Explore the words cloud of the HybridMiX project. It provides you a very rough idea of what is the project "HybridMiX" about.
The following table provides information about the project.
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
|Coordinator Country||Germany [DE]|
|Total cost||1˙499˙923 €|
|EC max contribution||1˙499˙923 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-08-01 to 2020-07-31|
Take a look of project's partnership.
|1||MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV||DE (Munich)||coordinator||1˙499˙923.00|
Discovering the genetic changes underlying species differences is a central goal in evolutionary genetics. Most evolutionarily important traits affecting fitness are complex or quantitative traits, whose genetic bases are elusive. In mammals, dissecting the genetic basis of complex trait variation is particularly challenging, because efficient genetic mapping requires enormous pedigrees or specialized genetic panels that are typically beyond the resources of individual groups. Using a radically novel method to circumvent breeding limitations by “breeding” mice in vitro, I propose to dissect the genetic basis of evolutionary developmental variation. This ground-breaking approach will allow me to create large genetic mapping panels of potentially any size from mouse interspecific hybrids of increasing evolutionary divergence. In vitro crosses promise a breakthrough in evolutionary biology: by bypassing hybrid sterility and inviability, we will ask which genetic changes underlie species differences. The proposed experiments address how genetic changes accumulate during evolution of new species to shape gene regulatory networks and cause phenotypic changes at the gene expression, fitness and organismal level. This research has the potential to revolutionize genetic mapping. If realized, its impact on personalized medicine, agricultural science and evolutionary research cannot be understated.
|year||authors and title||journal||last update|
Andreea DrÃ©au, Vrinda Venu, Elena Avdievich, Ludmila Gaspar, Felicity C. Jones
Genome-wide recombination map construction from single individuals using linked-read sequencing
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12210-9
|Nature Communications 10/1||2020-04-03|
Stefano Lazzarano, Marek KuÄka, JoÃ£o P. L. Castro, Ronald Naumann, Paloma Medina, Michael N. C. Fletcher, Rebecka Wombacher, Joost Gribnau, Tino Hochepied, Marc Van Montagu, Claude Libert, Yingguang Frank Chan
Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells
published pages: 201717474, ISSN: 0027-8424, DOI: 10.1073/pnas.1717474115
|Proceedings of the National Academy of Sciences||2019-05-28|
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The information about "HYBRIDMIX" are provided by the European Opendata Portal: CORDIS opendata.
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