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OlfSwitch SIGNED

OlfSwitch: Neural circuit switches from molecules to behaviour

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EC-Contrib. €

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Project "OlfSwitch" data sheet

The following table provides information about the project.

Coordinator
UNITED KINGDOM RESEARCH AND INNOVATION 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country United Kingdom [UK]
 Project website http://jefferislab.org
 Total cost 1˙990˙791 €
 EC max contribution 1˙990˙791 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNITED KINGDOM RESEARCH AND INNOVATION UK (SWINDON) coordinator 1˙537˙995.00
2    MEDICAL RESEARCH COUNCIL UK (SWINDON) coordinator 0.00
3    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 452˙796.00

Map

 Project objective

This proposal seeks to understand the logic of neural circuit switches in the relatively simple nervous system of Drosophila. Our goals are to examine the developmental, physiological and behavioural logic of several of these elementary circuit motifs. We will use innate olfactory behaviour as our primary model, investigating behaviours triggered by single or convergent odour stimuli and their modulation by memory and internal state. We will start with the favourable case of a sexually dimorphic circuit switch that we have recently characterised (for the first time in any animal). We have shown that a transcription factor, fruitless, determines the state of this switch in sex pheromone processing during development. We will now (1) identify the molecules that determine the layout of this specific circuit during development and (2) probe the behavioural relevance of this specific circuit switch.

In parallel with this work on pheromone processing, we will examine (3) the circuit basis of valence (simply put whether an odour is attractive or aversive) in which genetic instructions likely hardwire olfactory pathways to downstream modules of different behavioural significance. Finally we will examine the logic of dynamic switches in which a second stimulus (4) positively or (5) negatively gates the response to a stimulus.

 Publications

year authors and title journal last update
List of publications.
2017 Ben Sutcliffe, Julian Ng, Thomas O. Auer, Mathias Pasche, Richard Benton, Gregory S. X. E. Jefferis, Sebastian Cachero
Second-Generation Drosophila Chemical Tags: Sensitivity, Versatility, and Speed
published pages: 1399-1408, ISSN: 0016-6731, DOI: 10.1534/genetics.116.199281
Genetics 205/4 2020-01-15
2015 Johannes Kohl, Paavo Huoviala, Gregory SXE Jefferis
Pheromone processing in Drosophila
published pages: 149-157, ISSN: 0959-4388, DOI: 10.1016/j.conb.2015.06.009
Current Opinion in Neurobiology 34 2020-01-15
2017 Michael-John Dolan, Haojiang Luan, William C. Shropshire, Ben Sutcliffe, Benjamin Cocanougher, Robert L. Scott, Shahar Frechter, Marta Zlatic, Gregory S. X. E. Jefferis, Benjamin H. White
Facilitating Neuron-Specific Genetic Manipulations in Drosophila melanogaster Using a Split GAL4 Repressor
published pages: 775-784, ISSN: 0016-6731, DOI: 10.1534/genetics.116.199687
Genetics 206/2 2020-01-15
2016 Karin Panser; Laszlo Tirian; Florian Schulze; Santiago Villalba; Gregory S.X.E. Jefferis; Katja Bühler; Andrew D. Straw
Automatic Segmentation of Drosophila Neural Compartments Using GAL4 Expression Data Reveals Novel Visual Pathways
published pages: , ISSN: 0960-9822, DOI: 10.1016/j.cub.2016.05.052
Current Biology 2 2020-01-15
2016 Marta Costa; James D. Manton; Aaron D. Ostrovsky; Steffen Prohaska; Gregory S.X.E. Jefferis
NBLAST: Rapid, Sensitive Comparison of Neuronal Structure and Construction of Neuron Family Databases
published pages: , ISSN: 0896-6273, DOI: 10.1016/j.neuron.2016.06.012
Neuron 3 2020-01-15
2016 Julian Ng; Alyssa Browning; Lorenz Lechner; Masako Terada; Gillian Howard; Gregory Jefferis
Genetically targeted 3D visualisation ofDrosophilaneurons under Electron Microscopy and X-Ray Microscopy using miniSOG
published pages: , ISSN: 2045-2322, DOI: 10.1101/070755
Scientific Reports 4 2020-01-15

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The information about "OLFSWITCH" are provided by the European Opendata Portal: CORDIS opendata.

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