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MultiNav

Multisensory Navigation: Harnessing the Power of Multisensory Processing Optogenetic Stimulation to Aid The Blind

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MultiNav" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.ru.nl/neurophysiology/research/our_research/
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 177˙598.00

Map

 Project objective

In Europe 30M people are visually impaired (VI), 2.5M of which are entirely blind. Despite many efforts on the societal level, VIs are still ‘left in the dark’, when it comes to independent navigation. Neuroscience has the long-term potential to provide brain-prostheses, which circumvent damaged parts of the visual system. In the present project, we will investigate how spatial information can assist VIs during navigation by non-invasive and invasive information delivery. We will make use of multisensory integration and optogenetic stimulation to investigate these questions in an animal model of navigation in the dark. Mice use their sensory hairs (‘whiskers’) analogous to how VIs use their cane for exploring their local surroundings. During this tactile navigation VIs also utilize the sound generated by their cane to provide both spatial and material information about their surroundings, evidence for a multisensory strategy. Specifically we will first investigate the effect of multisensory information on the neural representation of tactile information during natural exploratory behaviour. For this purpose we will provide sounds rapidly (<1ms) in sync with each surface contact of the whisker. These sounds are modulated by the animal’s distance to the object or will provide contextually relevant spatial information (e.g. distant targets). We predict that even soft auditory information will boost the usefulness of tactile information (‘inverse effectiveness’) and allow faster behavioural judgments in a spatial task. Next, we will provide spatial information directly to the tactile cortex using optogenetic stimulation, emulating the functioning of future, spatial brain prostheses. We predict that animals will learn to integrate this additional information to optimize their navigation success. In summary, our research will contribute to providing navigation information to VIs non-invasively and invasively, and thus further the ongoing efforts of inclusion in Europe.

 Publications

year authors and title journal last update
List of publications.
2017 Yves Boubenec, Jennifer Lawlor, Urszula Górska, Shihab Shamma, Bernhard Englitz
Detecting changes in dynamic and complex acoustic environments
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.24910
eLife 6 2019-07-24
2016 Chao Huang, Andrey Resnik, Tansu Celikel, Bernhard Englitz
Adaptive Spike Threshold Enables Robust and Temporally Precise Neuronal Encoding
published pages: e1004984, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1004984
PLOS Computational Biology 12/6 2019-07-24
2017 Jesse J. Heckman, R?mi Proville, Gert J. Heckman, Alireza Azarfar, Tansu Celikel, Bernhard Englitz
High-precision spatial localization of mouse vocalizations during social interaction
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-02954-z
Scientific Reports 7/1 2019-07-24
2016 Christian Keine, Rudolf R?bsamen, Bernhard Englitz
Inhibition in the auditory brainstem enhances signal representation and regulates gain in complex acoustic environments
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.19295
eLife 5 2019-07-24
2016 Jesse Heckman, Brigit McGuinness, Tansu Celikel, Bernhard Englitz
Determinants of the mouse ultrasonic vocal structure and repertoire
published pages: 313–325, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2016.03.029
Neuroscience and Biobehavioral Reviews 65 2019-07-24

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The information about "MULTINAV" are provided by the European Opendata Portal: CORDIS opendata.

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