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NanoSmell SIGNED

NanoSmells: Artificial remote-controlled odorants

Total Cost €

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EC-Contrib. €

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Partnership

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Project "NanoSmell" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website http://www.nanosmell.org
 Total cost 3˙979˙069 €
 EC max contribution 3˙979˙069 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2014-2015-RIA
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 1˙019˙156.00
2    AUGMANITY NANO LTD IL (REHOVOT) participant 892˙219.00
3    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 844˙610.00
4    UNIVERSITE DE GENEVE CH (GENEVE) participant 713˙524.00
5    UNIVERSIDAD CARLOS III DE MADRID ES (GETAFE (MADRID)) participant 509˙560.00
6    BAR ILAN UNIVERSITY IL (RAMAT GAN) participant 0.00

Map

 Project objective

'Despite years of promise, an odor-emitting component in devices such as televisions, phones, computers and more has yet to be developed. Two major obstacles in the way of such development are poor understanding of the olfactory code (the link between odorant structure, neural activity, and odor perception), and technical inability to emit odors in a reversible manner. Here we propose a novel multidisciplinary path to solving this basic scientific question (the code), and in doing so generate a solution to the technical limitation (controlled odor emission). The Bachelet lab will design DNA strands that assume a 3D structure that will specifically bind to a single type of olfactory receptor and induce signal transduction. These DNA-based 'artificial odorants' will be tagged with a nanoparticle that changes their conformation in response to an external electromagnetic field. Thus, we will have in hand an artificial odorant that is remotely switchable. The Hansson lab will use tissue culture cells expressing insect olfactory receptors, functional imaging, and behavioral tests to validate the function and selectivity of these switchable odorants in insects. The Carleton lab will use imaging in order to investigate the patterns of neural activity induced by these artificial odorants in rodents. The Sobel lab will apply these artificial odorants to the human olfactory system, and measure perception and neural activity following switching the artificial smell on and off. Finally, given a potential role for olfactory receptors in skin, the Del Rio lab will test the efficacy of these artificial odorants in promoting wound healing. At the basic science level, this approach may allow solving the combinatorial code of olfaction. At the technology level, beyond novel pharmacology, we will provide proof-of-concept for countless novel applications ranging from insect pest-control to odor-controlled environments and odor-emitting devices such as televisions, phones, and computers.'

 Deliverables

List of deliverables.
Insect trap test Demonstrators, pilots, prototypes 2020-04-07 19:45:52
Final Human response Documents, reports 2020-04-07 19:45:52
Switchable wound treatment Demonstrators, pilots, prototypes 2020-04-07 19:45:51
Rodent bulb maps Websites, patent fillings, videos etc. 2020-04-07 19:45:52
4 submitted manuscripts describing 2.1-2.4 Documents, reports 2020-04-07 19:45:52
Final Fly response Documents, reports 2020-04-07 19:45:52
Final Rodent response Documents, reports 2020-04-07 19:45:51
Human rapidly switching odors (SmelloVision) Demonstrators, pilots, prototypes 2020-04-07 19:45:52
Final Skin response Documents, reports 2020-04-07 19:45:52
Group meetings Websites, patent fillings, videos etc. 2020-04-07 19:45:52
Data management plan (interim) Open Research Data Pilot 2020-04-07 19:45:51
Project website Websites, patent fillings, videos etc. 2020-04-07 19:45:51

Take a look to the deliverables list in detail:  detailed list of NanoSmell deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Anindya S. Bhattacharjee, Sasank Konakamchi, Dmitrij Turaev, Roberto Vincis, Daniel Nunes, Atharva A. Dingankar, Hartwig Spors, Alan Carleton, Thomas Kuner, Nixon M. Abraham
Similarity and Strength of Glomerular Odor Representations Define a Neural Metric of Sniff-Invariant Discrimination Time
published pages: 2966-2978.e5, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.08.015
Cell Reports 28/11 2020-04-07
2016 Tali Weiss, Sagit Shushan, Aharon Ravia, Avital Hahamy, Lavi Secundo, Aharon Weissbrod, Aya Ben-Yakov, Yael Holtzman, Smadar Cohen-Atsmoni, Yehudah Roth, Noam Sobel
From Nose to Brain: Un-Sensed Electrical Currents Applied in the Nose Alter Activity in Deep Brain Structures
published pages: , ISSN: 1047-3211, DOI: 10.1093/cercor/bhw222
Cerebral Cortex 2020-04-07
2016 Gschwend O, Beroud J, Vincis R, Rodriguez I, Carleton A.
Dense encoding of natural odorants by ensembles of sparsely activated neurons in the olfactory bulb
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep36514
Scientific Reports 2020-04-07

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The information about "NANOSMELL" are provided by the European Opendata Portal: CORDIS opendata.

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