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SurfaceInhibition SIGNED

The role of 5HT3a inhibitory interneurons in sensory processing

Total Cost €

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EC-Contrib. €

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Partnership

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 SurfaceInhibition project word cloud

Explore the words cloud of the SurfaceInhibition project. It provides you a very rough idea of what is the project "SurfaceInhibition" about.

computer    decision    subcellular    description    domains    comprised    insights    object    accessible    expressing    pyramidal    perceptions    dendrites    individual    principal    electrophysiology    circuits    mechanistic    serotonin    simultaneously    perception    influence    integration    vivo    functions    suggesting    hypothesize    3d    cortical    reveal    cortex    cells    head    models    whereby    poorly    light    mice    circuit    constructing    how    fixed    quantified    integrate    sensory    5ht3a    normal    whiskers    accurate    stimulus    neurons    contribution    inhibitory    subtypes    input    distal    record    receptor    types    receive    mainly    shed    diverse    dendritic    contextual    morphologically    roles    excitability    gain    disease    perceptual    recording    excitatory    optically    combination    leads    population    imaging    experimental    layers    pillars    location    cell    superficial    encoded    photon    interactions    stimuli    data   

Project "SurfaceInhibition" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITETET I OSLO 

Organization address
address: PROBLEMVEIEN 5-7
city: OSLO
postcode: 313
website: www.uio.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Project website http://www.vervaeke-lab.org
 Total cost 1˙350˙000 €
 EC max contribution 1˙350˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-12-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITETET I OSLO NO (OSLO) coordinator 1˙350˙000.00

Map

 Project objective

How do cortical circuits process sensory stimuli that leads to perception? Sensory input is encoded by complex interactions between principal excitatory neurons and a diverse population of inhibitory cells. Distinct inhibitory neurons control different subcellular domains of target principal neurons, suggesting specific roles of different cells during sensory processing. However, the individual contribution of these inhibitory subtypes to sensory processing remains poorly understood. This is mainly due to the technical challenges of recording the activity of identified cell types in-vivo, in response to quantified sensory stimuli. Therefore, I propose a novel approach based on four pillars: 1) An optically accessible circuit in the superficial layers of the cortex, comprised of inhibitory cells expressing the serotonin receptor 5HT3a, and the distal dendrites of pyramidal neurons. 2) A novel combination of electrophysiology and 3D two-photon imaging to simultaneously record the activity of morphologically identified 5HT3a cells and their dendritic targets. 3) A head-fixed perceptual decision task, whereby mice use their whiskers to determine the location of an object, allowing an accurate description of the sensory stimulus. 4) The integration of experimental data and computer models to gain mechanistic insights into circuit functions. The 5HT3a cells and the distal dendrites of pyramidal neurons receive ‘top-down’ contextual information from other cortical areas that is essential for constructing meaningful perceptions of sensory stimuli. Thus I hypothesize that 5HT3a cells influence sensory perceptions by controlling the excitability of the pyramidal cell distal dendrites that integrate top-down and sensory input. Thus, I will not only reveal novel functions of inhibitory neurons, I will also shed light on how top-down and sensory input is integrated, and I will provide novel methods to test the functions of other cell types in normal mice and disease models.

 Publications

year authors and title journal last update
List of publications.
2018 Hua Hu, Koen Vervaeke
Synaptic Integration in Cortical Inhibitory Neuron Dendrites
published pages: 115-131, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2017.06.065
Neuroscience 368 2019-03-11

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