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FibreRemodel SIGNED

Frontier research in arterial fibre remodelling for vascular disease diagnosis and tissue engineering

Total Cost €

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EC-Contrib. €

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Partnership

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 FibreRemodel project word cloud

Explore the words cloud of the FibreRemodel project. It provides you a very rough idea of what is the project "FibreRemodel" about.

vulnerable    vessels    silico    cell    mechanically    prevent    diseases    encourage    remodelling    architecture    differences    combination    regarded    tissues    degenerative    stiffer    wall    arterial    intimal    diagnose    loading    materials    fibrous    hyperplasia    orientation    tissue    macroscopic    plaque    parallel    underlying    environment    compatible    framework    carotid    vessel    core    linked    atherosclerosis    diffusion    imaging    magnetic    differentiation    quality    artery    vitro    vivo    patterns    vascular    rupture    tensor    risk    fibre    each    deaths    cardiovascular    stem    disease    human    invasively    revolutionise    collagen    directing    aetiology    mechanobiological    alter    models    composition    strategies    provides    mesenchymal    pressurisation    constructs    engineering    reinforced    bearing    aneurysms    diagnosis    engineered    excessive    mechanical    decellularised    optimum    hence    load    repopulation    arteries    resonance    48    view    fibres    biologically   

Project "FibreRemodel" data sheet

The following table provides information about the project.

Coordinator
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN 

Organization address
address: College Green
city: DUBLIN
postcode: 2
website: www.tcd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 1˙521˙875 €
 EC max contribution 1˙521˙875 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) coordinator 1˙521˙875.00

Map

 Project objective

Each year cardiovascular diseases such as atherosclerosis and aneurysms cause 48% of all deaths in Europe. Arteries may be regarded as fibre-reinforced materials, with the stiffer collagen fibres present in the arterial wall bearing most of the load during pressurisation. Degenerative vascular diseases such as atherosclerosis and aneurysms alter the macroscopic mechanical properties of arterial tissue and therefore change the arterial wall composition and the quality and orientation of the underlying fibrous architecture. Information on the complex fibre architecture of arterial tissues is therefore at the core of understanding the aetiology of vascular diseases. The current proposal aims to use a combination of in vivo Diffusion Tensor Magnetic Resonance Imaging, with parallel in silico modelling, to non-invasively identify differences in the fibre architecture of human carotid arteries which can be directly linked with carotid artery disease and hence used to diagnose vulnerable plaque rupture risk. Knowledge of arterial fibre patterns, and how these fibres alter in response to their mechanical environment, also provides a means of understanding remodelling of tissue engineered vessels. Therefore, in the second phase of this project, this novel imaging framework will be used to determine fibre patterns of decellularised arterial constructs in vitro with a view to directing mesenchymal stem cell growth and differentiation and creating a biologically and mechanically compatible tissue engineered vessel. In silico mechanobiological models will also be used to help identify the optimum loading environment for the vessels to encourage cell repopulation but prevent excessive intimal hyperplasia. This combination of novel in vivo, in vitro and in silico work has the potential to revolutionise approaches to early diagnosis of vascular diseases and vascular tissue engineering strategies.

 Publications

year authors and title journal last update
List of publications.
2016 Shahid, S.S., Kerskens, C., Gaul, R. Flamini, V., Lally, C.
Ex-vivo arterial collagen fibre tractography using micro-diffusion tensor imaging
published pages: , ISSN: , DOI:
Proceedings of the European Society for Magnetic Resonance in Medicine and Biology, September 29-October 1, Vienna, Austria. September 2016 (yearly) 2019-11-22
2016 Lally C., Dunphy, S., Mathieu, P., Nolan, D., Cahill, P.
Understanding the critical role of strain and structure in vascular remodelling, regeneration and disease.
published pages: , ISSN: , DOI:
Matrix Biology Ireland Abstract Proceedings November 2016 (Yearly) 2019-11-22
2017 Nolan, D.R., Ghasemi, M, Lally, C
Assessment of clinically relevant measure for identifying vulnerable carotid plaque
published pages: , ISSN: , DOI:
Bioengineering in Ireland 23 Conference January 2017 (yearly) 2019-11-22
2017 Caitríona Lally, Syed S. Shahid, Christian Kerskens, Céline Smekens, Robert Johnston,
Non-Destructive Characterisation of Arterial Structure using High-Resolution Diffusion MRI
published pages: , ISSN: , DOI:
Proceedings of the Matrix Biology Ireland Conference 2017 Yearly 2019-11-22
2018 Gaul, R T; Nolan, D R; Ristori, T; Loerakker, S; Lally, C.
STRAIN MEDIATED ARTERIAL DEGRADATION IS CRITICALLYINFLUENCED BY MATRIX CONTENT AND COLLAGEN CRIMP
published pages: , ISSN: , DOI:
24th Bioengineering in Ireland Conference yearly 2019-11-22
2018 Mathieu, P.S., Fitzpatrick, E., Cahill, P.A., Lally, C.
VASCULAR SMOOTH MUSCLE CELLS AND MULTIPOTENT VASCULAR STEM CELLS DIFFER IN THEIR RESPONSE TO CYCLIC TENSILE STRAIN
published pages: , ISSN: , DOI:
Proceedings of World Congress of Biomechanics 2018 Every 4 years 2019-11-22
2018 Ghasemi, M; Nolan, D R; Lally, C.
DAMAGE ACCUMULATION IN ARTERIAL TISSUE; EXPERIMENTALOBSERVATIONS ON THE ROLE OF MATRIX AND FIBRES ANDCONSTITUTIVE MODEL DEVELOPMENT
published pages: , ISSN: , DOI:
24th Bioengineering in Ireland Conference Yearly 2019-11-22
2018 Robert Johnston, David Nolan, Dorian Botella-Barriot, Milad Ghasemi, Christian Kerskens, Caitriona Lally
Optimization of Magnetic Resonance Imaging (MRI) based Patient Specific Models with mechanical property estimation from inverse finite element analysis
published pages: , ISSN: , DOI:
Proceedings of the European Mechanics of Materials Conference Yearly 2019-11-22
2017 Shahid, S.S., Kerskens, C., Gaul, R., Lally, C
Quantification of extracellular matrix components in arterial tissue using high-resolution micro diffusion tensor imaging
published pages: , ISSN: , DOI:
Proceedings of the European Molecular Imaging Meeting April 5-7, Cologne, Germany April 2016 (yearly) 2019-11-22
2018 Gaul, R.T., Nolan, D.R., Ristori, T., Loerakker S., Lally, C.
Degradation of arterial collagen with applied strain: critical influence of matrix content and collagen crimp
published pages: , ISSN: , DOI:
Proceedings of the World Congress of Biomechanics Every 4 years 2019-11-22
2017 Ghasemi, M., Nolan, D.R., Lally, C
Collagen fibre remodelling in arterial soft tissue
published pages: , ISSN: , DOI:
Bioengineering in Ireland 23 Conference January 2017 (yearly) 2019-11-22
2018 Johnston, R., Nolan, D., Ghasemi, M., Kerskens, C., Lally, C.
OPTIMIZATED PATIENT SPECIFIC FINITE ELEMENT MODELS AT THE CAROTID BIFURCATION
published pages: , ISSN: , DOI:
Proceedings of the World Congress of Biomechanics 2018 Every 4 years 2019-11-22
2018 Smekens, C J; Shahid, S S; Kerskens, C; Lally C.
PARAMETRIC MAPPING OF PORCINE CAROTID ARTERY MODELS FOR QUANTIFYING CELLULARITY IN DISEASED MODELS OF ARTERIAL TISSUE
published pages: , ISSN: , DOI:
24th Bioengineering in Ireland Conference Yearly 2019-11-22
2018 Johnston, R; Nolan, D; Ghasemi, M; Kerskens, C; Lally, C.
AN IN-VIVO STUDY ON THE IMPACT OF AXIAL RESOLUTION ONPEAK STRESSES AT THE CAROTID BIFURCATION
published pages: , ISSN: , DOI:
24th Bioengineering in Ireland Conference Yearly 2019-11-22
2016 Ghasemi, M., Nolan, D.R., Lally, C
A review of arterial tissue remodelling
published pages: , ISSN: , DOI:
Bioengineering in Ireland 22 Conference January 2016 (yearly) 2019-11-22
2017 Syed Salman Shahid, Robert Gaul, Christian M Kerskens, Vittoria Flamini, Caitriona Lally
Quantifying the ultrastructure of carotid artery using high-resolution micro-diffusion tensor imaging – comparison of intact vs. open cut tissue
published pages: , ISSN: 0031-9155, DOI: 10.1088/1361-6560/aa9159
Physics in Medicine and Biology 2019-11-22
2018 Ghasemi,M., Nolan, D., Lally, C.
A constituent specific study of damage accumulation in arterial tissue
published pages: , ISSN: , DOI:
Proceedings of the World Congress of Biomechanics 2018 Every 4 years 2019-11-22
2017 Shahid, S.S., Kerskens, C., Lally, C.
Use of high-resolution micro-diffusion tensor imaging to estimate the ultra-structure of the arterial wall
published pages: , ISSN: , DOI:
Bioengineering in Ireland 23 Conference January 2017 (yearly) 2019-11-22
2018 Ghasemi, M, Nolan, D, Lally, C.
Exploring the influence of damage accumulation on collagen fibre remodelling in arteries under supra-physiological loads
published pages: , ISSN: , DOI:
Proceedings of the European Mechanics of Materials Conference Yearly 2019-11-22
2018 Smekens, C. J.1,2, Shahid, S. S.3, Kerskens, C.4, Lally, C1,2
PARAMETRIC MAPPING OF PORCINE CAROTID ARTERY MODELS FOR QUANTIFYING CELLULARITY IN DISEASED MODELS OF ARTERIAL TISSUE
published pages: , ISSN: , DOI:
Proceedings of the World Congress of Biomechanics Every 4 years 2019-11-22
2017 R.T. Gaul, D.R. Nolan, C. Lally
Collagen fibre characterisation in arterial tissue under load using SALS
published pages: 359-368, ISSN: 1751-6161, DOI: 10.1016/j.jmbbm.2017.07.036
Journal of the Mechanical Behavior of Biomedical Materials 75 2019-11-22
2017 Robert Gaul, Caitríona Lally
Strain Mediated Enzyme Degradation of Arterial Tissue; Implications in Disease and Medical Device Design
published pages: , ISSN: , DOI:
Summer Biomechanics, Bioengineering and Biotransport Conference 2019-11-22
2018 R.T. Gaul, D.R. Nolan, T. Ristori, C.V.C. Bouten, S. Loerakker, C. Lally
Strain mediated enzymatic degradation of arterial tissue: Insights into the role of the non-collagenous tissue matrix and collagen crimp
published pages: 301-310, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.06.037
Acta Biomaterialia 77 2019-11-22
2018 C. Lally, D.R. Nolan, P.S. Mathieu, A. McMahon, P.A. Cahill, E. Fitzpatrick
Changes in the collagen fibre architecture within stented arterial tissue may play a critical role in directing the vascular cell response post stenting
published pages: , ISSN: , DOI:
Every four years 2019-11-22
2018 R.T. Gaul, D.R. Nolan, C. Lally
The use of small angle light scattering in assessing strain induced collagen degradation in arterial tissue ex vivo
published pages: , ISSN: 0021-9290, DOI: 10.1016/j.jbiomech.2018.10.006
Journal of Biomechanics 2019-11-22
2018 Milad Ghasemi, David R. Nolan, Caitríona Lally
An investigation into the role of different constituents in damage accumulation in arterial tissue and constitutive model development
published pages: , ISSN: 1617-7959, DOI: 10.1007/s10237-018-1054-3
Biomechanics and Modeling in Mechanobiology 2019-11-22
2017 Milad Ghasemi, David.R.Nolan, Caitríona Lally
TOWARD THE DEVELOPMENT OF A CONSTITUTIVE MODEL TOCAPTURE ARTERIAL COLLAGEN FIBRE REMODELLING AND DAMAGE
published pages: , ISSN: , DOI:
Proceedings of the European Society of Biomechanics Congress July 2017 2019-11-22

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