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RETMUS SIGNED

The interpretation of retinal activity by the visual thalamus.

Total Cost €

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EC-Contrib. €

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Partnership

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Project "RETMUS" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 2˙500˙000.00
2    INSTITUT FUR MOLEKULARE UND KLINISCHE OPHTHALMOLOGIE BASEL CH (BASEL) participant 0.00

Map

 Project objective

Sensory systems of the brain inform cortical centers about the outside world via the thalamus. Despite its central location between the sensory periphery and the primary sensory cortex, the functional role of the thalamus in sensory processing is still largely unknown. Understanding the role of thalamic circuits and their modulation by other brain areas is important for several reasons. First, in order to dissect the functional role of higher brain regions, such as sensory cortical areas, it is critical that we understand what kind of input they receive from the thalamus. The thalamus takes information from several different sensory channels, carrying different sensory features. Whether these features are simply relayed to higher centers, or perhaps recombined into new features in the thalamus, is not known. Second, as a central station in sensory processing, the thalamus is thought to gate behaviorally relevant sensory information. In addition to the input from the sensory periphery, the thalamus receives input from several other brain regions. How these inputs modulate or gate sensory information in vivo is not well understood. Finally, in the case of the visual system, an important unmet medical need is optic nerve degeneration caused by end-stage glaucoma, which leads to blindness. Here the input to thalamus is lost, yet the thalamic and cortical circuits are not severely affected. New methods to reactivate the thalamic neurons by channeling visual information directly to these neurons may help to restore some visual capability after the loss of optic nerve fibers.

 Publications

year authors and title journal last update
List of publications.
2017 Santiago B. Rompani, Fiona E. Müllner, Adrian Wanner, Chi Zhang, Chiara N. Roth, Keisuke Yonehara, Botond Roska
Different Modes of Visual Integration in the Lateral Geniculate Nucleus Revealed by Single-Cell-Initiated Transsynaptic Tracing
published pages: 767-776.e6, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.01.028
Neuron 93/4 2020-01-21
2018 Émilie Macé, Gabriel Montaldo, Stuart Trenholm, Cameron Cowan, Alexandra Brignall, Alan Urban, Botond Roska
Whole-Brain Functional Ultrasound Imaging Reveals Brain Modules for Visuomotor Integration
published pages: 1241-1251.e7, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.11.031
Neuron 100/5 2020-01-21
2017 Rajib Schubert, Stuart Trenholm, Kamill Balint, Georg Kosche, Cameron S Cowan, Manuel A Mohr, Martin Munz, David Martinez-Martin, Gotthold Fläschner, Richard Newton, Jacek Krol, Brigitte Gross Scherf, Keisuke Yonehara, Adrian Wertz, Aaron Ponti, Alexander Ghanem, Daniel Hillier, Karl-Klaus Conzelmann, Daniel J Müller, Botond Roska
Virus stamping for targeted single-cell infection in vitro and in vivo
published pages: 81-88, ISSN: 1087-0156, DOI: 10.1038/nbt.4034
Nature Biotechnology 36/1 2020-01-21
2017 Janine M Daum, Özkan Keles, Sjoerd JB Holwerda, Hubertus Kohler, Filippo M Rijli, Michael Stadler, Botond Roska
The formation of the light-sensing compartment of cone photoreceptors coincides with a transcriptional switch
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.31437
eLife 6 2020-01-21

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