Opendata, web and dolomites

GLION

Investigating glial glycogen utilization for ion homeostasis in the brain and its relevance to epileptogenesis: electrophysiology and pharmacology in awake behaving mice

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 GLION project word cloud

Explore the words cloud of the GLION project. It provides you a very rough idea of what is the project "GLION" about.

experimental    expertise    time    behaving    first    magnetic    kinetic    neuronally    energy    metabolism    underlying    signaling    epilepsy    resonance    understand    impairment    astrocytes    dependent    techniques    glycogen    cultures    brain    awake    store    operations    epileptogenic    molecules    characterization    ideas    potassium    pathologies    basis    mechanisms    insights    dysfunction    career    aberrations    mammalian    complement    demonstrated    consumption    requirement    mice    efficiency    metabolic    subjects    pharmacological    fueled    interactions    extracellular    ion    compounds    excitability    experiments    neuronal    homeostasis    electrophysiological    cell    astrocytic    transmitter    primary    supports    stages    invasive    animals    released    human    influences    constraints    glycogenolysis    seizures    susceptibility    preliminary    sole    functional    glucose    substantial    tackle    cerebral    outcomes    cellular    critical    skills    space    cells    normal    controls    hypothesize   

Project "GLION" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://www.glion.eu/
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 212˙194.00

Map

 Project objective

We do not yet fully understand the cellular basis of brain energy metabolism. The high energy consumption of mammalian brain sets information processing under critical metabolic constraints. Energy efficiency in brain signaling is supported by functional and metabolic interactions between neuronal and astrocytic cells. Specifically, during neuronal activity astrocytes rapidly take up neuronally-released compounds from the extracellular space, including potassium (K) and transmitter molecules. These operations affect brain excitability and their dysfunction can increase susceptibility to seizures and eventually lead to epilepsy. Importantly, ion homeostasis in astrocytes is fueled by astrocytic glycogen, the sole cerebral energy store. The primary aim of the present project is to investigate how metabolism of glycogen in astrocytes supports and influences the different stages of neuronal activity under normal and epileptogenic conditions. I hypothesize that K-induced glycogenolysis in astrocytes controls neuronal excitability (functional role) as well as neuronal glucose uptake (metabolic role). These ideas are supported by the recently demonstrated requirement of astrocytic glycogenolysis for the uptake of extracellular K obtained in cell cultures and by preliminary results that I obtained through kinetic analysis. The present project will tackle, for the first time in awake behaving mice, the characterization of activity-dependent brain glycogen metabolism by means of electrophysiological and pharmacological experiments. The outcomes will provide essential insights into the mechanisms underlying normal ion homeostasis and its impairment in epilepsy as well as other pathologies related to aberrations in brain energy metabolism. The project will have a substantial impact on my career, as new skills in invasive experimental techniques on awake animals will complement my previous expertise in non-invasive functional magnetic resonance methods on human subjects.

 Publications

year authors and title journal last update
List of publications.
2017 Mauro DiNuzzo, Federico Giove, Bruno Maraviglia, Silvia Mangia
Computational Flux Balance Analysis Predicts that Stimulation of Energy Metabolism in Astrocytes and their Metabolic Interactions with Neurons Depend on Uptake of K+ Rather than Glutamate
published pages: 202-216, ISSN: 0364-3190, DOI: 10.1007/s11064-016-2048-0
Neurochemical Research 42/1 2019-06-13
2017 Mauro DiNuzzo, Simon Sanggaard, Serhii Kostrikov, Anna Xavier, Sofie Christensen, Blanca Aldana, Lasse Bak, Ursula Sonnewald, Arne Schousboe, Helle Waagepetersen, Maiken Nedergaard
Intracisternal injection of [U-13C]glucose for investigating brain metabolism in freely moving mice
published pages: 146, ISSN: 0022-3042, DOI:
Journal of Neurochemistry 142 2019-06-13
2017 Mauro DiNuzzo, Maiken Nedergaard
Brain energetics during the sleep–wake cycle
published pages: 65-72, ISSN: 0959-4388, DOI: 10.1016/j.conb.2017.09.010
Current Opinion in Neurobiology 47 2019-06-13

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GLION" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "GLION" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

CoCoNat (2019)

Coordination in constrained and natural distributed systems

Read More  

STUDYES (2019)

Structure and Ultrafast Dynamics in Deep Eutectic Solvents

Read More