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COSI SIGNED

Cerebellar modules and the Ontogeny of Sensorimotor Integration

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EC-Contrib. €

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Project "COSI" data sheet

The following table provides information about the project.

Coordinator
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

Organization address
address: DR MOLEWATERPLEIN 40
city: ROTTERDAM
postcode: 3015 GD
website: www.erasmusmc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://schonewillelab.org
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) coordinator 1˙500˙000.00

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 Project objective

The perfect execution of a voluntary movement requires the appropriate integration of current bodily state, sensory input and desired outcome. To assure that this motor output becomes and remains appropriate, the brain needs to learn from the result of previous outputs. The cerebellum plays a central role in sensorimotor integration, yet -despite decades of studies- there is no generally excepted theory for cerebellar functioning. I recently demonstrated that cerebellar modules, identified based on anatomical connectivity and gene expression, differ distinctly in spike activity properties. It is my long-term goal to identify the ontogeny of anatomical and physiological differences between modules, and their functional consequences. My hypothesis is that these differences can explain existing controversies, and unify contradicting results into one central theory. To this end, I have designed three key objectives. First, I will identify the development of connectivity and activity patterns at the input stage of the cerebellar cortex in relation to the cerebellar modules (key objective A). Next, I will relate the differences in gene expression levels between modules to differences in basal activity and strength of plasticity mechanisms in juvenile mice (key objective B). Finally, I will determine how module specific output develops in relation to behavior and what the effect of module specific mutations is on cerebellum-dependent motor tasks and higher order functions (key objective C). Ultimately, the combined results of all key objectives will reveal how distinct difference between cerebellar modules develop, and how this ensemble ensures proper cerebellar information processing for optimal coordination of timing and force of movements. Combined with the growing body of evidence for a cerebellar role in higher order brain functions and neurodevelopmental disorders, a unifying theory would be fundamental for understanding how the juvenile brain develops.

 Publications

year authors and title journal last update
List of publications.
2018 Elisa Galliano, Martijn Schonewille, Saša Peter, Mandy Rutteman, Simone Houtman, Dick Jaarsma, Freek E. Hoebeek, Chris I. De Zeeuw
Impact of NMDA Receptor Overexpression on Cerebellar Purkinje Cell Activity and Motor Learning
published pages: ENEURO.0270-17.2, ISSN: 2373-2822, DOI: 10.1523/eneuro.0270-17.2018
eneuro 5/1 2019-06-19
2017 Suman Das, Marcella Spoor, Tafadzwa M. Sibindi, Peter Holland, Martijn Schonewille, Chris I. De Zeeuw, Maarten A. Frens, Opher Donchin
Impairment of Long-Term Plasticity of Cerebellar Purkinje Cells Eliminates the Effect of Anodal Direct Current Stimulation on Vestibulo-Ocular Reflex Habituation
published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2017.00444
Frontiers in Neuroscience 11 2019-06-19
2017 Kai Voges, Bin Wu, Laura Post, Martijn Schonewille, Chris I. De Zeeuw
Mechanisms underlying vestibulo-cerebellar motor learning in mice depend on movement direction
published pages: 5301-5326, ISSN: 0022-3751, DOI: 10.1113/JP274346
The Journal of Physiology 595/15 2019-06-19
2018 Richard Apps, Richard Hawkes, Sho Aoki, Fredrik Bengtsson, Amanda M. Brown, Gang Chen, Timothy J. Ebner, Philippe Isope, Henrik Jörntell, Elizabeth P. Lackey, Charlotte Lawrenson, Bridget Lumb, Martijn Schonewille, Roy V. Sillitoe, Ludovic Spaeth, Izumi Sugihara, Antoine Valera, Jan Voogd, Douglas R. Wylie, Tom J. H. Ruigrok
Cerebellar Modules and Their Role as Operational Cerebellar Processing Units
published pages: 654-682, ISSN: 1473-4222, DOI: 10.1007/s12311-018-0952-3
The Cerebellum 17/5 2019-03-06
2018 Dick Jaarsma, Francois G. C. Blot, Bin Wu, Subramanian Venkatesan, Jan Voogd, Dies Meijer, Tom J. H. Ruigrok, Zhenyu Gao, Martijn Schonewille, Chris I. De Zeeuw
The basal interstitial nucleus (BIN) of the cerebellum provides diffuse ascending inhibitory input to the floccular granule cell layer
published pages: 2231-2256, ISSN: 0021-9967, DOI: 10.1002/cne.24479
Journal of Comparative Neurology 526/14 2019-03-06

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