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PEPTICAPS

Design of polyPEPTIdes diblock copolymers as emulsifiers to produce safe, controlled and reliable novel stimuli-responsive nanoCAPSules for skin care applications

Total Cost €

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EC-Contrib. €

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Partnership

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 PEPTICAPS project word cloud

Explore the words cloud of the PEPTICAPS project. It provides you a very rough idea of what is the project "PEPTICAPS" about.

adjustment    enzyme    coral    constitute    polypeptide    ph    protocols    active    nanocapsules    biocompatible    nanomaterials    homogenizer    software    flow    chemical    eco    encapsulate    demonstrated    extensively    ingredient    toxicity    occurring    gmp    ethylene    elaborated    dermatology    scaling    care    lipophilic    triggered    actively    validation    release    finely    predict    macroemulsifiers    hydrophobic    models    either    amphiphilic    glycol    contactor    responsive    food    manufacturing    producing    polypeptides    balance    validating    pressure    risk    hydrophilic    tune    dossier    technique    stimuli    markets    regulation    skin    plan    participate    business    characterised    gathered    designed    pepticaps    standardization    ingredients    protect    cosmetic    safety    diblock    validated    commercialization    recommended    advantages    family    nanoemulsion    macroemulsifier    length    techniques    poly    assembled    physico    safe    encapsulation    full    nano    copolymers    block    tubular   

Project "PEPTICAPS" data sheet

The following table provides information about the project.

Coordinator
FUNDACION CIDETEC 

Organization address
address: PASEO MIRAMON 196 PARQUE TECNOLOGICO DE MIRAMON
city: SAN SEBASTIAN
postcode: 20014
website: www.cidetec.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.pepticaps.eu
 Total cost 3˙852˙293 €
 EC max contribution 3˙852˙293 € (100%)
 Programme 1. H2020-EU.2.1.2.2. (Ensuring the safe and sustainable development and application of nanotechnologies)
2. H2020-EU.2.1.2.5. (Developing and standardisation of capacity-enhancing techniques, measuring methods and equipment)
3. H2020-EU.2.1.2.3. (Developing the societal dimension of nanotechnology)
 Code Call H2020-NMP-PILOTS-2015
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-10-05   to  2018-10-04

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION CIDETEC ES (SAN SEBASTIAN) coordinator 895˙000.00
2    POLYPEPTIDE THERAPEUTIC SOLUTIONS SOCIEDAD LIMITADA ES (VALENCIA) participant 482˙875.00
3    UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA ES (LEIOA) participant 460˙656.00
4    ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI IT (MILANO) participant 435˙500.00
5    UNIVERSITE LYON 1 CLAUDE BERNARD FR (VILLEURBANNE CEDEX) participant 419˙093.00
6    UNIVERSITE DE BORDEAUX FR (BORDEAUX) participant 417˙278.00
7    AHAVA DEAD SEA LABORATORIES LTD IL (AIRPORT CITY) participant 371˙522.00
8    SPINVERSE OY FI (ESPOO) participant 222˙867.00
9    ANGEL CONSULTING SAS DI MATTEO ZANOTTI RUSSO & C IT (MILANO) participant 147˙500.00

Map

 Project objective

PeptiCaps aims at producing and validating a new family of stimuli-responsive nanocapsules able to encapsulate efficiently and protect specific active ingredients for skin care application. Those nanocapsules will be assembled by nanoemulsion technique using amphiphilic and biocompatible polypeptides diblock copolymers with one hydrophilic poly(ethylene glycol) block and one hydrophobic polypeptide block. Adjustment of the length of each block to finely tune the hydrophilic/Lipophilic balance of the macroemulsifier will allow the encapsulation of either hydrophobic or hydrophilic active ingredients. In addition, polypeptides block will be specifically designed to respond to changes in pH and the presence of enzyme occurring for the skin conditions targeted to allow a triggered release of the active ingredient. After scaling-up selected macroemulsifiers under GMP-like process, two manufacturing processes will be used for the production of the nanocapsules, i.e. high-pressure homogenizer and tubular flow contactor. The most promising process will be selected to produce selected nanocapsules. Physico-chemical properties and (eco)toxicity of the nanocapsules will be extensively characterised using techniques and protocols recommended by the EU Cosmetic regulation to establish their risk and safety assessment. The advantages of safe nanocapsules from PeptiCaps will be demonstrated on validated relevant skin models for each application. All results obtained will be gathered to constitute a Dossier for the validation of the nanocapsules as cosmetic product by the authorities. In addition, PeptiCaps will actively participate to the standardization for nano-safety by developing software to predict the toxicity of nanomaterials (CORAL). Finally, a business plan will be elaborated for the commercialization of PeptiCaps nanocapsules for all cosmetic applications as well as other markets (dermatology and food) to ensure full exploitation of the PeptiCaps technology.

 Deliverables

List of deliverables.
Visual identity, including Brochure, presentation, poster, leaflet Websites, patent fillings, videos etc. 2019-05-30 13:56:47
Project website Websites, patent fillings, videos etc. 2019-05-30 13:56:57
Master document with all data required for nanomaterials for product registration and validation Documents, reports 2019-05-30 13:56:46
Dissemination strategy Documents, reports 2019-05-30 13:56:51
Report on pre-normative solution for standardization of identified gaps Documents, reports 2019-05-07 20:23:42
New CORAL models available on the CORAL website Websites, patent fillings, videos etc. 2019-05-07 20:23:42
Open access summary report Documents, reports 2019-05-07 20:23:42

Take a look to the deliverables list in detail:  detailed list of PEPTICAPS deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Alla P. Toropova, Andrey A. Toropov, Marten Beeg, Marco Gobbi, Mario Salmona
Utilization of the Monte Carlo Method to Build up QSAR Models for Hemolysis and Cytotoxicity of Antimicrobial Peptides
published pages: , ISSN: 1570-1638, DOI: 10.2174/1570163814666170525114128
Current Drug Discovery Technologies 14/4 2019-05-14
2016 A. A. Toropov, A. P. Toropova, S. Begum, P. G. R. Achary
Towards predicting the solubility of CO 2 and N 2 in different polymers using a quasi-SMILES based QSPR approach
published pages: 293-301, ISSN: 1062-936X, DOI: 10.1080/1062936X.2016.1172666
SAR and QSAR in Environmental Research 27/4 2019-05-14
2017 Mariya A. Toropova, Ivan Raska Jr, Alla P. Toporova, Maria Raskova
CORAL Software: Analysis of Impacts of Pharmaceutical Agents Upon Metabolism via the Optimal Descriptors
published pages: , ISSN: 1389-2002, DOI: 10.2174/1389200218666170301105916
Current Drug Metabolism 18/6 2019-05-07
2018 Océane Alliod, Jean-Pierre Valour, Sébastien Urbaniak, Hatem Fessi, Damien Dupin, Catherine Charcosset
Preparation of oil-in-water nanoemulsions at large-scale using premix membrane emulsification and Shirasu Porous Glass (SPG) membranes
published pages: 76-84, ISSN: 0927-7757, DOI: 10.1016/j.colsurfa.2018.04.045
Colloids and Surfaces A: Physicochemical and Engineering Aspects 557 2019-05-07
2016 Alla P. Toropova, P. Ganga Raju Achary, Andrey A. Toropov
Quasi-SMILES for Nano-QSAR Prediction of Toxic Effect of Al2O3 Nanoparticles
published pages: 17-28, ISSN: 2379-7452, DOI: 10.4018/JNN.2016010102
Journal of Nanotoxicology and Nanomedicine 1 10 2019-05-07
2016 Marco Gobbi, Marten Beeg, Mariya A. Toropova, Andrey A. Toropov, Mario Salmona
Monte Carlo method for predicting of cardiac toxicity: hERG blocker compounds
published pages: 42-46, ISSN: 0378-4274, DOI: 10.1016/j.toxlet.2016.04.010
Toxicology Letters 250-251 2019-05-07
2016 Andrey A. Toropov, Alla P. Toropova, Luigi Cappellini, Emilio Benfenati, Enrico Davoli
Odor threshold prediction by means of the Monte Carlo method
published pages: 390-394, ISSN: 0147-6513, DOI: 10.1016/j.ecoenv.2016.07.039
Ecotoxicology and Environmental Safety 133 2019-05-07
2016 Mariya A. Toropova, Ivan RaŠka, Andrey A. Toropov, Mária RaŠková
The Utilization of the Monte Carlo Technique for Rational Drug Discovery
published pages: 676-687, ISSN: 1386-2073, DOI: 10.2174/1386207319666160725145852
Combinatorial Chemistry & High Throughput Screening 19/8 2019-05-07

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