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MolNANOtox SIGNED

Nanomaterial surface interactions at the molecular level and their impact on ecotoxicity

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MolNANOtox" data sheet

The following table provides information about the project.

Coordinator
UNITED KINGDOM RESEARCH AND INNOVATION 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country United Kingdom [UK]
 Project website https://www.ceh.ac.uk/our-science/science-areas/pollution
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-05   to  2018-03-18

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNITED KINGDOM RESEARCH AND INNOVATION UK (SWINDON) coordinator 195˙454.00
2    NATURAL ENVIRONMENT RESEARCH COUNCIL UK (SWINDON WILTSHIRE) coordinator 0.00

Map

 Project objective

As nanotechnology continues to advance at an exponential rate, new products are continuously introduced into the market for research and consumer use. Engineered nanomaterials (ENMs), the functional components in these products, are often specifically designed to exploit the unique properties that nanomaterials exhibit; however, there is a widespread uncertainty on how these new properties may also potentially translate into novel risk issues in the environment. In particular, their high specific surface area and surface reactivity may promote distinct interactions with organisms particularly at the lower trophic levels. This can depend on both the intrinsic and extrinsic properties of ENMs, and can be affected by the formation of an “eco-corona”, which is composed of environmentally derived macromolecules from the milieu in which the ENMs are exposed that adsorb to the ENMs surface. However, understanding these interactions at the molecular level and their mechanistic consequences are severely limited and technically challenging, requiring a cross discipline approach. This project aims to address this knowledge gap by uncovering the underlying mechanisms for the formation and persistence of eco-coronas on a range of ENMs by combining fundamental ENM chemistry, environmental toxicology, advanced optical and mass spectroscopy and imaging techniques. In particular, this project will apply surface enhanced spectroscopic methods to characterise eco-corona composition and evolution and how this affects ENM interactions with, and impact upon unicellular organisms. By correlating the eco-corona composition with uptake route (or accumulation at external membrane) and toxicity response, and by investigating how these ENMs are partitioned within model species, the project proposes to identify the molecular basis that determines the fate and toxicology of ENMs in the environment.

 Publications

year authors and title journal last update
List of publications.
2017 Ryo Sekine, Katie L. Moore, Marianne Matzke, Pascal Vallotton, Haibo Jiang, Gareth M. Hughes, Jason K. Kirby, Erica Donner, Chris R. M. Grovenor, Claus Svendsen, Enzo Lombi
Complementary Imaging of Silver Nanoparticle Interactions with Green Algae: Dark-Field Microscopy, Electron Microscopy, and Nanoscale Secondary Ion Mass Spectrometry
published pages: 10894-10902, ISSN: 1936-0851, DOI: 10.1021/acsnano.7b04556
ACS Nano 11/11 2019-06-18
2017 Ryo Sekine, Ezzat R. Marzouk, Maryam Khaksar, Kirk G. Scheckel, John P. Stegemeier, Gregory V. Lowry, Erica Donner, Enzo Lombi
Aging of Dissolved Copper and Copper-based Nanoparticles in Five Different Soils: Short-term Kinetics vs. Long-term Fate
published pages: 1198, ISSN: 0047-2425, DOI: 10.2134/jeq2016.12.0485
Journal of Environment Quality 46/6 2019-06-18

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The information about "MOLNANOTOX" are provided by the European Opendata Portal: CORDIS opendata.

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