Explore the words cloud of the PurinesDX project. It provides you a very rough idea of what is the project "PurinesDX" about.
The following table provides information about the project.
ROYAL COLLEGE OF SURGEONS IN IRELAND
|Coordinator Country||Ireland [IE]|
|Total cost||3˙487˙463 €|
|EC max contribution||3˙487˙463 € (100%)|
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
|Duration (year-month-day)||from 2017-09-01 to 2021-08-31|
Take a look of project's partnership.
|1||ROYAL COLLEGE OF SURGEONS IN IRELAND||IE (DUBLIN)||coordinator||531˙349.00|
|2||SARISSA BIOMEDICAL LIMITED||UK (BEDFORD)||participant||546˙575.00|
|3||FUNDACION TEOFILO HERNANDO||ES (MADRID)||participant||495˙745.00|
|4||UNIVERSIDAD COMPLUTENSE DE MADRID||ES (MADRID)||participant||495˙745.00|
|5||INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES||HU (Budapest)||participant||447˙827.00|
|6||LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN||DE (MUENCHEN)||participant||249˙216.00|
|7||MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV||DE (MUENCHEN)||participant||249˙216.00|
|8||CENTRO DE INVESTIGACION BIOMEDICA EN RED ENFERMEDADES NEURODEGENERATIVAS||ES (SEVILLA)||participant||247˙872.00|
|9||BIOTALENTUM TUDASFEJLESZTO KFT||HU (GOEDOELLO)||participant||223˙913.00|
|10||Affectis Phamaceuticals AG||DE (Dortmund)||partner||0.00|
|11||Dr. Seibt Genomics GmbH||DE (Bonn)||partner||0.00|
|12||Epilepsiezentrum Frankfurt Rhein-Main||DE (Frankfurt Rhein-Main)||partner||0.00|
|13||FUNDACION CENTRO DE INVESTIGACION DE ENFERMEDADES NEUROLOGICAS||ES (MADRID)||partner||0.00|
|14||FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO RAMON Y CAJAL||ES (MADRID)||partner||0.00|
|15||JANSSEN PHARMACEUTICA NV||BE (BEERSE)||partner||0.00|
|16||Longboat Clinical Ltd||IE (Dublin)||partner||0.00|
|17||MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV||DE (Munich)||partner||0.00|
|18||SEMMELWEIS EGYETEM||HU (BUDAPEST)||partner||0.00|
|19||SZENT ISTVAN UNIVERSITY||HU (GODOLLO)||partner||0.00|
|20||THE UNIVERSITY OF WARWICK||UK (COVENTRY)||partner||0.00|
|21||UNIVERSIDAD AUTONOMA DE MADRID||ES (MADRID)||partner||0.00|
Brain disorders affect ~179 million people and their families in Europe alone, with an annual cost to the taxpayer estimated at €800 billion- a greater economic burden than cardiovascular disease and cancer combined. Despite diverse etiology, overlap in clinical symptoms and comorbidities between brain disorders suggests shared patho-mechanisms. In particular, hyperexcitible states driven by glial activation and neuroinflammation appear near ubiquitous. Targeting these mechanisms offers the potential to ameliorate symptoms and reverse disease progression across a broad span of brain disorders. Functioning as a gatekeeper to neuroinflammation and mechanistic link between neuronal hyperexcitability and glial activation, the ATP-gated, ionotropic purinergic P2X7 receptor (P2X7R) offers the most promising target for pharmacological intervention in the neuroinflammation-hyperexcitability pathway, to date. With breakthroughs in understanding P2X7R function, highly promising effects demonstrated for antagonists in models of brain disease and vast investment in P2X7R-related drug development programmes, now is the perfect time to pool resources. PurinesDX brings together global leaders in translational research in purinergic signalling, Europe’s leading clinical specialists in a broad range of brain diseases, and industrial partners specializing in drug and biomarker development. Sharing unique genetic tools, newly developed diagnostic devices and novel, selective and brain-stable P2X7R antagonists, the synergism facilitated within PurinesDX will extend to the training of an urgently needed new generation of highly skilled, innovative, creative and entrepreneurial scientists. Alongside the provision of this interdisciplinary, international and intersectoral environment, an original and high level training in state-of-the-art neuroscience will be provided, nurturing a cohort of highly competitive researchers with potential to drive a new era of neuroscience research.
|Network-wide training events M18||Documents, reports||2020-02-12 17:31:28|
|Network-wide training events M24||Documents, reports||2020-02-12 17:31:30|
|Risk protocol M18||Documents, reports||2020-02-12 17:31:31|
|Dissemination diary and report of dissemination events M24||Other||2020-02-12 17:31:32|
|Report on communication and public engagement activities M24||Documents, reports||2020-02-12 17:31:29|
|Report on gender equality in PurinesDX M24||Documents, reports||2020-02-12 17:31:31|
|Launch of website, Twitter, Facebook, LinkedIn, GooglePlus||Documents, reports||2019-07-08 11:33:29|
|Network-wide training events M12||Documents, reports||2019-07-08 11:33:28|
|Dissemination diary and report of dissemination events M12||Other||2019-07-08 11:33:28|
|Report on communication and public engagement activities M12||Documents, reports||2019-07-08 11:33:28|
|Recruitment completion and ESR contracts||Other||2019-07-08 11:33:28|
|Report on communication and public engagement activities M6||Documents, reports||2019-07-08 11:33:28|
|Network-wide training events M8||Documents, reports||2019-07-08 11:33:28|
|Supervisory Board of the network||Other||2019-07-08 11:33:29|
|Report on gender equality in PurinesDX M12||Documents, reports||2019-07-08 11:33:29|
Take a look to the deliverables list in detail: detailed list of PurinesDX deliverables.
|year||authors and title||journal||last update|
Gabriele Stephan, Lumei Huang, Yong Tang, Sandra Vilotti, Elsa Fabbretti, Ye Yu, Wolfgang NÃ¶renberg, Heike Franke, FlÃ³ra GÃ¶lÃ¶ncsÃ©r, BeÃ¡ta SperlÃ¡gh, Anke Dopychai, Ralf Hausmann, GÃ¼nther Schmalzing, Patrizia Rubini, Peter Illes
The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03728-5
|Nature Communications 9/1||2019-11-07|
Edward H. Beamer, Jeronimo Jurado-Arjona, Eva M. Jimenez-Mateos, James Morgan, Cristina R. Reschke, Aidan Kenny, Gioacchino de Leo, Luis A. Olivos-OrÃ©, Marina Arribas-BlÃ¡zquez, Stephen F. Madden, JesÃºs MerchÃ¡n-Rubira, Norman Delanty, Michael A. Farrell, Donncha F. Oâ€™Brien, Jesus Avila, Miguel Diaz-Hernandez, M. Teresa Miras-Portugal, Antonio R. Artalejo, Felix Hernandez, David C. Henshall, T
MicroRNA-22 Controls Aberrant Neurogenesis and Changes in Neuronal Morphology After Status Epilepticus
published pages: , ISSN: 1662-5099, DOI: 10.3389/fnmol.2018.00442
|Frontiers in Molecular Neuroscience 11||2019-11-07|
Carlos MartÃnez-Frailes, Caterina Di Lauro, Carolina Bianchi, Laura de Diego-GarcÃa, Ãlvaro SebastiÃ¡n-Serrano, Lisardo BoscÃ¡, Miguel DÃaz-HernÃ¡ndez
Amyloid Peptide Induced Neuroinflammation Increases the P2X7 Receptor Expression in Microglial Cells, Impacting on Its Functionality
published pages: , ISSN: 1662-5102, DOI: 10.3389/fncel.2019.00143
|Frontiers in Cellular Neuroscience 13||2019-08-05|
Tobias Engel, Raquel GÃ³mez-Sintes, Mariana Alves, Eva M. Jimenez-Mateos, Marta FernÃ¡ndez-Nogales, Amaya Sanz-Rodriguez, James Morgan, Edward Beamer, Alberto RodrÃguez-MatellÃ¡n, Mark Dunleavy, Takanori Sano, Jesus Avila, Miguel Medina, Felix Hernandez, JosÃ© J. Lucas, David C. Henshall
Bi-directional genetic modulation of GSK-3Î² exacerbates hippocampal neuropathology in experimental status epilepticus
published pages: , ISSN: 2041-4889, DOI: 10.1038/s41419-018-0963-5
|Cell Death & Disease 9/10||2019-07-08|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PURINESDX" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "PURINESDX" are provided by the European Opendata Portal: CORDIS opendata.
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