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MorphoVES-PoC

Morphogenetically active blood vessels: Proof-of-Concept

Total Cost €

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EC-Contrib. €

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Partnership

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 MorphoVES-PoC project word cloud

Explore the words cloud of the MorphoVES-PoC project. It provides you a very rough idea of what is the project "MorphoVES-PoC" about.

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Project "MorphoVES-PoC" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ 

Organization address
address: Langenbeckstrasse 1
city: Mainz
postcode: 55131
website: http://www.um-mainz.de/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 149˙962 €
 EC max contribution 149˙962 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2016-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ DE (Mainz) coordinator 149˙962.00

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 Project objective

'Cardiovascular diseases are the leading causes of mortality in Europe and worldwide. Currently, synthetic prostheses used in bypass vascular surgery are produced from polyethylene terephthalate [PET] and expanded polytetrafluoroethylene [ePTFE]. Those materials show less than optimal, insufficient biocompatibility and durability properties, especially if used for SMALL DIAMETER BLOOD VESSELS. Within the frame of ERC Advanced Grant “BIOSILICA” (From gene to biomineral: Biosynthesis and application of sponge biosilica; Grant No. 268476), we unexpectedly discovered that distinct natural, biodegradable and biofunctional polymers, including biosilica and inorganic polyphosphate (anionic), are not only bio-printable but also morphogenetically active. Likewise attractive is that those biopolymers can be functionally processed by non-toxic and charged (cationic) linkers with growth/differentiation potencies. Therefore, these formulations, backbone polymers and bioactive linkers, allowed the fabrication of unprecedented “Modular Small Diameter Vascular Grafts (MSDVGs)' which combine in an optimal way physical strength with physiological activity. Furthermore, the fabrication of the synthetic vessels is performed by a home-made, easy to handle, extruder device which has been developed by our group. Therefore, this new ERC-PoC project will provide small diameter (< 6 mm) blood vessel implants (incl. the fabrication device - the extruder) urgently required in clinics, with superior properties and at low-costs, at the end of the project. We are definitively convinced that, in view of their advantages, our vessels will be preferentially used for patients requiring bypass surgery. The experimental data gathered disclose that we have in hand a product with a clear biomedical application potential. Besides of their economical value, our new type of artificial blood vessel will certainly improve the quality of life and well-being of patients with cardiovascular disorders.'

 Publications

year authors and title journal last update
List of publications.
2016 Werner E. G. Müller, Maximilian Ackermann, Emad Tolba, Meik Neufurth, Shunfeng Wang, Heinz C. Schröder, Xiaohong Wang
A bio-imitating approach to fabricate an artificial matrix for cartilage tissue engineering using magnesium-polyphosphate and hyaluronic acid
published pages: 88559-88570, ISSN: 2046-2069, DOI: 10.1039/C6RA17043A
RSC Adv. 6/91 2019-07-24
2015 Meik Neufurth, Xiaohong Wang, Emad Tolba, Bernhard Dorweiler, Heinz C. Schröder, Thorben Link, Bärbel Diehl-Seifert, Werner E. G. Müller
Modular Small Diameter Vascular Grafts with Bioactive Functionalities
published pages: e0133632, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0133632
PLOS ONE 10/7 2019-07-24
2016 Xiaohong Wang, Heinz C. Schröder, Werner E. G. Müller
Polyphosphate as a metabolic fuel in Metazoa: A foundational breakthrough invention for biomedical applications
published pages: 11-30, ISSN: 1860-6768, DOI: 10.1002/biot.201500168
Biotechnology Journal 11/1 2019-07-24

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