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HybridMiX SIGNED

Genetic Mapping of Evolutionary Developmental Variation using Hybrid Mouse in vitro Crosses

Total Cost €

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EC-Contrib. €

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Partnership

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Project "HybridMiX" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙499˙923 €
 EC max contribution 1˙499˙923 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2020-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 1˙499˙923.00

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 Project objective

Discovering the genetic changes underlying species differences is a central goal in evolutionary genetics. Most evolutionarily important traits affecting fitness are complex or quantitative traits, whose genetic bases are elusive. In mammals, dissecting the genetic basis of complex trait variation is particularly challenging, because efficient genetic mapping requires enormous pedigrees or specialized genetic panels that are typically beyond the resources of individual groups. Using a radically novel method to circumvent breeding limitations by “breeding” mice in vitro, I propose to dissect the genetic basis of evolutionary developmental variation. This ground-breaking approach will allow me to create large genetic mapping panels of potentially any size from mouse interspecific hybrids of increasing evolutionary divergence. In vitro crosses promise a breakthrough in evolutionary biology: by bypassing hybrid sterility and inviability, we will ask which genetic changes underlie species differences. The proposed experiments address how genetic changes accumulate during evolution of new species to shape gene regulatory networks and cause phenotypic changes at the gene expression, fitness and organismal level. This research has the potential to revolutionize genetic mapping. If realized, its impact on personalized medicine, agricultural science and evolutionary research cannot be understated.

 Publications

year authors and title journal last update
List of publications.
2019 Andreea Dréau, Vrinda Venu, Elena Avdievich, Ludmila Gaspar, Felicity C. Jones
Genome-wide recombination map construction from single individuals using linked-read sequencing
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12210-9
Nature Communications 10/1 2020-04-03
2018 Stefano Lazzarano, Marek Kučka, João P. L. Castro, Ronald Naumann, Paloma Medina, Michael N. C. Fletcher, Rebecka Wombacher, Joost Gribnau, Tino Hochepied, Marc Van Montagu, Claude Libert, Yingguang Frank Chan
Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells
published pages: 201717474, ISSN: 0027-8424, DOI: 10.1073/pnas.1717474115
Proceedings of the National Academy of Sciences 2019-05-28

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