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Mesoscale Brain Dynamics: Computing with Neuronal Pathways

Total Cost €


EC-Contrib. €






 BRAINCOMPATH project word cloud

Explore the words cloud of the BRAINCOMPATH project. It provides you a very rough idea of what is the project "BRAINCOMPATH" about.

formal    computations    proper    reward    complemented    cortical    manipulating    techniques    multiple    brain    mesoscopic    toolbox    microscopic    vivo    generate    neuronal    microcircuits    fmri    communicate    macro    anatomical    routed    connected    skilled    conceptualize    awake    understand    intermediate    difficult    networks    linking    network    scales    combining    create    principles    perspective    levels    theory    poorly    microscopy    tools    reveal    genetic    adopting    fresh    experiments    sensorimotor    regions    tackle    dynamics    start    meso    functional    mice    signal    respectively    experimentally    pathological    texture    fiber    centered    either    micro    physiological    wealth    local    bridging    hierarchical    discrimination    avenues    transform    rely    broad    axonal    measuring    behavior    optic    locomotion    blind    model    appropriate    photon    temporal    rapid    behaving    optical    opening    remained    flow    data    probing    learning    utilize    subcortical    despite    individual    specificity    spot    computational    macroscopic   

Project "BRAINCOMPATH" data sheet

The following table provides information about the project.


Organization address
address: RAMISTRASSE 71
city: Zürich
postcode: 8006

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙498˙915 €
 EC max contribution 2˙498˙915 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2021-01-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT ZURICH CH (Zürich) coordinator 2˙498˙915.00


 Project objective

Brain computations rely on proper signal flow through the complex network of connected brain regions. Despite a wealth of anatomical and functional data – from microscopic to macroscopic scale – we still poorly understand the principles of how signal flow is routed through neuronal networks to generate appropriate behavior. Brain dynamics on the 'mesoscopic' scale, the intermediate level where local microcircuits communicate via axonal pathways, has remained a particular blind spot of research as it has been difficult to access under in vivo conditions. Here, I propose to tackle the mesoscopic level of brain dynamics both experimentally and theoretically, adopting a fresh perspective centered on neuronal pathway dynamics. Experimentally, we will utilize and further advance state-of-the-art genetic and optical techniques to create a toolbox for measuring and manipulating signal flow in pathway networks across a broad range of temporal scales. In particular, we will improve fiber-optic based methods for probing the activity of either individual or multiple neuronal pathways with high specificity. Using these tools we will set out to reveal mesoscopic brain dynamics across relevant cortical and subcortical regions in awake, behaving mice. Specifically, we will investigate sensorimotor learning for a reward-based texture discrimination task and rapid sensorimotor control during skilled locomotion. Moreover, by combining fiber-optic methods with two-photon microscopy and fMRI, respectively, we will start linking the meso-level to the micro- and macro-levels. Throughout the project, experiments will be complemented by computational approaches to analyse data, model pathway dynamics, and conceptualize a formal theory of mesoscopic dynamics. This project may transform the field by bridging the hierarchical brain levels and opening significant new avenues to assess physiological as well as pathological signal flow in the brain.


year authors and title journal last update
List of publications.
2018 Ariel Gilad, Yasir Gallero-Salas, Dominik Groos, Fritjof Helmchen
Behavioral Strategy Determines Frontal or Posterior Location of Short-Term Memory in Neocortex
published pages: 814-828.e7, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.07.029
Neuron 99/4 2019-04-03
2018 Felix Schlegel, Yaroslav Sych, Aileen Schroeter, Jillian Stobart, Bruno Weber, Fritjof Helmchen, Markus Rudin
Fiber-optic implant for simultaneous fluorescence-based calcium recordings and BOLD fMRI in mice
published pages: 840-855, ISSN: 1754-2189, DOI: 10.1038/nprot.2018.003
Nature Protocols 13/5 2019-04-03
2018 Gregor-Alexander Pilz, Sara Bottes, Marion Betizeau, David J. Jörg, Stefano Carta, Benjamin D. Simons, Fritjof Helmchen, Sebastian Jessberger
Live imaging of neurogenesis in the adult mouse hippocampus
published pages: 658-662, ISSN: 0036-8075, DOI: 10.1126/science.aao5056
Science 359/6376 2019-04-03
2018 Fritjof Helmchen, Ariel Gilad, Jerry L. Chen
Neocortical Dynamics During Whisker-Based Sensory Discrimination in Head-Restrained Mice
published pages: 57-69, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2017.09.003
Neuroscience 368 2019-04-03

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