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ThyroTrust

A novel reliable diagnostic device to avoid unnecessary thyroid surgery

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 ThyroTrust project word cloud

Explore the words cloud of the ThyroTrust project. It provides you a very rough idea of what is the project "ThyroTrust" about.

hormone    fine    kit    planning    cos    expression    surgical    cytology    30    clinical    risk    either    5    effect    idea    manufacturing    prudentially    surgeries    organization    abolishment    business    thyrotrust    clinically    proposing    thyroidectomy    unnecessary    lesion    lt    measured    26    positive    innovation    ing    negative    italy    generation    replacement    category    nodules    price    80    genes    plan    cytological    diagnostic    44000    outcome    financial    surgery    addressable    diagnosis    time    740    estimation    variations    adverse    indeterminate    opportunity    market    benign    quality    ivd    aspiration    validated    300    performed    procedure    forcing    sequencing    patients    search    90    fna    introduce    virtually    million    first    malignant    classified    prevalence    tool    correct    frequent    gene    malignancy    47    diagnostics    social    cancer    route    histology    feasibility    66    rearrangements    needle    panel    ipr    thyroid    considerable    complications    fnac    scope    ce    types    reveal    postoperative    15    influences    life    strategy   

Project "ThyroTrust" data sheet

The following table provides information about the project.

Coordinator		 GENOMNIA SRL 

Organization address
address: CORSO MAGENTA 56
city: MILANO
postcode: 20123
website: www.genomnia.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Italy [IT]
 Project website http://www.genomnia.it
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SMEINST-1-2015
 Funding Scheme SME-1
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2016-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GENOMNIA SRL IT (MILANO) coordinator 50˙000.00

Map

 Project objective

Fine needle aspiration cytology (FNAC) is the best procedure for a timely and reliable diagnosis of either a benign or malignant thyroid lesion. However, the management of patients with indeterminate cytology (10-26%) is a frequent clinical and social problem, as this cytological category is associated with a 15 to 30% prevalence of malignancy, forcing most of these patients to diagnostic surgery. However, for the 80% of these patients the surgery is unnecessary as the postoperative histology reveal a benign lesion. The negative social and financial consequences of this approach are relevant in Europe (44000/year thyroidectomy only in Italy) as well as the adverse influences on the quality of life of the patients due to surgical complications and hormone replacement. We will introduce in the market the first clinically validated CE-IVD targeted Next Generation Sequencing diagnostic kit ThyroTrust for the correct diagnosis of thyroid nodules with indeterminate cytology. Our kit is the first to include a considerable number of variations in 47 genes, 66 types of rearrangements and 8 gene expression level measured at the same time and associated with malignant outcome. This will avoid diagnostic surgery if a risk of malignancy <5%. In the scope of the feasibility study we will assess: - Technology innovation opportunity and business idea - Development planning and partner search - IPR, quality, organization and manufacturing route - GO-TO-MARKET strategy and business plan 740,000 FNA are performed in Europe, so the addressable market, with an end-user price/kit of 300€, is over €50 Million/year. Prudentially, market estimation considers only FNA results classified as “indeterminate cytology”. The same approach could be evaluated and adopted for other cancer diagnostics, proposing a similar gene panel kit on the market. The positive effect resulting from such diagnostic tool can virtually lead to the abolishment of 90% of unnecessary surgeries and related cos

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The information about "THYROTRUST" are provided by the European Opendata Portal: CORDIS opendata.

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