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ENHANCE

Engineering the 3D Niche to enHANCE functionality of hepatocytes derived from human iPSCs

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ENHANCE" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.kcl.ac.uk/lsm/research/divisions/gmm/departments/stemcells/index.aspx
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

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 Project objective

Induced pluripotent stem cell derived hepatocytes (i-Heps) afford us the exciting possibility of redressing the growing shortage in liver transplantation tissue and heralding in a new era of patient specific drug and disease modelling. Clinical applications are restricted by their poor functionality in comparison to the gold standard – freshly isolated primary hepatocytes. Emerging evidence suggests the three dimensional environment surrounding a cell (the niche) critically influences cellular function. The objective of ENHANCE is to identify relevant factors from the extracellular niche which promote i-Hep function in 3D and the mechanisms by which they achieve this. This new knowledge will be used to generate functionally optimized i-Hep constructs suitable for clinical transplantation, with proof of concept studies being performed in rodent models of liver failure. This European Fellowship at Kings College London will provide the researcher with advanced training in iPSC technology, i-Hep generation, 2D niche component screening, 3D cell engineering and animal transplantation. A secondment to SME DefiniGEN Ltd will evaluate the feasibility of transfer to a commercial i-Hep production platform as a critical step towards clinical trials.

 Publications

year authors and title journal last update
List of publications.
2018 John Ong, Maria Paola Serra, Joe Segal, Ana-Maria Cujba, Soon Seng Ng, Richard Butler, Val Millar, Stephanie Hatch, Salman Zimri, Hiroyuki Koike, Karen Chan, Andrew Bonham, Michelle Walk, Ty Voss, Nigel Heaton, Ragai Mitry, Anil Dhawan, Daniel Ebner, Davide Danovi, Hiromitsu Nakauchi, S. Tamir Rashid
Imaging-Based Screen Identifies Laminin 411 as a Physiologically Relevant Niche Factor with Importance for i-Hep Applications
published pages: , ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.01.025
Stem Cell Reports 2019-06-13

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The information about "ENHANCE" are provided by the European Opendata Portal: CORDIS opendata.

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