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CApaCITy SIGNED

CAncer Stem Cell Imunoreceptors as potential Targets for skin Squamous cell carcinoma

Total Cost €

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EC-Contrib. €

0

Partnership

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 CApaCITy project word cloud

Explore the words cloud of the CApaCITy project. It provides you a very rough idea of what is the project "CApaCITy" about.

cd99    mfge8    regulated    pdx    cells    trials    perspective    biology    perez    embark    tam    possibilities    difficult    area    basic    supportive    explore    mutations    cell    ucph    dampen    therapy    expand    carcinomas    grow    acknowledged    copenhagen    signaling    renewal    omics    crosstalk    merete    moreno    powerful    resistance    sustain    human    lack    settings    nectin    ssc    therapeutic    immunoreceptors    unearth    clinical    medical    somatic    patient    squamous    prevalence    xerographs    csc    specificity    direct    mgaard    stem    clonal    microenvironment    tumors    wnt    governing    groups    expression    interdisciplinary    str    drug    interactions    genetic    initiate    researcher    international    models    dr    mouse    caveat    oslash    self    independent    translational    governed    macrophages    chemistry    haedersdal    efficient    scc    existence    tumor    arena    skin    capacity    university    uncovered    eradicate    interestingly    receptors    cancer   

Project "CApaCITy" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 207˙312 €
 EC max contribution 207˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 207˙312.00

Map

 Project objective

Cancer stem cells (CSC) initiate, sustain the prevalence, and resistance to therapy of skin squamous cell carcinomas (SCC). It is well acknowledged that CSC self-renewal and clonal growth is governed by genetic mutations, but also by complex interactions between CSC and the microenvironment. Genetic therapy is difficult to achieve in clinical settings, therefore, targeting cells of the supportive tumor microenvironment is a promising advance to eradicate SCC. Using mouse models of SCC, our previous basic research results uncovered the existence of a direct crosstalk between skin CSC and tumor-associated macrophages (TAM) via Wnt signaling. Interestingly, we observed that Wnt regulated the expression of three CSC receptors, CD99, MFGE8 and Nectin-2, and governed the CSC-TAM crosstalk. Here, I propose to expand this basic research into a translational perspective, to explore the potential of CD99, MFGE8 and Nectin-2 as therapeutic targets for human SCC. There is a major interest in this arena, since the major caveat of targeting Wnt signaling in cancer is the lack of specificity to target CSC, without affecting somatic cells. Moreover, most clinical trials have not been fully efficient to dampen the Wnt response in tumors. Using a comprehensive and integrated approach based on human SCC, cell biology, omics and medical chemistry, along with powerful patient derived xerographs (PDX), my results must likely unearth a role for these immunoreceptors in governing the CSC-TAM crosstalk, and their potential as drug targets for human SSC. This interdisciplinary project will be conducted at the University of Copenhagen (UCPH) in Dr. Perez-Moreno, Dr. Merete Haedersdal, and Dr. Strømgaard groups. Through the CApaCITy project, I will embark in a leading research area with several possibilities to grow into an independent international researcher.

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The information about "CAPACITY" are provided by the European Opendata Portal: CORDIS opendata.

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