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THYRAGE SIGNED

Resetting the THYRoid axis for prevention of AGE-related diseases and co-morbidities

Total Cost €

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EC-Contrib. €

0

Partnership

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 THYRAGE project word cloud

Explore the words cloud of the THYRAGE project. It provides you a very rough idea of what is the project "THYRAGE" about.

basic    modulators    muscle    healthy    biomarkers    expertise    exposed    prolonged    nervous    gerontologists    controls    half    mass    co    treatment    longevity    manipulate    reference    cognitive    dysregulation    inappropriate    temporal    humans    underpins    reproductive    mechanism    optimized    cutting    diseases    validate    exceptional    homeostasis    fitness    bone    last    tissue    evolution    suboptimal    risk    continuous    decline    cells    upper    skeletal    disciplinary    systemic    whilst    consistent    scientists    period    clinical    underlying    regulation    industry    neurodegeneration    ageing    morbidities    sarcopenia    dependent    osteoarthritis    susceptibility    population    repair    cartilage    chronic    prevention    tissues    disease    cell    integrates    fracture    disorders    cross    thyrage    peptide    thyroid    central    hormone    neuroscientists    age    action    decade    endocrinologists    edge    status    local    hypothesize    osteoporosis    strategies    paradigm    stimulating    degenerative   

Project "THYRAGE" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH ZIEKENHUIS LEIDEN 

Organization address
address: ALBINUSDREEF 2
city: LEIDEN
postcode: 2333 ZA
website: www.lumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.thyrage.eu
 Total cost 6˙000˙001 €
 EC max contribution 6˙000˙000 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) coordinator 1˙680˙410.00
2    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 1˙410˙151.00
3    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 799˙083.00
4    UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II IT (NAPOLI) participant 758˙500.00
5    INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES HU (Budapest) participant 749˙980.00
6    PEPSCAN THERAPEUTICS BV NL (LELYSTAD) participant 601˙875.00

Map

 Project objective

We hypothesize that inappropriate thyroid hormone action in target cells is a common mechanism underlying susceptibility to age-related degenerative diseases and co-morbidities. Although regulation of systemic thyroid status is well understood and underpins treatment of common thyroid disease, it is only in the last decade that the importance of local regulation of thyroid hormone action in tissue development, homeostasis and repair has been identified. During evolution, this complex temporal and cell-specific regulation has been optimized for development and reproductive fitness but NOT for ageing. Humans with their exceptional longevity are thus exposed to a prolonged period of suboptimal local thyroid hormone action. Consistent with this, thyroid status is a continuous variable within the population that is related to fracture risk, muscle mass and cognitive decline. Moreover, in healthy longevity thyroid status is characterized by thyroid stimulating hormone in the upper half of the reference range. In these studies, we will determine how local regulation of thyroid hormone action controls tissue homeostasis and repair, whilst its dysregulation is a common mechanism underlying chronic disease development during ageing. We focus on osteoporosis, osteoarthritis, neurodegeneration and sarcopenia as paradigm age-related, degenerative disorders. Using cutting-edge technology, we will (i) identify thyroid hormone dependent biomarkers for disease susceptibility in bone, cartilage, central nervous system and skeletal muscle, (ii) manipulate cell-specific thyroid hormone action in these tissues and (iii) develop cell-type specific modulators of thyroid hormone action. THYRAGE integrates cross-disciplinary expertise from clinical and basic scientists, endocrinologists, neuroscientists, gerontologists, and industry-based peptide scientists. These studies will identify and validate novel strategies for prevention and treatment of chronic age-related degenerative disease.

 Deliverables

List of deliverables.
Final plan for dissemination and exploitation of the project’s results Documents, reports 2019-05-30 19:01:01
Establishment of the THYRAGE consortium website Websites, patent fillings, videos etc. 2019-05-30 19:01:05
Establishment of external THYRAGE web site Websites, patent fillings, videos etc. 2019-05-30 19:01:03

Take a look to the deliverables list in detail:  detailed list of THYRAGE deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Evie van der Spoel, Jungyeon Choi, Ferdinand Roelfsema, Saskia le Cessie, Diana van Heemst, Olaf M. Dekkers
Comparing Methods for Measurement Error Detection in Serial 24-h Hormonal Data
published pages: 347-363, ISSN: 0748-7304, DOI: 10.1177/0748730419850917
Journal of Biological Rhythms 34/4 2020-02-13
2019 Evie van der Spoel, Nicolien A. van Vliet, Diana van Heemst
Viewpoint on the role of tissue maintenance in ageing: focus on biomarkers of bone, cartilage, muscle, and brain tissue maintenance
published pages: 100964, ISSN: 1568-1637, DOI: 10.1016/j.arr.2019.100964
Ageing Research Reviews 56 2020-02-13
2019 Jean‐David Gothié, Pieter Vancamp, Barbara Demeneix, Sylvie Remaud
Thyroid hormone regulation of neural stem cell fate: From development to ageing
published pages: , ISSN: 1748-1708, DOI: 10.1111/apha.13316
Acta Physiologica 228/1 2020-02-13
2019 Serena Sagliocchi, Annunziata Gaetana Cicatiello, Emery Di Cicco, Raffaele Ambrosio, Caterina Miro, Daniela Di Girolamo, Annarita Nappi, Giuseppina Mancino, Maria Angela De Stefano, Cristina Luongo, Maddalena Raia, Ashley N. Ogawa-Wong, Ann Marie Zavacki, Simona Paladino, Domenico Salvatore, Monica Dentice
The thyroid hormone activating enzyme, type 2 deiodinase, induces myogenic differentiation by regulating mitochondrial metabolism and reducing oxidative stress
published pages: 101228, ISSN: 2213-2317, DOI: 10.1016/j.redox.2019.101228
Redox Biology 24 2020-02-13
2019 Caterina Miro, Emery Di Cicco, Raffaele Ambrosio, Giuseppina Mancino, Daniela Di Girolamo, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Annarita Nappi, Maria Angela De Stefano, Cristina Luongo, Dario Antonini, Feliciano Visconte, Silvia Varricchio, Gennaro Ilardi, Luigi Del Vecchio, Stefania Staibano, Anita Boelen, Cedric Blanpain, Caterina Missero, Domenico Salvatore, Monica Dentice
Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-13140-2
Nature Communications 10/1 2020-02-13
2019 Pieter Vancamp, Jean-David Gothié, Cristina Luongo, Anthony Sébillot, Karine Le Blay, Lucile Butruille, Maurice Pagnin, Samantha J. Richardson, Barbara A. Demeneix, Sylvie Remaud
Gender-specific effects of transthyretin on neural stem cell fate in the subventricular zone of the adult mouse
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-56156-w
Scientific Reports 9/1 2020-02-13
2019 Victoria D. Leitch, Mary Jane Brassill, Sofia Rahman, Natalie C. Butterfield, Pattara Ma, John G. Logan, Alan Boyde, Holly Evans, Peter I. Croucher, Rachel L. Batterham, Graham R. Williams, J.H. Duncan Bassett
PYY is a negative regulator of bone mass and strength
published pages: 427-435, ISSN: 8756-3282, DOI: 10.1016/j.bone.2019.07.011
Bone 127 2020-02-13
2017 Remaud , Sylvie; Ortiz , Fernando ,; Perret-Jeanneret , Marine; Aigrot , Marie-Stéphane; Gothié , Jean-David; Fekete , Csaba; Kvárta-Papp , Zsuzsanna; Gereben , Balázs; Langui , Dominique; Lubetzki , Catherine; Angulo , Maria ,; Zalc , Bernard; Demeneix , Barbara
Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.29996.001
\"eLife, eLife Sciences Publication, 2017, 6, pp.e29996. 〈10.7554/eLife.29996.001〉\" 1 2019-03-18
2018 G. R. Williams, J. H. D. Bassett
Thyroid diseases and bone health
published pages: 99-109, ISSN: 1720-8386, DOI: 10.1007/s40618-017-0753-4
Journal of Endocrinological Investigation 41/1 2019-03-18
2017 Nicolien A. van Vliet, Evie van der Spoel, Marian Beekman, P. Eline Slagboom, Gerard Jan Blauw, Jacobijn Gussekloo, Rudi G.J. Westendorp, Diana van Heemst
Thyroid status and mortality in nonagenarians from long-lived families and the general population
published pages: 2223-2234, ISSN: 1945-4589, DOI: 10.18632/aging.101310
Aging 9/10 2019-03-18
2017 J.D. Gothié, A. Sébillot, C. Luongo, M. Legendre, C. Nguyen Van, K. Le Blay, M. Perret-Jeanneret, S. Remaud, B.A. Demeneix
Adult neural stem cell fate is determined by thyroid hormone activation of mitochondrial metabolism
published pages: 1551-1561, ISSN: 2212-8778, DOI: 10.1016/j.molmet.2017.08.003
Molecular Metabolism 6/11 2019-03-18
2019 Evie van der Spoel, Nicole Oei, Ricardo Cachucho, Ferdinand Roelfsema, Jimmy F.P. Berbée, Gerard J. Blauw, Hanno Pijl, Natasha M. Appelman-Dijkstra, Diana van Heemst
The 24-hour serum profiles of bone markers in healthy older men and women
published pages: 61-69, ISSN: 8756-3282, DOI: 10.1016/j.bone.2018.10.002
Bone 120 2019-03-18
2018 Nicolien A van Vliet, Raymond Noordam, Jan B van Klinken, Rudi GJ Westendorp, JH Duncan Bassett, Graham R Williams, Diana van Heemst
Thyroid Stimulating Hormone and Bone Mineral Density: Evidence From a Two-Sample Mendelian Randomization Study and a Candidate Gene Association Study
published pages: 1318-1325, ISSN: 0884-0431, DOI: 10.1002/jbmr.3426
Journal of Bone and Mineral Research 33/7 2019-03-18

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