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STC SIGNED

Synaptic Tagging and Capture: From Synapses to Behavior

Total Cost €

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EC-Contrib. €

0

Partnership

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 STC project word cloud

Explore the words cloud of the STC project. It provides you a very rough idea of what is the project "STC" about.

plasticity    color    dependent    explicit    happening    grant    remarkably    precise    formed    explicitly    activated    underlies    spatial    synaptic    optogenetic    converging    stabilization    put    heterosynaptic    stimuli    proteins    manipulation    caused    natural    resolution    divided    ltp    memories    optically    protein    fear    stimulus    populations    temporal    transiently    permits    inducible    fraction    optogenetics    population    associative    neurons    foot    naturally    potentiation    amygdala    memory    stability    events    model    animal    tone    selective    tagged    proposes    visual    preceded    induce    auditory    it    stc    tagging    stabilize    shown    subsequently    two    engineer    examine    forgotten    capturing    activation    manipulating    hypothesis    associates    inputs    optical    small    followed    synthesis    neuronal    inducing    expression    predicts    predictions    induction    shock    basis    stabilized    circuit    made    capture    mechanism    stable    cellular   

Project "STC" data sheet

The following table provides information about the project.

Coordinator
AARHUS UNIVERSITET 

Organization address
address: NORDRE RINGGADE 1
city: AARHUS C
postcode: 8000
website: www.au.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 1˙500˙000.00

Map

 Project objective

It is shown that long-term potentiation (LTP) is the cellular basis of memory formation. However, since all but small fraction of memories are forgotten, LTP has been further divided into early LTP (e-LTP), the mechanism by which short-term memories are formed, and a more stable late LTP (L-LTP), by which long-term memories are formed. Remarkably, it has been shown that an e-LTP can be stabilized if it is preceded or followed by heterosynaptic L-LTP. According to Synaptic Tagging and Capture (STC) hypothesis, e-LTP is stabilized by capturing proteins that are made by L-LTP induction. The model proposes that this mechanism underlies the formation of late associative memory, where the stability of a memory is not only defined by the stimuli that induce the change but also by events happening before and after these stimuli. As such, the model explicitly predicts that a short-term memory can be stabilized by inducing heterosynaptic L-LTP. In this grant, I will put this hypothesis into test. Specifically, I will test two explicit predictions of STC model: 1) A naturally formed short-term memory can be stabilized by induction of heterosynaptic L-LTP. 2) This stabilization is caused by the protein synthesis feature of L-LTP. To do this, using optogenetics, I will engineer a short-term memory in auditory fear circuit, in which an animal transiently associates a foot shock to a tone. Subsequently, I will examine if optogenetic delivery of L-LTP to the visual inputs converging on the same population of neurons in the amygdala will stabilize the short-term tone fear memory. To be able to engineer natural memory by manipulating synaptic plasticity I will develop two systems: 1) A two-color optical activation system which permits selective manipulation of distinct neuronal populations with precise temporal and spatial resolution; 2) An inducible and activity-dependent expression system by which those neurons that are activated by a natural stimulus will be optically tagged.

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The information about "STC" are provided by the European Opendata Portal: CORDIS opendata.

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