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BioMNP SIGNED

Understanding the interaction between metal nanoparticles and biological membranes

Total Cost €

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EC-Contrib. €

0

Partnership

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 BioMNP project word cloud

Explore the words cloud of the BioMNP project. It provides you a very rough idea of what is the project "BioMNP" about.

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Project "BioMNP" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI GENOVA 

Organization address
address: VIA BALBI 5
city: GENOVA
postcode: 16126
website: www.unige.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website https://www.difi.unige.it/it/dipartimento/persone/rossi-giulia
 Total cost 1˙131˙250 €
 EC max contribution 1˙131˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI GENOVA IT (GENOVA) coordinator 1˙131˙250.00

Map

 Project objective

The BioMNP objective is the molecular-level understanding of the interactions between surface functionalized metal nanoparticles and biological membranes, by means of cutting-edge computational techniques and new molecular models. Metal nanoparticles (NP) play more and more important roles in pharmaceutical and medical technology as diagnostic or therapeutic devices. Metal NPs can nowadays be engineered in a multitude of shapes, sizes and compositions, and they can be decorated with an almost infinite variety of functionalities. Despite such technological advances, there is still poor understanding of the molecular processes that drive the interactions of metal NPs with cells. Cell membranes are the first barrier encountered by NPs entering living organisms. The understanding and control of the interaction of nanoparticles with biological membranes is therefore of paramount importance to understand the molecular basis of the NP biological effects. BioMNP will go beyond the state of the art by rationalizing the complex interplay of NP size, composition, functionalization and aggregation state during the interaction with model biomembranes. Membranes, in turn, will be modelled at an increasing level of complexity in terms of lipid composition and phase. BioMNP will rely on cutting-edge simulation techniques and facilities, and develop new coarse-grained models grounded on finer-level atomistic simulations, to study the NP-membrane interactions on an extremely large range of length and time scales. BioMNP will benefit from important and complementary experimental collaborations, will propose interpretations of the available experimental data and make predictions to guide the design of functional, non-toxic metal nanoparticles for biomedical applications. BioMNP aims at answering fundamental questions at the crossroads of physics, biology and chemistry. Its results will have an impact on nanomedicine, toxicology, nanotechnology and material sciences.

 Publications

year authors and title journal last update
List of publications.
2018 S Salassi, F Simonelli, A Bartocci, G Rossi
A Martini coarse-grained model of the calcein fluorescent dye
published pages: 384002, ISSN: 0022-3727, DOI: 10.1088/1361-6463/aad4b8
Journal of Physics D: Applied Physics 51/38 2019-10-29
2018 Fabian Grunewald, Giulia Rossi, Alex H. de Vries, Siewert J. Marrink, Luca Monticelli
Transferable MARTINI Model of Poly(ethylene Oxide)
published pages: 7436-7449, ISSN: 1520-6106, DOI: 10.1021/acs.jpcb.8b04760
The Journal of Physical Chemistry B 122/29 2019-10-29
2017 Sebastian Salassi, Federica Simonelli, Davide Bochicchio, Riccardo Ferrando, Giulia Rossi
Au Nanoparticles in Lipid Bilayers: A Comparison between Atomistic and Coarse-Grained Models
published pages: 10927-10935, ISSN: 1932-7447, DOI: 10.1021/acs.jpcc.6b12148
The Journal of Physical Chemistry C 121/20 2019-09-04
2017 Andrea Torchi, Federica Simonelli, Riccardo Ferrando, Giulia Rossi
Local Enhancement of Lipid Membrane Permeability Induced by Irradiated Gold Nanoparticles
published pages: , ISSN: 1936-0851, DOI: 10.1021/acsnano.7b06690
ACS Nano 2019-09-04
2017 D. Bochicchio, E. Panizon, L. Monticelli, G. Rossi
Interaction of hydrophobic polymers with model lipid bilayers
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-06668-0
Scientific Reports 7/1 2019-09-04
2019 Federica Simonelli, Giulia Rossi, Luca Monticelli
Role of Ligand Conformation on Nanoparticle–Protein Interactions
published pages: 1764-1769, ISSN: 1520-6106, DOI: 10.1021/acs.jpcb.8b11204
The Journal of Physical Chemistry B 123/8 2019-09-04
2019 Sebastian Salassi, Ester Canepa, Riccardo Ferrando, Giulia Rossi
Anionic nanoparticle-lipid membrane interactions: the protonation of anionic ligands at the membrane surface reduces membrane disruption
published pages: 13992-13997, ISSN: 2046-2069, DOI: 10.1039/c9ra02462j
RSC Advances 9/25 2019-09-04

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