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BtRAIN SIGNED

Brain barriers training

Total Cost €

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EC-Contrib. €

0

Partnership

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 BtRAIN project word cloud

Explore the words cloud of the BtRAIN project. It provides you a very rough idea of what is the project "BtRAIN" about.

bbbhub    treatment    capacity    pool    hampered    platform    motivation    cns    ageing    neurotoxic    datamining    protect    12    alterations    compounds    drugs    innovative    traits    train    disease    interfaces    block    young    progress    validate    breach    barriers    regulating    diagnosis    accompanying    made    academic    alzheimer    combined    armamentarium    combining    roles    create    userfriendly    euopean    science    central    transcriptome    barrier    network    vertebrate    pathological    international    career    disorders    overcome    bioinformatics    brain    multiple    market    data    species    signature    entrepreneur    online    proper    gap    sclerosis    reliably    business    models    expert    unfortunately    hindering    communication    side    predict    suited    tools    diagnostic    bridges    genes    health    therapeutic    vitro    neurological    cross    nervous    unmet    unusual    therapeutics    untapped    btrain    complexity    vivo    function    broad    jointly    severely   

Project "BtRAIN" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET BERN 

Organization address
address: HOCHSCHULSTRASSE 6
city: BERN
postcode: 3012
website: http://www.unibe.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website http://www.btrain-2020.eu/
 Total cost 3˙067˙402 €
 EC max contribution 3˙067˙402 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 530˙453.00
2    THE OPEN UNIVERSITY UK (MILTON KEYNES) participant 273˙287.00
3    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) participant 265˙226.00
4    UNIVERSITE D'ARTOIS FR (ARRAS) participant 262˙875.00
5    IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE IT (MILANO) participant 258˙061.00
6    STICHTING VUMC NL (AMSTERDAM) participant 255˙374.00
7    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) participant 250˙560.00
8    GENXPRO GMBH DE (FRANKFURT) participant 249˙216.00
9    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 249˙216.00
10    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG DE (HEIDELBERG) participant 249˙216.00
11    SZEGEDI BIOLOGIAI KUTATOKOZPONT HU (SZEGED) participant 223˙913.00
12    STICHTING VU NL (AMSTERDAM) participant 0.00
13    BRAINS FOR BRAIN FOUNDATION ONLUS IT (PADOVA) partner 0.00
14    F. HOFFMANN-LA ROCHE AG CH (BASEL) partner 0.00
15    LAVISION BIOTEC GMBH DE (BIELEFELD) partner 0.00
16    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) partner 0.00
17    NCARDIA BV NL (LEIDEN) partner 0.00
18    Scitec-media GmbH CH (Winterthur) partner 0.00
19    TP21 GMBH DE (BERLIN) partner 0.00
20    UNIVERSITY OF SAN DIEGO US (SAN DIEGO) partner 0.00

Map

 Project objective

The brain barriers function to protect the central nervous system (CNS) from neurotoxic compounds. By the same traits they unfortunately block delivery of drugs to the CNS thus hindering proper diagnosis and effective treatment of neurological disorders including Alzheimer’s disease and multiple sclerosis. The unusual complexity of the brain barriers has severely hampered progress in the market of CNS targeting therapeutics. BtRAIN bridges this gap by creating particular knowledge on vertebrate brain barrier signature genes and their specific roles in regulating brain barrier function in development, health, ageing and disease. Brain barrier signature genes will be identified by combining cross-species and cross-system brain barrier transcriptome analysis with dedicated bioinformatics. These data will be made available for brain barrier datamining in the userfriendly online platform BBBHub. Within BtRAIN, the side-by-side comparison of a unique and broad armamentarium of different vertebrate in vitro and in vivo brain barrier models will allow to develop and validate particular in vitro brain barrier models that are suited to reliably predict brain barrier function in vivo. Combined with an accompanying in depth analysis of the pathological alterations of the brain barriers during neurological disorders BtRAIN will create unique knowledge to overcome the unmet need for the development of diagnostic and therapeutic tools able to breach the brain barriers. In BtRAIN 12 academic, 6 non-academic partners and 1 European network will jointly train young researchers at unique interfaces of brain barrier research, bioinformatics, business development and science communication for an international research or entrepreneur career. To create this expert pool is the motivation for the involved partners as it will advance the Euopean capacity to bring innovative approaches to the untapped potential of the CNS therapeutic market.

 Publications

year authors and title journal last update
List of publications.
2019 Monica Corada, Fabrizio Orsenigo, Ganesh Parameshwar Bhat, Lei Liu Conze, Ferruccio Breviario, Sara Isabel Cunha, Lena Claesson-Welsh, Galina V. Beznoussenko, Alexander A. Mironov, Marco Bacigaluppi, Gianvito Martino, Mara E. Pitulescu, Ralf H. Adams, Peetra Magnusson, Elisabetta Dejana
Fine-Tuning of Sox17 and Canonical Wnt Coordinates the Permeability Properties of the Blood-Brain Barrier
published pages: 511-525, ISSN: 0009-7330, DOI: 10.1161/circresaha.118.313316
Circulation Research 124/4 2019-10-29
2018 Marco F. Morini, Costanza Giampietro, Monica Corada, Federica Pisati, Elisa Lavarone, Sara I. Cunha, Lei L. Conze, Nicola O’Reilly, Dhira Joshi, Svend Kjaer, Roger George, Emma Nye, Anqi Ma, Jian Jin, Richard Mitter, Michela Lupia, Ugo Cavallaro, Diego Pasini, Dinis P. Calado, Elisabetta Dejana, Andrea Taddei
VE-Cadherin–Mediated Epigenetic Regulation of Endothelial Gene Expression
published pages: 231-245, ISSN: 0009-7330, DOI: 10.1161/circresaha.117.312392
Circulation Research 122/2 2019-10-29
2019 Lasse D. Jensen, Belma Hot, Daniel Ramsköld, Raoul F.V. Germano, Chika Yokota, Sarantis Giatrellis, Volker M. Lauschke, Dirk Hubmacher, Minerva X. Li, Mike Hupe, Thomas D. Arnold, Rickard Sandberg, Jonas Frisén, Marta Trusohamn, Agnieszka Martowicz, Joanna Wisniewska-Kruk, Daniel Nyqvist, Ralf H. Adams, Suneel S. Apte, Benoit Vanhollebeke, Jan M. Stenman, Julianna Kele
Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of β-Catenin Signaling
published pages: 1432-1447, ISSN: 1079-5642, DOI: 10.1161/atvbaha.119.312388
Arteriosclerosis, Thrombosis, and Vascular Biology 39/7 2019-10-16
2019 Fabienne Benz, Viraya Wichitnaowarat, Martin Lehmann, Raoul FV Germano, Diana Mihova, Jadranka Macas, Ralf H Adams, M Mark Taketo, Karl-Heinz Plate, Sylvaine Guérit, Benoit Vanhollebeke, Stefan Liebner
Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.43818
eLife 8 2019-10-16
2018 Almary Guerra, Raoul FV Germano, Oliver Stone, Rima Arnaout, Stefan Guenther, Suchit Ahuja, Verónica Uribe, Benoit Vanhollebeke, Didier YR Stainier, Sven Reischauer
Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.32833
eLife 7 2019-10-16

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