MorphoVES-PoC
Morphogenetically active blood vessels: Proof-of-Concept
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the MorphoVES-PoC project. It provides you a very rough idea of what is the project "MorphoVES-PoC" about.
Project "MorphoVES-PoC" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Total cost | 149˙962 € |
| EC max contribution | 149˙962 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-PoC |
| Funding Scheme | ERC-POC |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-04-01 to 2016-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ | DE (Mainz) | coordinator | 149˙962.00 |
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Project objective
'Cardiovascular diseases are the leading causes of mortality in Europe and worldwide. Currently, synthetic prostheses used in bypass vascular surgery are produced from polyethylene terephthalate [PET] and expanded polytetrafluoroethylene [ePTFE]. Those materials show less than optimal, insufficient biocompatibility and durability properties, especially if used for SMALL DIAMETER BLOOD VESSELS. Within the frame of ERC Advanced Grant “BIOSILICA” (From gene to biomineral: Biosynthesis and application of sponge biosilica; Grant No. 268476), we unexpectedly discovered that distinct natural, biodegradable and biofunctional polymers, including biosilica and inorganic polyphosphate (anionic), are not only bio-printable but also morphogenetically active. Likewise attractive is that those biopolymers can be functionally processed by non-toxic and charged (cationic) linkers with growth/differentiation potencies. Therefore, these formulations, backbone polymers and bioactive linkers, allowed the fabrication of unprecedented “Modular Small Diameter Vascular Grafts (MSDVGs)' which combine in an optimal way physical strength with physiological activity. Furthermore, the fabrication of the synthetic vessels is performed by a home-made, easy to handle, extruder device which has been developed by our group. Therefore, this new ERC-PoC project will provide small diameter (< 6 mm) blood vessel implants (incl. the fabrication device - the extruder) urgently required in clinics, with superior properties and at low-costs, at the end of the project. We are definitively convinced that, in view of their advantages, our vessels will be preferentially used for patients requiring bypass surgery. The experimental data gathered disclose that we have in hand a product with a clear biomedical application potential. Besides of their economical value, our new type of artificial blood vessel will certainly improve the quality of life and well-being of patients with cardiovascular disorders.'
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2016 |
Werner E. G. Müller, Maximilian Ackermann, Emad Tolba, Meik Neufurth, Shunfeng Wang, Heinz C. Schröder, Xiaohong Wang A bio-imitating approach to fabricate an artificial matrix for cartilage tissue engineering using magnesium-polyphosphate and hyaluronic acid published pages: 88559-88570, ISSN: 2046-2069, DOI: 10.1039/C6RA17043A |
RSC Adv. 6/91 | 2019-07-24 |
| 2015 |
Meik Neufurth, Xiaohong Wang, Emad Tolba, Bernhard Dorweiler, Heinz C. Schröder, Thorben Link, Bärbel Diehl-Seifert, Werner E. G. Müller Modular Small Diameter Vascular Grafts with Bioactive Functionalities published pages: e0133632, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0133632 |
PLOS ONE 10/7 | 2019-07-24 |
| 2016 |
Xiaohong Wang, Heinz C. Schröder, Werner E. G. Müller Polyphosphate as a metabolic fuel in Metazoa: A foundational breakthrough invention for biomedical applications published pages: 11-30, ISSN: 1860-6768, DOI: 10.1002/biot.201500168 |
Biotechnology Journal 11/1 | 2019-07-24 |
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