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SUNLIGHTING SIGNED

Harvesting the Sun

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SUNLIGHTING project word cloud

Explore the words cloud of the SUNLIGHTING project. It provides you a very rough idea of what is the project "SUNLIGHTING" about.

moss    breakthroughs    invigorated    extraction    optimization    ingredients    host    potent    of    platform    analogs    forskolin    greenhouse    demonstrated    powered    green    structures    erc    medicinal    predicted    discovery    exit    market    competitive    libraries    opportunity    screening    medicines    40    provides    pipelines    constitute    biology    grant    cyanobacteria    goals    isolation    mixtures    structural    desired    poc    fragrances    commercial    domain    world    combinatorial    functionalities    job    entirely    difficult    financial    profitable    harmony    chain    made    2025    flavors    cultivate    angelate    rare    horizon2020    adaptable    biobased    cells    prescribed    food    biological    diterpenoid    solar    drugs    edge    proof    europe2020    diterpenoids    full    entry    ingenol    industry    re    industrial    plants    points    medium    synthetic    offers    excreted    50    compounds    vision    contain    optimize    originate    final    attainable    algae    scientific    class    amounts    sustainable    easily    hotspot    envisioned    representing   

Project "SUNLIGHTING" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 142˙783 €
 EC max contribution 142˙783 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 142˙783.00

Map

 Project objective

Biological production of high-value compounds such as medicines, flavors, fragrances and food ingredients, is predicted to constitute 50% of the World market by 2025 thus representing a commercial hotspot. A competitive edge for European industry within this domain is therefore important. Today, 40% of prescribed medicinal drugs originate or are derived from rare or difficult to cultivate medicinal plants which typically contain the compounds in very low amounts and in complex mixtures. We have demonstrated that by using synthetic biology we can build a solar powered platform for production of key high-value compounds within the diterpenoid class in green cells (cyanobacteria/moss/algae). The diterpenoids are excreted into the growth medium offering easy isolation. This provides a highly profitable and attainable opportunity to produce a large number of medicinal compounds at highly reduced costs. The production platform is easily adaptable to make structural analogs and entirely new structures. Combinatorial libraries can be developed to enable screening for desired new functionalities. The envisioned production platform includes the full chain from pathway discovery, host optimization, scale-up, extraction and final product isolation and offers entry points for industrial development and exit points for adaptation to existing pipelines. Based on the advances made within the ERC Advanced Grant the focus of this PoC is to optimize the scientific breakthroughs’ market adaptation, specifically focused on the compounds Forskolin and Ingenol-3-angelate as proof-of-concept of the market value of the production platform. The envisioned full-chain focus offers potent financial opportunities and a new vision for biobased production across Europe in a re-invigorated sustainable greenhouse industry offering new job opportunities in full harmony with the envisioned Europe2020 and Horizon2020 goals.

 Publications

year authors and title journal last update
List of publications.
2016 Thiyagarajan Gnanasekaran, Daniel Karcher, Agnieszka Zygadlo Nielsen, Helle Juel Martens, Stephanie Ruf, Xenia Kroop, Carl Erik Olsen, Mohammed Saddik Motawie, Mathias Pribil, Birger Lindberg Møller, Ralph Bock, Poul Erik Jensen
Transfer of the cytochrome P450-dependent dhurrin pathway from Sorghum bicolor into Nicotiana tabacum chloroplasts for light-driven synthesis
published pages: 2495-2506, ISSN: 0022-0957, DOI: 10.1093/jxb/erw067
Journal of Experimental Botany 67/8 2019-06-19
2016 Silas Busck Mellor, Agnieszka Zygadlo Nielsen, Meike Burow, Mohammed Saddik Motawia, Dainius Jakubauskas, Birger Lindberg Møller, Poul Erik Jensen
Fusion of Ferredoxin and Cytochrome P450 Enables Direct Light-Driven Biosynthesis
published pages: 1862-1869, ISSN: 1554-8929, DOI: 10.1021/acschembio.6b00190
ACS Chemical Biology 11/7 2019-06-19
2017 Jean-Etienne Bassard, Birger Lindberg Møller, Tomas Laursen
Assembly of Dynamic P450-Mediated Metabolons—Order Versus Chaos
published pages: 37-51, ISSN: 2198-6428, DOI: 10.1007/s40610-017-0053-y
Current Molecular Biology Reports 3/1 2019-06-19
2016 Kim Olsson, Simon Carlsen, Angelika Semmler, Ernesto Simón, Michael Dalgaard Mikkelsen, Birger Lindberg Møller
Microbial production of next-generation stevia sweeteners
published pages: , ISSN: 1475-2859, DOI: 10.1186/s12934-016-0609-1
Microbial Cell Factories 15/1 2019-06-19
2017 Irini Pateraki, Johan Andersen-Ranberg, Niels Bjerg Jensen, Sileshi Gizachew Wubshet, Allison Maree Heskes, Victor Forman, Björn Hallström, Britta Hamberger, Mohammed Saddik Motawia, Carl Erik Olsen, Dan Staerk, Jørgen Hansen, Birger Lindberg Møller, Björn Hamberger
Total biosynthesis of the cyclic AMP booster forskolin from Coleus forskohlii
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.23001
eLife 6 2019-06-19
2016 Johan Andersen-Ranberg, Kenneth Thermann Kongstad, Morten Thrane Nielsen, Niels Bjerg Jensen, Irini Pateraki, Søren Spanner Bach, Britta Hamberger, Philipp Zerbe, Dan Staerk, Jörg Bohlmann, Birger Lindberg Møller, Björn Hamberger
Expanding the Landscape of Diterpene Structural Diversity through Stereochemically Controlled Combinatorial Biosynthesis
published pages: 2142-2146, ISSN: 1433-7851, DOI: 10.1002/anie.201510650
Angewandte Chemie International Edition 55/6 2019-06-19

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