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NanoPP

Large Scale Protein Library Screening Biosensor

Total Cost €

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EC-Contrib. €

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Partnership

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Project "NanoPP" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 149˙990 €
 EC max contribution 149˙990 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 149˙990.00

Map

 Project objective

In this application a platform is proposed that builds on preliminary work from ERC starting grant NanoP in order to develop a technology for high throughput electronic recognition of a large library of proteins using nanometer sized channels. These channel (or nanopore) dimensions are on the same order of magnitude as the proteins that we are using, making a natural confinement mechanism. Importantly, this allows for the efficient detection and screening of individual protein molecules and as will be shown in a high throughput manner. Here we propose to couple protein recognition to an electrical readout via a nanopore, that will result in improved prospects in efficiency, scalability, and sensitivity. Furthermore, this grant will allow for appropriate market research and IP landscaping to be performed in order to ensure the preferred option of setting up a spin-out company will be positioned correctly to ensure success.

 Publications

year authors and title journal last update
List of publications.
2015 William H. Pitchford, Hyung-Jun Kim, Aleksandar P. Ivanov, Hyun-Mi Kim, Jae-Seok Yu, Robin J. Leatherbarrow, Tim Albrecht, Ki-Bum Kim, Joshua B. Edel
Synchronized Optical and Electronic Detection of Biomolecules Using a Low Noise Nanopore Platform
published pages: 1740-1748, ISSN: 1936-0851, DOI: 10.1021/nn506572r
ACS Nano 9/2 2019-07-26
2015 Colin R. Crick, Pablo Albella, Binghao Ng, Aleksandar P. Ivanov, Tyler Roschuk, Michael P. Cecchini, Fernando Bresme, Stefan A. Maier, Joshua B. Edel
Precise Attoliter Temperature Control of Nanopore Sensors Using a Nanoplasmonic Bullseye
published pages: 553-559, ISSN: 1530-6984, DOI: 10.1021/nl504536j
Nano Letters 15/1 2019-07-26
2015 Aleksandar P. Ivanov, Paolo Actis, Peter Jönsson, David Klenerman, Yuri Korchev, Joshua B. Edel
On-Demand Delivery of Single DNA Molecules Using Nanopipets
published pages: 3587-3595, ISSN: 1936-0851, DOI: 10.1021/acsnano.5b00911
ACS Nano 9/4 2019-07-26
2016 Kevin J. Freedman, Colin R. Crick, Pablo Albella, Avijit Barik, Aleksandar P. Ivanov, Stefan A. Maier, Sang-Hyun Oh, Joshua B. Edel
On-Demand Surface- and Tip-Enhanced Raman Spectroscopy Using Dielectrophoretic Trapping and Nanopore Sensing
published pages: 1036-1044, ISSN: 2330-4022, DOI: 10.1021/acsphotonics.6b00119
ACS Photonics 3/6 2019-07-26
2017 Ren Ren, Yanjun Zhang, Binoy Paulose Nadappuram, Bernice Akpinar, David Klenerman, Aleksandar P. Ivanov, Joshua B. Edel, Yuri Korchev
Nanopore extended field-effect transistor for selective single-molecule biosensing
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00549-w
Nature Communications 8/1 2019-07-26
2017 Paolo Cadinu, Binoy Paulose Nadappuram, Dominic J. Lee, Jasmine Y. Y. Sze, Giulia Campolo, Yanjun Zhang, Andrew Shevchuk, Sylvain Ladame, Tim Albrecht, Yuri Korchev, Aleksandar P. Ivanov, Joshua B. Edel
Single Molecule Trapping and Sensing Using Dual Nanopores Separated by a Zeptoliter Nanobridge
published pages: , ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.7b03196
Nano Letters 2019-07-26
2017 Jasmine Y. Y. Sze, Aleksandar P. Ivanov, Anthony E. G. Cass, Joshua B. Edel
Single Molecule Multiplexed Nanopore Protein Screening in Human Serum using Aptamer modified DNA Carriers
published pages: , ISSN: 2041-1723, DOI:
Nature Communications 2019-07-26
2014 Aleksandar P. Ivanov, Kevin J. Freedman, Min Jun Kim, Tim Albrecht, Joshua B. Edel
High Precision Fabrication and Positioning of Nanoelectrodes in a Nanopore
published pages: 1940-1948, ISSN: 1936-0851, DOI: 10.1021/nn406586m
ACS Nano 8/2 2019-07-26
2016 Kevin J. Freedman, Lauren M. Otto, Aleksandar P. Ivanov, Avijit Barik, Sang-Hyun Oh, Joshua B. Edel
Nanopore sensing at ultra-low concentrations using single-molecule dielectrophoretic trapping
published pages: 10217, ISSN: 2041-1723, DOI: 10.1038/ncomms10217
Nature Communications 7 2019-07-26

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