Explore the words cloud of the PAINSTRAT project. It provides you a very rough idea of what is the project "PAINSTRAT" about.
The following table provides information about the project.
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
|Coordinator Country||Italy [IT]|
|Total cost||1˙627˙825 €|
|EC max contribution||1˙627˙825 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-01-01 to 2020-12-31|
Take a look of project's partnership.
|1||FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA||IT (GENOVA)||coordinator||795˙132.00|
|2||UNIVERSITY COLLEGE LONDON||UK (LONDON)||participant||832˙692.00|
In the last 15 years the advances in understanding the molecular mechanisms of pain have been spectacular. However, despite the >200 genes identified and the dramatic insights on transduction and transmission of nociceptive signals, very little has changed in the diagnosis and treatment of pain, at least in terms of analgesic drugs. Therefore, pain remains a major burden for the society (chronic pain alone costs the EU >€250 bns/yr). The reason is that pain is not a pattern of gene expression, but a state of neuronal activity. Therefore, the translation of mechanistic insights into effective treatments will depend critically on a better understanding of the electrophysiological changes that occur. For this reason, the European Federation of Neurological Society has called for a particular effort to identify reliable laboratory measures of pain, and having an objective biomarker for pain quantification and patient stratification would constitute a major breakthrough in medicine. To date, this need has not been satisfied. The project has two main objectives: (1) Developing neurophysiological biomarkers of pain perception: the main aim being quantification of spontaneous pain for patient management and clinical trials. (2) Developing neurophysiological biomarkers of the susceptibility to develop chronic pain: the main aim being patient stratification, development of prevention strategies, and personalised medicine for pain. We will apply novel analysis techniques to the neurophysiological information obtained using a range of techniques from a large number of healthy volunteers and patients with different types of chronic pain. Importantly, we will longitudinally study patients at high risk of developing chronic pain. We are fully confident that these goals - early diagnosis, identification of high risk patients and facilitating the development of new efficacious treatments through useful clinical trials - will positively impact the well-being of chronic pain patients.
|year||authors and title||journal||last update|
AndrÃ© Mouraux, Gian Domenico Iannetti
The search for pain biomarkers in the human brain
published pages: 3290-3307, ISSN: 0006-8950, DOI: 10.1093/brain/awy281
M. Algoet, J. Duque, G.D. Iannetti, A. Mouraux
Temporal Profile and Limb-specificity of Phasic Pain-Evoked Changes in Motor Excitability
published pages: 240-255, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2018.06.039
Flavia Mancini, Alessia Pepe, Alberto Bernacchia, Giulia Di Stefano, AndrÃ© Mouraux, Gian Domenico Iannetti
Characterizing the Short-Term Habituation of Event-Related Evoked Potentials
published pages: ENEURO.0014-18.2, ISSN: 2373-2822, DOI: 10.1523/ENEURO.0014-18.2018
Li Hu, Gian Domenico Iannetti
Painful Issues in Pain Prediction
published pages: 212-220, ISSN: 0166-2236, DOI: 10.1016/j.tins.2016.01.004
|Trends in Neurosciences 39/4||2019-05-20|
R. J. Bufacchi, C. F. Sambo, G. Di Stefano, G. Cruccu, G. D. Iannetti
Pain outside the body: defensive peripersonal space deformation in trigeminal neuralgia
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-12466-5
|Scientific Reports 7/1||2019-05-20|
Giacomo Novembre, Vijay M. Pawar, Rory J. Bufacchi, Marina Kilintari, Mandayam Srinivasan, John C. Rothwell, Patrick Haggard, Gian Domenico Iannetti
Saliency Detection as a Reactive Process: Unexpected Sensory Events Evoke Corticomuscular Coupling
published pages: 2385-2397, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.2474-17.2017
|The Journal of Neuroscience 38/9||2019-05-20|
E. R. FerrÃ¨, G. D. Iannetti, J. A. van Dijk, P. Haggard
Ineffectiveness of tactile gating shows cortical basis of nociceptive signaling in the Thermal Grill Illusion
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-24635-1
|Scientific Reports 8/1||2019-05-20|
Weiwei Peng, Xiaolei Xia, Ming Yi, Gan Huang, Zhiguo Zhang, Giandomenico Iannetti, Li Hu
Brain oscillations reflecting pain-related behavior in freely moving rats
published pages: 106-118, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000001069
Q.Q. Jin, G.Q. Wu, W.W. Peng, X.L. Xia, L. Hu, G.D. Iannetti
Somatotopic Representation of Second Pain in the Primary Somatosensory Cortex of Humans and Rodents
published pages: 5538-5550, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.3654-17.2018
|The Journal of Neuroscience 38/24||2019-05-20|
Karen D. Davis, Herta Flor, Henry T. Greely, Gian Domenico Iannetti, Sean Mackey, Markus Ploner, Amanda Pustilnik, Irene Tracey, Rolf-Detlef Treede, Tor D. Wager
Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations
published pages: 624-638, ISSN: 1759-4758, DOI: 10.1038/nrneurol.2017.122
|Nature Reviews Neurology 13/10||2019-05-20|
Rory John Bufacchi, Gian Domenico Iannetti
Gravitational cues modulate the shape of defensive peripersonal space
published pages: R1133-R1134, ISSN: 0960-9822, DOI: 10.1016/j.cub.2016.09.025
|Current Biology 26/21||2019-06-07|
Flavia Mancini, Karina Dolgevica, James Steckelmacher, Patrick Haggard, Karl Friston, Giandomenico D. Iannetti
Perceptual learning to discriminate the intensity and spatial location of nociceptive stimuli
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep39104
|Scientific Reports 6/1||2019-06-07|
Tim V. Salomons, Gian Domenico Iannetti, Meng Liang, John N. Wood
The â€œPain Matrixâ€ in Pain-Free Individuals
published pages: 755, ISSN: 2168-6149, DOI: 10.1001/jamaneurol.2016.0653
|JAMA Neurology 73/6||2019-06-07|
M. Liang, M. C. Lee, J. O\'Neill, A. H. Dickenson, G. D. Iannetti
Brain potentials evoked by intraepidermal electrical stimuli reflect the central sensitization of nociceptive pathways
published pages: 286-295, ISSN: 0022-3077, DOI: 10.1152/jn.00013.2016
|Journal of Neurophysiology 116/2||2019-06-07|
M. Moayedi, G. Di Stefano, M. T. Stubbs, B. Djeugam, M. Liang, G. D. Iannetti
Nociceptive-Evoked Potentials Are Sensitive to Behaviorally Relevant Stimulus Displacements in Egocentric Coordinates
published pages: , ISSN: 2373-2822, DOI: 10.1523/ENEURO.0151-15.2016
Tor D. Wager, Lauren Y. Atlas, Matthew M. Botvinick, Luke J. Chang, Robert C. Coghill, Karen Deborah Davis, Gian Domenico Iannetti, Russell A. Poldrack, Alexander J. Shackman, Tal Yarkoni
Pain in the ACC?
published pages: E2474-E2475, ISSN: 0027-8424, DOI: 10.1073/pnas.1600282113
|Proceedings of the National Academy of Sciences 113/18||2019-06-07|
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The information about "PAINSTRAT" are provided by the European Opendata Portal: CORDIS opendata.
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