Opendata, web and dolomites

STC SIGNED

Synaptic Tagging and Capture: From Synapses to Behavior

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 STC project word cloud

Explore the words cloud of the STC project. It provides you a very rough idea of what is the project "STC" about.

memories    heterosynaptic    model    optogenetic    proteins    caused    activation    naturally    stability    resolution    shock    stc    optogenetics    capturing    hypothesis    preceded    neurons    animal    stabilized    underlies    expression    basis    followed    auditory    manipulating    made    explicit    synthesis    optically    stabilization    tagging    natural    circuit    induce    grant    stable    divided    permits    capture    stabilize    it    neuronal    inducing    protein    potentiation    tone    activated    events    ltp    visual    shown    precise    transiently    optical    inducible    tagged    small    synaptic    dependent    formed    populations    associative    predicts    engineer    selective    amygdala    mechanism    inputs    put    foot    plasticity    manipulation    cellular    temporal    stimulus    population    forgotten    happening    fear    remarkably    proposes    spatial    converging    induction    examine    subsequently    associates    two    stimuli    fraction    memory    color    explicitly    predictions   

Project "STC" data sheet

The following table provides information about the project.

Coordinator
AARHUS UNIVERSITET 

Organization address
address: NORDRE RINGGADE 1
city: AARHUS C
postcode: 8000
website: www.au.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 1˙500˙000.00

Map

 Project objective

It is shown that long-term potentiation (LTP) is the cellular basis of memory formation. However, since all but small fraction of memories are forgotten, LTP has been further divided into early LTP (e-LTP), the mechanism by which short-term memories are formed, and a more stable late LTP (L-LTP), by which long-term memories are formed. Remarkably, it has been shown that an e-LTP can be stabilized if it is preceded or followed by heterosynaptic L-LTP. According to Synaptic Tagging and Capture (STC) hypothesis, e-LTP is stabilized by capturing proteins that are made by L-LTP induction. The model proposes that this mechanism underlies the formation of late associative memory, where the stability of a memory is not only defined by the stimuli that induce the change but also by events happening before and after these stimuli. As such, the model explicitly predicts that a short-term memory can be stabilized by inducing heterosynaptic L-LTP. In this grant, I will put this hypothesis into test. Specifically, I will test two explicit predictions of STC model: 1) A naturally formed short-term memory can be stabilized by induction of heterosynaptic L-LTP. 2) This stabilization is caused by the protein synthesis feature of L-LTP. To do this, using optogenetics, I will engineer a short-term memory in auditory fear circuit, in which an animal transiently associates a foot shock to a tone. Subsequently, I will examine if optogenetic delivery of L-LTP to the visual inputs converging on the same population of neurons in the amygdala will stabilize the short-term tone fear memory. To be able to engineer natural memory by manipulating synaptic plasticity I will develop two systems: 1) A two-color optical activation system which permits selective manipulation of distinct neuronal populations with precise temporal and spatial resolution; 2) An inducible and activity-dependent expression system by which those neurons that are activated by a natural stimulus will be optically tagged.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "STC" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "STC" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

HomoJuridicus (2019)

Homo Juridicus: Correcting Law's Behavioural Illiteracy

Read More  

PP-MAGIC (2020)

(Photo-)Control of Persisters: Targeting the Magic Spot

Read More  

CERQUTE (2020)

Certification of quantum technologies

Read More