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NANOMED SIGNED

Nanomedicine: an integrative approach

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

NANOMED project word cloud

Explore the words cloud of the NANOMED project. It provides you a very rough idea of what is the project "NANOMED" about.

nanotechnology reproducible performed translate disciplines translation decades academic nanomed incoming nm frameworks rooted sciences difficulty gmp setting beneficiaries proven scope nanocarriers moderate thoroughly regarded effectiveness training network effort synthesis generation pharmaceutical efficient developmental exploits commercial communicating nanosciences selectivity preclinical academia obstacles limitations poorly esrs expertise understand predictive 15 trajectory criteria clinical train excellence educate oversee introduction scalable disappointingly carrier backgrounds exposure therapies nanomedicines infrastructure types regulatory equipped extensive nanomedicine efficacy brings safety joint scientific encountered entire interacting combined scientists industry

Project "NANOMED" data sheet

The following table provides information about the project.

Coordinator	TECHNISCHE UNIVERSITEIT EINDHOVEN Organization address address: GROENE LOPER 3 city: EINDHOVEN postcode: 5612 AE website: www.tue.nl/en contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://nanomeditn.eu/
Total cost	3˙894˙543 €
EC max contribution	3˙894˙543 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-ETN
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	TECHNISCHE UNIVERSITEIT EINDHOVEN TECHNISCHE UNIVERSITEIT EINDHOVEN Organization address address: GROENE LOPER 3 city: EINDHOVEN postcode: 5612 AE website: www.tue.nl/en contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (EINDHOVEN)	coordinator	652˙623.00
2	UNIVERSITEIT GENT UNIVERSITEIT GENT Organization address address: SINT PIETERSNIEUWSTRAAT 25 city: GENT postcode: 9000 website: http://www.ugent.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (GENT)	participant	751˙680.00
3	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	546˙575.00
4	HELSINGIN YLIOPISTO HELSINGIN YLIOPISTO Organization address address: YLIOPISTONKATU 3 city: HELSINGIN YLIOPISTO postcode: 14 website: www.helsinki.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINGIN YLIOPISTO)	participant	538˙290.00
5	UNIVERSITE DE BORDEAUX UNIVERSITE DE BORDEAUX Organization address address: PLACE PEY BERLAND 35 city: BORDEAUX postcode: 33000 website: www.nouvelle-univ-bordeaux.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (BORDEAUX)	participant	525˙751.00
6	UNIVERSITEIT UTRECHT UNIVERSITEIT UTRECHT Organization address address: HEIDELBERGLAAN 8 city: UTRECHT postcode: 3584 CS website: www.uu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	510˙748.00
7	CHEMCONNECTION BV CHEMCONNECTION BV Organization address address: MOLENSTRAAT 110 city: OSS postcode: 5342 CC website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (OSS)	participant	255˙374.00
8	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	participant	113˙499.00
9	Enceladus Pharmaceuticals BV Enceladus Pharmaceuticals BV Organization address address: Sint Annastraat 38A city: Naarden postcode: 1411PH website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Naarden)	partner	0.00
10	OZ BIOSCIENCES SAS OZ BIOSCIENCES SAS Organization address address: PARC SCIENTIFIQUE ET TECHNOLOGIQUE DE LUMINY CASE 922 BAT CCIMP city: MARSEILLE postcode: 13288 website: www.ozbiosciences.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (MARSEILLE)	partner	0.00
11	POLYVATION BV POLYVATION BV Organization address address: KADIJK 7D city: GRONINGEN postcode: 9747 AT website: www.polyvation.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	partner	0.00
12	Retina International Retina International Organization address address: n.a. city: Zurich postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (Zurich)	partner	0.00
13	SYNTHON BIOPHARMACEUTICALS BV SYNTHON BIOPHARMACEUTICALS BV Organization address address: MICROWEG 22 city: NIJMEGEN postcode: 6503 GN website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	partner	0.00

Map

Project objective

Nanomedicine (NM) is regarded as one of the most promising applications of nanotechnology, as it would allow the development of tailored therapies, with a high level of selectivity and efficacy. Although much research has been performed over the past decades, translation from academia to commercial application remains disappointingly low. Reasons that explain the current moderate success of NM are: (1) promising preclinical results are often poorly predictive for clinical safety and effectiveness, (2) the efficient, scalable and reproducible GMP production of nanocarriers has proven to be challenging and (3) regulatory frameworks are not yet fully equipped to efficiently facilitate the introduction of novel nanomedicines. These obstacles are often encountered since the developmental process from carrier design to clinical assessment is performed by a range of scientists from different backgrounds who have difficulty interacting and communicating with each other to clearly understand the necessary design criteria and the scope and limitations of NM. NANOMED brings together all the necessary expertise to oversee the entire development trajectory required for NM. This is achieved by the combined effort of 7 beneficiaries from academia and industry and 5 non-academic partner organisations, which are all thoroughly rooted in nanosciences and pharmaceutical sciences. Our objective is to develop scalable and highly controllable design and synthesis methods for the most promising nanomedicine types in a preclinical setting. NANOMED will train the next generation of NM scientists by offering an extensive joint training programme to 15 incoming ESRs. It focuses on promoting scientific excellence and exploits the specific research and commercial expertise and infrastructure of the NANOMED network as a whole. The exposure to all elements of NM design enables NANOMED to translate expertise from all disciplines to the ESRs, to educate the future leading scientists in the NM field.

Deliverables

List of deliverables.
Website	Websites, patent fillings, videos etc.	2019-06-19 13:44:19
Certificates	Other	2019-06-19 13:44:19
Prizes	Other	2019-06-19 13:44:19

Take a look to the deliverables list in detail: detailed list of NANOMED deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Bano Subia, Mika Reinisalo, Namit Dey, Shirin Tavakoli, Astrid Subrizi, Munia Ganguli, Marika Ruponen Nucleic acid delivery to differentiated retinal pigment epithelial cells using cell-penetrating peptide as a carrier published pages: 91-99, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2019.05.003	European Journal of Pharmaceutics and Biopharmaceutics 140	2020-03-05
2019	Roberta Guagliardo, Pieterjan Merckx, Agata Zamborlin, Lynn De Backer, Mercedes Echaide, Jesus PÃ©rez-Gil, Stefaan C. De Smedt, Koen Raemdonck Nanocarrier Lipid Composition Modulates the Impact of Pulmonary Surfactant Protein B (SP-B) on Cellular Delivery of siRNA published pages: 431, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics11090431	Pharmaceutics 11/9	2020-03-05
2019	Neda Kordalivand, Elena Tondini, Chun Yin Jerry Lau, Tina Vermonden, Enrico Mastrobattista, Wim E. Hennink, Ferry Ossendorp, Cornelus F. van Nostrum Cationic synthetic long peptides-loaded nanogels: An efficient therapeutic vaccine formulation for induction of T-cell responses published pages: 114-125, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2019.10.048	Journal of Controlled Release 315	2020-03-05
2019	Mattias BjÃ¶rnmalm, Lok Man Wong, Jonathan P. Wojciechowski, Jelle Penders, Conor C. Horgan, Marsilea A. Booth, Nicholas G. Martin, Susanne Sattler, Molly M. Stevens In vivo biocompatibility and immunogenicity of metalâ€“phenolic gelation published pages: 10179-10194, ISSN: 2041-6520, DOI: 10.1039/c9sc03325d	Chemical Science 10/43	2020-03-05
2018	Jelle Penders, Isaac J. Pence, Conor C. Horgan, Mads S. Bergholt, Christopher S. Wood, Adrian Najer, Ulrike Kauscher, Anika Nagelkerke, Molly M. Stevens Single Particle Automated Raman Trapping Analysis published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06397-6	Nature Communications 9/1	2020-03-05
2018	Roberta Guagliardo, JesÃºs PÃ©rez-Gil, Stefaan De Smedt, Koen Raemdonck Pulmonary surfactant and drug delivery: Focusing on the role of surfactant proteins published pages: 116-126, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2018.10.012	Journal of Controlled Release 291	2020-03-05
2019	Jaleesa Bresseleers, Mahsa Bagheri, Gert Storm, Josbert M. Metselaar, Wim E. Hennink, Silvie A. Meeuwissen, Jan C. M. van Hest Scale-Up of the Manufacturing Process To Produce Docetaxel-Loaded mPEG- b -p(HPMA-Bz) Block Copolymer Micelles for Pharmaceutical Applications published pages: 2707-2715, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.9b00387	Organic Process Research & Development 23/12	2020-03-05
2019	Molood Shariati, Wouter Willaert, Wim Ceelen, Stefaan C. De Smedt, Katrien Remaut Aerosolization of Nanotherapeutics as a Newly Emerging Treatment Regimen for Peritoneal Carcinomatosis published pages: 906, ISSN: 2072-6694, DOI: 10.3390/cancers11070906	Cancers 11/7	2020-03-05
2018	Bo Lou, Stefaan De Koker, Chun Yin Jerry Lau, Wim E. Hennink, Enrico Mastrobattista mRNA Polyplexes with Post-Conjugated GALA Peptides Efficiently Target, Transfect, and Activate Antigen Presenting Cells published pages: 461-475, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.8b00524	Bioconjugate Chemistry 30/2	2020-03-05
2018	Pieterjan Merckx, Lynn De Backer, Lien Van Hoecke, Roberta Guagliardo, Mercedes Echaide, Pieter Baatsen, BÃ¡rbara Olmeda, Xavier Saelens, JÃ©sus PÃ©rez-Gil, Stefaan C. De Smedt, Koen Raemdonck Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy published pages: 236-246, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.08.012	Acta Biomaterialia 78	2020-03-05
2018	Roxane Ridolfo, Benjamin C. Ede, Paraskevi Diamanti, Paul B. White, Adam W. Perriman, Jan C. M. van Hest, Allison Blair, David S. Williams Biodegradable, Drug-Loaded Nanovectors via Direct Hydration as a New Platform for Cancer Therapeutics published pages: 1703774, ISSN: 1613-6810, DOI: 10.1002/smll.201703774	Small 14/32	2019-11-22
2019	Hailong Che, Jianzhi Zhu, Shidong Song, Alexander F. Mason, Shoupeng Cao, Imke A. B. Pijpers, Loai K. E. A. Abdelmohsen, Jan C. M. vanâ€…Hest ATP-Mediated Transient Behavior of Stomatocyte Nanosystems published pages: 13113-13118, ISSN: 1433-7851, DOI: 10.1002/anie.201906331	Angewandte Chemie International Edition 58/37	2019-11-22
2019	Shoupeng Cao, Jingxin Shao, Yifeng Xia, Hailong Che, Zhiyuan Zhong, Fenghua Meng, Jan C. M. van Hest, Loai K. E. A. Abdelmohsen, David S. Williams Molecular Programming of Biodegradable Nanoworms via Ionically Induced Morphology Switch toward Asymmetric Therapeutic Carriers published pages: 1901849, ISSN: 1613-6810, DOI: 10.1002/smll.201901849	Small 15/38	2019-11-22
2018	Shoupeng Cao, Loai K. E. A. Abdelmohsen, Jingxin Shao, Joep van den Dikkenberg, Enrico Mastrobattista, David S. Williams, Jan C. M. van Hest pH-Induced Transformation of Biodegradable Multilamellar Nanovectors for Enhanced Tumor Penetration published pages: 1394-1399, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.8b00807	ACS Macro Letters 7/11	2019-11-22
2019	Jingxin Shao, Imke A. B. Pijpers, Shoupeng Cao, David S. Williams, Xuehai Yan, Junbai Li, Loai K. E. A. Abdelmohsen, Jan C. M. van Hest Biomorphic Engineering of Multifunctional Polylactide Stomatocytes toward Therapeutic Nano-Red Blood Cells published pages: 1801678, ISSN: 2198-3844, DOI: 10.1002/advs.201801678	Advanced Science 6/5	2019-11-22
2019	Yigit Altay, Shoupeng Cao, Hailong Che, Loai K. E. A. Abdelmohsen, Jan C. M. van Hest Adaptive Polymeric Assemblies for Applications in Biomimicry and Nanomedicine published pages: 4053-4064, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.9b01341	Biomacromolecules 20/11	2019-11-22
2019	Jianzhi Zhu, Zhicong Li, Changchang Zhang, Lizhou Lin, Shoupeng Cao, Hailong Che, Xiangyang Shi, Han Wang, Jan C. M. van Hest Single enzyme loaded nanoparticles for combinational ultrasound-guided focused ultrasound ablation and hypoxia-relieved chemotherapy published pages: 8048-8060, ISSN: 1838-7640, DOI: 10.7150/thno.37054	Theranostics 9/26	2019-11-22
2018	Mahsa Bagheri, Jaleesa Bresseleers, Aida Varela-Moreira, Olivier Sandre, Silvie A. Meeuwissen, Raymond M. Schiffelers, Josbert M. Metselaar, Cornelus F. van Nostrum, Jan C. M. van Hest, Wim E. Hennink Effect of Formulation and Processing Parameters on the Size of mPEG- b -p(HPMA-Bz) Polymeric Micelles published pages: 15495-15506, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.8b03576	Langmuir 34/50	2019-11-14
2018	Imke A. B. Pijpers, Loai K. E. A. Abdelmohsen, Yifeng Xia, Shoupeng Cao, David S. Williams, Fenghua Meng, Jan C. M. Hest, Zhiyuan Zhong Adaptive Polymersome and Micelle Morphologies in Anticancer Nanomedicine: From Design Rationale to Fabrication and Proofâ€ofâ€Concept Studies published pages: 1800068, ISSN: 2366-3987, DOI: 10.1002/adtp.201800068	ADVANCED THERAPEUTICS 1/8	2019-11-14
2018	Jingxin Shao, Mona Abdelghani, Guizhi Shen, Shoupeng Cao, David S. Williams, Jan C. M. van Hest Erythrocyte Membrane Modified Janus Polymeric Motors for Thrombus Therapy published pages: 4877-4885, ISSN: 1936-0851, DOI: 10.1021/acsnano.8b01772	ACS Nano 12/5	2019-06-19
2018	Hailong Che, Shoupeng Cao, Jan C. M. van Hest Feedback-Induced Temporal Control of â€œBreathingâ€ Polymersomes To Create Self-Adaptive Nanoreactors published pages: 5356-5359, ISSN: 0002-7863, DOI: 10.1021/jacs.8b02387	Journal of the American Chemical Society 140/16	2019-06-19

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