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A novel reliable diagnostic device to avoid unnecessary thyroid surgery

Total Cost €


EC-Contrib. €






 ThyroTrust project word cloud

Explore the words cloud of the ThyroTrust project. It provides you a very rough idea of what is the project "ThyroTrust" about.

thyrotrust    80    life    malignancy    sequencing    procedure    gene    time    diagnosis    manufacturing    clinical    needle    kit    market    reveal    44000    surgical    performed    unnecessary       benign    90    generation    ing    47    fnac    cytological    either    route    positive    negative    search    first    surgeries    proposing    plan    scope    rearrangements    virtually    genes    prudentially    diagnostic    effect    thyroidectomy    opportunity    hormone    740    idea    tool    cos    category    cancer    panel    financial    quality    malignant    adverse    prevalence    business    frequent    addressable    innovation    ce    lt    feasibility    fine    15    66    replacement    thyroid    ivd    social    estimation    influences    outcome    diagnostics    measured    nodules    organization    types    planning    million    clinically    patients    considerable    classified    abolishment    strategy    expression    300    validated    histology    variations    aspiration    forcing    fna    complications    correct    introduce    indeterminate    postoperative    italy    26    ipr    cytology    surgery    price    risk    30    lesion   

Project "ThyroTrust" data sheet

The following table provides information about the project.


Organization address
address: CORSO MAGENTA 56
city: MILANO
postcode: 20123

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SMEINST-1-2015
 Funding Scheme SME-1
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2016-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GENOMNIA SRL IT (MILANO) coordinator 50˙000.00


 Project objective

Fine needle aspiration cytology (FNAC) is the best procedure for a timely and reliable diagnosis of either a benign or malignant thyroid lesion. However, the management of patients with indeterminate cytology (10-26%) is a frequent clinical and social problem, as this cytological category is associated with a 15 to 30% prevalence of malignancy, forcing most of these patients to diagnostic surgery. However, for the 80% of these patients the surgery is unnecessary as the postoperative histology reveal a benign lesion. The negative social and financial consequences of this approach are relevant in Europe (44000/year thyroidectomy only in Italy) as well as the adverse influences on the quality of life of the patients due to surgical complications and hormone replacement. We will introduce in the market the first clinically validated CE-IVD targeted Next Generation Sequencing diagnostic kit ThyroTrust for the correct diagnosis of thyroid nodules with indeterminate cytology. Our kit is the first to include a considerable number of variations in 47 genes, 66 types of rearrangements and 8 gene expression level measured at the same time and associated with malignant outcome. This will avoid diagnostic surgery if a risk of malignancy <5%. In the scope of the feasibility study we will assess: - Technology innovation opportunity and business idea - Development planning and partner search - IPR, quality, organization and manufacturing route - GO-TO-MARKET strategy and business plan 740,000 FNA are performed in Europe, so the addressable market, with an end-user price/kit of 300€, is over €50 Million/year. Prudentially, market estimation considers only FNA results classified as “indeterminate cytology”. The same approach could be evaluated and adopted for other cancer diagnostics, proposing a similar gene panel kit on the market. The positive effect resulting from such diagnostic tool can virtually lead to the abolishment of 90% of unnecessary surgeries and related cos

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The information about "THYROTRUST" are provided by the European Opendata Portal: CORDIS opendata.

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