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Novel neurophysiological techniques to quantify pain and stratify patients

Total Cost €


EC-Contrib. €






Project "PAINSTRAT" data sheet

The following table provides information about the project.


Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙627˙825 €
 EC max contribution 1˙627˙825 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
2    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 832˙692.00


 Project objective

In the last 15 years the advances in understanding the molecular mechanisms of pain have been spectacular. However, despite the >200 genes identified and the dramatic insights on transduction and transmission of nociceptive signals, very little has changed in the diagnosis and treatment of pain, at least in terms of analgesic drugs. Therefore, pain remains a major burden for the society (chronic pain alone costs the EU >€250 bns/yr). The reason is that pain is not a pattern of gene expression, but a state of neuronal activity. Therefore, the translation of mechanistic insights into effective treatments will depend critically on a better understanding of the electrophysiological changes that occur. For this reason, the European Federation of Neurological Society has called for a particular effort to identify reliable laboratory measures of pain, and having an objective biomarker for pain quantification and patient stratification would constitute a major breakthrough in medicine. To date, this need has not been satisfied. The project has two main objectives: (1) Developing neurophysiological biomarkers of pain perception: the main aim being quantification of spontaneous pain for patient management and clinical trials. (2) Developing neurophysiological biomarkers of the susceptibility to develop chronic pain: the main aim being patient stratification, development of prevention strategies, and personalised medicine for pain. We will apply novel analysis techniques to the neurophysiological information obtained using a range of techniques from a large number of healthy volunteers and patients with different types of chronic pain. Importantly, we will longitudinally study patients at high risk of developing chronic pain. We are fully confident that these goals - early diagnosis, identification of high risk patients and facilitating the development of new efficacious treatments through useful clinical trials - will positively impact the well-being of chronic pain patients.


year authors and title journal last update
List of publications.
2018 André Mouraux, Gian Domenico Iannetti
The search for pain biomarkers in the human brain
published pages: 3290-3307, ISSN: 0006-8950, DOI: 10.1093/brain/awy281
Brain 141/12 2019-05-20
2018 M. Algoet, J. Duque, G.D. Iannetti, A. Mouraux
Temporal Profile and Limb-specificity of Phasic Pain-Evoked Changes in Motor Excitability
published pages: 240-255, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2018.06.039
Neuroscience 386 2019-05-20
2018 Flavia Mancini, Alessia Pepe, Alberto Bernacchia, Giulia Di Stefano, André Mouraux, Gian Domenico Iannetti
Characterizing the Short-Term Habituation of Event-Related Evoked Potentials
published pages: ENEURO.0014-18.2, ISSN: 2373-2822, DOI: 10.1523/ENEURO.0014-18.2018
eneuro 5/5 2019-05-20
2016 Li Hu, Gian Domenico Iannetti
Painful Issues in Pain Prediction
published pages: 212-220, ISSN: 0166-2236, DOI: 10.1016/j.tins.2016.01.004
Trends in Neurosciences 39/4 2019-05-20
2017 R. J. Bufacchi, C. F. Sambo, G. Di Stefano, G. Cruccu, G. D. Iannetti
Pain outside the body: defensive peripersonal space deformation in trigeminal neuralgia
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-12466-5
Scientific Reports 7/1 2019-05-20
2018 Giacomo Novembre, Vijay M. Pawar, Rory J. Bufacchi, Marina Kilintari, Mandayam Srinivasan, John C. Rothwell, Patrick Haggard, Gian Domenico Iannetti
Saliency Detection as a Reactive Process: Unexpected Sensory Events Evoke Corticomuscular Coupling
published pages: 2385-2397, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.2474-17.2017
The Journal of Neuroscience 38/9 2019-05-20
2018 E. R. Ferrè, G. D. Iannetti, J. A. van Dijk, P. Haggard
Ineffectiveness of tactile gating shows cortical basis of nociceptive signaling in the Thermal Grill Illusion
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-24635-1
Scientific Reports 8/1 2019-05-20
2018 Weiwei Peng, Xiaolei Xia, Ming Yi, Gan Huang, Zhiguo Zhang, Giandomenico Iannetti, Li Hu
Brain oscillations reflecting pain-related behavior in freely moving rats
published pages: 106-118, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000001069
PAIN 159/1 2019-05-20
2018 Q.Q. Jin, G.Q. Wu, W.W. Peng, X.L. Xia, L. Hu, G.D. Iannetti
Somatotopic Representation of Second Pain in the Primary Somatosensory Cortex of Humans and Rodents
published pages: 5538-5550, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.3654-17.2018
The Journal of Neuroscience 38/24 2019-05-20
2017 Karen D. Davis, Herta Flor, Henry T. Greely, Gian Domenico Iannetti, Sean Mackey, Markus Ploner, Amanda Pustilnik, Irene Tracey, Rolf-Detlef Treede, Tor D. Wager
Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations
published pages: 624-638, ISSN: 1759-4758, DOI: 10.1038/nrneurol.2017.122
Nature Reviews Neurology 13/10 2019-05-20
2016 Rory John Bufacchi, Gian Domenico Iannetti
Gravitational cues modulate the shape of defensive peripersonal space
published pages: R1133-R1134, ISSN: 0960-9822, DOI: 10.1016/j.cub.2016.09.025
Current Biology 26/21 2019-06-07
2016 Flavia Mancini, Karina Dolgevica, James Steckelmacher, Patrick Haggard, Karl Friston, Giandomenico D. Iannetti
Perceptual learning to discriminate the intensity and spatial location of nociceptive stimuli
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep39104
Scientific Reports 6/1 2019-06-07
2016 Tim V. Salomons, Gian Domenico Iannetti, Meng Liang, John N. Wood
The “Pain Matrix” in Pain-Free Individuals
published pages: 755, ISSN: 2168-6149, DOI: 10.1001/jamaneurol.2016.0653
JAMA Neurology 73/6 2019-06-07
2016 M. Liang, M. C. Lee, J. O\'Neill, A. H. Dickenson, G. D. Iannetti
Brain potentials evoked by intraepidermal electrical stimuli reflect the central sensitization of nociceptive pathways
published pages: 286-295, ISSN: 0022-3077, DOI: 10.1152/jn.00013.2016
Journal of Neurophysiology 116/2 2019-06-07
2016 M. Moayedi, G. Di Stefano, M. T. Stubbs, B. Djeugam, M. Liang, G. D. Iannetti
Nociceptive-Evoked Potentials Are Sensitive to Behaviorally Relevant Stimulus Displacements in Egocentric Coordinates
published pages: , ISSN: 2373-2822, DOI: 10.1523/ENEURO.0151-15.2016
eNeuro 3/3 2019-06-07
2016 Tor D. Wager, Lauren Y. Atlas, Matthew M. Botvinick, Luke J. Chang, Robert C. Coghill, Karen Deborah Davis, Gian Domenico Iannetti, Russell A. Poldrack, Alexander J. Shackman, Tal Yarkoni
Pain in the ACC?
published pages: E2474-E2475, ISSN: 0027-8424, DOI: 10.1073/pnas.1600282113
Proceedings of the National Academy of Sciences 113/18 2019-06-07

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