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Remote memory traces SIGNED

Cellular and molecular mechanisms of remote fear attenuation

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Project "Remote memory traces" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙494˙325 €
 EC max contribution 1˙494˙325 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 1˙494˙325.00

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 Project objective

Traumatic events generate some of the most enduring forms of memories. Despite an elevated lifetime prevalence of related fear and anxiety disorders, effective treatments for traumatic memories are scarce and the mechanisms behind successful memory attenuation poorly understood. This discrepancy is particularly pronounced for remote traumata, when the original insult occurred in the distant past.

Here, we propose to identify, isolate to analyze, and causally determine neuronal subpopulations involved in remote fear memory attenuation. To achieve these goals, we will use a combination of transgenic mice with direct in situ manipulations of neuronal subpopulations and cell type-specific transcriptomic and epigenetic profiling. Specifically, we will inducibly and persistently tag neurons activated by remote memory recall, and subsequently capitalize on this tag threefold: First, by visualizing this tag after successful memory attenuation, we will identify neuronal subpopulations that promote remote memory reduction. Second, by using this tag as an anchor for pharmacological manipulations interfering with neuronal activity, we will determine a causal implication of these neurons in successful memory attenuation. Lastly, by employing this tag as bait, we will isolate neuronal subpopulations that promote memory attenuation to analyze their epigenetic regulation of gene expression, a core component of enduring forms of memories. By investigating these mechanisms in three independent protocols for memory attenuation, we seek to provide proof-of-principle that successful memory attenuation is defined by a unique molecular signature, which can serve as a template to better ascertain the potential of other treatments aimed at attenuating remote memories.

We expect this project to deepen our understanding of remote traumatic memories and their attenuation at an unprecedented cellular and molecular resolution.

 Publications

year authors and title journal last update
List of publications.
2019 Bianca A. Silva, Allison M. Burns, Johannes Gräff
A cFos activation map of remote fear memory attenuation
published pages: , ISSN: 0033-3158, DOI: 10.1007/s00213-018-5000-y
Psychopharmacology 2019-04-18
2018 Zimbul Albo, Johannes Gräff
The mysteries of remote memory
published pages: 20170029, ISSN: 0962-8436, DOI: 10.1098/rstb.2017.0029
Philosophical Transactions of the Royal Society B: Biological Sciences 373/1742 2019-04-18
2017 Laura Frangeul, Vassilis Kehayas, Jose V. Sanchez-Mut, Sabine Fièvre, K. Krishna-K, Gabrielle Pouchelon, Ludovic Telley, Camilla Bellone, Anthony Holtmaat, Johannes Gräff, Jeffrey D. Macklis, Denis Jabaudon
Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02172-1
Nature Communications 8/1 2019-04-18
2018 Ossama Khalaf, Siegfried Resch, Lucie Dixsaut, Victoire Gorden, Liliane Glauser, Johannes Gräff
Reactivation of recall-induced neurons contributes to remote fear memory attenuation
published pages: 1239-1242, ISSN: 0036-8075, DOI: 10.1126/science.aas9875
Science 360/6394 2019-04-18
2016 Bianca A. Silva, Cornelius T. Gross, Johannes Gräff
The neural circuits of innate fear: detection, integration, action, and memorization
published pages: 544-555, ISSN: 1549-5485, DOI: 10.1101/lm.042812.116
Learning & Memory 23/10 2019-06-19

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