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NANOMED SIGNED

Nanomedicine: an integrative approach

Total Cost €

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EC-Contrib. €

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Partnership

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Project "NANOMED" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT EINDHOVEN 

Organization address
address: GROENE LOPER 3
city: EINDHOVEN
postcode: 5612 AE
website: www.tue.nl/en

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://nanomeditn.eu/
 Total cost 3˙894˙543 €
 EC max contribution 3˙894˙543 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-ETN
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) coordinator 652˙623.00
2    UNIVERSITEIT GENT BE (GENT) participant 751˙680.00
3    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 546˙575.00
4    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) participant 538˙290.00
5    UNIVERSITE DE BORDEAUX FR (BORDEAUX) participant 525˙751.00
6    UNIVERSITEIT UTRECHT NL (UTRECHT) participant 510˙748.00
7    CHEMCONNECTION BV NL (OSS) participant 255˙374.00
8    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) participant 113˙499.00
9    Enceladus Pharmaceuticals BV NL (Naarden) partner 0.00
10    OZ BIOSCIENCES SAS FR (MARSEILLE) partner 0.00
11    POLYVATION BV NL (GRONINGEN) partner 0.00
12    Retina International CH (Zurich) partner 0.00
13    SYNTHON BIOPHARMACEUTICALS BV NL (NIJMEGEN) partner 0.00

Map

 Project objective

Nanomedicine (NM) is regarded as one of the most promising applications of nanotechnology, as it would allow the development of tailored therapies, with a high level of selectivity and efficacy. Although much research has been performed over the past decades, translation from academia to commercial application remains disappointingly low. Reasons that explain the current moderate success of NM are: (1) promising preclinical results are often poorly predictive for clinical safety and effectiveness, (2) the efficient, scalable and reproducible GMP production of nanocarriers has proven to be challenging and (3) regulatory frameworks are not yet fully equipped to efficiently facilitate the introduction of novel nanomedicines. These obstacles are often encountered since the developmental process from carrier design to clinical assessment is performed by a range of scientists from different backgrounds who have difficulty interacting and communicating with each other to clearly understand the necessary design criteria and the scope and limitations of NM. NANOMED brings together all the necessary expertise to oversee the entire development trajectory required for NM. This is achieved by the combined effort of 7 beneficiaries from academia and industry and 5 non-academic partner organisations, which are all thoroughly rooted in nanosciences and pharmaceutical sciences. Our objective is to develop scalable and highly controllable design and synthesis methods for the most promising nanomedicine types in a preclinical setting. NANOMED will train the next generation of NM scientists by offering an extensive joint training programme to 15 incoming ESRs. It focuses on promoting scientific excellence and exploits the specific research and commercial expertise and infrastructure of the NANOMED network as a whole. The exposure to all elements of NM design enables NANOMED to translate expertise from all disciplines to the ESRs, to educate the future leading scientists in the NM field.

 Deliverables

List of deliverables.
Website Websites, patent fillings, videos etc. 2019-06-19 13:44:19
Certificates Other 2019-06-19 13:44:19
Prizes Other 2019-06-19 13:44:19

Take a look to the deliverables list in detail:  detailed list of NANOMED deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Bano Subia, Mika Reinisalo, Namit Dey, Shirin Tavakoli, Astrid Subrizi, Munia Ganguli, Marika Ruponen
Nucleic acid delivery to differentiated retinal pigment epithelial cells using cell-penetrating peptide as a carrier
published pages: 91-99, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2019.05.003
European Journal of Pharmaceutics and Biopharmaceutics 140 2020-03-05
2019 Roberta Guagliardo, Pieterjan Merckx, Agata Zamborlin, Lynn De Backer, Mercedes Echaide, Jesus Pérez-Gil, Stefaan C. De Smedt, Koen Raemdonck
Nanocarrier Lipid Composition Modulates the Impact of Pulmonary Surfactant Protein B (SP-B) on Cellular Delivery of siRNA
published pages: 431, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics11090431
Pharmaceutics 11/9 2020-03-05
2019 Neda Kordalivand, Elena Tondini, Chun Yin Jerry Lau, Tina Vermonden, Enrico Mastrobattista, Wim E. Hennink, Ferry Ossendorp, Cornelus F. van Nostrum
Cationic synthetic long peptides-loaded nanogels: An efficient therapeutic vaccine formulation for induction of T-cell responses
published pages: 114-125, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2019.10.048
Journal of Controlled Release 315 2020-03-05
2019 Mattias Björnmalm, Lok Man Wong, Jonathan P. Wojciechowski, Jelle Penders, Conor C. Horgan, Marsilea A. Booth, Nicholas G. Martin, Susanne Sattler, Molly M. Stevens
In vivo biocompatibility and immunogenicity of metal–phenolic gelation
published pages: 10179-10194, ISSN: 2041-6520, DOI: 10.1039/c9sc03325d
Chemical Science 10/43 2020-03-05
2018 Jelle Penders, Isaac J. Pence, Conor C. Horgan, Mads S. Bergholt, Christopher S. Wood, Adrian Najer, Ulrike Kauscher, Anika Nagelkerke, Molly M. Stevens
Single Particle Automated Raman Trapping Analysis
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06397-6
Nature Communications 9/1 2020-03-05
2018 Roberta Guagliardo, Jesús Pérez-Gil, Stefaan De Smedt, Koen Raemdonck
Pulmonary surfactant and drug delivery: Focusing on the role of surfactant proteins
published pages: 116-126, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2018.10.012
Journal of Controlled Release 291 2020-03-05
2019 Jaleesa Bresseleers, Mahsa Bagheri, Gert Storm, Josbert M. Metselaar, Wim E. Hennink, Silvie A. Meeuwissen, Jan C. M. van Hest
Scale-Up of the Manufacturing Process To Produce Docetaxel-Loaded mPEG- b -p(HPMA-Bz) Block Copolymer Micelles for Pharmaceutical Applications
published pages: 2707-2715, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.9b00387
Organic Process Research & Development 23/12 2020-03-05
2019 Molood Shariati, Wouter Willaert, Wim Ceelen, Stefaan C. De Smedt, Katrien Remaut
Aerosolization of Nanotherapeutics as a Newly Emerging Treatment Regimen for Peritoneal Carcinomatosis
published pages: 906, ISSN: 2072-6694, DOI: 10.3390/cancers11070906
Cancers 11/7 2020-03-05
2018 Bo Lou, Stefaan De Koker, Chun Yin Jerry Lau, Wim E. Hennink, Enrico Mastrobattista
mRNA Polyplexes with Post-Conjugated GALA Peptides Efficiently Target, Transfect, and Activate Antigen Presenting Cells
published pages: 461-475, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.8b00524
Bioconjugate Chemistry 30/2 2020-03-05
2018 Pieterjan Merckx, Lynn De Backer, Lien Van Hoecke, Roberta Guagliardo, Mercedes Echaide, Pieter Baatsen, Bárbara Olmeda, Xavier Saelens, Jésus Pérez-Gil, Stefaan C. De Smedt, Koen Raemdonck
Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy
published pages: 236-246, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.08.012
Acta Biomaterialia 78 2020-03-05
2018 Roxane Ridolfo, Benjamin C. Ede, Paraskevi Diamanti, Paul B. White, Adam W. Perriman, Jan C. M. van Hest, Allison Blair, David S. Williams
Biodegradable, Drug-Loaded Nanovectors via Direct Hydration as a New Platform for Cancer Therapeutics
published pages: 1703774, ISSN: 1613-6810, DOI: 10.1002/smll.201703774
Small 14/32 2019-11-22
2019 Hailong Che, Jianzhi Zhu, Shidong Song, Alexander F. Mason, Shoupeng Cao, Imke A. B. Pijpers, Loai K. E. A. Abdelmohsen, Jan C. M. van Hest
ATP-Mediated Transient Behavior of Stomatocyte Nanosystems
published pages: 13113-13118, ISSN: 1433-7851, DOI: 10.1002/anie.201906331
Angewandte Chemie International Edition 58/37 2019-11-22
2019 Shoupeng Cao, Jingxin Shao, Yifeng Xia, Hailong Che, Zhiyuan Zhong, Fenghua Meng, Jan C. M. van Hest, Loai K. E. A. Abdelmohsen, David S. Williams
Molecular Programming of Biodegradable Nanoworms via Ionically Induced Morphology Switch toward Asymmetric Therapeutic Carriers
published pages: 1901849, ISSN: 1613-6810, DOI: 10.1002/smll.201901849
Small 15/38 2019-11-22
2018 Shoupeng Cao, Loai K. E. A. Abdelmohsen, Jingxin Shao, Joep van den Dikkenberg, Enrico Mastrobattista, David S. Williams, Jan C. M. van Hest
pH-Induced Transformation of Biodegradable Multilamellar Nanovectors for Enhanced Tumor Penetration
published pages: 1394-1399, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.8b00807
ACS Macro Letters 7/11 2019-11-22
2019 Jingxin Shao, Imke A. B. Pijpers, Shoupeng Cao, David S. Williams, Xuehai Yan, Junbai Li, Loai K. E. A. Abdelmohsen, Jan C. M. van Hest
Biomorphic Engineering of Multifunctional Polylactide Stomatocytes toward Therapeutic Nano-Red Blood Cells
published pages: 1801678, ISSN: 2198-3844, DOI: 10.1002/advs.201801678
Advanced Science 6/5 2019-11-22
2019 Yigit Altay, Shoupeng Cao, Hailong Che, Loai K. E. A. Abdelmohsen, Jan C. M. van Hest
Adaptive Polymeric Assemblies for Applications in Biomimicry and Nanomedicine
published pages: 4053-4064, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.9b01341
Biomacromolecules 20/11 2019-11-22
2019 Jianzhi Zhu, Zhicong Li, Changchang Zhang, Lizhou Lin, Shoupeng Cao, Hailong Che, Xiangyang Shi, Han Wang, Jan C. M. van Hest
Single enzyme loaded nanoparticles for combinational ultrasound-guided focused ultrasound ablation and hypoxia-relieved chemotherapy
published pages: 8048-8060, ISSN: 1838-7640, DOI: 10.7150/thno.37054
Theranostics 9/26 2019-11-22
2018 Mahsa Bagheri, Jaleesa Bresseleers, Aida Varela-Moreira, Olivier Sandre, Silvie A. Meeuwissen, Raymond M. Schiffelers, Josbert M. Metselaar, Cornelus F. van Nostrum, Jan C. M. van Hest, Wim E. Hennink
Effect of Formulation and Processing Parameters on the Size of mPEG- b -p(HPMA-Bz) Polymeric Micelles
published pages: 15495-15506, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.8b03576
Langmuir 34/50 2019-11-14
2018 Imke A. B. Pijpers, Loai K. E. A. Abdelmohsen, Yifeng Xia, Shoupeng Cao, David S. Williams, Fenghua Meng, Jan C. M. Hest, Zhiyuan Zhong
Adaptive Polymersome and Micelle Morphologies in Anticancer Nanomedicine: From Design Rationale to Fabrication and Proof‐of‐Concept Studies
published pages: 1800068, ISSN: 2366-3987, DOI: 10.1002/adtp.201800068
ADVANCED THERAPEUTICS 1/8 2019-11-14
2018 Jingxin Shao, Mona Abdelghani, Guizhi Shen, Shoupeng Cao, David S. Williams, Jan C. M. van Hest
Erythrocyte Membrane Modified Janus Polymeric Motors for Thrombus Therapy
published pages: 4877-4885, ISSN: 1936-0851, DOI: 10.1021/acsnano.8b01772
ACS Nano 12/5 2019-06-19
2018 Hailong Che, Shoupeng Cao, Jan C. M. van Hest
Feedback-Induced Temporal Control of “Breathing” Polymersomes To Create Self-Adaptive Nanoreactors
published pages: 5356-5359, ISSN: 0002-7863, DOI: 10.1021/jacs.8b02387
Journal of the American Chemical Society 140/16 2019-06-19

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