Explore the words cloud of the GLION project. It provides you a very rough idea of what is the project "GLION" about.
The following table provides information about the project.
|Coordinator Country||Denmark [DK]|
|Total cost||212˙194 €|
|EC max contribution||212˙194 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2016-03-01 to 2018-02-28|
Take a look of project's partnership.
|1||KOBENHAVNS UNIVERSITET||DK (KOBENHAVN)||coordinator||212˙194.00|
We do not yet fully understand the cellular basis of brain energy metabolism. The high energy consumption of mammalian brain sets information processing under critical metabolic constraints. Energy efficiency in brain signaling is supported by functional and metabolic interactions between neuronal and astrocytic cells. Specifically, during neuronal activity astrocytes rapidly take up neuronally-released compounds from the extracellular space, including potassium (K) and transmitter molecules. These operations affect brain excitability and their dysfunction can increase susceptibility to seizures and eventually lead to epilepsy. Importantly, ion homeostasis in astrocytes is fueled by astrocytic glycogen, the sole cerebral energy store. The primary aim of the present project is to investigate how metabolism of glycogen in astrocytes supports and influences the different stages of neuronal activity under normal and epileptogenic conditions. I hypothesize that K-induced glycogenolysis in astrocytes controls neuronal excitability (functional role) as well as neuronal glucose uptake (metabolic role). These ideas are supported by the recently demonstrated requirement of astrocytic glycogenolysis for the uptake of extracellular K obtained in cell cultures and by preliminary results that I obtained through kinetic analysis. The present project will tackle, for the first time in awake behaving mice, the characterization of activity-dependent brain glycogen metabolism by means of electrophysiological and pharmacological experiments. The outcomes will provide essential insights into the mechanisms underlying normal ion homeostasis and its impairment in epilepsy as well as other pathologies related to aberrations in brain energy metabolism. The project will have a substantial impact on my career, as new skills in invasive experimental techniques on awake animals will complement my previous expertise in non-invasive functional magnetic resonance methods on human subjects.
|year||authors and title||journal||last update|
Mauro DiNuzzo, Federico Giove, Bruno Maraviglia, Silvia Mangia
Computational Flux Balance Analysis Predicts that Stimulation of Energy Metabolism in Astrocytes and their Metabolic Interactions with Neurons Depend on Uptake of K+ Rather than Glutamate
published pages: 202-216, ISSN: 0364-3190, DOI: 10.1007/s11064-016-2048-0
|Neurochemical Research 42/1||2019-06-13|
Mauro DiNuzzo, Simon Sanggaard, Serhii Kostrikov, Anna Xavier, Sofie Christensen, Blanca Aldana, Lasse Bak, Ursula Sonnewald, Arne Schousboe, Helle Waagepetersen, Maiken Nedergaard
Intracisternal injection of [U-13C]glucose for investigating brain metabolism in freely moving mice
published pages: 146, ISSN: 0022-3042, DOI:
|Journal of Neurochemistry 142||2019-06-13|
Mauro DiNuzzo, Maiken Nedergaard
Brain energetics during the sleepâ€“wake cycle
published pages: 65-72, ISSN: 0959-4388, DOI: 10.1016/j.conb.2017.09.010
|Current Opinion in Neurobiology 47||2019-06-13|
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