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GLION

Investigating glial glycogen utilization for ion homeostasis in the brain and its relevance to epileptogenesis: electrophysiology and pharmacology in awake behaving mice

Total Cost €

0

EC-Contrib. €

0

Partnership

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 GLION project word cloud

Explore the words cloud of the GLION project. It provides you a very rough idea of what is the project "GLION" about.

demonstrated    complement    influences    space    invasive    magnetic    efficiency    substantial    human    skills    mice    astrocytes    sole    electrophysiological    subjects    interactions    mammalian    basis    brain    tackle    potassium    outcomes    fueled    ion    glycogenolysis    metabolic    energy    transmitter    cultures    signaling    kinetic    understand    glycogen    pathologies    career    stages    glucose    mechanisms    seizures    insights    expertise    experimental    normal    neuronal    cellular    extracellular    metabolism    dysfunction    ideas    consumption    underlying    compounds    neuronally    store    homeostasis    primary    cell    pharmacological    critical    functional    astrocytic    animals    cerebral    epilepsy    operations    time    requirement    epileptogenic    controls    impairment    aberrations    resonance    behaving    hypothesize    preliminary    characterization    cells    excitability    susceptibility    awake    released    experiments    molecules    supports    constraints    dependent    first    techniques   

Project "GLION" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://www.glion.eu/
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 212˙194.00

Map

 Project objective

We do not yet fully understand the cellular basis of brain energy metabolism. The high energy consumption of mammalian brain sets information processing under critical metabolic constraints. Energy efficiency in brain signaling is supported by functional and metabolic interactions between neuronal and astrocytic cells. Specifically, during neuronal activity astrocytes rapidly take up neuronally-released compounds from the extracellular space, including potassium (K) and transmitter molecules. These operations affect brain excitability and their dysfunction can increase susceptibility to seizures and eventually lead to epilepsy. Importantly, ion homeostasis in astrocytes is fueled by astrocytic glycogen, the sole cerebral energy store. The primary aim of the present project is to investigate how metabolism of glycogen in astrocytes supports and influences the different stages of neuronal activity under normal and epileptogenic conditions. I hypothesize that K-induced glycogenolysis in astrocytes controls neuronal excitability (functional role) as well as neuronal glucose uptake (metabolic role). These ideas are supported by the recently demonstrated requirement of astrocytic glycogenolysis for the uptake of extracellular K obtained in cell cultures and by preliminary results that I obtained through kinetic analysis. The present project will tackle, for the first time in awake behaving mice, the characterization of activity-dependent brain glycogen metabolism by means of electrophysiological and pharmacological experiments. The outcomes will provide essential insights into the mechanisms underlying normal ion homeostasis and its impairment in epilepsy as well as other pathologies related to aberrations in brain energy metabolism. The project will have a substantial impact on my career, as new skills in invasive experimental techniques on awake animals will complement my previous expertise in non-invasive functional magnetic resonance methods on human subjects.

 Publications

year authors and title journal last update
List of publications.
2017 Mauro DiNuzzo, Federico Giove, Bruno Maraviglia, Silvia Mangia
Computational Flux Balance Analysis Predicts that Stimulation of Energy Metabolism in Astrocytes and their Metabolic Interactions with Neurons Depend on Uptake of K+ Rather than Glutamate
published pages: 202-216, ISSN: 0364-3190, DOI: 10.1007/s11064-016-2048-0
Neurochemical Research 42/1 2019-06-13
2017 Mauro DiNuzzo, Simon Sanggaard, Serhii Kostrikov, Anna Xavier, Sofie Christensen, Blanca Aldana, Lasse Bak, Ursula Sonnewald, Arne Schousboe, Helle Waagepetersen, Maiken Nedergaard
Intracisternal injection of [U-13C]glucose for investigating brain metabolism in freely moving mice
published pages: 146, ISSN: 0022-3042, DOI:
Journal of Neurochemistry 142 2019-06-13
2017 Mauro DiNuzzo, Maiken Nedergaard
Brain energetics during the sleep–wake cycle
published pages: 65-72, ISSN: 0959-4388, DOI: 10.1016/j.conb.2017.09.010
Current Opinion in Neurobiology 47 2019-06-13

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