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CraNOC

Cracking the Nucleo-Olivary Code

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CraNOC project word cloud

Explore the words cloud of the CraNOC project. It provides you a very rough idea of what is the project "CraNOC" about.

computations    cognitive    theory    neurological    for    cerebellar    viral    constitute    reverberating    motor    orchestration    cortex    environments    functions    interactions    timing    harder    crack    humans    catch    beating    links    complexity    temporal    decades    olive    loop    sensorimotor    intrinsic    interestingly    codes    perturbed    olivo    falling    changing    oscillatory    examine    microcircuit    brain    completion    operations    tools    activated    ocs    mental    adjusted    nuclei    io    olivary    ctx    methodological    correct    generate    smooth    fairly    cn    muscles    movements    timescale    executive    function    ultimate    imposes    cctx    inferior    hindering    disorders    formed    unable    ed    output    proper    generating    millisecond    requiring    timed    learning    critical    optogenetic    individual    object    mediated    accurate    rest    difficulties    tripartite    happens    behavior    place    requests    constantly    nucleo    successful    animals   

Project "CraNOC" data sheet

The following table provides information about the project.

Coordinator
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

Organization address
address: DR MOLEWATERPLEIN 40
city: ROTTERDAM
postcode: 3015 GD
website: www.erasmusmc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://neuro.nl/research.php
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) coordinator 165˙598.00

Map

 Project objective

For animals and humans to be successful in their environments, their motor and cognitive behavior must be adjusted to the constantly changing reality at a millisecond-timescale. For example, it is fairly simple for a brain to determine which muscles need to be activated to catch a falling object, but much harder to determine when and for how long. Without correct timing of the executive brain functions, as happens in some neurological disorders, the individual is unable to produce smooth and accurate movements and will also have difficulties with a range of cognitive functions requiring orchestration of distinct mental operations. The tripartite olivo-cerebellar system (OCS), which is formed by the inferior olive (IO), cerebellar cortex (CCTX) and cerebellar nuclei (CN), is considered critical for generating proper timing for many motor and cognitive operations. Interestingly, all three areas, IO, CTX and CN, have intrinsic oscillatory properties and together they constitute a reverberating microcircuit, beating with well-timed responses to requests from the sensorimotor system. The ultimate timing of the output of this system, by which it imposes its effects upon the rest of the brain, is mediated by the CN. Indeed, decades of research on the OCS has resulted in detailed concepts as to how it may generate and control computations with high temporal complexity. However, due to methodological difficulties the function of the nucleo-olivary (NO) pathway, which links the CN with the IO, has been neglected, hindering completion of the cerebellar theory. To crack the relevant temporal codes of this loop I have developed specific viral optogenetic tools that allow for targeted control of the NO pathway. Using them I will define the NO interactions that take place during behavior and learning, and examine how these interactions are perturbed in neurological disorders.

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The information about "CRANOC" are provided by the European Opendata Portal: CORDIS opendata.

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