Explore the words cloud of the Remote memory traces project. It provides you a very rough idea of what is the project "Remote memory traces" about.
The following table provides information about the project.
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
|Coordinator Country||Switzerland [CH]|
|Total cost||1˙494˙325 €|
|EC max contribution||1˙494˙325 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-05-01 to 2021-04-30|
Take a look of project's partnership.
|1||ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE||CH (LAUSANNE)||coordinator||1˙494˙325.00|
Traumatic events generate some of the most enduring forms of memories. Despite an elevated lifetime prevalence of related fear and anxiety disorders, effective treatments for traumatic memories are scarce and the mechanisms behind successful memory attenuation poorly understood. This discrepancy is particularly pronounced for remote traumata, when the original insult occurred in the distant past.
Here, we propose to identify, isolate to analyze, and causally determine neuronal subpopulations involved in remote fear memory attenuation. To achieve these goals, we will use a combination of transgenic mice with direct in situ manipulations of neuronal subpopulations and cell type-specific transcriptomic and epigenetic profiling. Specifically, we will inducibly and persistently tag neurons activated by remote memory recall, and subsequently capitalize on this tag threefold: First, by visualizing this tag after successful memory attenuation, we will identify neuronal subpopulations that promote remote memory reduction. Second, by using this tag as an anchor for pharmacological manipulations interfering with neuronal activity, we will determine a causal implication of these neurons in successful memory attenuation. Lastly, by employing this tag as bait, we will isolate neuronal subpopulations that promote memory attenuation to analyze their epigenetic regulation of gene expression, a core component of enduring forms of memories. By investigating these mechanisms in three independent protocols for memory attenuation, we seek to provide proof-of-principle that successful memory attenuation is defined by a unique molecular signature, which can serve as a template to better ascertain the potential of other treatments aimed at attenuating remote memories.
We expect this project to deepen our understanding of remote traumatic memories and their attenuation at an unprecedented cellular and molecular resolution.
|year||authors and title||journal||last update|
Bianca A. Silva, Allison M. Burns, Johannes GrÃ¤ff
A cFos activation map of remote fear memory attenuation
published pages: , ISSN: 0033-3158, DOI: 10.1007/s00213-018-5000-y
Zimbul Albo, Johannes GrÃ¤ff
The mysteries of remote memory
published pages: 20170029, ISSN: 0962-8436, DOI: 10.1098/rstb.2017.0029
|Philosophical Transactions of the Royal Society B: Biological Sciences 373/1742||2019-04-18|
Laura Frangeul, Vassilis Kehayas, Jose V. Sanchez-Mut, Sabine FiÃ¨vre, K. Krishna-K, Gabrielle Pouchelon, Ludovic Telley, Camilla Bellone, Anthony Holtmaat, Johannes GrÃ¤ff, Jeffrey D. Macklis, Denis Jabaudon
Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02172-1
|Nature Communications 8/1||2019-04-18|
Ossama Khalaf, Siegfried Resch, Lucie Dixsaut, Victoire Gorden, Liliane Glauser, Johannes GrÃ¤ff
Reactivation of recall-induced neurons contributes to remote fear memory attenuation
published pages: 1239-1242, ISSN: 0036-8075, DOI: 10.1126/science.aas9875
Bianca A. Silva, Cornelius T. Gross, Johannes GrÃ¤ff
The neural circuits of innate fear: detection, integration, action, and memorization
published pages: 544-555, ISSN: 1549-5485, DOI: 10.1101/lm.042812.116
|Learning & Memory 23/10||2019-06-19|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "REMOTE MEMORY TRACES" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "REMOTE MEMORY TRACES" are provided by the European Opendata Portal: CORDIS opendata.