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SurfaceInhibition SIGNED

The role of 5HT3a inhibitory interneurons in sensory processing

Total Cost €

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EC-Contrib. €

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Partnership

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 SurfaceInhibition project word cloud

Explore the words cloud of the SurfaceInhibition project. It provides you a very rough idea of what is the project "SurfaceInhibition" about.

combination    models    photon    leads    cortex    receptor    3d    excitatory    receive    expressing    encoded    whiskers    imaging    integrate    perception    suggesting    constructing    vivo    light    poorly    accurate    types    distal    stimuli    contribution    roles    layers    individual    cortical    simultaneously    mice    domains    data    computer    integration    shed    mechanistic    disease    experimental    principal    gain    object    circuits    interactions    how    pyramidal    cells    whereby    excitability    record    accessible    subcellular    description    input    influence    circuit    population    dendrites    comprised    stimulus    location    dendritic    reveal    morphologically    cell    fixed    hypothesize    serotonin    functions    diverse    sensory    recording    neurons    perceptions    electrophysiology    insights    perceptual    superficial    mainly    contextual    inhibitory    5ht3a    head    optically    decision    normal    pillars    quantified    subtypes   

Project "SurfaceInhibition" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITETET I OSLO 

Organization address
address: PROBLEMVEIEN 5-7
city: OSLO
postcode: 313
website: www.uio.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Project website http://www.vervaeke-lab.org
 Total cost 1˙350˙000 €
 EC max contribution 1˙350˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-12-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITETET I OSLO NO (OSLO) coordinator 1˙350˙000.00

Map

 Project objective

How do cortical circuits process sensory stimuli that leads to perception? Sensory input is encoded by complex interactions between principal excitatory neurons and a diverse population of inhibitory cells. Distinct inhibitory neurons control different subcellular domains of target principal neurons, suggesting specific roles of different cells during sensory processing. However, the individual contribution of these inhibitory subtypes to sensory processing remains poorly understood. This is mainly due to the technical challenges of recording the activity of identified cell types in-vivo, in response to quantified sensory stimuli. Therefore, I propose a novel approach based on four pillars: 1) An optically accessible circuit in the superficial layers of the cortex, comprised of inhibitory cells expressing the serotonin receptor 5HT3a, and the distal dendrites of pyramidal neurons. 2) A novel combination of electrophysiology and 3D two-photon imaging to simultaneously record the activity of morphologically identified 5HT3a cells and their dendritic targets. 3) A head-fixed perceptual decision task, whereby mice use their whiskers to determine the location of an object, allowing an accurate description of the sensory stimulus. 4) The integration of experimental data and computer models to gain mechanistic insights into circuit functions. The 5HT3a cells and the distal dendrites of pyramidal neurons receive ‘top-down’ contextual information from other cortical areas that is essential for constructing meaningful perceptions of sensory stimuli. Thus I hypothesize that 5HT3a cells influence sensory perceptions by controlling the excitability of the pyramidal cell distal dendrites that integrate top-down and sensory input. Thus, I will not only reveal novel functions of inhibitory neurons, I will also shed light on how top-down and sensory input is integrated, and I will provide novel methods to test the functions of other cell types in normal mice and disease models.

 Publications

year authors and title journal last update
List of publications.
2018 Hua Hu, Koen Vervaeke
Synaptic Integration in Cortical Inhibitory Neuron Dendrites
published pages: 115-131, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2017.06.065
Neuroscience 368 2019-03-11

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