Opendata, web and dolomites

LDC4PCaTher

BMX-targeted ligand-drug conjugates for prostate cancer therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 LDC4PCaTher project word cloud

Explore the words cloud of the LDC4PCaTher project. It provides you a very rough idea of what is the project "LDC4PCaTher" about.

inflammatory    drug    benefit    treatments    dependent    cytokines    chemotherapy    minimal    risk    ligand    limited    weight    patient    treatment    blood    therapy    cancer    time    tumour    producing    efficacy    bone    heavily    systematically    marrow    building    payload    whilst    chromosome    cancers    applicable    site    ldc    tyrosine    date    cells    fine    superior    severe    tissue    adme    performance    antibodies    markedly    alternative    damage    healthy    injection    agents    avenues    standard    tumours    modify    significantly    penetration    disease    care    prostate    negligible    tuning    ldcs    ligands    release    index    vehicles    accumulate    bmx    regulated    ratio    malignant    relies    radionuclides    molecular    overexpressing    selectively    pro    therapeutic    chemically    profile    maximizing    radiation    explore    cytotoxic    immunogenic    toxicities    conjugated    kinase    antibody    interferes    easier    monoclonal    conjugates    drugs    strategies    substances    chemical    safe   

Project "LDC4PCaTher" data sheet

The following table provides information about the project.

Coordinator
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES 

Organization address
address: AVENIDA PROF EGAS MONIZ
city: LISBOA
postcode: 1649 028
website: www.imm.ul.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 160˙635 €
 EC max contribution 160˙635 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2019-01-12

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES PT (LISBOA) coordinator 160˙635.00

Map

 Project objective

Standard of care strategies for the treatment of cancer still relies heavily on non-specific radiation and chemotherapy. These treatments are commonly associated with severe toxicities and in many cases only offer limited benefit for the patient. The targeted delivery of radionuclides, cytotoxic drugs and pro-inflammatory cytokines into malignant tissue, on the other hand, can markedly improve the therapeutic index and overall efficacy of such substances. Whilst monoclonal antibodies are the most widely used delivery vehicles to date, low molecular weight targeted agents are emerging as a promising alternative to antibody-based drug delivery. These ligands have negligible immunogenic risk and are easier to chemically modify enabling fine tuning of their ADME profile. As a result, it is possible to achieve a time dependent release of the cytotoxic payload at the target tissue maximizing its therapeutic efficacy while producing minimal damage to healthy cells. Most importantly, depth of tumour penetration and tumour-to-blood distribution ratio after injection should be significantly superior. We therefore propose to systematically investigate the targeting performance of bone marrow tyrosine kinase in chromosome X (BMX) ligands for the targeted delivery of cytotoxic drugs into BMX-overexpressing tumours, namely prostate cancer. This project aims at (1) demonstrate that a BMX ligand can selectively accumulate in BMX-overexpressing cancers; (2) developing a general chemical approach for building safe ligand-drug conjugates (LDCs); and (3) when site-specifically conjugated to cytotoxic drug, this novel LDC is highly effective for the treatment of prostate cancer. This project is expected to explore new avenues for drug delivery systems since the concepts here proposed go beyond prostate cancer therapy as they can be applicable to any ligand that interferes with up-regulated disease-related pathways.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "LDC4PCATHER" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "LDC4PCATHER" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

TOPOCIRCUS (2019)

Simulations of Topological Phases in Superconducting Circuits

Read More  

SpaTime_AnTB (2020)

Single-cell spatiotemporal analysis of Mycobacterium tuberculosis responses to antibiotics within host microenvironments

Read More