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Lx Micelles

Coordination chemistry in doubly stabilized micelles for the tageted delivery of cytostatic drugs in cancer therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Lx Micelles project word cloud

Explore the words cloud of the Lx Micelles project. It provides you a very rough idea of what is the project "Lx Micelles" about.

training    hybrid    intracellular    blood    advantages    enhanced    transfer    core    competitive    constituting    ease    pursuing    act    bioresorbable    accumulate    retention    micelles    stabilizer    tissue    coordinative    vivo    crosslinking    stability    biodistribution    stream    toxicity    introducing    significantly    crosslink    release    effect    negligible    treatment    cancer    platinum    linker    glutathione    stable    sites    polymeric    reduce    reversible    conjugation    onto    researcher    complementarity    amount    transdisciplinary    molecule    broaden    permeability    tumor    dose    deposited    limiting    lively    versatility    fast    therapy    lx    prolonged    mobility    circulation    molecules    polymer    micelle    chemotherapeutic    displacement    therapeutic    loaded    released    showed    cytoplasm    transnational    safe    powerful    nanometer    scientific    drugs    insufficient    intracellularly    skills    severe    excellent    drug    tolerated    functions    fellowship    destabilized    sized   

Project "Lx Micelles" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 173˙076.00

Map

 Project objective

The treatment of cancer with chemotherapeutic drugs is very often associated with severe side effects limiting their tolerated dose and leading to insufficient therapeutic effects. The application of such drugs in nanometer-sized micelles may improve their biodistribution, but in vivo studies showed fast drug release in the blood stream. We aim for prolonged drug retention and intracellular release by introducing the stable, yet reversible Lx linker in the core of bioresorbable polymeric micelles. This coordinative platinum linker will have two functions: (1) it will facilitate the stable conjugation between the drug molecule and the polymer molecules constituting the micelle and (2) it will act as a stabilizer between the polymer molecules constituting the micelle. This will result in excellent stability of the drug-loaded micelles in circulation. Due to the enhanced permeability and retention effect the micelles will accumulate in tumor tissue, where they will be destabilized intracellularly and the drugs will be released from the linker in the cytoplasm after competitive glutathione displacement. The Lx linker presents various advantages over other crosslink methods, such as versatility and ease of crosslinking. No platinum-related toxicity was observed in vivo for the linker in previous research. In addition, the amount of platinum may be considered negligible since powerful drugs will be loaded onto the micelles. This approach represents a safe and unique hybrid method which has the potential to significantly increase the amount of drug deposited at the target tissue and to reduce side effects at non-target sites. By pursuing this significant step forward in cancer therapy, the fellowship will broaden the Experienced Researcher’s scientific and non-scientific skills via advanced training as well as transnational and transdisciplinary mobility. Furthermore, it will facilitate a lively transfer of knowledge between the participants due to their complementarity.

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