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RENALTRACT SIGNED

Development and disease of the renal tract

Total Cost €

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EC-Contrib. €

0

Partnership

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 RENALTRACT project word cloud

Explore the words cloud of the RENALTRACT project. It provides you a very rough idea of what is the project "RENALTRACT" about.

medicine    pools    biology    omics    first    complementary    organ    pathological    excellent    combining    training    renal    deficits    technologies    developmental    team    scientists    rtm    public    stage    kidneys    corrected    incompatible    embark    clinical    alteration    bridge    birth    therapies    human    frequent    young    outstanding    distinguishing    differentiation    direct    immense    clinician    tract    private    variety    embryonic    patterning    chronic    international    healthy    class    amongst    solutions    urinary    esrs    intersectoral    life    ureters    disciplinary    exposure    disciplines    multidisciplinary    arises    socio    leads    supervision    models    remained    precursor    entities    physiology    normal    group    surgically    building    patients    leaders    body    animal    bladder    benefit    complemented    poorly    components    malformations    network    underlie    economic    basic    morphogenesis    defects    burden    congenital    maintaining    uniting    homeostasis    envision    renaltract    programs    exchange    expert    health    environment    inter   

Project "RENALTRACT" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://renaltract.eu
 Total cost 3˙137˙377 €
 EC max contribution 3˙137˙377 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙051˙502.00
2    UNIVERSITY OF GLASGOW UK (GLASGOW) participant 546˙575.00
3    UNIVERSITATSKLINIKUM HEIDELBERG DE (HEIDELBERG) participant 373˙824.00
4    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) participant 273˙287.00
5    OULUN YLIOPISTO FI (OULU) participant 269˙145.00
6    MEDIZINISCHE HOCHSCHULE HANNOVER DE (HANNOVER) participant 249˙216.00
7    MOSAIQUES DIAGNOSTICS GMBH DE (HANNOVER) participant 249˙216.00
8    DITABIS DIGITAL BIOMEDICAL IMAGING SYSTEMS AG DE (PFORZHEIM) participant 124˙608.00
9    ACQUIFER AG DE (PFORZHEIM) participant 0.00

Map

 Project objective

The renal tract (kidneys, the ureters, bladder) is a complex organ system crucial for maintaining the body homeostasis. This organ system arises from different precursor pools through a complex program of patterning, differentiation and morphogenesis in embryonic development. Alteration of this program leads to renal tract malformations (RTM) that are incompatible with a healthy life. While some of these RTM can be surgically corrected, others develop into chronic entities that may lead to renal failure; the burden for the patients and for the socio-economic impact for the health systems is immense. Although congenital RTM are amongst the most frequent human birth defects, the different programs that direct normal and pathological development have remained poorly understood. The RENALTRACT training network aims to address these deficits and provide a better understanding of the programs that underlie RTM and provide solutions to clinical problems. This shall be achieved by using a multidisciplinary team approach with partners working in complementary disciplines (developmental biology, renal physiology, Omics, clinical medicine). RENALTRACT has unique and distinguishing features by uniting studies on components of the urinary tract, by building a bridge between basic and clinician scientists and by combining state of the art methods from a number of complementary fields in a variety of animal models. RENALTRACT aims to establish a first class multidisciplinary training program for outstanding Early-Stage Researchers (ESRs) to provide a group of young scientists with expert knowledge to envision and embark on novel therapies of renal tract malformations in the future. ESRs will benefit from an excellent working environment with state-of-the-art technologies and supervision by international leaders in the field and an inter-disciplinary approach. This will be complemented by intersectoral exposure and exchange between the RENALTRACT public and private participants.

 Deliverables

List of deliverables.
Phenotypic characterisation of Phf19 knockout mice Documents, reports 2019-11-15 11:18:15
RENALTRACT international symposium Other 2019-11-15 11:17:53
List of genes involved in regulation of nephrogenesis induction Documents, reports 2019-11-15 11:17:02
Award of doctoral degrees Documents, reports 2019-11-15 11:18:18
Functional characterisation of novel genes for kidney and ureter development Documents, reports 2019-11-15 11:18:16
Characterization of the regulatory network required for the different steps of the ureteric myogenic program Documents, reports 2019-11-15 11:17:02
Role of pax8 targets in the Xenopus kidney Documents, reports 2019-11-15 11:18:28
Characterization of the regulatory network required for the progression of the ureteric myogenic program Documents, reports 2019-11-15 11:17:01
Establishment of bioinformatic model of kidney development Documents, reports 2019-11-15 11:17:01
Phenotypic characterisation of urofacial syndrome mutant mouse renal tracts and hindguts Documents, reports 2019-11-15 11:17:51
In vivo functional characterisation of selected miRNAs and the identification of mRNA-feedback loops Documents, reports 2019-11-15 11:17:59
Screen and metabolomics analysis for genes for nephrolithiasis and IEM diseases Documents, reports 2019-11-15 11:17:49
List of RTM-related peptide biomarkers in urine Documents, reports 2019-09-06 08:43:39
Two “Young Researcher Training Workshops” Other 2019-09-06 08:43:39
Periodic report Documents, reports 2019-09-06 08:43:39
Outreach activities Other 2019-09-06 08:43:39
Ethics Documents, reports 2019-09-06 08:43:39
Mid-term review Meeting Documents, reports 2019-09-06 08:43:39
Supervisory Board of Network Documents, reports 2019-09-06 08:43:39
Progress Report Documents, reports 2019-09-06 08:43:39
List of novel genetic vari-ants causing maldevelopment of human lower urinary tract Documents, reports 2019-09-06 08:43:39
Identification of target genes of Tgfrb-, Pdgfra and/or retinoic acid-signalling in the ureter Documents, reports 2019-09-06 08:43:39
Positions’ advertisement Other 2019-09-06 08:43:39

Take a look to the deliverables list in detail:  detailed list of RENALTRACT deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Sunder Sims-Lucas, Misty Good, Seppo J. Vainio
Editorial: Organogenesis: From Development to Disease
published pages: , ISSN: 2296-634X, DOI: 10.3389/fcell.2017.00085
Frontiers in Cell and Developmental Biology 5 2019-10-29
2019 Saurav Ghimire, Selim Terhzaz, Pablo Cabrero, Michael F. Romero, Shireen Davies, Julian A.T. Dow
Targeted renal knockdown of Na + /H + exchanger regulatory factor Sip1 produces uric acid nephrolithiasis in Drosophila
published pages: , ISSN: 1931-857X, DOI: 10.1152/ajprenal.00551.2018
American Journal of Physiology-Renal Physiology 2019-10-01
2019 Adrian S. Woolf, Filipa M. Lopes, Parisa Ranjzad, Neil A. Roberts
Congenital Disorders of the Human Urinary Tract: Recent Insights From Genetic and Molecular Studies
published pages: , ISSN: 2296-2360, DOI: 10.3389/fped.2019.00136
Frontiers in Pediatrics 7 2019-09-06
2018 Zenglai Tan, Jingdong Shan, Aleksandra Rak-Raszewska, Seppo J. Vainio
Embryonic Stem Cells Derived Kidney Organoids as Faithful Models to Target Programmed Nephrogenesis
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-34995-3
Scientific Reports 8/1 2019-09-06
2019 Neil A. Roberts, Emma N. Hilton, Filipa M. Lopes, Subir Singh, Michael J. Randles, Natalie J. Gardiner, Karl Chopra, Riccardo Coletta, Zunera Bajwa, Robert J. Hall, Wyatt W. Yue, Franz Schaefer, Stefanie Weber, Roger Henriksson, Helen M. Stuart, HÃ¥kan Hedman, William G. Newman, Adrian S. Woolf
Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder
published pages: 1138-1152, ISSN: 0085-2538, DOI: 10.1016/j.kint.2018.11.040
Kidney International 95/5 2019-09-06
2019 Pierbruno Ricci, Pedro Magalhães, Magdalena Krochmal, Martin Pejchinovski, Erica Daina, Maria Rosa Caruso, Laura Goea, Iwona Belczacka, Giuseppe Remuzzi, Muriel Umbhauer, Jens Drube, Lars Pape, Harald Mischak, Stéphane Decramer, Franz Schaefer, Joost P. Schanstra, Silvia Cereghini, Petra Zürbig
Urinary proteome signature of Renal Cysts and Diabetes syndrome in children
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-38713-5
Scientific Reports 9/1 2019-09-06
2018 Pedro Magalhães, Claudia Pontillo, Martin Pejchinovski, Justyna Siwy, Magdalena Krochmal, Manousos Makridakis, Emma Carrick, Julie Klein, William Mullen, Joachim Jankowski, Antonia Vlahou, Harald Mischak, Joost P. Schanstra, Petra Zürbig, Lars Pape
Comparison of Urine and Plasma Peptidome Indicates Selectivity in Renal Peptide Handling
published pages: 1700163, ISSN: 1862-8346, DOI: 10.1002/prca.201700163
PROTEOMICS - Clinical Applications 12/5 2019-09-06
2018 Yasmine Neirijnck, Antoine Reginensi, Kirsten Y. Renkema, Filippo Massa, Vladimir M. Kozlov, Haroun Dhib, Ernie M.H.F. Bongers, Wout F. Feitz, Albertien M. van Eerde, Veronique Lefebvre, Nine V.A.M. Knoers, Mansoureh Tabatabaei, Herbert Schulz, Helen McNeill, Franz Schaefer, Michael Wegner, Elisabeth Sock, Andreas Schedl
Sox11 gene disruption causes congenital anomalies of the kidney and urinary tract (CAKUT)
published pages: 1142-1153, ISSN: 0085-2538, DOI: 10.1016/j.kint.2017.11.026
Kidney International 93/5 2019-09-06
2017 Pedro Magalhães, Martin Pejchinovski, Katerina Markoska, Miroslaw Banasik, Marian Klinger, Dominika Švec-Billá, Ivan Rychlík, Merita Rroji, Arianna Restivo, Giovambattista Capasso, Flaviu Bob, Adalbert Schiller, Alberto Ortiz, Maria Vanessa Perez-Gomez, Pablo Cannata, Maria Dolores Sanchez-Niño, Radomir Naumovic, Voin Brkovic, Momir Polenakovic, William Mullen, Antonia Vlahou, Petra Zürbig,
Association of kidney fibrosis with urinary peptides: a path towards non-invasive liquid biopsies?
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-17083-w
Scientific Reports 7/1 2019-09-06
2019 Guillermo Martínez-Corrales, Pablo Cabrero, Julian A. T. Dow, Selim Terhzaz, Shireen-A. Davies
Novel roles for GATAe in growth, maintenance and proliferation of cell populations in the Drosophila renal tubule
published pages: dev178087, ISSN: 0950-1991, DOI: 10.1242/dev.178087
Development 146/9 2019-09-06
2017 Magdalena Krochmal, Georgia Kontostathi, Pedro Magalhães, Manousos Makridakis, Julie Klein, Holger Husi, Johannes Leierer, Gert Mayer, Jean-Loup Bascands, Colette Denis, Jerome Zoidakis, Petra Zürbig, Christian Delles, Joost P. Schanstra, Harald Mischak, Antonia Vlahou
Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-15359-9
Scientific Reports 7/1 2019-09-06
2019 L. Pelander, V. Brunchault, B. Buffin-Meyer, J. Klein, B. Breuil, P. Zürbig, P. Magalhães, W. Mullen, J. Elliott, H. Syme, J.P. Schanstra, J. Häggström, I. Ljungvall
Urinary peptidome analyses for the diagnosis of chronic kidney disease in dogs
published pages: 73-79, ISSN: 1090-0233, DOI: 10.1016/j.tvjl.2019.05.010
The Veterinary Journal 249 2019-09-06
2019 Gunjan Pandey, Jens Westhoff, Franz Schaefer, Jochen Gehrig
A Smart Imaging Workflow for Organ-Specific Screening in a Cystic Kidney Zebrafish Disease Model
published pages: 1290, ISSN: 1422-0067, DOI: 10.3390/ijms20061290
International Journal of Molecular Sciences 20/6 2019-09-06
2016 Pedro Magalhães, Harald Mischak, Petra Zürbig
Urinary proteomics using capillary electrophoresis coupled to mass spectrometry for diagnosis and prognosis in kidney diseases
published pages: 494-501, ISSN: 1062-4821, DOI: 10.1097/MNH.0000000000000278
Current Opinion in Nephrology and Hypertension 25/6 2019-09-06
2016 Pedro Magalhães, Joost P. Schanstra, Emma Carrick, Harald Mischak, Petra Zürbig
Urinary biomarkers for renal tract malformations
published pages: 1121-1129, ISSN: 1478-9450, DOI: 10.1080/14789450.2016.1254555
Expert Review of Proteomics 13/12 2019-09-06

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