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LDC4PCaTher

BMX-targeted ligand-drug conjugates for prostate cancer therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 LDC4PCaTher project word cloud

Explore the words cloud of the LDC4PCaTher project. It provides you a very rough idea of what is the project "LDC4PCaTher" about.

pro    severe    chemically    therapy    toxicities    strategies    systematically    risk    benefit    conjugated    dependent    limited    heavily    standard    safe    index    cytokines    selectively    date    performance    site    superior    tyrosine    interferes    efficacy    ldcs    chemotherapy    minimal    tissue    maximizing    immunogenic    markedly    overexpressing    chemical    disease    chromosome    ratio    kinase    profile    producing    tuning    substances    vehicles    conjugates    marrow    negligible    accumulate    easier    adme    radiation    regulated    tumours    cancer    ldc    time    whilst    building    blood    penetration    therapeutic    cancers    ligand    malignant    treatment    molecular    healthy    cells    drug    care    payload    monoclonal    applicable    ligands    prostate    relies    tumour    fine    bmx    alternative    inflammatory    patient    damage    modify    radionuclides    agents    antibody    explore    drugs    release    weight    significantly    bone    treatments    avenues    antibodies    cytotoxic    injection   

Project "LDC4PCaTher" data sheet

The following table provides information about the project.

Coordinator
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES 

Organization address
address: AVENIDA PROF EGAS MONIZ
city: LISBOA
postcode: 1649 028
website: www.imm.ul.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 160˙635 €
 EC max contribution 160˙635 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2019-01-12

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES PT (LISBOA) coordinator 160˙635.00

Map

 Project objective

Standard of care strategies for the treatment of cancer still relies heavily on non-specific radiation and chemotherapy. These treatments are commonly associated with severe toxicities and in many cases only offer limited benefit for the patient. The targeted delivery of radionuclides, cytotoxic drugs and pro-inflammatory cytokines into malignant tissue, on the other hand, can markedly improve the therapeutic index and overall efficacy of such substances. Whilst monoclonal antibodies are the most widely used delivery vehicles to date, low molecular weight targeted agents are emerging as a promising alternative to antibody-based drug delivery. These ligands have negligible immunogenic risk and are easier to chemically modify enabling fine tuning of their ADME profile. As a result, it is possible to achieve a time dependent release of the cytotoxic payload at the target tissue maximizing its therapeutic efficacy while producing minimal damage to healthy cells. Most importantly, depth of tumour penetration and tumour-to-blood distribution ratio after injection should be significantly superior. We therefore propose to systematically investigate the targeting performance of bone marrow tyrosine kinase in chromosome X (BMX) ligands for the targeted delivery of cytotoxic drugs into BMX-overexpressing tumours, namely prostate cancer. This project aims at (1) demonstrate that a BMX ligand can selectively accumulate in BMX-overexpressing cancers; (2) developing a general chemical approach for building safe ligand-drug conjugates (LDCs); and (3) when site-specifically conjugated to cytotoxic drug, this novel LDC is highly effective for the treatment of prostate cancer. This project is expected to explore new avenues for drug delivery systems since the concepts here proposed go beyond prostate cancer therapy as they can be applicable to any ligand that interferes with up-regulated disease-related pathways.

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The information about "LDC4PCATHER" are provided by the European Opendata Portal: CORDIS opendata.

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