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CraNOC

Cracking the Nucleo-Olivary Code

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 CraNOC project word cloud

Explore the words cloud of the CraNOC project. It provides you a very rough idea of what is the project "CraNOC" about.

object    brain    sensorimotor    hindering    neurological    nuclei    falling    loop    ultimate    olivo    millisecond    interestingly    examine    timescale    ocs    accurate    place    ed    critical    executive    muscles    tools    function    reverberating    functions    temporal    oscillatory    proper    smooth    requiring    cn    cognitive    motor    animals    io    output    learning    methodological    movements    codes    ctx    individual    environments    computations    olive    disorders    activated    viral    mental    difficulties    generating    decades    timing    operations    cctx    rest    correct    cerebellar    timed    harder    orchestration    perturbed    intrinsic    theory    crack    for    olivary    tripartite    formed    imposes    changing    humans    links    complexity    mediated    adjusted    unable    microcircuit    beating    constitute    nucleo    behavior    happens    fairly    generate    interactions    completion    catch    successful    optogenetic    requests    cortex    constantly    inferior   

Project "CraNOC" data sheet

The following table provides information about the project.

Coordinator
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

Organization address
address: DR MOLEWATERPLEIN 40
city: ROTTERDAM
postcode: 3015 GD
website: www.erasmusmc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://neuro.nl/research.php
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) coordinator 165˙598.00

Map

 Project objective

For animals and humans to be successful in their environments, their motor and cognitive behavior must be adjusted to the constantly changing reality at a millisecond-timescale. For example, it is fairly simple for a brain to determine which muscles need to be activated to catch a falling object, but much harder to determine when and for how long. Without correct timing of the executive brain functions, as happens in some neurological disorders, the individual is unable to produce smooth and accurate movements and will also have difficulties with a range of cognitive functions requiring orchestration of distinct mental operations. The tripartite olivo-cerebellar system (OCS), which is formed by the inferior olive (IO), cerebellar cortex (CCTX) and cerebellar nuclei (CN), is considered critical for generating proper timing for many motor and cognitive operations. Interestingly, all three areas, IO, CTX and CN, have intrinsic oscillatory properties and together they constitute a reverberating microcircuit, beating with well-timed responses to requests from the sensorimotor system. The ultimate timing of the output of this system, by which it imposes its effects upon the rest of the brain, is mediated by the CN. Indeed, decades of research on the OCS has resulted in detailed concepts as to how it may generate and control computations with high temporal complexity. However, due to methodological difficulties the function of the nucleo-olivary (NO) pathway, which links the CN with the IO, has been neglected, hindering completion of the cerebellar theory. To crack the relevant temporal codes of this loop I have developed specific viral optogenetic tools that allow for targeted control of the NO pathway. Using them I will define the NO interactions that take place during behavior and learning, and examine how these interactions are perturbed in neurological disorders.

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The information about "CRANOC" are provided by the European Opendata Portal: CORDIS opendata.

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