Opendata, web and dolomites

Lx Micelles

Coordination chemistry in doubly stabilized micelles for the tageted delivery of cytostatic drugs in cancer therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Lx Micelles project word cloud

Explore the words cloud of the Lx Micelles project. It provides you a very rough idea of what is the project "Lx Micelles" about.

tissue    severe    act    complementarity    effect    nanometer    mobility    transnational    skills    safe    stable    significantly    deposited    vivo    glutathione    linker    powerful    dose    crosslinking    toxicity    scientific    permeability    release    polymeric    conjugation    lively    retention    treatment    introducing    destabilized    amount    functions    therapy    researcher    onto    loaded    advantages    coordinative    constituting    stabilizer    prolonged    molecule    insufficient    chemotherapeutic    versatility    intracellular    fast    transdisciplinary    cytoplasm    therapeutic    excellent    biodistribution    drugs    reduce    accumulate    blood    displacement    molecules    fellowship    transfer    core    released    micelle    hybrid    drug    pursuing    training    limiting    enhanced    competitive    lx    bioresorbable    tolerated    broaden    intracellularly    reversible    polymer    showed    ease    tumor    cancer    micelles    stability    platinum    circulation    crosslink    sized    stream    sites    negligible   

Project "Lx Micelles" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 173˙076.00

Map

 Project objective

The treatment of cancer with chemotherapeutic drugs is very often associated with severe side effects limiting their tolerated dose and leading to insufficient therapeutic effects. The application of such drugs in nanometer-sized micelles may improve their biodistribution, but in vivo studies showed fast drug release in the blood stream. We aim for prolonged drug retention and intracellular release by introducing the stable, yet reversible Lx linker in the core of bioresorbable polymeric micelles. This coordinative platinum linker will have two functions: (1) it will facilitate the stable conjugation between the drug molecule and the polymer molecules constituting the micelle and (2) it will act as a stabilizer between the polymer molecules constituting the micelle. This will result in excellent stability of the drug-loaded micelles in circulation. Due to the enhanced permeability and retention effect the micelles will accumulate in tumor tissue, where they will be destabilized intracellularly and the drugs will be released from the linker in the cytoplasm after competitive glutathione displacement. The Lx linker presents various advantages over other crosslink methods, such as versatility and ease of crosslinking. No platinum-related toxicity was observed in vivo for the linker in previous research. In addition, the amount of platinum may be considered negligible since powerful drugs will be loaded onto the micelles. This approach represents a safe and unique hybrid method which has the potential to significantly increase the amount of drug deposited at the target tissue and to reduce side effects at non-target sites. By pursuing this significant step forward in cancer therapy, the fellowship will broaden the Experienced Researcher’s scientific and non-scientific skills via advanced training as well as transnational and transdisciplinary mobility. Furthermore, it will facilitate a lively transfer of knowledge between the participants due to their complementarity.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "LX MICELLES" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "LX MICELLES" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ICARUS (2020)

Information Content of locAlisation: fRom classical to qUantum Systems

Read More  

Mel.Photo.Protect (2019)

Unraveling the Photoprotecting Mechanism of Melanin - From a Library of Fragments to Simulation of Spectra and Function

Read More  

CoCoNat (2019)

Coordination in constrained and natural distributed systems

Read More