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RECEPIANCE SIGNED

Molecular reconstitution of epigenetic centromere inheritance

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EC-Contrib. €

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 RECEPIANCE project word cloud

Explore the words cloud of the RECEPIANCE project. It provides you a very rough idea of what is the project "RECEPIANCE" about.

reductionist    atp    operates    deposition    exclusively    h3    eukaryotes    accurate    cellular    vital    reconstitute    notably    rsf    epigenetic    viability    mechanism    ideal    fact    binding    named    dna    transformation    hjurp    division    cycle    48    microtubules    cell    rely    containing    inner    centromeres    exchange    chromosomes    structurally    chaperones    chromosomal    genome    recombinant    specification    sprout    rbab46    dissect    neighboring    prominent    pillars    biochemically    organismal    centromere    mis18    cenp    kinetochore    daughter    puts    remodelling    mitosis    regulated    additional    kinetochores    inspiring    parental    machinery    molecular    maintenance    least    chromosome    proteins    nucleosome    structural    chromatin    chd1    mechanisms    reconstitution    biochemical    interface    segregation    recruited    variant    vitro    dissecting    manner    sequences    accessory    relies    consists    loci    death    recepiance    canonical    dependent    position    histone    latter    interfaces    enrichment    protecting    ultimate    cells    link    spindle    hypothesis   

Project "RECEPIANCE" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙064˙583 €
 EC max contribution 2˙064˙583 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2020-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 2˙064˙583.00

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 Project objective

Accurate segregation of the parental genome to the daughter cells during mitosis is essential for cell and organismal viability, protecting against cell death or cellular transformation. Kinetochores are crucial for accurate chromosome segregation because they link chromosomes to spindle microtubules. Kinetochores sprout from unique chromosomal loci named centromeres. In most eukaryotes, centromere specification does not rely on defined DNA sequences. Rather, centromere specification relies on epigenetic mechanisms, the most prominent of which is identified in the enrichment at centromeres of the histone H3 variant CENP-A. Deposition of new CENP-A at every cell cycle is vital for centromere maintenance through cell division. RECEPIANCE aims to dissect the molecular mechanism of CENP-A deposition through reductionist approach based on two main pillars, biochemical reconstitution and structural analysis.

The CENP-A deposition machinery consists of chromatin-remodelling factors, histone chaperones, and accessory factors, including the Mis18 complex, HJURP, RbAb46/48, the FACT complex, RSF, CHD1, and additional currently less characterized proteins. The CENP-A deposition machinery is recruited to centromeres in a cell cycle-regulated manner by inner kinetochore proteins associated with CENP-A, most notably CENP-C. The hypothesis inspiring this proposal is that the CENP-A deposition machinery operates on a unit containing at least one CENP-A nucleosome and a neighboring canonical H3 nucleosome, with the latter being the target for exchange with new CENP-A. Our ability to reconstitute the centromere-inner kinetochore interface puts us in an ideal position to study how the CENP-A deposition machinery is recruited to centromeres in vitro, dissecting the crucial binding interfaces and studying them biochemically and structurally. The ultimate goal of RECEPIANCE is to reconstitute the ATP-dependent exchange of H3 with CENP-A in vitro exclusively with recombinant proteins.

 Publications

year authors and title journal last update
List of publications.
2017 Satyakrishna Pentakota, Keda Zhou, Charlotte Smith, Stefano Maffini, Arsen Petrovic, Garry P Morgan, John R Weir, Ingrid R Vetter, Andrea Musacchio, Karolin Luger
Decoding the centromeric nucleosome through CENP-N
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.33442
eLife 6 2019-10-08
2018 Giuseppe Ciossani, Katharina Overlack, Arsen Petrovic, Pim J. Huis in \'t Veld, Carolin Koerner, Sabine Wohlgemuth, Stefano Maffini, Andrea Musacchio
The kinetochore proteins CENP-E and CENP-F directly and specifically interact with distinct BUB mitotic checkpoint Ser/Thr kinases
published pages: 10084-10101, ISSN: 0021-9258, DOI: 10.1074/jbc.RA118.003154
Journal of Biological Chemistry 293/26 2019-10-08
2018 Marion E. Pesenti, Daniel Prumbaum, Philip Auckland, Charlotte M. Smith, Alex C. Faesen, Arsen Petrovic, Muriel Erent, Stefano Maffini, Satyakrishna Pentakota, John R. Weir, Yu-Chih Lin, Stefan Raunser, Andrew D. McAinsh, Andrea Musacchio
Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80
published pages: 923-939.e10, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2018.07.038
Molecular Cell 71/6 2019-10-08
2017 Katharina Overlack, Tanja Bange, Florian Weissmann, Alex C. Faesen, Stefano Maffini, Ivana Primorac, Franziska Müller, Jan-Michael Peters, Andrea Musacchio
BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling
published pages: 2915-2927.e7, ISSN: 0960-9822, DOI: 10.1016/j.cub.2017.08.033
Current Biology 27/19 2019-10-08
2018 Vladimir A Volkov, Pim J Huis in \'t Veld, Marileen Dogterom, Andrea Musacchio
Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.36764
eLife 7 2019-10-08
2015 Andrea Musacchio
The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics
published pages: R1002-R1018, ISSN: 0960-9822, DOI: 10.1016/j.cub.2015.08.051
Current Biology 25/20 2019-07-04
2016 Yahui Liu, Arsen Petrovic, Pascaline Rombaut, Shyamal Mosalaganti, Jenny Keller, Stefan Raunser, Franz Herzog, Andrea Musacchio
Insights from the reconstitution of the divergent outer kinetochore of Drosophila melanogaster
published pages: 150236, ISSN: 2046-2441, DOI: 10.1098/rsob.150236
Open Biology 6/2 2019-07-04
2016 Arsen Petrovic, Jenny Keller, Yahui Liu, Katharina Overlack, Juliane John, Yoana N. Dimitrova, Simon Jenni, Suzan van Gerwen, Patricia Stege, Sabine Wohlgemuth, Pascaline Rombaut, Franz Herzog, Stephen C. Harrison, Ingrid R. Vetter, Andrea Musacchio
Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores
published pages: 1028-1040.e15, ISSN: 0092-8674, DOI: 10.1016/j.cell.2016.10.005
Cell 167/4 2019-07-04
2017 Dongqing Pan, Kerstin Klare, Arsen Petrovic, Annika Take, Kai Walstein, Priyanka Singh, Arnaud Rondelet, Alexander W Bird, Andrea Musacchio
CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.23352
eLife 6 2019-07-04
2017 Shyamal Mosalaganti, Jenny Keller, Anika Altenfeld, Michael Winzker, Pascaline Rombaut, Michael Saur, Arsen Petrovic, Annemarie Wehenkel, Sabine Wohlgemuth, Franziska Müller, Stefano Maffini, Tanja Bange, Franz Herzog, Herbert Waldmann, Stefan Raunser, Andrea Musacchio
Structure of the RZZ complex and molecular basis of its interaction with Spindly
published pages: 961-981, ISSN: 0021-9525, DOI: 10.1083/jcb.201611060
The Journal of Cell Biology 216/4 2019-07-04
2017 Alex C. Faesen, Maria Thanasoula, Stefano Maffini, Claudia Breit, Franziska Müller, Suzan van Gerwen, Tanja Bange, Andrea Musacchio
Basis of catalytic assembly of the mitotic checkpoint complex
published pages: 498-502, ISSN: 0028-0836, DOI: 10.1038/nature21384
Nature 542/7642 2019-07-04
2016 Pim J Huis in \'t Veld, Sadasivam Jeganathan, Arsen Petrovic, Priyanka Singh, Juliane John, Veronica Krenn, Florian Weissmann, Tanja Bange, Andrea Musacchio
Molecular basis of outer kinetochore assembly on CENP-T
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.21007
eLife 5 2019-07-04
2015 Veronica Krenn, Andrea Musacchio
The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling
published pages: , ISSN: 2234-943X, DOI: 10.3389/fonc.2015.00225
Frontiers in Oncology 5 2019-07-04
2017 Andrea Musacchio, Arshad Desai
A Molecular View of Kinetochore Assembly and Function
published pages: 5, ISSN: 2079-7737, DOI: 10.3390/biology6010005
Biology 6/4 2019-07-04
2016 Marion E Pesenti, John R Weir, Andrea Musacchio
Progress in the structural and functional characterization of kinetochores
published pages: 152-163, ISSN: 0959-440X, DOI: 10.1016/j.sbi.2016.03.003
Current Opinion in Structural Biology 37 2019-07-04
2016 John R. Weir, Alex C. Faesen, Kerstin Klare, Arsen Petrovic, Federica Basilico, Josef Fischböck, Satyakrishna Pentakota, Jenny Keller, Marion E. Pesenti, Dongqing Pan, Doro Vogt, Sabine Wohlgemuth, Franz Herzog, Andrea Musacchio
Insights from biochemical reconstitution into the architecture of human kinetochores
published pages: 249-253, ISSN: 0028-0836, DOI: 10.1038/nature19333
Nature 537/7619 2019-07-04

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