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FORMILK SIGNED

Innovative technology for the detection of enzyme activity in milk

Total Cost €

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EC-Contrib. €

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Partnership

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Project "FORMILK" data sheet

The following table provides information about the project.

Coordinator
UNIVERZITA KOMENSKEHO V BRATISLAVE 

Organization address
address: SAFARIKOVO NAM 6
city: BRATISLAVA
postcode: 814 99
website: http://www.uniba.sk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Slovakia [SK]
 Project website http://www.formilk.fmph.uniba.sk
 Total cost 1˙323˙000 €
 EC max contribution 1˙228˙500 € (93%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2015
 Funding Scheme MSCA-RISE
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERZITA KOMENSKEHO V BRATISLAVE SK (BRATISLAVA) coordinator 409˙500.00
2    TERMESZETTUDOMANYI KUTATOKOZPONT HU (BUDAPEST) participant 301˙500.00
3    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) participant 193˙500.00
4    POWERTEC SRO SK (BRATISLAVA) participant 180˙000.00
5    MAGYAR TEJGAZDASAGI KISERLETI INTEZET KORLATOLT FELELOSSEGU TARSASAG HU (MOSONMAGYAROVAR) participant 121˙500.00
6    SONAS TECHNOLOGIES LIMITED IE (DUBLIN) participant 13˙500.00
7    CROSSCARE LIMITED IE (DUBLIN) participant 9˙000.00
8    THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO CA (TORONTO) partner 0.00
9    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US (OAKLAND CA) partner 0.00
10    UT BATTELLE LLC US (OAK RIDGE TENNESSEE) partner 0.00

Map

 Project objective

The proposal is focused on the development of novel methods of detection of activity of enzymes, such as plasmin and lactase, important for milk industry and for lactose-free diet. Six experienced academic/research institutions, two SMEs, one governmental business company and one manufacturing company from 3 EU member states (Slovakia, Hungary, Ireland), USA and Canada will be involved in the research, development and validation. The main focus will be on application of high-resolution ultrasonic spectroscopy, surface acoustic and electrochemical methods involving nanofabricated surfaces for detection of enzyme activity in volume and at the surfaces. The output of the project will be the novel analytical assays and electrochemical sensor applicable in dairy farms and analytical laboratories, staff exchange between academic institutions and SME, training of the students in novel analytical methods and sensor developments in a world leading laboratories. The optimised enzyme based technologies for efficient control of levels of lactose in milk and milk based drinks will be one of important results of project, which could be commercialised by the project industrial participants. The organisation of training schools, workshops and transfer of novel technology will be among priorities of this proposal.

 Deliverables

List of deliverables.
Miniature potentiostat, software and sensor Demonstrators, pilots, prototypes 2020-04-14 21:34:09
Protocol of enzyme assay in a volume Documents, reports 2020-04-14 21:34:10
Report on secondments Documents, reports 2020-04-14 21:34:10
Open Research Data Pilot Open Research Data Pilot 2020-04-14 21:34:10
Peer reviewed articles Documents, reports 2020-04-14 21:34:10
Protocol of enzyme assay at surfaces Documents, reports 2020-04-14 21:34:09
Second progress report Documents, reports 2020-04-14 21:34:09
Data Management Plan Documents, reports 2020-04-14 21:34:07
First progress report Documents, reports 2020-04-14 21:34:09
Website Websites, patent fillings, videos etc. 2020-04-14 21:34:09
Workshops and summer schools Demonstrators, pilots, prototypes 2020-04-14 21:34:09
Mid-term meeting Other 2020-04-14 21:34:07

Take a look to the deliverables list in detail:  detailed list of FORMILK deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 T. Szabo, B. Csupor, P. Pekker, Z. Keresztes
Tunable size gold nanoparticle-enzyme substrate conjugates: posible sensor applications
published pages: 176, ISSN: , DOI:
Book of Abstracts, Matrafured 2019, International Conference on Chemical Sensors, Visegrad, Hungary, 2019 June 16-21, 2019 2020-04-14
2019 Zuzana Garaiová, Gulcin Bolat, Berta Esteban-Fernández de Ávila, Hua Gong, Natalia Sanz del Olmo, Paula Ortega, Francisco Javier de la Mata, Sylwia Michlewska, Joseph Wang, Tibor Hianik
Combination of Ruthenium Dendrimers and Acoustically Propelled Gold Nanowires as a Platform for Active Intracellular Drug Delivery Towards Breast Cancer Therapy
published pages: 1-5, ISSN: 2613-4942, DOI: 10.31487/j.cor.2019.04.08
Clinical Oncology and Research 2020-04-14
2019 Veronika Stepanova, Vladimir Smolko, Vladimir Gorbatchuk, Ivan Stoikov, Gennady Evtugyn, Tibor Hianik
DNA-Polylactide Modified Biosensor for Electrochemical Determination of the DNA-Drugs and Aptamer-Aflatoxin M1 Interactions
published pages: 4962, ISSN: 1424-8220, DOI: 10.3390/s19224962
Sensors 19/22 2020-04-14
2019 Gennady Evtugyn, Tibor Hianik
Electrochemical Immuno- and Aptasensors for Mycotoxin Determination
published pages: 10, ISSN: 2227-9040, DOI: 10.3390/chemosensors7010010
Chemosensors 7/1 2020-04-14
2018 Stefanos Karapetis, Dimitrios Nikolelis, Tibor Hianik
Label-Free and Redox Markers-Based Electrochemical Aptasensors for Aflatoxin M1 Detection
published pages: 4218, ISSN: 1424-8220, DOI: 10.3390/s18124218
Sensors 18/12 2020-04-14
2018 Loránd Románszki, Marek Tatarko, Mengchi Jiao, Zsófia Keresztes, Tibor Hianik, Michael Thompson
Casein probe–based fast plasmin determination in the picomolar range by an ultra-high frequency acoustic wave biosensor
published pages: 206-214, ISSN: 0925-4005, DOI: 10.1016/j.snb.2018.08.025
Sensors and Actuators B: Chemical 275 2020-04-14
2018 Marek Tatarko, Eric S. Muckley, Veronika Subjakova, Monojoy Goswami, Bobby G. Sumpter, Tibor Hianik, Ilia N. Ivanov
Machine learning enabled acoustic detection of sub-nanomolar concentration of trypsin and plasmin in solution
published pages: 282-288, ISSN: 0925-4005, DOI: 10.1016/j.snb.2018.05.100
Sensors and Actuators B: Chemical 272 2020-04-14
2017 J. Byrne
Colief® lactase enzyme infant drops product origin and application development
published pages: 9, ISSN: , DOI:
\"International workshop \"\"Recent applications of high-resolution ultrasonic spectroscopy for monitoring of hydrolytic activities in milks\"\"\" November 2017 2020-04-14
2018 Vitaly Buckin
High-resolution ultrasonic spectroscopy
published pages: 207-217, ISSN: 2194-878X, DOI: 10.5194/jsss-7-207-2018
Journal of Sensors and Sensor Systems 7/1 2020-04-14
2017 J. Nagy, Z. S. Steinerné, A. Poturnayova, A. Hucker, K. Szabo, T. Hianik
Detection of microorganisms in food products by atomic force microscopy
published pages: 12, ISSN: , DOI:
\"International workshop \"\"Recent applications of high-resolution ultrasonic spectroscopy for monitoring of hydrolytic activities in milks\"\"\" November 2017 2020-04-14
2018 M. Dizon, M. Caras-Altas, V. Buckin
Application of high resolution ultrasonic spectroscopy (HR–US) on realtime monitoring of whey protein hydrolysis
published pages: , ISSN: , DOI:
Book of Abstracts, Third Year PhD Talks 2018, Dublin Chemistry Graduate Seminars 2017-18 29th May, 2018 2020-04-14
2017 V. Buckin , M. Altas
Ultrasonic Monitoring of Biocatalysis in Solutions and Complex Dispersions
published pages: 336, ISSN: 2073-4344, DOI: 10.3390/catal7110336
Catalysts 7/11 2020-04-14
2017 I. Piovarci, A. Poturnayova, J. Nagy, R. Sarok, T. Hianik
Development of acoustic sensor for detection chymotrypsin activity at surfaces
published pages: 218, ISSN: , DOI:
BioSensor 2017,1st European and 10th German BioSensor Symposium 2017 2020-04-14
2017 Marek Tatarko, Ilia N. Ivanov, Tibor Hianik
Stability monitoring of casein layer on hydrophilic SO2 surface using quartz crystal microbalance with dissipation
published pages: 178, ISSN: , DOI:
BioSensors 2017, 1st European and 10th German BioSensor Symposium, Potsdam, Germany 2017 2020-04-14
2018 Vladimir Smolko, Dmitry Shurpik, Anna Porfireva, Gennady Evtugyn, Ivan Stoikov, Tibor Hianik
Electrochemical Aptasensor Based on Poly(Neutral Red) and Carboxylated Pillar[5]arene for Sensitive Determination of Aflatoxin M1
published pages: 486-496, ISSN: 1040-0397, DOI: 10.1002/elan.201700735
Electroanalysis 30/3 2020-04-14
2016 Eric S. Muckley, Cristain Anazagasty, Christopher B. Jacobs, Tibor Hianik, Ilia N. Ivanov
Low-cost scalable quartz crystal microbalance array for environmental sensing
published pages: 99440Y, ISSN: , DOI: 10.1117/12.2237942
Organic Sensors and Bioelectronics IX 2020-04-14
2017 Tibor Hianik, Christer L. Øpstad, Jana Šandorová, Zuzana Garaiová, Vassilia Partali, Hans-Richard Sliwka
Surface properties of polyene glycol phospholipid monolayers
published pages: 13-20, ISSN: 0009-3084, DOI: 10.1016/j.chemphyslip.2016.11.007
Chemistry and Physics of Lipids 202 2020-04-14
2016 A. Poturnayova, M. Tatarko, I. Karpisova, G. Castillo, Z. Keresztes, T. Hianik
Detection of plasmin based on specific peptide substrate and casein using acousttic transducer
published pages: P3.161, ISSN: , DOI:
26 Aniversary World Congress on Biosensors, Gothenburg, Sweden 25-27 May 2016 2020-04-14
2017 M. Tatarko, I.N. Ivanov, T. Hianik
Stability monitoring of casein layer on hydrophilic SiO2 surface using quartz crystal microbalance with dissipation
published pages: 178, ISSN: , DOI:
BioSensor 2017. 1st European and 10th German BioSensor Symposium March 2017 2020-04-14
2017 S. Melikishvili, Mark Dizon, B. O’Driscoll3, V. Buckin, T. Hianik
Application of High-Resolution Ultrasonic Spectroscopy for real- time monitoring of trypsin activity in β - casein solution
published pages: 16, ISSN: , DOI:
\"International workshop \"\"Recent applications of high-resolution ultrasonic spectroscopy for monitoring of hydrolytic activities in milks\"\"\" November 2017 2020-04-14
2017 R. Sarok, A. Poturnayova, K. Szabo, A. Hucker, T. Hianik
Determination of aflatoxin M1 in milk and milk samples using ELISA
published pages: 10, ISSN: , DOI:
\"International workshop \"\"Recent applications of high-resolution ultrasonic spectroscopy for monitoring of hydrolytic activities in milks\" November 2017 2020-04-14

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