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SurfaceInhibition SIGNED

The role of 5HT3a inhibitory interneurons in sensory processing

Total Cost €


EC-Contrib. €






 SurfaceInhibition project word cloud

Explore the words cloud of the SurfaceInhibition project. It provides you a very rough idea of what is the project "SurfaceInhibition" about.

cells    contextual    location    pillars    description    disease    individual    superficial    mice    accessible    principal    accurate    quantified    vivo    whiskers    hypothesize    object    imaging    sensory    inhibitory    combination    neurons    constructing    cell    subcellular    light    data    optically    photon    pyramidal    contribution    5ht3a    recording    perceptual    roles    3d    circuits    electrophysiology    circuit    subtypes    excitatory    gain    integrate    domains    cortical    computer    types    perception    excitability    normal    functions    mainly    expressing    leads    distal    head    mechanistic    interactions    diverse    poorly    encoded    population    comprised    receive    dendrites    input    serotonin    shed    models    perceptions    whereby    insights    dendritic    experimental    receptor    suggesting    morphologically    decision    how    cortex    integration    record    stimuli    fixed    stimulus    layers    simultaneously    influence    reveal   

Project "SurfaceInhibition" data sheet

The following table provides information about the project.


Organization address
address: PROBLEMVEIEN 5-7
city: OSLO
postcode: 313

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Project website
 Total cost 1˙350˙000 €
 EC max contribution 1˙350˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-12-01   to  2020-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITETET I OSLO NO (OSLO) coordinator 1˙350˙000.00


 Project objective

How do cortical circuits process sensory stimuli that leads to perception? Sensory input is encoded by complex interactions between principal excitatory neurons and a diverse population of inhibitory cells. Distinct inhibitory neurons control different subcellular domains of target principal neurons, suggesting specific roles of different cells during sensory processing. However, the individual contribution of these inhibitory subtypes to sensory processing remains poorly understood. This is mainly due to the technical challenges of recording the activity of identified cell types in-vivo, in response to quantified sensory stimuli. Therefore, I propose a novel approach based on four pillars: 1) An optically accessible circuit in the superficial layers of the cortex, comprised of inhibitory cells expressing the serotonin receptor 5HT3a, and the distal dendrites of pyramidal neurons. 2) A novel combination of electrophysiology and 3D two-photon imaging to simultaneously record the activity of morphologically identified 5HT3a cells and their dendritic targets. 3) A head-fixed perceptual decision task, whereby mice use their whiskers to determine the location of an object, allowing an accurate description of the sensory stimulus. 4) The integration of experimental data and computer models to gain mechanistic insights into circuit functions. The 5HT3a cells and the distal dendrites of pyramidal neurons receive ‘top-down’ contextual information from other cortical areas that is essential for constructing meaningful perceptions of sensory stimuli. Thus I hypothesize that 5HT3a cells influence sensory perceptions by controlling the excitability of the pyramidal cell distal dendrites that integrate top-down and sensory input. Thus, I will not only reveal novel functions of inhibitory neurons, I will also shed light on how top-down and sensory input is integrated, and I will provide novel methods to test the functions of other cell types in normal mice and disease models.


year authors and title journal last update
List of publications.
2018 Hua Hu, Koen Vervaeke
Synaptic Integration in Cortical Inhibitory Neuron Dendrites
published pages: 115-131, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2017.06.065
Neuroscience 368 2019-03-11

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The information about "SURFACEINHIBITION" are provided by the European Opendata Portal: CORDIS opendata.

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