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SmartCardiacPatch SIGNED

Next-Generation Cardiac Tissue Engineering: Smart Self-Regulating Patches

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EC-Contrib. €

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Project "SmartCardiacPatch" data sheet

The following table provides information about the project.

Coordinator
TEL AVIV UNIVERSITY 

Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978
website: http://www.tau.ac.il/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website http://www.dvirlab.tau.ac.il/
 Total cost 1˙499˙500 €
 EC max contribution 1˙499˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 1˙499˙500.00

Map

 Project objective

Ischemic heart disease is a major cause of death in the Western world. There is no sustainable regenerative therapy available at the moment, with cardiac transplantation being the only therapy. However, tissue engineering is envisioned as a true regenerative therapeutic alternative. Despite the incremental improvements no technology is currently available that can provide on-line monitoring and reporting of the engineered tissue performance, and if needed, automatically activate regenerative processes. As one initial step in that direction, we have recently shown on a non-implantable chip-supported level that a sensory system can be integrated with engineered tissues, providing report on cardiac electrical activity. In this proposal, I plan to expand far beyond the state-of-the-art and develop a conceptually new approach to engineer the next generation of smart implantable cardiac patches. These patches will integrate complex electronics with engineered cardiac tissues to enable on-line monitoring and at the same time self-regulation of the tissue function. Since cardiac performance will be recorded over time, physicians could follow heart regeneration in real-time, providing new means for the disease management. To achieve this goal I will first develop new porous, stretchable and biocompatible microelectronics enabling electrical activity recording and stimulation. The electronics will interact with an efficient electroactive controlled release system enabling on-demand release of biomolecules. The system will be integrated with a 3D biomaterial scaffold and cardiac cells to compose the microelectronic cardiac patch (microECP). Development of feedback loop software will ensure efficient regulation of the patch’s function over time. Next, we will elucidate the interplay between the electronics, scaffold and cells, and provide a proof-of-principle for the microECP in vitro. Finally, we will investigate the regenerative potential of the system following infarction.

 Publications

year authors and title journal last update
List of publications.
2019 Ron Feiner, Lior Wertheim, Danielle Gazit, Or Kalish, Gal Mishal, Assaf Shapira, Tal Dvir
A Stretchable and Flexible Cardiac Tissue–Electronics Hybrid Enabling Multiple Drug Release, Sensing, and Stimulation
published pages: 1805526, ISSN: 1613-6810, DOI: 10.1002/smll.201805526
Small 15/14 2020-04-01
2019 LeeRon Shefet Carasso, Itai Benhar, Tal Dvir
Universal Biofactor-Releasing Scaffold Enabling in Vivo Reloading
published pages: 1838-1843, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.8b04927
Nano Letters 19/3 2020-04-01
2016 Ron Feiner, Tal Dvir
An electromechanical hug for the failing heart
published pages: 412-412, ISSN: 2305-5839, DOI: 10.21037/atm.2016.08.36
Annals of Translational Medicine 4/20 2019-08-30
2017 Ron Feiner, Tal Dvir
Tissue–electronics interfaces: from implantable devices to engineered tissues
published pages: 17076, ISSN: 2058-8437, DOI: 10.1038/natrevmats.2017.76
Nature Reviews Materials 3/1 2019-08-30
2017 Sharon Fleischer, Assaf Shapira, Ron Feiner, Tal Dvir
Modular assembly of thick multifunctional cardiac patches
published pages: 1898-1903, ISSN: 0027-8424, DOI: 10.1073/pnas.1615728114
Proceedings of the National Academy of Sciences 114/8 2019-08-30
2017 Sharon Fleischer, Ron Feiner, Tal Dvir
Cardiac tissue engineering: from matrix design to the engineering of bionic hearts
published pages: 275-284, ISSN: 1746-0751, DOI: 10.2217/rme-2016-0150
Regenerative Medicine 12/3 2019-08-30
2018 Maayan Malki, Sharon Fleischer, Assaf Shapira, Tal Dvir
Gold Nanorod-Based Engineered Cardiac Patch for Suture-Free Engraftment by Near IR
published pages: , ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.7b04924
Nano Letters 2019-08-30
2016 Ron Feiner, Leeya Engel, Sharon Fleischer, Maayan Malki, Idan Gal, Assaf Shapira, Yosi Shacham-Diamand, Tal Dvir
Engineered hybrid cardiac patches with multifunctional electronics for online monitoring and regulation of tissue function
published pages: , ISSN: 1476-1122, DOI: 10.1038/nmat4590
Nature Materials 2019-08-30
2017 Sharon Fleischer, Ron Feiner, Tal Dvir
Cutting-edge platforms in cardiac tissue engineering
published pages: 23-29, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2017.05.008
Current Opinion in Biotechnology 47 2019-08-30
2019 Nadav Noor, Assaf Shapira, Reuven Edri, Idan Gal, Lior Wertheim, Tal Dvir
3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts
published pages: 1900344, ISSN: 2198-3844, DOI: 10.1002/advs.201900344
Advanced Science 2019-08-30

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