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PANDORA SIGNED

Pandemics Outbreaks Rationalized: towards a universal therapy to eliminate intracellular pathogens and drug resistance

Total Cost €

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EC-Contrib. €

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Partnership

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 PANDORA project word cloud

Explore the words cloud of the PANDORA project. It provides you a very rough idea of what is the project "PANDORA" about.

human    bacterial    create    region    eradicate    completely    pandemics    model    designed    nanocarriers    infection    diseases    car    attack    sequence    repertoire    probe    polymersomes    bar    first    circulating    bind    organism    inspired    recognising    resistance    antigen    immunity    infections    super    bacteriophages    revolutionise    chase    reproduce    causing    expressed    vision    wall    caused    species    drug    chimeric    codes    intracellular    pathogens    abs    either    ligands    cells    memory    recognise    triggered    tuberculosis    mycobacteriophages    mycobacterial    receptor    carry    infectious    therapy    nanoparticles    infected    counteract    reversely    pillars    agent    effector    antimicrobial    antibodies    combine    combined    ab    polymeric    worst    membrane    leaving    phagocytosis    proteasome    macrophage    proteins    clearance    express    locally    mycobacteria    fight    core    pandora    invented    complete    binding    engineer    eradicating    fusion    nature    autolisins    revolution    payload    selectively    cure    universal    untouched    selective    eradication    ubiquitin    molecular   

Project "PANDORA" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA 

Organization address
address: CARRER BALDIRI REIXAC PLANTA 2A 10-12
city: BARCELONA
postcode: 8028
website: http://www.ibecbarcelona.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙495˙018 €
 EC max contribution 1˙495˙018 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-08-01   to  2025-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) coordinator 1˙495˙018.00

Map

 Project objective

I propose here a research vision that aims to revolutionise the way we cure infections caused by intracellular pathogens, with the aim to find a universal therapy to infectious diseases that will also counteract the development of drug resistance. In PANDORA, I will specifically focus on eradicating human tuberculosis, one of the worst pandemics so far. To do this, I will first probe what are the molecular ‘bar-codes’ of infected cells, namely those specific membrane proteins that cells express upon infection. I will use this to reversely engineer a repertoire of super-selective polymeric nanoparticles - known as Polymersomes - that will carry ligands to recognise, bind, and selectively attack infected cells only, while leaving non-infected cells completely untouched. Such nanocarriers will access the infected cells and locally deliver their payload, which is the core technology of the therapy. Such technology will be inspired by what nature invented: I will reproduce the binding sequence of autolisins, proteins expressed by bacteriophages that specifically bind the wall of Mycobacteria species (the agent causing tuberculosis). I will thus create fusion antibodies (Ab) characterized by (i) the binding sequence of mycobacteriophages autolisins (for selective recognising intracellular Mycobacterial wall) and (ii) an effector region promoting bacterial clearance through either the macrophage-triggered phagocytosis or an ubiquitin-proteasome system. This therapy will represent a complete revolution in the field of new antimicrobial development, as it will combine complete bacterial eradication, development of memory immunity and fight against drug resistance, the three core pillars of this project. The super-selective polymersomes carrying the Abs-based universal therapy will be combined with the development of chimeric antigen receptor T-cells (CAR-T) against infection. These T-cells will be designed to chase and eradicate circulating infected cells in model organism.

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The information about "PANDORA" are provided by the European Opendata Portal: CORDIS opendata.

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