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SensApp SIGNED

Super-sensitive detection of Alzheimer’s disease biomarkers in plasma by an innovative droplet split-and-stack approach

Total Cost €

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EC-Contrib. €

0

Partnership

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 SensApp project word cloud

Explore the words cloud of the SensApp project. It provides you a very rough idea of what is the project "SensApp" about.

signal    uses    reaction    dramatically    fluorescence    droplet    optical    elisa    ad    determined    fluid    simply    body    detection    micro    microlitre    routine    hospitalization    sorbent    nowadays    detect    materials    invasive    society    csf    immunoreactions    mother    volumes    sensapp    innovative    diagnosis    plasma    tiny    significantly    immuno    site    electric    fluids    public    lumbar    stack    lod    causing    outstanding    intervention    bench    falls    collection    techniques    vital    variety    puncture    sub    droplets    disease    microscale    lay    assay    industrial    drop    alzheimer    requiring    below    sensor    polar    mentioned    cerebrospinal    fail    enzyme    abundant    limit    super    foundations    immunoassay    biomarkers    molecules    accumulate    concentration    limits    avoiding    leadership    blood    dss    solid    linked    welfare    health    split    diffusion    unfortunately    biomarker    patient    automated    clinical    peripheral   

Project "SensApp" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 3˙287˙562 €
 EC max contribution 3˙287˙562 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 831˙562.00
2    Teknologian tutkimuskeskus VTT Oy FI (Espoo) participant 762˙477.00
3    VRIJE UNIVERSITEIT BRUSSEL BE (BRUSSEL) participant 654˙200.00
4    GINOLIS OY FI (OULUNSALO) participant 498˙750.00
5    UNIVERSITAT LINZ AT (LINZ) participant 416˙197.00
6    IRCCS CENTRO NEUROLESI BONINO PULEJO IT (MESSINA) participant 124˙375.00

Map

 Project objective

The detection of biomarkers in body fluids is of great importance for disease early diagnosis. The clinical practice uses typically immunoassay methods (e.g. ELISA, Enzyme-Linked Immuno Sorbent Assay, and related techniques) for biomarker determination. Unfortunately, these techniques fail dramatically in a wide variety of cases where the concentration of biomarkers falls below the limit of detection (LOD). The Alzheimer’s disease (AD) is one real example. Nowadays the AD diagnosis from blood collection is not possible just for the above-mentioned reason. The AD biomarkers are low abundant in blood and they can be determined only in cerebrospinal fluid (CSF), thus requiring a highly invasive intervention on the patient (lumbar puncture) under hospitalization, causing also high costs for the public health. SensApp seeks to develop a bench-top “super-sensor” able to determine low abundant AD biomarkers simply in plasma, from peripheral blood, for very early and non-invasive diagnosis in routine clinical practice. We will develop an outstanding innovative technology that we call droplet split-and-stack (DSS), able to stack the biomarker molecules in sub-microlitre volumes on a solid support before the immunoreactions, thus avoiding diffusion limits and improving significantly the LOD. The super-sensor will be fully automated and cost-effective. An integrated micro-system in polar materials will split the mother drop of the plasma sample in tiny droplets through electric fields and will accumulate them on a microscale site, while an innovative integrated optical system will detect the fluorescence signal directly on the reaction support. SensApp will lay the foundations for a future European industrial leadership involved in all of those clinical studies where the detection of low abundant biomarkers is of vital importance for the welfare of society.

 Deliverables

List of deliverables.
Technical/scientific review meeting 1 documents Documents, reports 2020-04-02 09:34:33
Flyers with project targets and first results and promotional movie Websites, patent fillings, videos etc. 2020-04-02 09:34:19
Logo and webpage Websites, patent fillings, videos etc. 2020-04-02 09:34:02

Take a look to the deliverables list in detail:  detailed list of SensApp deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Veronica Vespini
SensApp_Deliverable_D1.3_Plan for data management
published pages: , ISSN: , DOI: 10.5281/zenodo.3530473
2020-03-05
2020 Veronica Vespini
SensApp_Deliverable_D1.4_First plan for dissemination and exploitation
published pages: , ISSN: , DOI: 10.5281/zenodo.3608710
2020-03-05
2019 Veronica Vespini
SensApp_Deliverable_D1.1_Logo and webpage
published pages: , ISSN: , DOI: 10.5281/zenodo.3531836
2020-03-05
2019 Anna Faraone
Dispensing pico droplets by pyroelectrohydrodynamic jetting: simulations and experimental results
published pages: , ISSN: , DOI: 10.5281/zenodo.3530462
2020-03-05
2020 Veronica Vespini; Simonetta Grilli
SensApp_First Brochure
published pages: , ISSN: , DOI: 10.5281/zenodo.3689359
2020-03-05
2019 Sara Coppola
SensApp_Deliverable_D2.2_Functional and design specifications
published pages: , ISSN: , DOI: 10.5281/zenodo.3530514
2020-03-05
2020 Sara Coppola; Veronica Vespini; Simonetta Grilli
Flyers with project targets and first results
published pages: , ISSN: , DOI: 10.5281/zenodo.3689351
2020-03-05
2019 Simonetta Grilli
SensApp_Deliverable_D1.2_IP Agreement
published pages: , ISSN: , DOI: 10.5281/zenodo.3530508
2020-03-05
2019 Simonetta Grilli; Mazzon Emanuela
SensApp_Deliverable_D2.1_User requirements specification.
published pages: , ISSN: , DOI: 10.5281/zenodo.3237493
2020-03-05
2020 Sara Coppola; Veronica Vespini; Simonetta Grilli
SensApp_Deliverable_D1.5_Flyer and Promotional movie
published pages: , ISSN: , DOI: 10.5281/zenodo.3689312
2020-03-05
2020 Veronica Vespini
SensApp_Deliverable_D1.6_Technical scientific review meeting 1 documents
published pages: , ISSN: , DOI: 10.5281/zenodo.3689337
2020-03-05
2020 Simonetta Grilli; Veronica Vespini
Promotional movie
published pages: , ISSN: , DOI: 10.5281/zenodo.3689347
2020-03-05

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The information about "SENSAPP" are provided by the European Opendata Portal: CORDIS opendata.

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