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Magnetic approaches for Tissue Mechanics and Engineering

Total Cost €


EC-Contrib. €






 MaTissE project word cloud

Explore the words cloud of the MaTissE project. It provides you a very rough idea of what is the project "MaTissE" about.

explore    clinical    forced    magnetic    surgeon    self    remotely    biophysics    maturation    macroscopic    functional    handling    safely    opens    translation    forces    combined    questions    differentiation    magnetized    resonance    largely    tissue    centimetric    external    stresses    cell    pressing    cells    inherently    cartilage    bricks    shape    amenable    advantages    regenerative    engineering    nanomaterial    cellular    manipulations    tool    interface    shaped    physical    agents    mapping    techniques    rarely    medicine    therapy    fate    tissues    corollary    nanoscale    nanoparticles    patented    magnets    inherent    nanomaterials    constructs    size    stimulation    2012    functions    bioreactor    3d    alignment    explored    situ    multidisciplinary    therapeutic    tissular    manipulated    integrating    standpoint    nanomedicine    repair    mechanical    unexplored    form    nanomagnetic    answer    lying    cardiac    perspectives    imaging    scaffold    magnetically   

Project "MaTissE" data sheet

The following table provides information about the project.


There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country France [FR]
 Total cost 1˙589˙000 €
 EC max contribution 1˙589˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2020-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE PARIS FR (PARIS) coordinator 1˙589˙000.00


 Project objective

'While magnetic nanomaterials are increasingly used as clinical agents for imaging and therapy, their use as a tool for tissue engineering opens up challenging perspectives that have rarely been explored. Lying at the interface between biophysics and nanomedicine, and based on magnetic techniques, the proposed project aims to magnetically design functional tissues and to explore the tissular fate of nanomaterials. Magnetic nanoparticles will be safely introduced into therapeutic cells, thus allowing them to be remotely manipulated by external magnets. 3D manipulations of the magnetized cells (patented in 2012) will be used to form tissues with a controlled size and shape through the development of a unique magnetic bioreactor. In a self-integrating all-in-one process, 3D tissue will be shaped from cellular 'bricks' without the need for a scaffold. The magnetic tissue will be amenable to mechanical stimulation and in situ imaging at each step of its maturation. The project is inherently multidisciplinary: 1) From a biophysics standpoint, controlled tissue stimulation, forced cell alignment, and mapping of cell-cell forces, will be used to answer pressing questions on the role of physical stresses in cell and tissue functions, such as differentiation. 2) From a regenerative medicine standpoint, this magnetic technology will be applied to cartilage and cardiac tissue repair. The functionality of the constructs and their centimetric size range, combined with a surgeon-friendly tissue handling with a dedicated magnetic tool, and the inherent magnetic resonance imaging properties of the constructs will be major advantages for clinical translation. 3) From a nanomaterials standpoint, nanomaterial fate will be explored in situ using nanomagnetic methods, both at the tissue scale (macroscopic) and at the nanoscale. This is a necessary corollary for the use of nanomaterials in regenerative medicine, and one that is largely unexplored.'


year authors and title journal last update
List of publications.
2017 Vicard Du, Nathalie Luciani, Sophie Richard, Gaëtan Mary, Cyprien Gay, François Mazuel, Myriam Reffay, Philippe Menasché, Onnik Agbulut, Claire Wilhelm
A 3D magnetic tissue stretcher for remote mechanical control of embryonic stem cell differentiation
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00543-2
Nature Communications 8/1 2020-03-17
2017 François Mazuel, Samuel Mathieu, Riccardo Di Corato, Jean-Claude Bacri, Thierry Meylheuc, Teresa Pellegrino, Myriam Reffay, Claire Wilhelm
Forced- and Self-Rotation of Magnetic Nanorods Assembly at the Cell Membrane: A Biomagnetic Torsion Pendulum
published pages: 1701274, ISSN: 1613-6810, DOI: 10.1002/smll.201701274
Small 13/31 2020-03-17
2016 Van de Walle A, Faissal W, Du V, Richert A, Gazeau F, Le Visage C, Luciani N, Wilhelm C.
Magnetic Stem Cell Confinement for Articular Cartilage Repair
published pages: S117-S118, ISSN: , DOI:
Tissue Engineering Part A 22 2020-03-17
2017 Aurore Van de Walle, Claire Wilhelm, Nathalie Luciani
3D Magnetic Stem Cell Aggregation and Bioreactor Maturation for Cartilage Regeneration
published pages: , ISSN: 1940-087X, DOI: 10.3791/55221
Journal of Visualized Experiments 122 2020-03-17
2016 Mazuel F, Van de Walle A, Espinosa A, Lalatonne Y, Luciani N, Wilhelm C.
Biodegradation of Magnetic Nanoparticles During Stem Cells Chondrogenesis: Implications for Regenerative Medicine Applications
published pages: S107, ISSN: , DOI:
Tissue Engineering Part A 22 2020-03-17
2016 François Mazuel, Ana Espinosa, Nathalie Luciani, Myriam Reffay, Rémi Le Borgne, Laurence Motte, Karine Desboeufs, Aude Michel, Teresa Pellegrino, Yoann Lalatonne, Claire Wilhelm
Massive Intracellular Biodegradation of Iron Oxide Nanoparticles Evidenced Magnetically at Single-Endosome and Tissue Levels
published pages: 7627-7638, ISSN: 1936-0851, DOI: 10.1021/acsnano.6b02876
ACS nano 10 2020-03-17
2016 Nathalie Luciani, Vicard Du, Florence Gazeau, Alain Richert, Didier Letourneur, Catherine Le Visage, Claire Wilhelm
Successful chondrogenesis within scaffolds, using magnetic stem cell confinement and bioreactor maturation
published pages: 101-110, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2016.04.009
Acta Biomateriala 37 2020-03-17
2017 François Mazuel, Ana Espinosa, Guillaume Radtke, Matthieu Bugnet, Sophie Neveu, Yoann Lalatonne, Gianluigi A Botton, Ali Abou‐Hassan, Claire Wilhelm
Magneto‐Thermal Metrics Can Mirror the Long‐Term Intracellular Fate of Magneto‐Plasmonic Nanohybrids and Reveal the Remarkable Shielding Effect of Gold
published pages: 1605997, ISSN: 1616-301X, DOI: 10.1002/adfm.201605997
Advanced Functional Materials 27 2020-03-17

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