Explore the words cloud of the OlfSwitch project. It provides you a very rough idea of what is the project "OlfSwitch" about.
The following table provides information about the project.
UNITED KINGDOM RESEARCH AND INNOVATION
There are not information about this coordinator. Please contact Fabio for more information, thanks.
|Coordinator Country||United Kingdom [UK]|
|Total cost||1˙990˙791 €|
|EC max contribution||1˙990˙791 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-07-01 to 2020-06-30|
Take a look of project's partnership.
|1||UNITED KINGDOM RESEARCH AND INNOVATION||UK (SWINDON)||coordinator||1˙537˙995.00|
|2||MEDICAL RESEARCH COUNCIL||UK (SWINDON)||coordinator||0.00|
|3||THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE||UK (CAMBRIDGE)||participant||452˙796.00|
This proposal seeks to understand the logic of neural circuit switches in the relatively simple nervous system of Drosophila. Our goals are to examine the developmental, physiological and behavioural logic of several of these elementary circuit motifs. We will use innate olfactory behaviour as our primary model, investigating behaviours triggered by single or convergent odour stimuli and their modulation by memory and internal state. We will start with the favourable case of a sexually dimorphic circuit switch that we have recently characterised (for the first time in any animal). We have shown that a transcription factor, fruitless, determines the state of this switch in sex pheromone processing during development. We will now (1) identify the molecules that determine the layout of this specific circuit during development and (2) probe the behavioural relevance of this specific circuit switch.
In parallel with this work on pheromone processing, we will examine (3) the circuit basis of valence (simply put whether an odour is attractive or aversive) in which genetic instructions likely hardwire olfactory pathways to downstream modules of different behavioural significance. Finally we will examine the logic of dynamic switches in which a second stimulus (4) positively or (5) negatively gates the response to a stimulus.
|year||authors and title||journal||last update|
Ben Sutcliffe, Julian Ng, Thomas O. Auer, Mathias Pasche, Richard Benton, Gregory S. X. E. Jefferis, Sebastian Cachero
Second-Generation Drosophila Chemical Tags: Sensitivity, Versatility, and Speed
published pages: 1399-1408, ISSN: 0016-6731, DOI: 10.1534/genetics.116.199281
Johannes Kohl, Paavo Huoviala, Gregory SXE Jefferis
Pheromone processing in Drosophila
published pages: 149-157, ISSN: 0959-4388, DOI: 10.1016/j.conb.2015.06.009
|Current Opinion in Neurobiology 34||2020-01-15|
Michael-John Dolan, Haojiang Luan, William C. Shropshire, Ben Sutcliffe, Benjamin Cocanougher, Robert L. Scott, Shahar Frechter, Marta Zlatic, Gregory S. X. E. Jefferis, Benjamin H. White
Facilitating Neuron-Specific Genetic Manipulations in Drosophila melanogaster Using a Split GAL4 Repressor
published pages: 775-784, ISSN: 0016-6731, DOI: 10.1534/genetics.116.199687
Karin Panser; Laszlo Tirian; Florian Schulze; Santiago Villalba; GregoryÂ S.X.E. Jefferis; Katja BÃ¼hler; AndrewÂ D. Straw
Automatic Segmentation of Drosophila Neural Compartments Using GAL4 Expression Data Reveals Novel Visual Pathways
published pages: , ISSN: 0960-9822, DOI: 10.1016/j.cub.2016.05.052
|Current Biology 2||2020-01-15|
Marta Costa; James D. Manton; Aaron D. Ostrovsky; Steffen Prohaska; Gregory S.X.E. Jefferis
NBLAST: Rapid, Sensitive Comparison of Neuronal Structure and Construction of Neuron Family Databases
published pages: , ISSN: 0896-6273, DOI: 10.1016/j.neuron.2016.06.012
Julian Ng; Alyssa Browning; Lorenz Lechner; Masako Terada; Gillian Howard; Gregory Jefferis
Genetically targeted 3D visualisation ofDrosophilaneurons under Electron Microscopy and X-Ray Microscopy using miniSOG
published pages: , ISSN: 2045-2322, DOI: 10.1101/070755
|Scientific Reports 4||2020-01-15|
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The information about "OLFSWITCH" are provided by the European Opendata Portal: CORDIS opendata.
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