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PANDORA SIGNED

Pandemics Outbreaks Rationalized: towards a universal therapy to eliminate intracellular pathogens and drug resistance

Total Cost €

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EC-Contrib. €

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Partnership

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 PANDORA project word cloud

Explore the words cloud of the PANDORA project. It provides you a very rough idea of what is the project "PANDORA" about.

codes    nature    eradicate    antimicrobial    organism    pillars    bind    leaving    universal    selective    fusion    polymeric    infectious    drug    nanoparticles    bar    expressed    create    cells    chase    human    reproduce    bacterial    tuberculosis    super    caused    infection    resistance    first    nanocarriers    mycobacteria    selectively    invented    ab    sequence    probe    revolution    molecular    diseases    counteract    either    designed    proteins    combined    car    causing    core    memory    express    mycobacteriophages    worst    repertoire    intracellular    fight    macrophage    untouched    infections    ubiquitin    combine    vision    region    bacteriophages    clearance    locally    proteasome    recognising    pandora    recognise    antibodies    abs    chimeric    mycobacterial    membrane    ligands    therapy    payload    pandemics    binding    eradication    polymersomes    pathogens    reversely    immunity    model    completely    triggered    revolutionise    receptor    phagocytosis    engineer    wall    circulating    agent    eradicating    autolisins    antigen    complete    cure    infected    attack    carry    species    inspired    effector   

Project "PANDORA" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA 

Organization address
address: CARRER BALDIRI REIXAC PLANTA 2A 10-12
city: BARCELONA
postcode: 8028
website: http://www.ibecbarcelona.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙495˙018 €
 EC max contribution 1˙495˙018 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-08-01   to  2025-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) coordinator 1˙495˙018.00

Map

 Project objective

I propose here a research vision that aims to revolutionise the way we cure infections caused by intracellular pathogens, with the aim to find a universal therapy to infectious diseases that will also counteract the development of drug resistance. In PANDORA, I will specifically focus on eradicating human tuberculosis, one of the worst pandemics so far. To do this, I will first probe what are the molecular ‘bar-codes’ of infected cells, namely those specific membrane proteins that cells express upon infection. I will use this to reversely engineer a repertoire of super-selective polymeric nanoparticles - known as Polymersomes - that will carry ligands to recognise, bind, and selectively attack infected cells only, while leaving non-infected cells completely untouched. Such nanocarriers will access the infected cells and locally deliver their payload, which is the core technology of the therapy. Such technology will be inspired by what nature invented: I will reproduce the binding sequence of autolisins, proteins expressed by bacteriophages that specifically bind the wall of Mycobacteria species (the agent causing tuberculosis). I will thus create fusion antibodies (Ab) characterized by (i) the binding sequence of mycobacteriophages autolisins (for selective recognising intracellular Mycobacterial wall) and (ii) an effector region promoting bacterial clearance through either the macrophage-triggered phagocytosis or an ubiquitin-proteasome system. This therapy will represent a complete revolution in the field of new antimicrobial development, as it will combine complete bacterial eradication, development of memory immunity and fight against drug resistance, the three core pillars of this project. The super-selective polymersomes carrying the Abs-based universal therapy will be combined with the development of chimeric antigen receptor T-cells (CAR-T) against infection. These T-cells will be designed to chase and eradicate circulating infected cells in model organism.

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The information about "PANDORA" are provided by the European Opendata Portal: CORDIS opendata.

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