Opendata, web and dolomites


Investigating glial glycogen utilization for ion homeostasis in the brain and its relevance to epileptogenesis: electrophysiology and pharmacology in awake behaving mice

Total Cost €


EC-Contrib. €






 GLION project word cloud

Explore the words cloud of the GLION project. It provides you a very rough idea of what is the project "GLION" about.

mammalian    insights    space    influences    dependent    mice    efficiency    extracellular    resonance    energy    kinetic    mechanisms    cultures    glucose    first    glycogenolysis    store    primary    awake    electrophysiological    neuronally    requirement    molecules    impairment    fueled    signaling    skills    metabolic    experimental    controls    interactions    potassium    metabolism    basis    invasive    career    functional    normal    time    experiments    cells    ion    susceptibility    excitability    cerebral    tackle    human    epileptogenic    ideas    glycogen    cell    complement    neuronal    substantial    compounds    operations    magnetic    released    techniques    astrocytic    constraints    expertise    understand    cellular    animals    consumption    pharmacological    demonstrated    seizures    transmitter    epilepsy    supports    characterization    dysfunction    hypothesize    sole    outcomes    aberrations    brain    subjects    homeostasis    critical    stages    behaving    pathologies    preliminary    underlying    astrocytes   

Project "GLION" data sheet

The following table provides information about the project.


Organization address
address: NORREGADE 10
postcode: 1165

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 212˙194.00


 Project objective

We do not yet fully understand the cellular basis of brain energy metabolism. The high energy consumption of mammalian brain sets information processing under critical metabolic constraints. Energy efficiency in brain signaling is supported by functional and metabolic interactions between neuronal and astrocytic cells. Specifically, during neuronal activity astrocytes rapidly take up neuronally-released compounds from the extracellular space, including potassium (K) and transmitter molecules. These operations affect brain excitability and their dysfunction can increase susceptibility to seizures and eventually lead to epilepsy. Importantly, ion homeostasis in astrocytes is fueled by astrocytic glycogen, the sole cerebral energy store. The primary aim of the present project is to investigate how metabolism of glycogen in astrocytes supports and influences the different stages of neuronal activity under normal and epileptogenic conditions. I hypothesize that K-induced glycogenolysis in astrocytes controls neuronal excitability (functional role) as well as neuronal glucose uptake (metabolic role). These ideas are supported by the recently demonstrated requirement of astrocytic glycogenolysis for the uptake of extracellular K obtained in cell cultures and by preliminary results that I obtained through kinetic analysis. The present project will tackle, for the first time in awake behaving mice, the characterization of activity-dependent brain glycogen metabolism by means of electrophysiological and pharmacological experiments. The outcomes will provide essential insights into the mechanisms underlying normal ion homeostasis and its impairment in epilepsy as well as other pathologies related to aberrations in brain energy metabolism. The project will have a substantial impact on my career, as new skills in invasive experimental techniques on awake animals will complement my previous expertise in non-invasive functional magnetic resonance methods on human subjects.


year authors and title journal last update
List of publications.
2017 Mauro DiNuzzo, Federico Giove, Bruno Maraviglia, Silvia Mangia
Computational Flux Balance Analysis Predicts that Stimulation of Energy Metabolism in Astrocytes and their Metabolic Interactions with Neurons Depend on Uptake of K+ Rather than Glutamate
published pages: 202-216, ISSN: 0364-3190, DOI: 10.1007/s11064-016-2048-0
Neurochemical Research 42/1 2019-06-13
2017 Mauro DiNuzzo, Simon Sanggaard, Serhii Kostrikov, Anna Xavier, Sofie Christensen, Blanca Aldana, Lasse Bak, Ursula Sonnewald, Arne Schousboe, Helle Waagepetersen, Maiken Nedergaard
Intracisternal injection of [U-13C]glucose for investigating brain metabolism in freely moving mice
published pages: 146, ISSN: 0022-3042, DOI:
Journal of Neurochemistry 142 2019-06-13
2017 Mauro DiNuzzo, Maiken Nedergaard
Brain energetics during the sleep–wake cycle
published pages: 65-72, ISSN: 0959-4388, DOI: 10.1016/j.conb.2017.09.010
Current Opinion in Neurobiology 47 2019-06-13

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GLION" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "GLION" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

NeoPur (2019)

New treatments and novel diagnostic tests for neonatal seizures based on purinergic signaling.

Read More  

InProSMod (2021)

Cholinergic and NMDAR-dependent recruitment of Layer 1 Interneuron shapes cortical motor Processing through network States Modulation

Read More  


The missing pillar. European social policy and Eurosceptic challenges (SOCIALEU)

Read More