Explore the words cloud of the microCardio project. It provides you a very rough idea of what is the project "microCardio" about.
The following table provides information about the project.
CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO
|EC max contribution
|148˙635 € (100%)
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|from 2016-03-01 to 2018-02-28
Take a look of project's partnership.
|CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO
Ischemia-reperfusion injury is a major cause of morbidity and mortality transversal to different clinical settings and pathologies, including myocardial infarction. Ischemia is characterised by insufficient supply of blood to tissues causing tissue oxygen deprivation. Importantly, damage by prolonged ischemia is further aggravated by reperfusion, leading to irreversible tissue damage. Identifying and understanding the factors contributing to ischemia-reperfusion injury is essential to counteract the irreversible damage and to potentially develop novel therapeutic approaches to intervene in myocardial infarction. Recent studies have shown that microRNAs control various aspects of heart disease, including ischemia-reperfusion injury. Although a few microRNAs have already been implicated in this process, a comprehensive analysis of the functional role of microRNAs in cardiac ischemia-reperfusion injury is still missing.
The main goal of this project is to identify microRNAs controlling the resistance/susceptibility of cardiomyocytes to ischemia-reperfusion injury and characterise the molecular mechanisms underlying their function. This will be achieved through the combination of gain- and loss-of-function high-throughput screenings using genome-wide microRNA libraries, and deep-sequencing analysis of microRNA expression in conditions mimicking ischemia and ischemia-reperfusion in vitro and in vivo. The identification and characterisation of the molecular targets of the selected microRNAs will entail a combination of computational and experimental approaches
This project uses innovative experimental approaches and will unravel a previously unappreciated network of microRNAs and microRNA targets critical to ischemia-reperfusion injury, which may reveal novel opportunities for therapeutic intervention, with important clinical implications.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MICROCARDIO" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "MICROCARDIO" are provided by the European Opendata Portal: CORDIS opendata.