Explore the words cloud of the CureCKDHeart project. It provides you a very rough idea of what is the project "CureCKDHeart" about.
The following table provides information about the project.
|Coordinator Country||Germany [DE]|
|Total cost||1˙497˙888 €|
|EC max contribution||1˙497˙888 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-05-01 to 2021-04-30|
Take a look of project's partnership.
|1||UNIVERSITAETSKLINIKUM AACHEN||DE (AACHEN)||coordinator||1˙497˙888.00|
Chronic kidney disease (CKD) is a growing public health problem with a massively increased cardiovascular mortality. Patients with advanced CKD mostly die from sudden cardiac death and recurrent heart failure due to premature cardiac aging with hypertrophy, fibrosis, and capillary rarefaction. I have recently identified the long sought key cardiac myofibroblast progenitor population, an emerging breakthrough that carries the potential to develop novel targeted therapeutics. Genetic ablation of these Gli1 perivascular progenitors ameliorates fibrosis, cardiac hypertrophy and rescues left-ventricular function. I propose that Gli1 cells are critically involved in all major pathophysiologic changes in cardiac aging and uremic cardiomyopathy including fibrosis, hypertrophy and capillary rarefaction. I will perform state of the art genetic fate tracing, ablation and in vivo CRISPR/Cas9 genome editing experiments to untangle their complex mechanism of activation and communication with endothelial cells and cardiomyocytes promoting fibrosis, capillary rarefaction, cardiac hypertrophy and heart failure. To identify novel druggable targets I will utilize new mouse models that allow comparative transcript and proteasome profiling assays of these critical myofibroblast precusors in homeostasis, aging and premature aging in CKD. Novel assays with immortalized cardiac Gli1 cells will allow high throughput screens to identify uremia associated factors of cell activation and inhibitory compounds to facilitate the development of novel therapeutics. This ambitious interdisciplinary project requires the expertise of chemists, physiologists, biomedical researchers and physician scientists to develop novel targeted therapies in cardiac remodeling during aging and CKD. The passion that drives this project results from a simple emerging hypothesis: It is possible to treat heart failure and sudden cardiac death in aging and CKD by targeting perivascular myofibroblast progenitors.
|year||authors and title||journal||last update|
Rafael Kramann, Claudia Goettsch, Janewit Wongboonsin, Hiroshi Iwata, RebekkaÂ K. Schneider, Christoph Kuppe, Nadine Kaesler, Monica Chang-Panesso, FlaviaÂ G. Machado, Susannah Gratwohl, Kaushal Madhurima, JoshuaÂ D. Hutcheson, Sanjay Jain, Elena Aikawa, BenjaminÂ D. Humphreys
Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease
published pages: 628-642, ISSN: 1934-5909, DOI: 10.1016/j.stem.2016.08.001
|Cell Stem Cell 19/5||2019-07-08|
Rebekka K. Schneider, Ann Mullally, Aurelien Dugourd, Fabian Peisker, Remco Hoogenboezem, Paulina M.H. Van Strien, Eric M. Bindels, Dirk Heckl, Guntram BÃ¼sche, David Fleck, Gerhard MÃ¼ller-Newen, Janewit Wongboonsin, Monica Ventura Ferreira, Victor G. Puelles, Julio Saez-Rodriguez, Benjamin L. Ebert, Benjamin D. Humphreys, Rafael Kramann
Gli1 + Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target
published pages: 785-800.e8, ISSN: 1934-5909, DOI: 10.1016/j.stem.2017.03.008
|Cell Stem Cell 20/6||2019-07-08|
Rafael Kramann, Janewit Wongboonsin, Monica Chang-Panesso, Flavia G. Machado, Benjamin D. Humphreys
Gli1 + Pericyte Loss Induces Capillary Rarefaction and Proximal Tubular Injury
published pages: 776-784, ISSN: 1046-6673, DOI: 10.1681/ASN.2016030297
|Journal of the American Society of Nephrology 28/3||2019-07-08|
HÃ©lÃ¨ne FE Gleitz, Rafael Kramann, Rebekka K Schneider
Understanding deregulated cellular and molecular dynamics in the haematopoietic stem cell niche to develop novel therapeutics for bone marrow fibrosis
published pages: 138-146, ISSN: 0022-3417, DOI: 10.1002/path.5078
|The Journal of Pathology 245/2||2019-05-04|
Leon J. Schurgers, Asim C. Akbulut, Dawid M. Kaczor, Maurice Halder, Rory R. Koenen, Rafael Kramann
Initiation and Propagation of Vascular Calcification Is Regulated by a Concert of Platelet- and Smooth Muscle Cell-Derived Extracellular Vesicles
published pages: , ISSN: 2297-055X, DOI: 10.3389/fcvm.2018.00036
|Frontiers in Cardiovascular Medicine 5||2019-05-04|
Rafael Kramann, Flavia Machado, Haojia Wu, Tetsuro Kusaba, Konrad Hoeft, Rebekka K. Schneider, Benjamin D. Humphreys
Parabiosis and single-cell RNA sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis
published pages: , ISSN: 2379-3708, DOI: 10.1172/jci.insight.99561
|JCI Insight 3/9||2019-05-04|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CURECKDHEART" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (email@example.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "CURECKDHEART" are provided by the European Opendata Portal: CORDIS opendata.
High throughput multiplexed trace-analyte screening for diagnostics applicationsRead More
Field Control of Cold Molecular CollisionsRead More
Streamlined carbon dioxide conversion in ionic liquids – a platform strategy for modern carbonylation chemistryRead More