Explore the words cloud of the SmartCardiacPatch project. It provides you a very rough idea of what is the project "SmartCardiacPatch" about.
The following table provides information about the project.
TEL AVIV UNIVERSITY
|Coordinator Country||Israel [IL]|
|Total cost||1˙499˙500 €|
|EC max contribution||1˙499˙500 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-07-01 to 2021-06-30|
Take a look of project's partnership.
|1||TEL AVIV UNIVERSITY||IL (TEL AVIV)||coordinator||1˙499˙500.00|
Ischemic heart disease is a major cause of death in the Western world. There is no sustainable regenerative therapy available at the moment, with cardiac transplantation being the only therapy. However, tissue engineering is envisioned as a true regenerative therapeutic alternative. Despite the incremental improvements no technology is currently available that can provide on-line monitoring and reporting of the engineered tissue performance, and if needed, automatically activate regenerative processes. As one initial step in that direction, we have recently shown on a non-implantable chip-supported level that a sensory system can be integrated with engineered tissues, providing report on cardiac electrical activity. In this proposal, I plan to expand far beyond the state-of-the-art and develop a conceptually new approach to engineer the next generation of smart implantable cardiac patches. These patches will integrate complex electronics with engineered cardiac tissues to enable on-line monitoring and at the same time self-regulation of the tissue function. Since cardiac performance will be recorded over time, physicians could follow heart regeneration in real-time, providing new means for the disease management. To achieve this goal I will first develop new porous, stretchable and biocompatible microelectronics enabling electrical activity recording and stimulation. The electronics will interact with an efficient electroactive controlled release system enabling on-demand release of biomolecules. The system will be integrated with a 3D biomaterial scaffold and cardiac cells to compose the microelectronic cardiac patch (microECP). Development of feedback loop software will ensure efficient regulation of the patch’s function over time. Next, we will elucidate the interplay between the electronics, scaffold and cells, and provide a proof-of-principle for the microECP in vitro. Finally, we will investigate the regenerative potential of the system following infarction.
|year||authors and title||journal||last update|
Ron Feiner, Lior Wertheim, Danielle Gazit, Or Kalish, Gal Mishal, Assaf Shapira, Tal Dvir
A Stretchable and Flexible Cardiac Tissueâ€“Electronics Hybrid Enabling Multiple Drug Release, Sensing, and Stimulation
published pages: 1805526, ISSN: 1613-6810, DOI: 10.1002/smll.201805526
LeeRon Shefet Carasso, Itai Benhar, Tal Dvir
Universal Biofactor-Releasing Scaffold Enabling in Vivo Reloading
published pages: 1838-1843, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.8b04927
|Nano Letters 19/3||2020-04-01|
Ron Feiner, Tal Dvir
An electromechanical hug for the failing heart
published pages: 412-412, ISSN: 2305-5839, DOI: 10.21037/atm.2016.08.36
|Annals of Translational Medicine 4/20||2019-08-30|
Ron Feiner, Tal Dvir
Tissueâ€“electronics interfaces: from implantable devices to engineered tissues
published pages: 17076, ISSN: 2058-8437, DOI: 10.1038/natrevmats.2017.76
|Nature Reviews Materials 3/1||2019-08-30|
Sharon Fleischer, Assaf Shapira, Ron Feiner, Tal Dvir
Modular assembly of thick multifunctional cardiac patches
published pages: 1898-1903, ISSN: 0027-8424, DOI: 10.1073/pnas.1615728114
|Proceedings of the National Academy of Sciences 114/8||2019-08-30|
Sharon Fleischer, Ron Feiner, Tal Dvir
Cardiac tissue engineering: from matrix design to the engineering of bionic hearts
published pages: 275-284, ISSN: 1746-0751, DOI: 10.2217/rme-2016-0150
|Regenerative Medicine 12/3||2019-08-30|
Maayan Malki, Sharon Fleischer, Assaf Shapira, Tal Dvir
Gold Nanorod-Based Engineered Cardiac Patch for Suture-Free Engraftment by Near IR
published pages: , ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.7b04924
Ron Feiner, Leeya Engel, Sharon Fleischer, Maayan Malki, Idan Gal, Assaf Shapira, Yosi Shacham-Diamand, Tal Dvir
Engineered hybrid cardiac patches with multifunctional electronics for online monitoringÂ and regulation of tissue function
published pages: , ISSN: 1476-1122, DOI: 10.1038/nmat4590
Sharon Fleischer, Ron Feiner, Tal Dvir
Cutting-edge platforms in cardiac tissue engineering
published pages: 23-29, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2017.05.008
|Current Opinion in Biotechnology 47||2019-08-30|
Nadav Noor, Assaf Shapira, Reuven Edri, Idan Gal, Lior Wertheim, Tal Dvir
3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts
published pages: 1900344, ISSN: 2198-3844, DOI: 10.1002/advs.201900344
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The information about "SMARTCARDIACPATCH" are provided by the European Opendata Portal: CORDIS opendata.
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