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Engineering Complex Intestinal Epithelial Tissue Models

Total Cost €


EC-Contrib. €






Project "COMIET" data sheet

The following table provides information about the project.


Organization address
postcode: 8028

contact info
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name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Spain [ES]
 Total cost 1˙997˙190 €
 EC max contribution 1˙997˙190 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-12-01   to  2020-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Epithelial barriers protect the body against physical, chemical, and microbial insults. Intestinal epithelium is one of the most actively renewing tissues in the body and a major site of carcinogenesis. Functional in vitro models of intestinal epithelium have been pursued for a long time. They are key elements in basic research, disease modelling, drug discovery, and tissue replacing and have become prime models for adult stem cell research. By taking advantage of the self-organizing properties of intestinal stem cells, intestinal organoids have been recently established, showing cell renewal’s kinetics resembling to the one found in vivo. However, the development of in vitro 3D tissue equivalents accounting for the dimensions, architecture and access to the luminal contents of the in vivo human intestinal tissue together with its self-renewal properties and cell complexity, remains a challenge. The goal of this project is to engineer intestinal epithelial tissue models that mimic physiological characteristics found in in vivo human intestinal tissue, to open up new areas of research on human intestinal diseases. The proposed models will address the in vivo intestinal epithelial cell renewal and migration, the multicell-type differentiation and the epithelial cell interactions with the underlying basement membrane while providing access to the luminal content to go beyond the state-of-the-art organoid models. To do this, we propose to develop an experimental setup that combines microfabrication techniques, tissue engineering components and recent advances in intestinal stem cell research, exploiting stem cell self-organizing characteristics. We anticipate this setup to recapitulate the 3D morphology, the spatio-chemical gradients and the dynamic microenvironment of the living tissue. We expect the new device to prove useful in understanding cell physiology, adult stem cell behaviour, and organ development as well as in modelling human intestinal diseases.


year authors and title journal last update
List of publications.
2019 Gizem Altay, Enara Larrañaga, Sébastien Tosi, Francisco M. Barriga, Eduard Batlle, Vanesa Fernández-Majada, Elena Martínez
Self-organized intestinal epithelial monolayers in crypt and villus-like domains show effective barrier function
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-46497-x
Scientific Reports 9/1 2020-01-28
2017 Verónica Hortigüela, Enara Larrañaga, Francesco Cutrale, Anna Seriola, María García-Díaz, Anna Lagunas, Jordi Andilla, Pablo Loza-Alvarez, Josep Samitier, Samuel Ojosnegros, Elena Martínez
Nanopatterns of Surface-Bound EphrinB1 Produce Multivalent Ligand–Receptor Interactions That Tune EphB2 Receptor Clustering
published pages: 629-637, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.7b04904
Nano Letters 18/1 2020-01-28
2017 Samuel Ojosnegros, Francesco Cutrale, Daniel Rodríguez, Jason J. Otterstrom, Chi Li Chiu, Verónica Hortigüela, Carolina Tarantino, Anna Seriola, Stephen Mieruszynski, Elena Martínez, Melike Lakadamyali, Angel Raya, Scott E. Fraser
Eph-ephrin signaling modulated by polymerization and condensation of receptors
published pages: 13188-13193, ISSN: 0027-8424, DOI: 10.1073/pnas.1713564114
Proceedings of the National Academy of Sciences 114/50 2020-01-28
2019 Verónica Hortigüela, Enara Larrañaga, Anna Lagunas, Gerardo A. Acosta, Fernando Albericio, Jordi Andilla, Pablo Loza-Alvarez, Elena Martínez
Large-Area Biomolecule Nanopatterns on Diblock Copolymer Surfaces for Cell Adhesion Studies
published pages: 579, ISSN: 2079-4991, DOI: 10.3390/nano9040579
Nanomaterials 9/4 2020-01-28
2018 Núria Torras, María García-Díaz, Vanesa Fernández-Majada, Elena Martínez
Mimicking Epithelial Tissues in Three-Dimensional Cell Culture Models
published pages: 1-7, ISSN: 2296-4185, DOI: 10.3389/fbioe.2018.00197
Frontiers in Bioengineering and Biotechnology 6 2020-01-28
2019 Francesco Cutrale, Daniel Rodriguez, Verónica Hortigüela, Chi-Li Chiu, Jason Otterstrom, Stephen Mieruszynski, Anna Seriola, Enara Larrañaga, Angel Raya, Melike Lakadamyali, Scott E. Fraser, Elena Martinez, Samuel Ojosnegros
Using enhanced number and brightness to measure protein oligomerization dynamics in live cells
published pages: 616-638, ISSN: 1754-2189, DOI: 10.1038/s41596-018-0111-9
Nature Protocols 14/2 2020-01-28
2019 Albert G Castaño, María García-Díaz, Núria Torras, Gizem Altay, Jordi Comelles, Elena Martínez
Dynamic photopolymerization produces complex microstructures on hydrogels in a moldless approach to generate a 3D intestinal tissue model
published pages: 25007, ISSN: 1758-5090, DOI: 10.1088/1758-5090/ab0478
Biofabrication 11/2 2020-01-28

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