Explore the words cloud of the AdaptoSCOPE project. It provides you a very rough idea of what is the project "AdaptoSCOPE" about.
The following table provides information about the project.
UNIVERSITAET ZU KOELN
|Coordinator Country||Germany [DE]|
|Total cost||1˙683˙120 €|
|EC max contribution||1˙683˙120 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-09-01 to 2020-08-31|
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|1||UNIVERSITAET ZU KOELN||DE (KOELN)||coordinator||1˙683˙120.00|
The goal of this project is to demonstrate that novel aspects of the molecular basis of Darwinian adaptation can be discovered if the polygenic basis of adaptation is taken into account. This project will use the genome-wide distribution of cis-regulatory variants to discover the molecular pathways that are optimized during adaptation via accumulation of small effect mutations. Current approaches include scans for outlier genes with strong population genetics signatures of selection, or large effect QTL associating with fitness. They can only reveal a small subset of the molecular changes recruited along adaptive paths. Here, instead, the distribution of small effect mutations will be used to make inferences on the targets of polygenic adaptation across divergent populations in each of the two closely related species, A. thaliana and A. lyrata. These species are both found at diverse latitudes and show sign of local adaptation to climatic differences. Mutations affecting cis-regulation will be identified in leaves of plants exposed to various temperature regimes triggering phenotypic responses of adaptive relevance. Their distribution in clusters of functionally connected genes will be quantified. The phylogeographic differences in the distribution of the mutations will be used to disentangle neutral from adaptive clusters of functionally connected genes in each of the two species. This project will identify the molecular pathways subjected collectively to natural selection and provide a completely novel view on adaptive landscapes. It will further examine whether local adaptation occurs by convergent evolution of molecular systems in plants. This approach has the potential to find broad applications in ecology and agriculture.
|year||authors and title||journal||last update|
Juliette de Meaux
Cis -regulatory variation in plant genomes and the impact of natural selection
published pages: , ISSN: 0002-9122, DOI: 10.1002/ajb2.1180
|American Journal of Botany||2019-07-25|
Jinyong Hu, Li Lei, Juliette de Meaux
Temporal fitness fluctuations in experimental Arabidopsis thaliana populations
published pages: e0178990, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0178990
|PLOS ONE 12/6||2019-07-25|
Hannes Dittberner, Arthur Korte, Tabea Mettler-Altmann, Andreas P. M. Weber, Grey Monroe, Juliette de Meaux
Natural variation in stomata size contributes to the local adaptation of water-use efficiency in Arabidopsis thaliana
published pages: 4052-4065, ISSN: 0962-1083, DOI: 10.1111/mec.14838
|Molecular Ecology 27/20||2019-07-25|
Ulrike GÃ¶bel, Agustin L Arce, Fei He, Alain Rico, Gregor Schmitz, Juliette de Meaux
Robustness of Transposable Element Regulation but No Genomic Shock Observed in Interspecific Arabidopsis Hybrids
published pages: 1403-1415, ISSN: 1759-6653, DOI: 10.1093/gbe/evy095
|Genome Biology and Evolution 10/6||2019-07-25|
Shirin Glander, Fei He, Gregor Schmitz, Anika Witten, Arndt Telschow, Juliette de Meaux
Assortment of Flowering Time and Immunity Alleles in Natural Arabidopsis thaliana Populations Suggests Immunity and Vegetative Lifespan Strategies Coevolve
published pages: 2278-2291, ISSN: 1759-6653, DOI: 10.1093/gbe/evy124
|Genome Biology and Evolution 10/9||2019-07-25|
Fei He, Agustin L. Arce, Gregor Schmitz, Maarten Koornneef, Polina Novikova, Andreas Beyer, Juliette de Meaux
The Footprint of Polygenic Adaptation on Stress-Responsive Cis -Regulatory Divergence in the Arabidopsis Genus
published pages: 2088-2101, ISSN: 0737-4038, DOI: 10.1093/molbev/msw096
|Molecular Biology and Evolution 33/8||2019-07-25|
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The information about "ADAPTOSCOPE" are provided by the European Opendata Portal: CORDIS opendata.