Explore the words cloud of the SYSMET project. It provides you a very rough idea of what is the project "SYSMET" about.
The following table provides information about the project.
|Coordinator Country||Italy [IT]|
|Total cost||2˙241˙250 €|
|EC max contribution||2˙241˙250 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-01-01 to 2020-12-31|
Take a look of project's partnership.
|1||FONDAZIONE TELETHON||IT (ROMA)||coordinator||2˙241˙250.00|
Membrane trafficking is fundamental for homeostasis of the internal membrane system and transport to and from the extracellular medium. Although we have gained detailed knowledge on the molecular organization of membrane trafficking machineries a global view of its function and regulation is lacking. To date membrane trafficking is often regarded as a constitutive process with a high degree of functional redundancy. However, the fact that mutations of single trafficking genes with ubiquitous expression give rise to tissue-specific human diseases and discrete sets of trafficking genes have differential effects on tissue development challenge this view.
Here, using a combination of state-of the-art technologies, we will apply a systems biology approach in specialized cell types to establish a physiological and functional spatiotemporal map of membrane trafficking genes and proteins (membrane trafficking modules; MTMs). To this end we have curated a list of 1,187 genes representing ER, Golgi, Endosomes and Lysosomes (EGEL) around which we develop independent but interconnected approaches: (i) RNA-seq and antibody microarrays to identify co-regulated MTMs; (ii) high-content siRNA screening to define functional MTMs; (iii) epistatic functional analysis between EGEL genes and five membrane trafficking disease genes (TRAPPC2 in chondrocytes, Sec23A in osteoblasts, OCRL and CLCN5 in proximal tubular epithelial kidney cells, and VAPB in neuronal cells); and (iv) studies of protein-protein interactions to generate functional and physical networks centered on the disease genes.
SYSMET will generate a unique resource by defining the impact and interplay of the different regulatory layers of the entire membrane trafficking system with important implications for human health.
|year||authors and title||journal||last update|
Francesca Zappa, Rossella Venditti, Maria Antonietta De Matteis
TRAPPing Rab18 in lipid droplets
published pages: 394-396, ISSN: 0261-4189, DOI: 10.15252/embj.201696287
|The EMBO Journal 36/4||2019-07-05|
Maria Giovanna De Leo, Leopoldo Staiano, Mariella Vicinanza, Alessandro Luciani, Annamaria Carissimo, Margherita Mutarelli, Antonella Di Campli, Elena Polishchuk, Giuseppe Di Tullio, Valentina Morra, Elena Levtchenko, Francesca Oltrabella, Tobias Starborg, Michele Santoro, Diego di Bernardo, Olivier Devuyst, Martin Lowe, Diego L. Medina, Andrea Ballabio, Maria Antonietta De Matteis
Autophagosomeâ€“lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL
published pages: 839-850, ISSN: 1465-7392, DOI: 10.1038/ncb3386
|Nature Cell Biology 18/8||2019-07-05|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SYSMET" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "SYSMET" are provided by the European Opendata Portal: CORDIS opendata.