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AUTOSTEM SIGNED

Development of closed, scalable and AUTOmated robotic systems for therapeutic STEM cell manufacturing: aseptic systems from “Donor-to-Patient”

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

AUTOSTEM project word cloud

Explore the words cloud of the AUTOSTEM project. It provides you a very rough idea of what is the project "AUTOSTEM" about.

therapeutic partnership routine clinical ready scaleable vision cell consistent compliance autologous bioreactors automated industry marrow differentiation economic disciplines harvest academic goods healthcare tests utilise regulatory centres expertise xeno monitoring allogeneic containing scaled industrial media dose involve cells flow maximise tissues manufacture gmp therapies goals closed free contamination factory sensing cryobag reduce minimise ultimately microscopy aseptic patient donor formulations cytometry manufacturing remote karyotyping autostem specified fat therapy final hospital tissue biological retrieval thawing

Project "AUTOSTEM" data sheet

The following table provides information about the project.

Coordinator	NATIONAL UNIVERSITY OF IRELAND GALWAY Organization address address: UNIVERSITY ROAD city: Galway postcode: H91 website: www.nuigalway.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Project website	http://www.autostem2020.eu
Total cost	5˙995˙761 €
EC max contribution	5˙995˙761 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2015-two-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2018-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	NATIONAL UNIVERSITY OF IRELAND GALWAY NATIONAL UNIVERSITY OF IRELAND GALWAY Organization address address: UNIVERSITY ROAD city: Galway postcode: H91 website: www.nuigalway.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Galway)	coordinator	849˙375.00
2	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Organization address address: HANSASTRASSE 27C city: MUNCHEN postcode: 80686 website: www.fraunhofer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	participant	1˙207˙041.00
3	UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK Organization address address: WESTERN ROAD city: Cork postcode: T12 YN60 website: www.ucc.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Cork)	participant	757˙353.00
4	CROSPON LIMITED CROSPON LIMITED Organization address address: GALWAY BUSINESS PARK DANGAN city: GALWAY postcode: H91 website: www.crospon.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (GALWAY)	participant	685˙000.00
5	ASTON UNIVERSITY ASTON UNIVERSITY Organization address address: ASTON TRIANGLE city: BIRMINGHAM postcode: B4 7ET website: www.aston.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BIRMINGHAM)	participant	549˙913.00
6	ZELLWERK GMBH ZELLWERK GMBH Organization address address: ZIEGELEISTRASSE 7 city: OBERKRAMER postcode: 16727 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (OBERKRAMER)	participant	498˙750.00
7	UNIVERSITA DEGLI STUDI DI GENOVA UNIVERSITA DEGLI STUDI DI GENOVA Organization address address: VIA BALBI 5 city: GENOVA postcode: 16126 website: www.unige.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (GENOVA)	participant	450˙000.00
8	ORBSEN THERAPEUTICS LIMITED ORBSEN THERAPEUTICS LIMITED Organization address address: UNIT 1 GALWAY BUSINESS PARK city: Galway postcode: H91 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Galway)	participant	448˙375.00
9	CELL THERAPY CATAPULT LIMITED CELL THERAPY CATAPULT LIMITED Organization address address: 12TH FLOOR TOWER WING GUY'S HOSPITAL GREAT MAZE POND city: LONDON postcode: SE1 9RT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	299˙952.00
10	PINTAIL LTD PINTAIL LTD Organization address address: SPRINGHILL AVENUE 77 city: Blackrock postcode: A94 K542 website: www.pintail.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Blackrock)	participant	250˙000.00

Map

Project objective

AUTOSTEM will develop closed, scaleable and automated systems for therapeutic cell manufacture. The project vision is a donor-to-patient system where all aspects of processing, from tissue harvest to patient delivery are fully closed and aseptic. The process will involve new methods of biological cell selection from marrow, fat or other tissues, bioreactors to achieve scale and media formulations that are fully xeno-free. Process monitoring will utilise remote sensing and the automated retrieval of cells for microscopy, flow cytometry, karyotyping, differentiation or other tests. The final product will be a cryobag containing a specified cell dose, ready for thawing and clinical delivery.

AUTOSTEM will be the factory of the future for therapeutic cell manufacturing. This system could ultimately be scaled for hospital-based use to produce autologous cells or at industrial scale for allogeneic therapy. It will achieve consistent cell production, minimise contamination, maximise scale and reduce cost of goods, thus enabling routine clinical use of cell therapies.

The consortium will be a partnership of academic centres and industry with expertise across the disciplines relevant to the research and development goals. It will also include expertise in GMP and regulatory compliance and in healthcare economic analysis.

Publications

List of publications.
year	authors and title	journal	last update
2016	Richard P Harrison, Qasim A Rafiq, Nicholas Medcalf Automating decentralized manufacturing of cell & gene therapy products published pages: 489-497, ISSN: 2059-7800, DOI: 10.18609/cgti.2016.059	Cell and Gene Therapy Insights 2/4	2020-01-30
2016	Richard P Harrison, Qasim A Rafiq & Nicholas Medcalf Cell and gene therapy manufacturing: the necessity for a cost-based development approach published pages: 489-497, ISSN: 2059-7800, DOI: 10.18609/cgti.2016.014	Cell and Gene Therapy Insights 2/1	2020-01-30

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The information about "AUTOSTEM" are provided by the European Opendata Portal: CORDIS opendata.

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