Institute of Nutrition and Health, University of Aberdeen, an Institute with more than a century of focused state-of-the-art obesity and nutrition research. This will supply an optimal environment for a MSC providing me with the opportunity to broaden my research interests, and allowing me to construct an international network of obesity researchers. A MSC will also provide the opportunity for me to be trained in transferable next generation engineered genetic technology that will allow me to rigorously and definitively test my current research hypothesis and to provide state-of-the-art expertise that will form a platform for my future career. 5-HT, brown adipose tissue, browning, raphe pallidus, ventromedial hypothalamus

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