Explore the words cloud of the G4invivo project. It provides you a very rough idea of what is the project "G4invivo" about.
The following table provides information about the project.
|Coordinator Country||Denmark [DK]|
|Total cost||212˙194 €|
|EC max contribution||212˙194 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2016-01-01 to 2017-12-31|
Take a look of project's partnership.
|1||AARHUS UNIVERSITET||DK (AARHUS C)||coordinator||212˙194.00|
Telomeres, the ends of linear eukaryotic chromosomes, are one of the most versatile “molecular machines” of life. They perform a vital role in several fundamental processes in biology, as maintenance of genome integrity and the regulation of cell growth. Human telomeric DNA consists of thousands of tandem repeats of guanine-rich sequences, terminating the chromosomes. Under physiological conditions, such guanine-rich repeats are capable of adopting four stranded structures, called G-quadruplex DNA. Considerable research has been dedicated to an understanding of functions of telomeres, and during the past decades, much progress has been made towards identifying the underlying processes for G-quadruplex DNA isolated in vitro. However, most of our knowledge of conformation and mechanistic understanding of the balance between the structure and function of telomeric DNA inside cells has remained very limited, largely due to a lack of suitable methods. An opportunity to bridge this gap is single-molecule fluorescence microscopy in combination with Förster resonance energy transfer (FRET), a powerful technique that allows distances, distance distributions, and dynamics of individual biological molecules to be measured even in complex and heterogeneous environments, as cellular milieu. The goal of this project is to employ such optical single-molecule techniques to perform a comprehensive biophysical analysis of the folding and dynamics of G-quadruplex DNA within live cells. This investigation will provide an idea of how accurately our current understanding of the folding and dynamics of G-quadruplex DNA in vitro describes the situation inside the living cell, and will, among other aspects, be crucial for understanding the biological functions of G-quadruplexes and in particular may stimulate the enhancement of the efficacy of the novel anticancer therapies, which use these structures as an active target for drug development.
|year||authors and title||journal||last update|
Andreas Sprengel, Pascal Lill, Pierre Stegemann, Kenny Bravo-Rodriguez, Elisa-C. SchÃ¶neweiÃŸ, Melisa Merdanovic, Daniel Gudnason, Mikayel Aznauryan, Lisa Gamrad, Stephan Barcikowski, Elsa Sanchez-Garcia, Victoria Birkedal, Christos Gatsogiannis, Michael Ehrmann, Barbara SaccÃ
Tailored protein encapsulation into a DNA host using geometrically organized supramolecular interactions
published pages: 14472, ISSN: 2041-1723, DOI: 10.1038/ncomms14472
|Nature Communications 8||2019-06-18|
Mikayel Aznauryan, Siri SÃ¸ndergaard, Sofie L. Noer, Birgit SchiÃ¸tt, Victoria Birkedal
A direct view of the complex multi-pathway folding of telomeric G-quadruplexes
published pages: 11024-11032, ISSN: 0305-1048, DOI: 10.1093/nar/gkw1010
|Nucleic Acids Research 44/22||2019-06-18|
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