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PurinesDX SIGNED

Interdisciplinary training network on the purinergic P2X7 receptor to control neuroinflammation and hyperexcitability in brain diseases.

Total Cost €

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EC-Contrib. €

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Partnership

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 PurinesDX project word cloud

Explore the words cloud of the PurinesDX project. It provides you a very rough idea of what is the project "PurinesDX" about.

cohort    date    translational    progression    neuroscience    signalling    specializing    functioning    cancer    entrepreneurial    comorbidities    mechanistic    179    selective    pharmacological    international    nurturing    synergism    disorders    offers    hyperexcitible    people    interdisciplinary    link    ameliorate    despite    competitive    facilitated    pool    cardiovascular    neuronal    skilled    etiology    original    brings    brain    reverse    diverse    scientists    biomarker    burden    demonstrated    billion    training    innovative    economic    patho    function    purinesdx    purinergic    suggests    industrial    appear    neuroinflammation    shared    newly    intervention    alongside    million    leaders    hyperexcitability    near    models    urgently    gatekeeper    atp    alone    800    span    generation    perfect    tools    genetic    activation    combined    era    p2x7    drive    drug    families    breakthroughs    glial    symptoms    time    broad    extend    ionotropic    environment    p2x7r    intersectoral    taxpayer    vast    overlap    specialists    creative    stable    diseases    diagnostic    receptor    clinical    annual    ubiquitous    mechanisms    global    gated    investment    sharing    disease    provision    antagonists   

Project "PurinesDX" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website http://www.purinesdx.eu
 Total cost 3˙487˙463 €
 EC max contribution 3˙487˙463 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2017
 Funding Scheme MSCA-ITN-ETN
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 531˙349.00
2    SARISSA BIOMEDICAL LIMITED UK (BEDFORD) participant 546˙575.00
3    FUNDACION TEOFILO HERNANDO ES (MADRID) participant 495˙745.00
4    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) participant 495˙745.00
5    INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES HU (Budapest) participant 447˙827.00
6    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 249˙216.00
7    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 249˙216.00
8    CENTRO DE INVESTIGACION BIOMEDICA EN RED ENFERMEDADES NEURODEGENERATIVAS ES (SEVILLA) participant 247˙872.00
9    BIOTALENTUM TUDASFEJLESZTO KFT HU (GOEDOELLO) participant 223˙913.00
10    Affectis Phamaceuticals AG DE (Dortmund) partner 0.00
11    Dr. Seibt Genomics GmbH DE (Bonn) partner 0.00
12    Epilepsiezentrum Frankfurt Rhein-Main DE (Frankfurt Rhein-Main) partner 0.00
13    FUNDACION CENTRO DE INVESTIGACION DE ENFERMEDADES NEUROLOGICAS ES (MADRID) partner 0.00
14    FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO RAMON Y CAJAL ES (MADRID) partner 0.00
15    JANSSEN PHARMACEUTICA NV BE (BEERSE) partner 0.00
16    Longboat Clinical Ltd IE (Dublin) partner 0.00
17    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) partner 0.00
18    SEMMELWEIS EGYETEM HU (BUDAPEST) partner 0.00
19    SZENT ISTVAN UNIVERSITY HU (GODOLLO) partner 0.00
20    THE UNIVERSITY OF WARWICK UK (COVENTRY) partner 0.00
21    UNIVERSIDAD AUTONOMA DE MADRID ES (MADRID) partner 0.00

Map

 Project objective

Brain disorders affect ~179 million people and their families in Europe alone, with an annual cost to the taxpayer estimated at €800 billion- a greater economic burden than cardiovascular disease and cancer combined. Despite diverse etiology, overlap in clinical symptoms and comorbidities between brain disorders suggests shared patho-mechanisms. In particular, hyperexcitible states driven by glial activation and neuroinflammation appear near ubiquitous. Targeting these mechanisms offers the potential to ameliorate symptoms and reverse disease progression across a broad span of brain disorders. Functioning as a gatekeeper to neuroinflammation and mechanistic link between neuronal hyperexcitability and glial activation, the ATP-gated, ionotropic purinergic P2X7 receptor (P2X7R) offers the most promising target for pharmacological intervention in the neuroinflammation-hyperexcitability pathway, to date. With breakthroughs in understanding P2X7R function, highly promising effects demonstrated for antagonists in models of brain disease and vast investment in P2X7R-related drug development programmes, now is the perfect time to pool resources. PurinesDX brings together global leaders in translational research in purinergic signalling, Europe’s leading clinical specialists in a broad range of brain diseases, and industrial partners specializing in drug and biomarker development. Sharing unique genetic tools, newly developed diagnostic devices and novel, selective and brain-stable P2X7R antagonists, the synergism facilitated within PurinesDX will extend to the training of an urgently needed new generation of highly skilled, innovative, creative and entrepreneurial scientists. Alongside the provision of this interdisciplinary, international and intersectoral environment, an original and high level training in state-of-the-art neuroscience will be provided, nurturing a cohort of highly competitive researchers with potential to drive a new era of neuroscience research.

 Deliverables

List of deliverables.
Network-wide training events M18 Documents, reports 2020-02-12 17:31:28
Network-wide training events M24 Documents, reports 2020-02-12 17:31:30
Risk protocol M18 Documents, reports 2020-02-12 17:31:31
Dissemination diary and report of dissemination events M24 Other 2020-02-12 17:31:32
Report on communication and public engagement activities M24 Documents, reports 2020-02-12 17:31:29
Report on gender equality in PurinesDX M24 Documents, reports 2020-02-12 17:31:31
Launch of website, Twitter, Facebook, LinkedIn, GooglePlus Documents, reports 2019-07-08 11:33:29
Network-wide training events M12 Documents, reports 2019-07-08 11:33:28
Dissemination diary and report of dissemination events M12 Other 2019-07-08 11:33:28
Report on communication and public engagement activities M12 Documents, reports 2019-07-08 11:33:28
Recruitment completion and ESR contracts Other 2019-07-08 11:33:28
Report on communication and public engagement activities M6 Documents, reports 2019-07-08 11:33:28
Network-wide training events M8 Documents, reports 2019-07-08 11:33:28
Supervisory Board of the network Other 2019-07-08 11:33:29
Report on gender equality in PurinesDX M12 Documents, reports 2019-07-08 11:33:29

Take a look to the deliverables list in detail:  detailed list of PurinesDX deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Gabriele Stephan, Lumei Huang, Yong Tang, Sandra Vilotti, Elsa Fabbretti, Ye Yu, Wolfgang Nörenberg, Heike Franke, Flóra Gölöncsér, Beáta Sperlágh, Anke Dopychai, Ralf Hausmann, Günther Schmalzing, Patrizia Rubini, Peter Illes
The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03728-5
Nature Communications 9/1 2019-11-07
2018 Edward H. Beamer, Jeronimo Jurado-Arjona, Eva M. Jimenez-Mateos, James Morgan, Cristina R. Reschke, Aidan Kenny, Gioacchino de Leo, Luis A. Olivos-Oré, Marina Arribas-Blázquez, Stephen F. Madden, Jesús Merchán-Rubira, Norman Delanty, Michael A. Farrell, Donncha F. O’Brien, Jesus Avila, Miguel Diaz-Hernandez, M. Teresa Miras-Portugal, Antonio R. Artalejo, Felix Hernandez, David C. Henshall, T
MicroRNA-22 Controls Aberrant Neurogenesis and Changes in Neuronal Morphology After Status Epilepticus
published pages: , ISSN: 1662-5099, DOI: 10.3389/fnmol.2018.00442
Frontiers in Molecular Neuroscience 11 2019-11-07
2019 Carlos Martínez-Frailes, Caterina Di Lauro, Carolina Bianchi, Laura de Diego-García, Álvaro Sebastián-Serrano, Lisardo Boscá, Miguel Díaz-Hernández
Amyloid Peptide Induced Neuroinflammation Increases the P2X7 Receptor Expression in Microglial Cells, Impacting on Its Functionality
published pages: , ISSN: 1662-5102, DOI: 10.3389/fncel.2019.00143
Frontiers in Cellular Neuroscience 13 2019-08-05
2018 Tobias Engel, Raquel Gómez-Sintes, Mariana Alves, Eva M. Jimenez-Mateos, Marta Fernández-Nogales, Amaya Sanz-Rodriguez, James Morgan, Edward Beamer, Alberto Rodríguez-Matellán, Mark Dunleavy, Takanori Sano, Jesus Avila, Miguel Medina, Felix Hernandez, José J. Lucas, David C. Henshall
Bi-directional genetic modulation of GSK-3β exacerbates hippocampal neuropathology in experimental status epilepticus
published pages: , ISSN: 2041-4889, DOI: 10.1038/s41419-018-0963-5
Cell Death & Disease 9/10 2019-07-08

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