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CraNOC

Cracking the Nucleo-Olivary Code

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CraNOC project word cloud

Explore the words cloud of the CraNOC project. It provides you a very rough idea of what is the project "CraNOC" about.

timescale    ultimate    motor    links    temporal    perturbed    happens    cn    sensorimotor    crack    loop    ctx    object    methodological    successful    adjusted    critical    interactions    operations    reverberating    olivary    rest    timing    generate    theory    environments    ocs    function    interestingly    orchestration    brain    intrinsic    individual    proper    behavior    muscles    timed    place    output    generating    for    formed    examine    changing    cortex    catch    inferior    beating    falling    ed    millisecond    accurate    tools    tripartite    animals    cerebellar    requests    activated    complexity    movements    mediated    hindering    learning    neurological    correct    microcircuit    oscillatory    computations    disorders    nucleo    harder    codes    imposes    constantly    executive    unable    olive    constitute    nuclei    olivo    cognitive    humans    functions    requiring    smooth    fairly    completion    io    optogenetic    cctx    mental    decades    viral    difficulties   

Project "CraNOC" data sheet

The following table provides information about the project.

Coordinator
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

Organization address
address: DR MOLEWATERPLEIN 40
city: ROTTERDAM
postcode: 3015 GD
website: www.erasmusmc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://neuro.nl/research.php
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) coordinator 165˙598.00

Map

 Project objective

For animals and humans to be successful in their environments, their motor and cognitive behavior must be adjusted to the constantly changing reality at a millisecond-timescale. For example, it is fairly simple for a brain to determine which muscles need to be activated to catch a falling object, but much harder to determine when and for how long. Without correct timing of the executive brain functions, as happens in some neurological disorders, the individual is unable to produce smooth and accurate movements and will also have difficulties with a range of cognitive functions requiring orchestration of distinct mental operations. The tripartite olivo-cerebellar system (OCS), which is formed by the inferior olive (IO), cerebellar cortex (CCTX) and cerebellar nuclei (CN), is considered critical for generating proper timing for many motor and cognitive operations. Interestingly, all three areas, IO, CTX and CN, have intrinsic oscillatory properties and together they constitute a reverberating microcircuit, beating with well-timed responses to requests from the sensorimotor system. The ultimate timing of the output of this system, by which it imposes its effects upon the rest of the brain, is mediated by the CN. Indeed, decades of research on the OCS has resulted in detailed concepts as to how it may generate and control computations with high temporal complexity. However, due to methodological difficulties the function of the nucleo-olivary (NO) pathway, which links the CN with the IO, has been neglected, hindering completion of the cerebellar theory. To crack the relevant temporal codes of this loop I have developed specific viral optogenetic tools that allow for targeted control of the NO pathway. Using them I will define the NO interactions that take place during behavior and learning, and examine how these interactions are perturbed in neurological disorders.

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The information about "CRANOC" are provided by the European Opendata Portal: CORDIS opendata.

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