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SUNLIGHTING SIGNED

Harvesting the Sun

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SUNLIGHTING project word cloud

Explore the words cloud of the SUNLIGHTING project. It provides you a very rough idea of what is the project "SUNLIGHTING" about.

adaptable    proof    cultivate    rare    job    40    synthetic    diterpenoids    market    harmony    horizon2020    optimize    offers    pipelines    discovery    sustainable    excreted    hotspot    cells    medicinal    diterpenoid    biological    demonstrated    moss    europe2020    erc    competitive    industry    difficult    amounts    entirely    predicted    potent    full    poc    provides    scientific    host    green    class    vision    easily    angelate    world    isolation    grant    breakthroughs    solar    constitute    made    cyanobacteria    screening    structural    algae    of    optimization    originate    chain    forskolin    desired    points    goals    domain    functionalities    mixtures    final    plants    2025    drugs    analogs    platform    biobased    compounds    combinatorial    exit    representing    extraction    flavors    medicines    industrial    commercial    invigorated    re    ingenol    financial    powered    fragrances    opportunity    attainable    entry    libraries    envisioned    50    medium    contain    structures    greenhouse    prescribed    biology    food    profitable    edge    ingredients   

Project "SUNLIGHTING" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 142˙783 €
 EC max contribution 142˙783 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 142˙783.00

Map

 Project objective

Biological production of high-value compounds such as medicines, flavors, fragrances and food ingredients, is predicted to constitute 50% of the World market by 2025 thus representing a commercial hotspot. A competitive edge for European industry within this domain is therefore important. Today, 40% of prescribed medicinal drugs originate or are derived from rare or difficult to cultivate medicinal plants which typically contain the compounds in very low amounts and in complex mixtures. We have demonstrated that by using synthetic biology we can build a solar powered platform for production of key high-value compounds within the diterpenoid class in green cells (cyanobacteria/moss/algae). The diterpenoids are excreted into the growth medium offering easy isolation. This provides a highly profitable and attainable opportunity to produce a large number of medicinal compounds at highly reduced costs. The production platform is easily adaptable to make structural analogs and entirely new structures. Combinatorial libraries can be developed to enable screening for desired new functionalities. The envisioned production platform includes the full chain from pathway discovery, host optimization, scale-up, extraction and final product isolation and offers entry points for industrial development and exit points for adaptation to existing pipelines. Based on the advances made within the ERC Advanced Grant the focus of this PoC is to optimize the scientific breakthroughs’ market adaptation, specifically focused on the compounds Forskolin and Ingenol-3-angelate as proof-of-concept of the market value of the production platform. The envisioned full-chain focus offers potent financial opportunities and a new vision for biobased production across Europe in a re-invigorated sustainable greenhouse industry offering new job opportunities in full harmony with the envisioned Europe2020 and Horizon2020 goals.

 Publications

year authors and title journal last update
List of publications.
2016 Thiyagarajan Gnanasekaran, Daniel Karcher, Agnieszka Zygadlo Nielsen, Helle Juel Martens, Stephanie Ruf, Xenia Kroop, Carl Erik Olsen, Mohammed Saddik Motawie, Mathias Pribil, Birger Lindberg Møller, Ralph Bock, Poul Erik Jensen
Transfer of the cytochrome P450-dependent dhurrin pathway from Sorghum bicolor into Nicotiana tabacum chloroplasts for light-driven synthesis
published pages: 2495-2506, ISSN: 0022-0957, DOI: 10.1093/jxb/erw067
Journal of Experimental Botany 67/8 2019-06-19
2016 Silas Busck Mellor, Agnieszka Zygadlo Nielsen, Meike Burow, Mohammed Saddik Motawia, Dainius Jakubauskas, Birger Lindberg Møller, Poul Erik Jensen
Fusion of Ferredoxin and Cytochrome P450 Enables Direct Light-Driven Biosynthesis
published pages: 1862-1869, ISSN: 1554-8929, DOI: 10.1021/acschembio.6b00190
ACS Chemical Biology 11/7 2019-06-19
2017 Jean-Etienne Bassard, Birger Lindberg Møller, Tomas Laursen
Assembly of Dynamic P450-Mediated Metabolons—Order Versus Chaos
published pages: 37-51, ISSN: 2198-6428, DOI: 10.1007/s40610-017-0053-y
Current Molecular Biology Reports 3/1 2019-06-19
2016 Kim Olsson, Simon Carlsen, Angelika Semmler, Ernesto Simón, Michael Dalgaard Mikkelsen, Birger Lindberg Møller
Microbial production of next-generation stevia sweeteners
published pages: , ISSN: 1475-2859, DOI: 10.1186/s12934-016-0609-1
Microbial Cell Factories 15/1 2019-06-19
2017 Irini Pateraki, Johan Andersen-Ranberg, Niels Bjerg Jensen, Sileshi Gizachew Wubshet, Allison Maree Heskes, Victor Forman, Björn Hallström, Britta Hamberger, Mohammed Saddik Motawia, Carl Erik Olsen, Dan Staerk, Jørgen Hansen, Birger Lindberg Møller, Björn Hamberger
Total biosynthesis of the cyclic AMP booster forskolin from Coleus forskohlii
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.23001
eLife 6 2019-06-19
2016 Johan Andersen-Ranberg, Kenneth Thermann Kongstad, Morten Thrane Nielsen, Niels Bjerg Jensen, Irini Pateraki, Søren Spanner Bach, Britta Hamberger, Philipp Zerbe, Dan Staerk, Jörg Bohlmann, Birger Lindberg Møller, Björn Hamberger
Expanding the Landscape of Diterpene Structural Diversity through Stereochemically Controlled Combinatorial Biosynthesis
published pages: 2142-2146, ISSN: 1433-7851, DOI: 10.1002/anie.201510650
Angewandte Chemie International Edition 55/6 2019-06-19

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