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STC SIGNED

Synaptic Tagging and Capture: From Synapses to Behavior

Total Cost €

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EC-Contrib. €

0

Partnership

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 STC project word cloud

Explore the words cloud of the STC project. It provides you a very rough idea of what is the project "STC" about.

stimuli    stabilization    small    optogenetics    circuit    optically    happening    proteins    predictions    cellular    shock    preceded    fear    permits    remarkably    mechanism    resolution    stability    protein    memory    followed    manipulating    fraction    inputs    stimulus    associative    animal    optical    proposes    expression    auditory    two    plasticity    tagged    stable    engineer    stabilize    model    stc    grant    memories    synaptic    neurons    natural    capture    capturing    basis    it    shown    activation    formed    associates    foot    activated    divided    tone    ltp    inducing    subsequently    underlies    spatial    explicitly    induction    hypothesis    predicts    dependent    examine    heterosynaptic    explicit    made    color    events    synthesis    selective    visual    converging    potentiation    neuronal    tagging    transiently    populations    stabilized    manipulation    forgotten    induce    caused    amygdala    temporal    precise    optogenetic    put    naturally    inducible    population   

Project "STC" data sheet

The following table provides information about the project.

Coordinator
AARHUS UNIVERSITET 

Organization address
address: NORDRE RINGGADE 1
city: AARHUS C
postcode: 8000
website: www.au.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 1˙500˙000.00

Map

 Project objective

It is shown that long-term potentiation (LTP) is the cellular basis of memory formation. However, since all but small fraction of memories are forgotten, LTP has been further divided into early LTP (e-LTP), the mechanism by which short-term memories are formed, and a more stable late LTP (L-LTP), by which long-term memories are formed. Remarkably, it has been shown that an e-LTP can be stabilized if it is preceded or followed by heterosynaptic L-LTP. According to Synaptic Tagging and Capture (STC) hypothesis, e-LTP is stabilized by capturing proteins that are made by L-LTP induction. The model proposes that this mechanism underlies the formation of late associative memory, where the stability of a memory is not only defined by the stimuli that induce the change but also by events happening before and after these stimuli. As such, the model explicitly predicts that a short-term memory can be stabilized by inducing heterosynaptic L-LTP. In this grant, I will put this hypothesis into test. Specifically, I will test two explicit predictions of STC model: 1) A naturally formed short-term memory can be stabilized by induction of heterosynaptic L-LTP. 2) This stabilization is caused by the protein synthesis feature of L-LTP. To do this, using optogenetics, I will engineer a short-term memory in auditory fear circuit, in which an animal transiently associates a foot shock to a tone. Subsequently, I will examine if optogenetic delivery of L-LTP to the visual inputs converging on the same population of neurons in the amygdala will stabilize the short-term tone fear memory. To be able to engineer natural memory by manipulating synaptic plasticity I will develop two systems: 1) A two-color optical activation system which permits selective manipulation of distinct neuronal populations with precise temporal and spatial resolution; 2) An inducible and activity-dependent expression system by which those neurons that are activated by a natural stimulus will be optically tagged.

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The information about "STC" are provided by the European Opendata Portal: CORDIS opendata.

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