Opendata, web and dolomites

NeuroPioneers SIGNED

A developmental engram for the organization of adult hippocampal circuits

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 NeuroPioneers project word cloud

Explore the words cloud of the NeuroPioneers project. It provides you a very rough idea of what is the project "NeuroPioneers" about.

silent    absence    glutamate    2011    minority    delineates    critical    marissal    external    true    sequences    specialization    et    fast    vivo    distance    neuron    situation    examine    hub    al    considerably    determinant    analyze    hypothesis    transmission    2012    connectivity    earliest    distributed    adulthood    hence    participate    network    subtype    original    preserved    cells    most    hippocampus    adult    predetermined    vitro    mass    encoded    ca3    picardo    multidisciplinary    structure    extensive    animal    born    projecting    birthdate    rules    networks    hypothesize    pattern    relationship    translated    powerful    single    dominated    uncover    fed    cortical    spiking    primed    circumscribed    specifies    shown    pacemaker    spikes    2009    neuronal    perinatal    gabaergic    function    recurrent    orchestrate    gaba    sparse    bonifazi    mainly    neurons    dynamics    understand    active    activation    landmarks    drive    behavior    mouse    assemble    recruitment    self   

Project "NeuroPioneers" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.cnrs.fr/insb/recherche/erc/COG-2014-Cossart.html
 Total cost 1˙996˙947 €
 EC max contribution 1˙996˙947 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙996˙947.00

Map

 Project objective

Most adult cortical dynamics are dominated by a minority of highly active neurons distributed within a silent neuronal mass. If cortical spikes are sparse, spiking of single distinct neurons can impact on network dynamics and drive an animal’s behavior. It is thus essential to understand whether this active and powerful minority is predetermined and if true to uncover the rules by which it is set during development. I hypothesize that birthdate is a critical determinant of neuronal network function into adulthood. More specifically, I reason that neurons that are born the earliest are primed to participate into adult network dynamics. The goal of this proposal is to challenge this original hypothesis, which is considerably fed by our past work aiming at understanding how cortical networks function and assemble during development. Hence, we have shown that an early birthdate: (1) specifies the specialization of GABA neurons with a hub function, that orchestrate perinatal network dynamics in the mouse hippocampus (Bonifazi et al. 2009) and develop into long-range projecting GABA neurons into adulthood (Picardo et al. 2011); (2) delineates a subtype of CA3 glutamate neuron with a “pacemaker” function in the absence of fast GABAergic transmission (Marissal et al. 2012). We will analyze the structure and function of early born GABA and glutamate neurons, in the adult mouse hippocampus, mainly in vivo, where the extensive and long-range connectivity of these cells is preserved. To this aim, we have translated from the in vitro to the in vivo situation, our multidisciplinary method to investigate structure-dynamics relationship in cortical networks. Using this approach, we have recently shown that, in the absence of external landmarks, distance is encoded within the hippocampus in recurrent and self-circumscribed sequences of neuronal activation. Our proposal will specifically examine the recruitment of early born neurons in this sparse network dynamics pattern.

 Publications

year authors and title journal last update
List of publications.
2018 Laurène Save, Agnès Baude, Rosa Cossart
Temporal Embryonic Origin Critically Determines Cellular Physiology in the Dentate Gyrus
published pages: , ISSN: 1047-3211, DOI: 10.1093/cercor/bhy132
Cerebral Cortex 2019-05-31
2015 Vincent Villette, Arnaud Malvache, Thomas Tressard, Nathalie Dupuy, Rosa Cossart
Internally Recurring Hippocampal Sequences as a Population Template of Spatiotemporal Information
published pages: 357-366, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2015.09.052
Neuron 88/2 2019-05-31
2016 Vincent Villette, Philippe Guigue, Michel Aimé Picardo, Vitor Hugo Sousa, Erwan Leprince, Philippe Lachamp, Arnaud Malvache, Thomas Tressard, Rosa Cossart, Agnès Baude
Development of early-born γ-Aminobutyric acid hub neurons in mouse hippocampus from embryogenesis to adulthood
published pages: 2440-2461, ISSN: 0021-9967, DOI: 10.1002/cne.23961
Journal of Comparative Neurology 524/12 2019-05-31
2017 D. Champelovier, J. Teixeira, J.-M. Conan, N. Balla, L. M. Mugnier, T. Tressard, S. Reichinnek, S. Meimon, R. Cossart, H. Rigneault, S. Monneret, A. Malvache
Image-based adaptive optics for in vivo imaging in the hippocampus
published pages: 42924, ISSN: 2045-2322, DOI: 10.1038/srep42924
Scientific Reports 7 2019-05-31
2016 A. Malvache, S. Reichinnek, V. Villette, C. Haimerl, R. Cossart
Awake hippocampal reactivations project onto orthogonal neuronal assemblies
published pages: 1280-1283, ISSN: 0036-8075, DOI: 10.1126/science.aaf3319
Science 353/6305 2019-05-31

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NEUROPIONEERS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "NEUROPIONEERS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

EASY-IPS (2019)

a rapid and efficient method for generation of iPSC

Read More  

ORGANITRA (2019)

Transport of phosphorylated compounds across lipid bilayers by supramolecular receptors

Read More  

ENTRAPMENT (2019)

Septins: from bacterial entrapment to cellular immunity

Read More