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CP-RehOP

Responding or not responding to training; prediction of balance rehabilitation outcome from structural and functional brain networks in Cerebral Palsy.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 CP-RehOP project word cloud

Explore the words cloud of the CP-RehOP project. It provides you a very rough idea of what is the project "CP-RehOP" about.

mixed    neuroplastic    combined    treatment    muscle    risk    basic    resting    tool    abnormal    disability    assessments    prevalence    effectiveness    sensorimotor    balance    depends    postural    medical    world    births    quality    live    gait    life    responsive    occurs    kurtosis    unknown    measuring    experiment    underlying    cerebral    magnetic    falls    images    primary    neural    fundamental    weakness    clinical    networks    innovative    child    diagnose    palsy    daily    first    diagnostic    imaging    diffusion    causes    machine    training    developmental    independent    revealed    children    suggested    scales    hypothesized    insights    provides    cp    experimental    neurological    injury    examine    prediction    behavioral    when    functional    combination    physical    deficit    resonance    learning    rehabilitation    imbalance    structural    components    individual    identification    responsiveness    disorders    brain    poor    1000    ataxia    mobility   

Project "CP-RehOP" data sheet

The following table provides information about the project.

Coordinator
STICHTING VUMC 

Organization address
address: DE BOELELAAN 1117
city: AMSTERDAM
postcode: 1081 HV
website: www.vumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website https://www.vumc.nl/afdelingen/revalidatiegeneeskunde/map/CP-RehOP/
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VUMC NL (AMSTERDAM) coordinator 177˙598.00
2    STICHTING VU NL (AMSTERDAM) participant 0.00

Map

 Project objective

When an injury occurs to the developing brain, as in Cerebral Palsy (CP), these children typically experience sensorimotor disorders such as muscle weakness, abnormal muscle activity, and ataxia. Poor balance control is a primary deficit in CP, which has a large impact on a child’s daily life, since it is crucial for independent mobility and greatly affects the risk of falls. CP is the most common developmental cause of physical disability in the world, with a prevalence of 2-3 in 1000 live births. To improve their quality of life, adequate treatment is essential. However, studies investigating the effectiveness of balance rehabilitation in CP have revealed mixed results. This is due to two reasons. First, due to the various clinical scales and experimental measures available, each measuring different components of balance, it is very complex to diagnose balance control in CP. Second, it is currently unknown which are the underlying neural causes of poor balance control in CP. Since the success of well-targeted treatment depends on this basic knowledge, a novel experiment is suggested that provides fundamental insights in both areas. I will investigate whether balance training can promote postural and gait balance control in CP children. Clinical and experimental measures will be combined to allow for the determination of the best diagnostic tool for imbalance in CP. Using diffusion kurtosis imaging and resting state functional magnetic resonance imaging, I will examine the structural and functional brain networks involved in balance control in CP and whether advances in balance control are supported by neuroplastic changes. As some children will be less responsive to training, it is hypothesized that this innovative combination of behavioral and neurological assessments allows for the identification of the underlying causes of responsiveness, and, most importantly, the prediction of individual responsiveness based on medical brain images, using machine learning.

 Publications

year authors and title journal last update
List of publications.
2017 Pieter Meyns, Jaap Harlaar, Laura van de Pol, Frederik Barkhof, Annemieke Buizer
Can Virtual Reality games improve scores on clinical balance scales in children with cerebral palsy: preliminary results of a randomized controlled clinical trial
published pages: 234-235, ISSN: 0966-6362, DOI: 10.1016/j.gaitpost.2017.06.390
Gait & Posture 57 2019-07-24

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The information about "CP-REHOP" are provided by the European Opendata Portal: CORDIS opendata.

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