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ChromoCellDev SIGNED

Chromosome Architecture and the Fidelity of Mitosis during Development

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ChromoCellDev" data sheet

The following table provides information about the project.

Coordinator
FUNDACAO CALOUSTE GULBENKIAN 

Organization address
address: AVENIDA BERNA 45
city: LISBOA
postcode: 1000
website: www.igc.gulbenkian.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website http://www.chromosomedynamicslab.pt
 Total cost 1˙492˙000 €
 EC max contribution 1˙492˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACAO CALOUSTE GULBENKIAN PT (LISBOA) coordinator 1˙492˙000.00

Map

 Project objective

Genome stability relies on accurate partition of the genome during nuclear division. Proper mitosis, in turn, depends on changes in chromosome organization, such as chromosome condensation and sister chromatid cohesion. Despite the importance of these structural changes, chromatin itself has been long assumed to play a rather passive role during mitosis and chromosomes are usually compared to a “corpse at a funeral: they provide the reason for the proceedings but do not take an active part in them.” (Mazia, 1961). Recent evidence, however, suggests that chromosomes play a more active role in the process of their own segregation. The present proposal tests the “active chromosome” hypothesis by investigating how chromosome morphology influences the fidelity of mitosis. I will use innovative methods for acute protein inactivation, developed during my postdoctoral studies, to evaluate the role of two key protein complexes involved in mitotic chromosome architecture - Condensins and Cohesins. Using a multidisciplinary approach, combining acute protein inactivation, 3D-live cell imaging and quantitative methods, I propose to investigate the role of mitotic chromosomes in the fidelity of mitosis at three different levels. The first one will use novel approaches to uncover the process of mitotic chromosome assembly, which is still largely unknown. The second will explore how mitotic chromosomes take an active part in mitosis by examining how chromosome condensation and cohesion influence chromosome movement and the signalling of the surveillance mechanisms that control nuclear division. Lastly we will evaluate how mitotic errors arising from abnormal chromosome structure impact on development. We aim to evaluate, at the cellular and organism level, how the cell perceives such errors and how (indeed if) they tolerate mitotic abnormalities. By conceptually challenging the passive chromosome view this project has the potential to redefine the role of chromatin during mitosis.

 Publications

year authors and title journal last update
List of publications.
2017 Ewa Piskadlo
Maintenance of metaphase chromosome architecture by condensin I
published pages: , ISSN: , DOI:
2020-01-15
2018 Rui D. Silva, Mihailo Mirkovic, Leonardo G. Guilgur, Om S. Rathore, Rui Gonçalo Martinho, Raquel A. Oliveira
Absence of the Spindle Assembly Checkpoint Restores Mitotic Fidelity upon Loss of Sister Chromatid Cohesion
published pages: 2837-2844.e3, ISSN: 0960-9822, DOI: 10.1016/j.cub.2018.06.062
Current Biology 28/17 2020-01-15
2017 Ewa Piskadlo and Raquel A Oliveira
A Topology-Centric View on Mitotic Chromosome Architecture
published pages: 2751, ISSN: 1422-0067, DOI: 10.3390/ijms18122751
International Journal of Molecular Sciences 18/12 2020-01-15
2017 Ewa Piskadlo, Alexandra Tavares, Raquel A Oliveira
Metaphase chromosome structure is dynamically maintained by condensin I-directed DNA (de)catenation
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.26120
eLife 6 2020-01-15
2018 Mihailo Mirkovic
Cohesion failure and Mitosis: From Molecular Mechanisms to Organismal Consequences
published pages: , ISSN: , DOI:
2020-01-15
2018 Sara Carvalhal, Alexandra Tavares, Mariana B. Santos, Mihailo Mirkovic, Raquel A. Oliveira
A quantitative analysis of cohesin decay in mitotic fidelity
published pages: 3343-3353, ISSN: 0021-9525, DOI: 10.1083/jcb.201801111
The Journal of Cell Biology 217/10 2020-01-15

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The information about "CHROMOCELLDEV" are provided by the European Opendata Portal: CORDIS opendata.

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