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Systems Biology of Membrane Trafficking

Total Cost €


EC-Contrib. €






 SYSMET project word cloud

Explore the words cloud of the SYSMET project. It provides you a very rough idea of what is the project "SYSMET" about.

entire    mtms    microarrays    health    technologies    proximal    golgi    degree    sec23a    functional    homeostasis    layers    fact    epithelial    sirna    egel    list    single    co    redundancy    chondrocytes    neuronal    give    interplay    osteoblasts    content    lysosomes    expression    proteins    spatiotemporal    modules    vapb    gained    epistatic    187    transport    cell    human    ubiquitous    molecular    global    discrete    resource    ocrl    implications    regulated    physiological    regulatory    screening    protein    centered    view    membrane    cells    antibody    er    endosomes    map    independent    differential    trappc2    regarded    tissue    sysmet    networks    regulation    internal    date    types    curated    kidney    interactions    lacking    machineries    organization    fundamental    constitutive    interconnected    seq    trafficking    tubular    biology    generate    specialized    disease    extracellular    physical    rna    function    diseases    genes    clcn5    representing    combination    medium    mutations   

Project "SYSMET" data sheet

The following table provides information about the project.


Organization address
address: VIA VARESE 16/B
city: ROMA
postcode: 185

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 2˙241˙250 €
 EC max contribution 2˙241˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE TELETHON IT (ROMA) coordinator 2˙241˙250.00


 Project objective

Membrane trafficking is fundamental for homeostasis of the internal membrane system and transport to and from the extracellular medium. Although we have gained detailed knowledge on the molecular organization of membrane trafficking machineries a global view of its function and regulation is lacking. To date membrane trafficking is often regarded as a constitutive process with a high degree of functional redundancy. However, the fact that mutations of single trafficking genes with ubiquitous expression give rise to tissue-specific human diseases and discrete sets of trafficking genes have differential effects on tissue development challenge this view.

Here, using a combination of state-of the-art technologies, we will apply a systems biology approach in specialized cell types to establish a physiological and functional spatiotemporal map of membrane trafficking genes and proteins (membrane trafficking modules; MTMs). To this end we have curated a list of 1,187 genes representing ER, Golgi, Endosomes and Lysosomes (EGEL) around which we develop independent but interconnected approaches: (i) RNA-seq and antibody microarrays to identify co-regulated MTMs; (ii) high-content siRNA screening to define functional MTMs; (iii) epistatic functional analysis between EGEL genes and five membrane trafficking disease genes (TRAPPC2 in chondrocytes, Sec23A in osteoblasts, OCRL and CLCN5 in proximal tubular epithelial kidney cells, and VAPB in neuronal cells); and (iv) studies of protein-protein interactions to generate functional and physical networks centered on the disease genes.

SYSMET will generate a unique resource by defining the impact and interplay of the different regulatory layers of the entire membrane trafficking system with important implications for human health.


year authors and title journal last update
List of publications.
2017 Francesca Zappa, Rossella Venditti, Maria Antonietta De Matteis
TRAPPing Rab18 in lipid droplets
published pages: 394-396, ISSN: 0261-4189, DOI: 10.15252/embj.201696287
The EMBO Journal 36/4 2019-07-05
2016 Maria Giovanna De Leo, Leopoldo Staiano, Mariella Vicinanza, Alessandro Luciani, Annamaria Carissimo, Margherita Mutarelli, Antonella Di Campli, Elena Polishchuk, Giuseppe Di Tullio, Valentina Morra, Elena Levtchenko, Francesca Oltrabella, Tobias Starborg, Michele Santoro, Diego di Bernardo, Olivier Devuyst, Martin Lowe, Diego L. Medina, Andrea Ballabio, Maria Antonietta De Matteis
Autophagosome–lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL
published pages: 839-850, ISSN: 1465-7392, DOI: 10.1038/ncb3386
Nature Cell Biology 18/8 2019-07-05

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