Explore the words cloud of the COMIET project. It provides you a very rough idea of what is the project "COMIET" about.
The following table provides information about the project.
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
|Coordinator Country||Spain [ES]|
|Total cost||1˙997˙190 €|
|EC max contribution||1˙997˙190 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-12-01 to 2020-11-30|
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|1||FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA||ES (BARCELONA)||coordinator||1˙997˙190.00|
Epithelial barriers protect the body against physical, chemical, and microbial insults. Intestinal epithelium is one of the most actively renewing tissues in the body and a major site of carcinogenesis. Functional in vitro models of intestinal epithelium have been pursued for a long time. They are key elements in basic research, disease modelling, drug discovery, and tissue replacing and have become prime models for adult stem cell research. By taking advantage of the self-organizing properties of intestinal stem cells, intestinal organoids have been recently established, showing cell renewal’s kinetics resembling to the one found in vivo. However, the development of in vitro 3D tissue equivalents accounting for the dimensions, architecture and access to the luminal contents of the in vivo human intestinal tissue together with its self-renewal properties and cell complexity, remains a challenge. The goal of this project is to engineer intestinal epithelial tissue models that mimic physiological characteristics found in in vivo human intestinal tissue, to open up new areas of research on human intestinal diseases. The proposed models will address the in vivo intestinal epithelial cell renewal and migration, the multicell-type differentiation and the epithelial cell interactions with the underlying basement membrane while providing access to the luminal content to go beyond the state-of-the-art organoid models. To do this, we propose to develop an experimental setup that combines microfabrication techniques, tissue engineering components and recent advances in intestinal stem cell research, exploiting stem cell self-organizing characteristics. We anticipate this setup to recapitulate the 3D morphology, the spatio-chemical gradients and the dynamic microenvironment of the living tissue. We expect the new device to prove useful in understanding cell physiology, adult stem cell behaviour, and organ development as well as in modelling human intestinal diseases.
|year||authors and title||journal||last update|
Gizem Altay, Enara LarraÃ±aga, SÃ©bastien Tosi, Francisco M. Barriga, Eduard Batlle, Vanesa FernÃ¡ndez-Majada, Elena MartÃnez
Self-organized intestinal epithelial monolayers in crypt and villus-like domains show effective barrier function
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-46497-x
|Scientific Reports 9/1||2020-01-28|
VerÃ³nica HortigÃ¼ela, Enara LarraÃ±aga, Francesco Cutrale, Anna Seriola, MarÃa GarcÃa-DÃaz, Anna Lagunas, Jordi Andilla, Pablo Loza-Alvarez, Josep Samitier, Samuel Ojosnegros, Elena MartÃnez
Nanopatterns of Surface-Bound EphrinB1 Produce Multivalent Ligandâ€“Receptor Interactions That Tune EphB2 Receptor Clustering
published pages: 629-637, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.7b04904
|Nano Letters 18/1||2020-01-28|
Samuel Ojosnegros, Francesco Cutrale, Daniel RodrÃguez, Jason J. Otterstrom, Chi Li Chiu, VerÃ³nica HortigÃ¼ela, Carolina Tarantino, Anna Seriola, Stephen Mieruszynski, Elena MartÃnez, Melike Lakadamyali, Angel Raya, Scott E. Fraser
Eph-ephrin signaling modulated by polymerization and condensation of receptors
published pages: 13188-13193, ISSN: 0027-8424, DOI: 10.1073/pnas.1713564114
|Proceedings of the National Academy of Sciences 114/50||2020-01-28|
VerÃ³nica HortigÃ¼ela, Enara LarraÃ±aga, Anna Lagunas, Gerardo A. Acosta, Fernando Albericio, Jordi Andilla, Pablo Loza-Alvarez, Elena MartÃnez
Large-Area Biomolecule Nanopatterns on Diblock Copolymer Surfaces for Cell Adhesion Studies
published pages: 579, ISSN: 2079-4991, DOI: 10.3390/nano9040579
NÃºria Torras, MarÃa GarcÃa-DÃaz, Vanesa FernÃ¡ndez-Majada, Elena MartÃnez
Mimicking Epithelial Tissues in Three-Dimensional Cell Culture Models
published pages: 1-7, ISSN: 2296-4185, DOI: 10.3389/fbioe.2018.00197
|Frontiers in Bioengineering and Biotechnology 6||2020-01-28|
Francesco Cutrale, Daniel Rodriguez, VerÃ³nica HortigÃ¼ela, Chi-Li Chiu, Jason Otterstrom, Stephen Mieruszynski, Anna Seriola, Enara LarraÃ±aga, Angel Raya, Melike Lakadamyali, Scott E. Fraser, Elena Martinez, Samuel Ojosnegros
Using enhanced number and brightness to measure protein oligomerization dynamics in live cells
published pages: 616-638, ISSN: 1754-2189, DOI: 10.1038/s41596-018-0111-9
|Nature Protocols 14/2||2020-01-28|
Albert G CastaÃ±o, MarÃa GarcÃa-DÃaz, NÃºria Torras, Gizem Altay, Jordi Comelles, Elena MartÃnez
Dynamic photopolymerization produces complex microstructures on hydrogels in a moldless approach to generate a 3D intestinal tissue model
published pages: 25007, ISSN: 1758-5090, DOI: 10.1088/1758-5090/ab0478
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