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MaTissE SIGNED

Magnetic approaches for Tissue Mechanics and Engineering

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MaTissE project word cloud

Explore the words cloud of the MaTissE project. It provides you a very rough idea of what is the project "MaTissE" about.

lying functions size engineering interface stimulation translation pressing unexplored manipulated nanomagnetic therapy clinical cells forced biophysics magnetized safely constructs maturation tissue magnets bioreactor nanomaterial nanomaterials nanoscale form therapeutic regenerative patented tissular amenable explore corollary nanomedicine answer self stresses shaped opens tissues repair rarely advantages perspectives alignment fate integrating agents mapping combined inherently explored magnetically inherent handling macroscopic forces 3d cartilage imaging tool standpoint physical medicine manipulations multidisciplinary largely nanoparticles remotely situ cell resonance surgeon cardiac external functional 2012 questions scaffold techniques mechanical shape cellular magnetic bricks differentiation centimetric

Project "MaTissE" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITE PARIS DIDEROT - PARIS 7 There are not information about this coordinator. Please contact Fabio for more information, thanks.
Coordinator Country	France [FR]
Total cost	1˙589˙000 €
EC max contribution	1˙589˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-CoG
Funding Scheme	ERC-COG
Starting year	2015
Duration (year-month-day)	from 2015-07-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITE DE PARIS UNIVERSITE DE PARIS Organization address address: 85 BD SAINT GERMAIN city: PARIS postcode: 75006 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	1˙589˙000.00
2	UNIVERSITE PARIS DIDEROT - PARIS 7 UNIVERSITE PARIS DIDEROT - PARIS 7 Organization address address: RUE THOMAS MANN 5 city: PARIS postcode: 75205 website: www.univ-paris-diderot.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	0.00

Map

Project objective

'While magnetic nanomaterials are increasingly used as clinical agents for imaging and therapy, their use as a tool for tissue engineering opens up challenging perspectives that have rarely been explored. Lying at the interface between biophysics and nanomedicine, and based on magnetic techniques, the proposed project aims to magnetically design functional tissues and to explore the tissular fate of nanomaterials. Magnetic nanoparticles will be safely introduced into therapeutic cells, thus allowing them to be remotely manipulated by external magnets. 3D manipulations of the magnetized cells (patented in 2012) will be used to form tissues with a controlled size and shape through the development of a unique magnetic bioreactor. In a self-integrating all-in-one process, 3D tissue will be shaped from cellular 'bricks' without the need for a scaffold. The magnetic tissue will be amenable to mechanical stimulation and in situ imaging at each step of its maturation. The project is inherently multidisciplinary: 1) From a biophysics standpoint, controlled tissue stimulation, forced cell alignment, and mapping of cell-cell forces, will be used to answer pressing questions on the role of physical stresses in cell and tissue functions, such as differentiation. 2) From a regenerative medicine standpoint, this magnetic technology will be applied to cartilage and cardiac tissue repair. The functionality of the constructs and their centimetric size range, combined with a surgeon-friendly tissue handling with a dedicated magnetic tool, and the inherent magnetic resonance imaging properties of the constructs will be major advantages for clinical translation. 3) From a nanomaterials standpoint, nanomaterial fate will be explored in situ using nanomagnetic methods, both at the tissue scale (macroscopic) and at the nanoscale. This is a necessary corollary for the use of nanomaterials in regenerative medicine, and one that is largely unexplored.'

Publications

List of publications.
year	authors and title	journal	last update
2017	Vicard Du, Nathalie Luciani, Sophie Richard, GaÃ«tan Mary, Cyprien Gay, FranÃ§ois Mazuel, Myriam Reffay, Philippe MenaschÃ©, Onnik Agbulut, Claire Wilhelm A 3D magnetic tissue stretcher for remote mechanical control of embryonic stem cell differentiation published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00543-2	Nature Communications 8/1	2020-03-17
2017	FranÃ§ois Mazuel, Samuel Mathieu, Riccardo Di Corato, Jean-Claude Bacri, Thierry Meylheuc, Teresa Pellegrino, Myriam Reffay, Claire Wilhelm Forced- and Self-Rotation of Magnetic Nanorods Assembly at the Cell Membrane: A Biomagnetic Torsion Pendulum published pages: 1701274, ISSN: 1613-6810, DOI: 10.1002/smll.201701274	Small 13/31	2020-03-17
2016	Van de Walle A, Faissal W, Du V, Richert A, Gazeau F, Le Visage C, Luciani N, Wilhelm C. Magnetic Stem Cell Confinement for Articular Cartilage Repair published pages: S117-S118, ISSN: , DOI:	Tissue Engineering Part A 22	2020-03-17
2017	Aurore Van de Walle, Claire Wilhelm, Nathalie Luciani 3D Magnetic Stem Cell Aggregation and Bioreactor Maturation for Cartilage Regeneration published pages: , ISSN: 1940-087X, DOI: 10.3791/55221	Journal of Visualized Experiments 122	2020-03-17
2016	Mazuel F, Van de Walle A, Espinosa A, Lalatonne Y, Luciani N, Wilhelm C. Biodegradation of Magnetic Nanoparticles During Stem Cells Chondrogenesis: Implications for Regenerative Medicine Applications published pages: S107, ISSN: , DOI:	Tissue Engineering Part A 22	2020-03-17
2016	FranÃ§ois Mazuel, Ana Espinosa, Nathalie Luciani, Myriam Reffay, RÃ©mi Le Borgne, Laurence Motte, Karine Desboeufs, Aude Michel, Teresa Pellegrino, Yoann Lalatonne, Claire Wilhelm Massive Intracellular Biodegradation of Iron Oxide Nanoparticles Evidenced Magnetically at Single-Endosome and Tissue Levels published pages: 7627-7638, ISSN: 1936-0851, DOI: 10.1021/acsnano.6b02876	ACS nano 10	2020-03-17
2016	Nathalie Luciani, Vicard Du, Florence Gazeau, Alain Richert, Didier Letourneur, Catherine Le Visage, Claire Wilhelm Successful chondrogenesis within scaffolds, using magnetic stem cell confinement and bioreactor maturation published pages: 101-110, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2016.04.009	Acta Biomateriala 37	2020-03-17
2017	FranÃ§ois Mazuel, Ana Espinosa, Guillaume Radtke, Matthieu Bugnet, Sophie Neveu, Yoann Lalatonne, Gianluigi A Botton, Ali Abouâ€Hassan, Claire Wilhelm Magnetoâ€Thermal Metrics Can Mirror the Longâ€Term Intracellular Fate of Magnetoâ€Plasmonic Nanohybrids and Reveal the Remarkable Shielding Effect of Gold published pages: 1605997, ISSN: 1616-301X, DOI: 10.1002/adfm.201605997	Advanced Functional Materials 27	2020-03-17

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MATISSE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MATISSE" are provided by the European Opendata Portal: CORDIS opendata.