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TBVAC2020 SIGNED

TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development

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EC-Contrib. €

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Project "TBVAC2020" data sheet

The following table provides information about the project.

Coordinator
STICHTING TUBERCULOSIS VACCINE INITIATIVE 

Organization address
address: Runderweg 6
city: LELYSTAD
postcode: 8219 PH
website: www.tbvi.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.tbvi.eu/for-partners/tbvac2020/tbvac2020-project-description
 Total cost 25˙056˙507 €
 EC max contribution 18˙200˙000 € (73%)
 Programme 1. H2020-EU.3.1.2. (Preventing disease)
 Code Call H2020-PHC-2014-single-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2019-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING TUBERCULOSIS VACCINE INITIATIVE NL (LELYSTAD) coordinator 2˙473˙986.00
2    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 1˙714˙513.00
3    STATENS SERUM INSTITUT DK (KOBENHAVN S) participant 1˙586˙952.00
4    Department of Health UK (Leeds) participant 1˙416˙150.00
5    LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER UK (LONDON) participant 1˙194˙647.00
6    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 957˙480.00
7    UNIVERSIDAD DE ZARAGOZA ES (ZARAGOZA) participant 951˙792.00
8    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 936˙937.00
9    STICHTING BIOMEDICAL PRIMATE RESEARCH CENTER NL (RIJSWIJK ZH) participant 918˙194.00
10    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 755˙642.00
11    UNIVERSITAET ULM DE (ULM) participant 604˙824.00
12    INSTITUT PASTEUR DE LILLE FONDATION FR (LILLE) participant 538˙464.00
13    INSTITUT PASTEUR FR (PARIS CEDEX 15) participant 528˙980.00
14    INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL ES (BADALONA BARCELONA) participant 415˙224.00
15    UNITED KINGDOM RESEARCH AND INNOVATION UK (SWINDON) participant 396˙294.00
16    UNIVERSITY OF CAPE TOWN ZA (RONDEBOSCH) participant 355˙500.00
17    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 308˙100.00
18    STELLENBOSCH UNIVERSITY ZA (STELLENBOSCH) participant 284˙400.00
19    THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS UK (LONDON) participant 252˙686.00
20    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) participant 220˙030.00
21    ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO IT (ROMA) participant 218˙040.00
22    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) participant 218˙040.00
23    ISTITUTO SUPERIORE DI SANITA IT (ROMA) participant 206˙664.00
24    KWAZULU NATAL RESEARCH INSTITUTE FOR TB-HIV (K-RITH) NPC ZA (DURBAN) participant 167˙227.00
25    UNIVERSITY OF STRATHCLYDE UK (GLASGOW) participant 159˙264.00
26    FRIEDRICH LOEFFLER INSTITUT - BUNDESFORSCHUNGSINSTITUT FUER TIERGESUNDHEIT DE (GREIFSWALD-INSEL RIEMS) participant 142˙200.00
27    AZIENDA OSPEDALIERA UNIVERSITARIA POLICLINICO PAOLO GIACCONE DI PALERMO IT (PALERMO) participant 118˙500.00
28    SCIENSANO BE (ELSENE) participant 111˙864.00
29    BANGOR UNIVERSITY UK (BANGOR) participant 23˙700.00
30    UNIVERSITEIT GENT BE (GENT) participant 23˙700.00
31    AERAS GLOBAL TB VACCINE FOUNDATION US (ROCKVILLE MD) participant 0.00
32    ASTON UNIVERSITY UK (BIRMINGHAM) participant 0.00
33    BUNDESINSTITUT FUR IMPFSTOFFE UND BIOMEDIZINISCHE ARZNEIMITTEL DE (LANGEN) participant 0.00
34    CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS CH (LAUSANNE) participant 0.00
35    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) participant 0.00
36    GLAXOSMITHKLINE BIOLOGICALS SA BE (RIXENSART) participant 0.00
37    INSTITUT SCIENTIFIQUE DE SANTE PUBLIQUE BE (BRUXELLES) participant 0.00
38    INTERNATIONAL TUBERCULOSIS RESEARCH CENTER KR (GYEONGSANGNAM DO) participant 0.00
39    MEDICAL RESEARCH COUNCIL UK (SWINDON) participant 0.00
40    THE UNIVERSITY OF SYDNEY AU (SYDNEY) participant 0.00
41    TRANSGENE SA FR (ILLKIRCH-GRAFFENSTADEN) participant 0.00
42    UNIVERSITAT BASEL CH (BASEL) participant 0.00
43    UNIVERSITAT ZURICH CH (ZURICH) participant 0.00
44    UNIVERSITE DE GENEVE CH (GENEVE) participant 0.00
45    UNIVERSITE DE LAUSANNE CH (LAUSANNE) participant 0.00
46    YONSEI UNIVERSITY KR (SEOUL) participant 0.00

Map

 Project objective

The TBVAC2020 proposal builds on the highly successful and long-standing collaborations in subsequent EC-FP5-, FP6- and FP7-funded TB vaccine and biomarker projects, but also brings in a large number of new key partners from excellent laboratories from Europe, USA, Asia, Africa and Australia, many of which are global leaders in the TB field. This was initiated by launching an open call for Expressions of Interest (EoI) prior to this application and to which interested parties could respond. In total, 115 EoIs were received and ranked by the TBVI Steering Committee using proposed H2020 evaluation criteria. This led to the prioritisation of 52 R&D approaches included in this proposal. TBVAC2020 aims to innovate and diversify the current TB vaccine and biomarker pipeline while at the same time applying portfolio management using gating and priority setting criteria to select as early as possible the most promising TB vaccine candidates, and accelerate their development. TBVAC2020 proposes to achieve this by combining creative “bottom-up” approaches for vaccine discovery (WP1), new preclinical models addressing clinical challenges (WP2) and identification and characterisation of correlates of protection (WP5) with a directive “top-down” portfolio management approach aiming to select the most promising TB vaccine candidates by their comparative evaluation using objective gating and priority setting criteria (WP6) and by supporting direct, head-to head or comparative preclinical and early clinical evaluation (WP3, WP4). This approach will both innovate and diversify the existing TB vaccine and biomarker pipeline as well as accelerate development of most promising TB vaccine candidates through early development stages. The proposed approach and involvement of many internationally leading groups in the TB vaccine and biomarker area in TBVAC2020 fully aligns with the Global TB Vaccine Partnerships (GTBVP).

 Deliverables

List of deliverables.
Data from measurements of selected immune mediators Documents, reports 2020-02-26 16:37:33
Evaluation of ex-vivo frequencies, phenotype and functional properties of M.tb-specific CD4- and CD8 Tcells Documents, reports 2020-02-26 16:37:33
Combination of HBHA and adjuvant has been selected Documents, reports 2020-02-26 16:37:33
Correlate the quantity and quality of lipid-specific immune responses in CD1b-transgenic mice, guinea pigs and human Documents, reports 2020-02-26 16:37:33
Validate biomarkers that predict the development of active TB in HIV infected persons Documents, reports 2020-02-26 16:37:33
List of the autophagic and miRNA markers analyzed and correlatio Documents, reports 2020-02-26 16:37:33
Transcriptome analyses of approx. 700 microarrays of Belarus cohort Documents, reports 2020-02-26 16:37:34
RNA expression correlate of functional Documents, reports 2020-02-26 16:37:34
Identification of potential immune correlates from the human mycobacterial challenge model Documents, reports 2020-02-26 16:37:33
Identification of a signature that distinguishes long term non- progressors from recently infected individuals Documents, reports 2020-02-26 16:37:34
Correlates of risk for, and protection from, active TB based on host markers obtained by 4 different analytical platforms on the same participants Documents, reports 2020-02-26 16:37:34
Transcriptomic, immunomic and metabolic correlates of TB infection Documents, reports 2020-02-26 16:37:33
Evaluation of the association between the lymphocyte granule release and cytotoxic molecules, and the clinical status of Mtb infection” Documents, reports 2020-02-26 16:37:33
head-to-head assay comparisons and finalised SOPs for whole blood and PBMC ICS, and MGIA Documents, reports 2020-02-26 16:37:33
Identification of a repertoire of surface molecules on NK cells and DC subsets and related cytokines associated with latent versus active TB Documents, reports 2020-02-26 16:37:33
Bioinformatic signature validation and data integration Documents, reports 2020-02-26 16:37:34
Frequencies of vaccine-induced antigen-specific CD4 and CD8 T cells and their transcriptomic profiles Documents, reports 2020-02-26 16:37:34
3 Annual project meetings Documents, reports 2020-02-26 16:37:33
A first version TB Biomarker data base Documents, reports 2020-02-26 16:37:33
Targeted Luminex analysis to define M.tb-specific soluble host bio-signatures Documents, reports 2020-02-26 16:37:33
Collection of samples from S. Korean LTBI cohort Documents, reports 2020-02-26 16:37:33
Detection of cytotoxic and bactericidal molecules intracellularly a Documents, reports 2020-02-26 16:37:33
Establish Portfolio management committee Documents, reports 2020-02-26 16:37:30
Cohort data base and related specimen bank collection Documents, reports 2020-02-26 16:37:30
Discovery Luminex analysis define key antigen-analyte and dcRT-MLPA RNA analysis combinations Documents, reports 2020-02-26 16:37:31
Global TB vaccine meeting Documents, reports 2020-02-26 16:37:30
Project website established Websites, patent fillings, videos etc. 2020-02-26 16:37:30
Correlates of risk for, and protection from, active TB Documents, reports 2020-02-26 16:37:31
Evaluation of transcriptomic and other immune correlates identified in MVA85A infant efficacy trial Documents, reports 2020-02-26 16:37:30
Identification of transcriptomic biomarkers predictive of an efficient immune response Documents, reports 2020-02-26 16:37:31
Fully optimized protocols for isolation and ICS characterization of Suction Blister Documents, reports 2020-02-26 16:37:31
Evaluate M.tb- and lipid-specific gene- and protein expression in a sample bank Documents, reports 2020-02-26 16:37:30
Obtain the transcriptomic signature of whole blood from HIV infected patients longitudinally on ART Documents, reports 2020-02-26 16:37:31
Systems biology analysis to define biosignatures of protection to latent TB Documents, reports 2020-02-26 16:37:31
correlation of hematopoietic progenitor cell populations Documents, reports 2020-02-26 16:37:30

Take a look to the deliverables list in detail:  detailed list of TBVAC2020 deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Sophie Henrard, Véronique Corbière, Liliane Schandené, Martine Ducarme, Anne Van Praet, Emmanuelle Petit, Mahavir Singh, Camille Locht, Violette Dirix, Françoise Mascart
Proportions of interferon-γ-producing ascites lymphocytes in response to mycobacterial antigens: A help for early diagnosis of peritoneal tuberculosis in a low TB incidence country
published pages: e0214333, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0214333
PLOS ONE 14/4 2020-02-26
2019 David Pejoski, Marie Ballester, Floriane Auderset, Maria Vono, Dennis Christensen, Peter Andersen, Paul-Henri Lambert, Claire-Anne Siegrist
Site-Specific DC Surface Signatures Influence CD4+ T Cell Co-stimulation and Lung-Homing
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01650
Frontiers in Immunology 10 2020-02-26
2019 Catherine Riou, Nishtha Jhilmeet, Molebogeng X Rangaka, Robert J Wilkinson, Katalin A Wilkinson
Tuberculosis antigen-specific T cell responses during the first 6 months of antiretroviral treatment
published pages: , ISSN: 0022-1899, DOI: 10.1093/infdis/jiz417
The Journal of Infectious Diseases 2020-02-26
2018 Frank Vrieling, Katharina Ronacher, Léanie Kleynhans, Erik van den Akker, Gerhard Walzl, Tom H.M. Ottenhoff, Simone A. Joosten
Patients with Concurrent Tuberculosis and Diabetes Have a Pro-Atherogenic Plasma Lipid Profile
published pages: 192-200, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2018.05.011
EBioMedicine 32 2020-02-26
2018 Roberto Nisini, Noemi Poerio, Sabrina Mariotti, Federica De Santis, Maurizio Fraziano
The Multirole of Liposomes in Therapy and Prevention of Infectious Diseases
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00155
Frontiers in Immunology 9 2020-02-26
2017 Gang Pei, Hellen Buijze, Haipeng Liu, Pedro Moura-Alves, Christian Goosmann, Volker Brinkmann, Hiroshi Kawabe, Anca Dorhoi, Stefan H. E. Kaufmann
The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy
published pages: 2041-2055, ISSN: 1554-8627, DOI: 10.1080/15548627.2017.1376160
Autophagy 13/12 2020-02-26
2018 Sergio Arregui, María José Iglesias, Sofía Samper, Dessislava Marinova, Carlos Martin, Joaquín Sanz, Yamir Moreno
Data-driven model for the assessment of Mycobacterium tuberculosis transmission in evolving demographic structures
published pages: E3238-E3245, ISSN: 0027-8424, DOI: 10.1073/pnas.1720606115
Proceedings of the National Academy of Sciences 115/14 2020-02-26
2018 Romain Veyron-Churlet, Vincent Dupres, Jean-Michel Saliou, Frank Lafont, Dominique Raze, Camille Locht
Rv0613c/MSMEG_1285 Interacts with HBHA and Mediates Its Proper Cell-Surface Exposure in Mycobacteria
published pages: 1673, ISSN: 1422-0067, DOI: 10.3390/ijms19061673
International Journal of Molecular Sciences 19/6 2020-02-26
2018 Leonar Arroyo, Diana Marín, Kees L. M. C. Franken, Tom H. M. Ottenhoff, Luis F. Barrera
Potential of DosR and Rpf antigens from Mycobacterium tuberculosis to discriminate between latent and active tuberculosis in a tuberculosis endemic population of Medellin Colombia
published pages: , ISSN: 1471-2334, DOI: 10.1186/s12879-017-2929-0
BMC Infectious Diseases 18/1 2020-02-26
2017 Christophe J. Queval, Roland Brosch, Roxane Simeone
The Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.02284
Frontiers in Microbiology 8 2020-02-26
2018 Jesús Gonzalo-Asensio, Irene Pérez, Nacho Aguiló, Santiago Uranga, Ana Picó, Carlos Lampreave, Alberto Cebollada, Isabel Otal, Sofía Samper, Carlos Martín
New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages
published pages: e1007282, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1007282
PLOS Genetics 14/4 2020-02-26
2019 Linda Petrone, Vincent Bondet, Valentina Vanini, Gilda Cuzzi, Fabrizio Palmieri, Ivana Palucci, Giovanni Delogu, Fabiola Ciccosanti, Gian Maria Fimia, Thomas Blauenfeldt, Morten Ruhwald, Darragh Duffy, Delia Goletti
First description of agonist and antagonist IP-10 in urine of patients with active TB
published pages: 15-21, ISSN: 1201-9712, DOI: 10.1016/j.ijid.2018.09.001
International Journal of Infectious Diseases 78 2020-02-26
2018 Cheleka A. M. Mpande, One B. Dintwe, Munyaradzi Musvosvi, Simbarashe Mabwe, Nicole Bilek, Mark Hatherill, Elisa Nemes, Thomas J. Scriba
Functional, Antigen-Specific Stem Cell Memory (TSCM) CD4+ T Cells Are Induced by Human Mycobacterium tuberculosis Infection
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00324
Frontiers in Immunology 9 2020-02-26
2016 Claudio Counoupas, Rachel Pinto, Gayathri Nagalingam, Grant A Hill-Cawthorne, Carl G Feng, Warwick J Britton, James A Triccas
Mycobacterium tuberculosis components expressed during chronic infection of the lung contribute to long-term control of pulmonary tuberculosis in mice
published pages: , ISSN: 2059-0105, DOI: 10.1038/npjvaccines.2016.12
npj Vaccines 1/1 2020-02-26
2017 D. Barlerin, G. Bessière, J. Domingues, M. Schuette, C. Feuillet, A. Peixoto
Biosafety Level 3 setup for multiphoton microscopy in vivo
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-00702-x
Scientific Reports 7/1 2020-02-26
2018 Andrea Zelmer, Lisa Stockdale, Satria A. Prabowo, Felipe Cia, Natasha Spink, Matthew Gibb, Ayad Eddaoudi, Helen A. Fletcher
High monocyte to lymphocyte ratio is associated with impaired protection after subcutaneous administration of BCG in a mouse model of tuberculosis
published pages: 296, ISSN: 2046-1402, DOI: 10.12688/f1000research.14239.1
F1000Research 7 2020-02-26
2018 Thomas Blauenfeldt, Linda Petrone, Franca del Nonno, Andrea Baiocchini, Laura Falasca, Teresa Chiacchio, Vincent Bondet, Valentina Vanini, Fabrizio Palmieri, Gianni Galluccio, Armanda Casrouge, Jesper Eugen-Olsen, Matthew L. Albert, Delia Goletti, Darragh Duffy, Morten Ruhwald
Interplay of DDP4 and IP-10 as a Potential Mechanism for Cell Recruitment to Tuberculosis Lesions
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01456
Frontiers in Immunology 9 2020-02-26
2017 John Espen Gjøen, Synne Jenum, Dhanasekaran Sivakumaran, Aparna Mukherjee, Ragini Macaden, Sushil K. Kabra, Rakesh Lodha, Tom H. M. Ottenhoff, Marielle C. Haks, Timothy Mark Doherty, Christian Ritz, Harleen M. S. Grewal
Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-05057-x
Scientific Reports 7/1 2020-02-26
2016 Helen A. Fletcher
Sleeping Beauty and the Story of the Bacille Calmette-Guérin Vaccine
published pages: , ISSN: 2150-7511, DOI: 10.1128/mBio.01370-16
mBio 7/4 2020-02-26
2018 Louis S. Ates, Fadel Sayes, Wafa Frigui, Roy Ummels, Merel P. M. Damen, Daria Bottai, Marcel A. Behr, Jeroen W. J. van Heijst, Wilbert Bitter, Laleh Majlessi, Roland Brosch
RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection
published pages: e1007139, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1007139
PLOS Pathogens 14/6 2020-02-26
2018 Natalie E. Nieuwenhuizen, Stefan H. E. Kaufmann
Next-Generation Vaccines Based on Bacille Calmette–Guérin
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00121
Frontiers in Immunology 9 2020-02-26
2018 Marco Lepore, Lucia Mori, Gennaro De Libero
The Conventional Nature of Non-MHC-Restricted T Cells
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01365
Frontiers in Immunology 9 2020-02-26
2018 Mariateresa Coppola, Susan J. F. van den Eeden, Naoko Robbins, Louis Wilson, Kees L. M. C. Franken, Linda B. Adams, Tom P. Gillis, Tom H. M. Ottenhoff, Annemieke Geluk
Vaccines for Leprosy and Tuberculosis: Opportunities for Shared Research, Development, and Application
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00308
Frontiers in Immunology 9 2020-02-26
2015 Ulrich von Both, Myrsini Kaforou, Michael Levin, Sandra M. Newton
Understanding immune protection against tuberculosis using RNA expression profiling
published pages: 5289-5293, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2015.05.025
Vaccine 33/40 2020-02-26
2018 Valentina Orlando, Marco P. La Manna, Delia Goletti, Fabrizio Palmieri, Elena Lo Presti, Simone A. Joosten, Carmela La Mendola, Simona Buccheri, Tom H. M. Ottenhoff, Francesco Dieli, Nadia Caccamo
Human CD4 T-Cells With a Naive Phenotype Produce Multiple Cytokines During Mycobacterium Tuberculosis Infection and Correlate With Active Disease
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01119
Frontiers in Immunology 9 2020-02-26
2018 Stéphane Leung-Theung-Long, Charles-Antoine Coupet, Marie Gouanvic, Doris Schmitt, Aurélie Ray, Chantal Hoffmann, Huguette Schultz, Sandeep Tyagi, Heena Soni, Paul J. Converse, Lilibeth Arias, Patricia Kleinpeter, Benoît Sansas, Khisimuzi Mdluli, Cristina Vilaplana, Pere-Joan Cardona, Eric Nuermberger, Jean-Baptiste Marchand, Nathalie Silvestre, Geneviève Inchauspé
A multi-antigenic MVA vaccine increases efficacy of combination chemotherapy against Mycobacterium tuberculosis
published pages: e0196815, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0196815
PLOS ONE 13/5 2020-02-26
2017 Teresa Chiacchio, Giovanni Delogu, Valentina Vanini, Gilda Cuzzi, Flavio De Maio, Carmela Pinnetti, Alessandro Sampaolesi, Andrea Antinori, Delia Goletti
Immune characterization of the HBHA-specific response in Mycobacterium tuberculosis-infected patients with or without HIV infection
published pages: e0183846, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0183846
PLOS ONE 12/8 2020-02-26
2017 Aïcha Bah, Isabelle Vergne
Macrophage Autophagy and Bacterial Infections
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.01483
Frontiers in Immunology 8 2020-02-26
2019 Frank Vrieling, Louis Wilson, Patrick C. N. Rensen, Gerhard Walzl, Tom H. M. Ottenhoff, Simone A. Joosten
Oxidized low-density lipoprotein (oxLDL) supports Mycobacterium tuberculosis survival in macrophages by inducing lysosomal dysfunction
published pages: e1007724, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1007724
PLOS Pathogens 15/4 2020-02-26
2018 Jeroen Maertzdorf, Mario Tönnies, Laura Lozza, Sandra Schommer-Leitner, Hans Mollenkopf, Torsten T. Bauer, Stefan H. E. Kaufmann
Mycobacterium tuberculosis Invasion of the Human Lung: First Contact
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01346
Frontiers in Immunology 9 2020-02-26
2018 Line L. Holm, Milica Vukmanovic-Stejic, Thomas Blauenfeldt, Thomas Benfield, Peter Andersen, Arne N. Akbar, Morten Ruhwald
A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
published pages: , ISSN: 1940-087X, DOI: 10.3791/57554
Journal of Visualized Experiments 138 2020-02-26
2016 Daria Bottai, Roland Brosch
The BCG Strain Pool: Diversity Matters
published pages: 201-203, ISSN: 1525-0016, DOI: 10.1038/mt.2016.18
Molecular Therapy 24/2 2020-02-26
2016 Joshua S. Woodworth, Peter Andersen
Reprogramming the T Cell Response to Tuberculosis
published pages: 81-83, ISSN: 1471-4906, DOI: 10.1016/j.it.2015.12.009
Trends in Immunology 37/2 2020-02-26
2017 Matthias I. Gröschel, Fadel Sayes, Sung Jae Shin, Wafa Frigui, Alexandre Pawlik, Mickael Orgeur, Robin Canetti, Nadine Honoré, Roxane Simeone, Tjip S. van der Werf, Wilbert Bitter, Sang-Nae Cho, Laleh Majlessi, Roland Brosch
Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection
published pages: 2752-2765, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.02.057
Cell Reports 18/11 2020-02-26
2017 Marco Cavallari, Gennaro De Libero
From Immunologically Archaic to Neoteric Glycovaccines
published pages: 4, ISSN: 2076-393X, DOI: 10.3390/vaccines5010004
Vaccines 5/4 2020-02-26
2016 Steven G. Smith, Andrea Zelmer, Rose Blitz, Helen A. Fletcher, Hazel M. Dockrell
Polyfunctional CD4 T-cells correlate with in vitro mycobacterial growth inhibition following Mycobacterium bovis BCG-vaccination of infants
published pages: 5298-5305, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2016.09.002
Vaccine 34/44 2020-02-26
2017 Luisa Paris, Ruben Magni, Fatima Zaidi, Robyn Araujo, Neal Saini, Michael Harpole, Jorge Coronel, Daniela E. Kirwan, Hannah Steinberg, Robert H. Gilman, Emanuel F. Petricoin, Roberto Nisini, Alessandra Luchini, Lance Liotta
Urine lipoarabinomannan glycan in HIV-negative patients with pulmonary tuberculosis correlates with disease severity
published pages: eaal2807, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aal2807
Science Translational Medicine 9/420 2020-02-26
2016 Helen A. Fletcher, Margaret A. Snowden, Bernard Landry, Wasima Rida, Iman Satti, Stephanie A. Harris, Magali Matsumiya, Rachel Tanner, Matthew K. O’Shea, Veerabadran Dheenadhayalan, Leah Bogardus, Lisa Stockdale, Leanne Marsay, Agnieszka Chomka, Rachel Harrington-Kandt, Zita-Rose Manjaly-Thomas, Vivek Naranbhai, Elena Stylianou, Fatoumatta Darboe, Adam Penn-Nicholson, Elisa Nemes, Mark Hatheril, Gregory Hussey, Hassan Mahomed, Michele Tameris, J Bruce McClain, Thomas G. Evans, Willem A. Hanekom, Thomas J. Scriba, Helen McShane
T-cell activation is an immune correlate of risk in BCG vaccinated infants
published pages: 11290, ISSN: 2041-1723, DOI: 10.1038/ncomms11290
Nature Communications 7 2020-02-26
2018 Thomas Lindenstrøm, Albanus Moguche, Mie Damborg, Else Marie Agger, Kevin Urdahl, Peter Andersen
T Cells Primed by Live Mycobacteria Versus a Tuberculosis Subunit Vaccine Exhibit Distinct Functional Properties
published pages: 27-39, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2017.12.004
EBioMedicine 27 2020-02-26
2017 Christina Jensen, Line Lindebo Holm, Erik Svensson, Claus Aagaard, Morten Ruhwald
Optimisation of a murine splenocyte mycobacterial growth inhibition assay using virulent Mycobacterium tuberculosis
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-02116-1
Scientific Reports 7/1 2020-02-26
2016 Muriel Smet, Charlotte Pollard, Ans De Beuckelaer, Lien Van Hoecke, Seppe Vander Beken, Stefaan De Koker, Juma\'a R. Al Dulayymi, Kris Huygen, Jan Verschoor, Mark S. Baird, Johan Grooten
Mycobacterium tuberculosis -associated synthetic mycolates differentially exert immune stimulatory adjuvant activity
published pages: 2149-2154, ISSN: 0014-2980, DOI: 10.1002/eji.201646357
European Journal of Immunology 46/9 2020-02-26
2016 E. Kaufmann, C. Spohr, S. Battenfeld, D. De Paepe, T. Holzhauser, E. Balks, S. Homolka, N. Reiling, M. Gilleron, M. Bastian
BCG Vaccination Induces Robust CD4+ T Cell Responses to Mycobacterium tuberculosis Complex-Specific Lipopeptides in Guinea Pigs
published pages: 2723-2732, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1502307
The Journal of Immunology 196/6 2020-02-26
2016 Helen A. Fletcher, Ali Filali-Mouhim, Elisa Nemes, Anthony Hawkridge, Alana Keyser, Samuel Njikan, Mark Hatherill, Thomas J. Scriba, Brian Abel, Benjamin M. Kagina, Ashley Veldsman, Nancy Marín Agudelo, Gilla Kaplan, Gregory D. Hussey, Rafick-Pierre Sekaly, Willem A. Hanekom
Human newborn bacille Calmette–Guérin vaccination and risk of tuberculosis disease: a case-control study
published pages: , ISSN: 1741-7015, DOI: 10.1186/s12916-016-0617-3
BMC Medicine 14/1 2020-02-26
2017 Inmaculada Yruela, Bruno Contreras-Moreira, Carlos Magalhães, Nuno S. Osório, Jesús Gonzalo-Asensio
Mycobacterium tuberculosis Complex Exhibits Lineage-Specific Variations Affecting Protein Ductility and Epitope Recognition
published pages: evw279, ISSN: 1759-6653, DOI: 10.1093/gbe/evw279
Genome Biology and Evolution 2020-02-26
2016 Sameer Joshi, Maryam T. Hussain, Carla B. Roces, Giulia Anderluzzi, Elisabeth Kastner, Stefano Salmaso, Daniel J. Kirby, Yvonne Perrie
Microfluidics based manufacture of liposomes simultaneously entrapping hydrophilic and lipophilic drugs
published pages: 160-168, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2016.09.027
International Journal of Pharmaceutics 514/1 2020-02-26
2016 James A. Triccas, Claudio Counoupas
Novel vaccination approaches to prevent tuberculosis in children
published pages: , ISSN: 2200-6133, DOI: 10.1186/s41479-016-0020-z
Pneumonia 8/1 2020-02-26
2015 Mariateresa Coppola, Susan J. F. van den Eeden, Louis Wilson, Kees L. M. C. Franken, Tom H. M. Ottenhoff, Annemieke Geluk
Synthetic Long Peptide Derived from Mycobacterium tuberculosis Latency Antigen Rv1733c Protects against Tuberculosis
published pages: 1060-1069, ISSN: 1556-6811, DOI: 10.1128/CVI.00271-15
Clinical and Vaccine Immunology 22/9 2020-02-26
2015 Steven G. Smith, Kaatje Smits, Simone A. Joosten, Krista E. van Meijgaarden, Iman Satti, Helen A. Fletcher, Nadia Caccamo, Francesco Dieli, Francoise Mascart, Helen McShane, Hazel M. Dockrell, Tom H. M. Ottenhoff
Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines
published pages: e0138042, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0138042
PLOS ONE 10/9 2020-02-26
2016 Hermann Giresse Tima, Kris Huygen, Marta Romano
Innate signaling by mycobacterial cell wall components and relevance for development of adjuvants for subunit vaccines
published pages: 1409-1420, ISSN: 1476-0584, DOI: 10.1080/14760584.2016.1187067
Expert Review of Vaccines 15/11 2020-02-26
2016 Daniel E Zak, Adam Penn-Nicholson, Thomas J Scriba, Ethan Thompson, Sara Suliman, Lynn M Amon, Hassan Mahomed, Mzwandile Erasmus, Wendy Whatney, Gregory D Hussey, Deborah Abrahams, Fazlin Kafaar, Tony Hawkridge, Suzanne Verver, E Jane Hughes, Martin Ota, Jayne Sutherland, Rawleigh Howe, Hazel M Dockrell, W Henry Boom, Bonnie Thiel, Tom H M Ottenhoff, Harriet Mayanja-Kizza, Amelia C Crampin, Katrina Downing, Mark Hatherill, Joe Valvo, Smitha Shankar, Shreemanta K Parida, Stefan H E Kaufmann, Gerhard Walzl, Alan Aderem, Willem A Hanekom
A blood RNA signature for tuberculosis disease risk: a prospective cohort study
published pages: 2312-2322, ISSN: 0140-6736, DOI: 10.1016/S0140-6736(15)01316-1
The Lancet 387/10035 2020-02-26
2017 Jesus Gonzalo-Asensio, Dessislava Marinova, Carlos Martin, Nacho Aguilo
MTBVAC: Attenuating the Human Pathogen of Tuberculosis (TB) Toward a Promising Vaccine against the TB Epidemic
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.01803
Frontiers in Immunology 8 2020-02-26
2015 Etienne Caron, Lucia Espona, Daniel J Kowalewski, Heiko Schuster, Nicola Ternette, Adán Alpízar, Ralf B Schittenhelm, Sri H Ramarathinam, Cecilia S Lindestam Arlehamn, Ching Chiek Koh, Ludovic C Gillet, Armin Rabsteyn, Pedro Navarro, Sangtae Kim, Henry Lam, Theo Sturm, Miguel Marcilla, Alessandro Sette, David S Campbell, Eric W Deutsch, Robert L Moritz, Anthony W Purcell, Hans-Georg Rammensee, Stefan Stevanovic, Ruedi Aebersold
An open-source computational and data resource to analyze digital maps of immunopeptidomes
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.07661
eLife 4 2020-02-26
2018 Rolf Billeskov, Thomas Lindenstrøm, Joshua Woodworth, Cristina Vilaplana, Pere-Joan Cardona, Joseph P. Cassidy, Rasmus Mortensen, Else Marie Agger, Peter Andersen
High Antigen Dose Is Detrimental to Post-Exposure Vaccine Protection against Tuberculosis
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.01973
Frontiers in Immunology 8 2020-02-26
2017 Natalie E. Nieuwenhuizen, Prasad S. Kulkarni, Umesh Shaligram, Mark F. Cotton, Cyrill A. Rentsch, Bernd Eisele, Leander Grode, Stefan H. E. Kaufmann
The Recombinant Bacille Calmette–Guérin Vaccine VPM1002: Ready for Clinical Efficacy Testing
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.01147
Frontiers in Immunology 8 2020-02-26
2016 Fadel Sayes, Alexandre Pawlik, Wafa Frigui, Matthias I. Gröschel, Samuel Crommelynck, Catherine Fayolle, Felipe Cia, Gregory J. Bancroft, Daria Bottai, Claude Leclerc, Roland Brosch, Laleh Majlessi
CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection
published pages: e1005770, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1005770
PLOS Pathogens 12/7 2020-02-26
2017 Vimal K. Udhayakumar, Ans De Beuckelaer, Joanne McCaffrey, Cian M. McCrudden, Jonathan L. Kirschman, Daryll Vanover, Lien Van Hoecke, Kenny Roose, Kim Deswarte, Bruno G. De Geest, Stefan Lienenklaus, Philip J. Santangelo, Johan Grooten, Helen O. McCarthy, Stefaan De Koker
Arginine-Rich Peptide-Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide
published pages: 1601412, ISSN: 2192-2640, DOI: 10.1002/adhm.201601412
Advanced Healthcare Materials 6/13 2020-02-26
2017 Neesha Rockwood, Diego L. Costa, Eduardo P. Amaral, Elsa Du Bruyn, Andre Kubler, Leonardo Gil-Santana, Kiyoshi F. Fukutani, Charles A. Scanga, JoAnne L. Flynn, Sharon H. Jackson, Katalin A. Wilkinson, William R. Bishai, Alan Sher, Robert J. Wilkinson, Bruno B. Andrade
Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.00542
Frontiers in Immunology 8 2020-02-26
2017 Steven G. Smith, Johanneke Kleinnijenhuis, Mihai G. Netea, Hazel M. Dockrell
Whole Blood Profiling of Bacillus Calmette–Guérin-Induced Trained Innate Immunity in Infants Identifies Epidermal Growth Factor, IL-6, Platelet-Derived Growth Factor-AB/BB, and Natural Killer Cell Activation
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.00644
Frontiers in Immunology 8 2020-02-26
2017 Alexandra Dreesman, Véronique Corbière, Violette Dirix, Kaat Smits, Sara Debulpaep, Iris De Schutter, Myriam Libin, Mahavir Singh, Anne Malfroot, Camille Locht, Françoise Mascart
Age-Stratified T Cell Responses in Children Infected with Mycobacterium tuberculosis
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.01059
Frontiers in Immunology 8 2020-02-26
2016 Martin Gengenbacher, Peggy Kaiser, Stefanie Schuerer, Doris Lazar, Stefan H.E. Kaufmann
Post-exposure vaccination with the vaccine candidate Bacillus Calmette–Guérin ΔureC::hly induces superior protection in a mouse model of subclinical tuberculosis
published pages: 364-368, ISSN: 1286-4579, DOI: 10.1016/j.micinf.2016.03.005
Microbes and Infection 18/5 2020-02-26
2016 Ekta Lachmandas, Macarena Beigier-Bompadre, Shih-Chin Cheng, Vinod Kumar, Arjan van Laarhoven, Xinhui Wang, Anne Ammerdorffer, Lily Boutens, Dirk de Jong, Thirumala-Devi Kanneganti, Mark S. Gresnigt, Tom H.M. Ottenhoff, Leo A.B. Joosten, Rinke Stienstra, Cisca Wijmenga, Stefan H.E. Kaufmann, Reinout van Crevel, Mihai G. Netea
Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells
published pages: 2574-2586, ISSN: 0014-2980, DOI: 10.1002/eji.201546259
European Journal of Immunology 46/11 2020-02-26
2017 Claudio Counoupas, Rachel Pinto, Gayathri Nagalingam, Warwick J. Britton, Nikolai Petrovsky, James A. Triccas
Delta inulin-based adjuvants promote the generation of polyfunctional CD4+ T cell responses and protection against Mycobacterium tuberculosis infection
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-09119-y
Scientific Reports 7/1 2020-02-26
2015 Stephanie Kallert, Sebastian F. Zenk, Paul Walther, Mark Grieshober, Tanja Weil, Steffen Stenger
Liposomal delivery of lipoarabinomannan triggers Mycobacterium tuberculosis specific T-cells
published pages: 452-462, ISSN: 1472-9792, DOI: 10.1016/j.tube.2015.04.001
Tuberculosis 95/4 2020-02-26
2015 J. Maertzdorf, S.H.E. Kaufmann, J. Weiner
Molecular signatures for vaccine development
published pages: 5256-5261, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2015.03.075
Vaccine 33/40 2020-02-26
2015 Maria M. Esterhuyse, January Weiner, Etienne Caron, Andre G. Loxton, Marco Iannaccone, Chandre Wagman, Philippe Saikali, Kim Stanley, Witold E. Wolski, Hans-Joachim Mollenkopf, Matthias Schick, Ruedi Aebersold, Heinz Linhart, Gerhard Walzl, Stefan H. E. Kaufmann
Epigenetics and Proteomics Join Transcriptomics in the Quest for Tuberculosis Biomarkers
published pages: e01187-15, ISSN: 2150-7511, DOI: 10.1128/mBio.01187-15
mBio 6/5 2020-02-26
2017 Nacho Aguilo, Jesus Gonzalo-Asensio, Samuel Alvarez-Arguedas, Dessislava Marinova, Ana Belen Gomez, Santiago Uranga, Ralf Spallek, Mahavir Singh, Regine Audran, François Spertini, Carlos Martin
Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis
published pages: 16085, ISSN: 2041-1723, DOI: 10.1038/ncomms16085
Nature Communications 8 2020-02-26
2017 Stefan H.E. Kaufmann, January Weiner, C. Fordham von Reyn
Novel approaches to tuberculosis vaccine development
published pages: 263-267, ISSN: 1201-9712, DOI: 10.1016/j.ijid.2016.10.018
International Journal of Infectious Diseases 56 2020-02-26
2017 January Weiner, Stefan H.E. Kaufmann
High-throughput and computational approaches for diagnostic and prognostic host tuberculosis biomarkers
published pages: 258-262, ISSN: 1201-9712, DOI: 10.1016/j.ijid.2016.10.017
International Journal of Infectious Diseases 56 2020-02-26
2015 Esther Broset, Carlos Martín, Jesús Gonzalo-Asensio
Evolutionary Landscape of the Mycobacterium tuberculosis Complex from the Viewpoint of PhoPR: Implications for Virulence Regulation and Application to Vaccine Development
published pages: e01289-15, ISSN: 2150-7511, DOI: 10.1128/mBio.01289-15
mBio 6/5 2020-02-26
2016 Anca Dorhoi, Stefan H.E. Kaufmann
Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis
published pages: 153-166, ISSN: 1863-2297, DOI: 10.1007/s00281-015-0531-3
Seminars in Immunopathology 38/2 2020-02-26
2017 Marco Lepore, Artem Kalinichenko, Salvatore Calogero, Pavanish Kumar, Bhairav Paleja, Mathias Schmaler, Vipin Narang, Francesca Zolezzi, Michael Poidinger, Lucia Mori, Gennaro De Libero
Functionally diverse human T cells recognize non-microbial antigens presented by MR1
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.24476
eLife 6 2020-02-26
2017 Dessislava Marinova, Jesus Gonzalo-Asensio, Nacho Aguilo, Carlos Martin
MTBVAC from discovery to clinical trials in tuberculosis-endemic countries
published pages: 565-576, ISSN: 1476-0584, DOI: 10.1080/14760584.2017.1324303
Expert Review of Vaccines 16/6 2020-02-26
2017 Hermann Giresse Tima, Juma\'\'a Raheem Al Dulayymi, Olivier Denis, Pauline Lehebel, Klarah Sherzad Baols, Mohsin Omar Mohammed, Laurent L\'Homme, Mohaned Mohammed Sahb, Georges Potemberg, Sylvie Legrand, Roland Lang, Rudi Beyaert, Jacques Piette, Mark Stephen Baird, Kris Huygen, Marta Romano
Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis
published pages: 162-180, ISSN: 1662-811X, DOI: 10.1159/000450955
Journal of Innate Immunity 9/2 2020-02-26
2016 Santiago Uranga, Dessislava Marinova, Carlos Martin, Julián Pardo, Nacho Aguilo
Granzyme A Is Expressed in Mouse Lungs during Mycobacterium tuberculosis Infection but Does Not Contribute to Protection In Vivo
published pages: e0153028, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0153028
PLOS ONE 11/4 2020-02-26
2016 J S Woodworth, S B Cohen, A O Moguche, C R Plumlee, E M Agger, K B Urdahl, P Andersen
Subunit vaccine H56/CAF01 induces a population of circulating CD4 T cells that traffic into the Mycobacterium tuberculosis-infected lung
published pages: 555-564, ISSN: 1933-0219, DOI: 10.1038/mi.2016.70
Mucosal Immunology 10/2 2020-02-26
2016 Natalie Zimmermann, Verena Thormann, Bo Hu, Anne‐Britta Köhler, Aki Imai‐Matsushima, Camille Locht, Eusondia Arnett, Larry S Schlesinger, Thomas Zoller, Mariana Schürmann, Stefan HE Kaufmann, Hedda Wardemann
Human isotype‐dependent inhibitory antibody responses against Mycobacterium tuberculosis
published pages: 1325-1339, ISSN: 1757-4676, DOI: 10.15252/emmm.201606330
EMBO Molecular Medicine 8/11 2020-02-26
2017 Yvonne Perrie, Elisabeth Kastner, Swapnil Khadke, Carla B. Roces, Peter Stone
Manufacturing Methods for Liposome Adjuvants
published pages: 127-144, ISSN: , DOI: 10.1007/978-1-4939-6445-1_9
2020-02-26
2017 Rachel Tanner, Matthew K. O’Shea, Andrew D. White, Julius Müller, Rachel Harrington-Kandt, Magali Matsumiya, Mike J. Dennis, Eneida A. Parizotto, Stephanie Harris, Elena Stylianou, Vivek Naranbhai, Paulo Bettencourt, Hal Drakesmith, Sally Sharpe, Helen A. Fletcher, Helen McShane
The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays
published pages: 43478, ISSN: 2045-2322, DOI: 10.1038/srep43478
Scientific Reports 7 2020-02-26
2017 Jesus Gonzalo-Asensio, Nacho Aguilo, Dessislava Marinova, Carlos Martin
Breaking Transmission with Vaccines: The Case of Tuberculosis
published pages: , ISSN: 2165-0497, DOI: 10.1128/microbiolspec.MTBP-0001-2016
Microbiology Spectrum 5/4 2020-02-26
2017 Noemi Poerio, Francesca Bugli, Francesco Taus, Marilina B. Santucci, Carlo Rodolfo, Francesco Cecconi, Riccardo Torelli, Francesco Varone, Riccardo Inchingolo, Fabio Majo, Vincenzina Lucidi, Sabrina Mariotti, Roberto Nisini, Maurizio Sanguinetti, Maurizio Fraziano
Liposomes loaded with bioactive lipids enhance antibacterial innate immunity irrespective of drug resistance
published pages: 45120, ISSN: 2045-2322, DOI: 10.1038/srep45120
Scientific Reports 7 2020-02-26
2017 Marco Pio La Manna, Valentina Orlando, Francesco Dieli, Paola Di Carlo, Antonio Cascio, Gilda Cuzzi, Fabrizio Palmieri, Delia Goletti, Nadia Caccamo
Quantitative and qualitative profiles of circulating monocytes may help identifying tuberculosis infection and disease stages
published pages: e0171358, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0171358
PLOS ONE 12/2 2020-02-26
2015 Kaatje Smits Veronique
Immunological Signatures Identifying Different Stages of Latent Mycobacterium tuberculosis Infection and Discriminating Latent from Active Tuberculosis in Humans
published pages: , ISSN: 2155-9899, DOI: 10.4172/2155-9899.1000341
Journal of Clinical & Cellular Immunology 06/04 2020-02-26
2016 Emilie Dumas, Eva Christina Boritsch, Mathias Vandenbogaert, Ricardo C. Rodríguez de la Vega, Jean-Michel Thiberge, Valerie Caro, Jean-Louis Gaillard, Beate Heym, Fabienne Girard-Misguich, Roland Brosch, Guillaume Sapriel
Mycobacterial Pan-Genome Analysis Suggests Important Role of Plasmids in the Radiation of Type VII Secretion Systems
published pages: 387-402, ISSN: 1759-6653, DOI: 10.1093/gbe/evw001
Genome Biology and Evolution 8/2 2020-02-26
2015 Truc Hoang, Else Marie Agger, Joseph P. Cassidy, Jan P. Christensen, Peter Andersen
Protein Energy Malnutrition during Vaccination Has Limited Influence on Vaccine Efficacy but Abolishes Immunity if Administered during Mycobacterium tuberculosis Infection
published pages: 2118-2126, ISSN: 0019-9567, DOI: 10.1128/IAI.03030-14
Infection and Immunity 83/5 2020-02-26
2017 Stefan H. E. Kaufmann, Hazel M. Dockrell, Nick Drager, Mei Mei Ho, Helen McShane, Olivier Neyrolles, Tom H. M. Ottenhoff, Brij Brij, Danielle Roordink, François Spertini, Steffen Stenger, Jelle Thole, Frank A. W. Verreck, Ann Williams
TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.01203
Frontiers in Immunology 8 2020-02-26
2017 Wenguang Shao, Patrick G A Pedrioli, Witold Wolski, Cristian Scurtescu, Emanuel Schmid, Juan A Vizcaíno, Mathieu Courcelles, Heiko Schuster, Daniel Kowalewski, Fabio Marino, Cecilia S L Arlehamn, Kerrie Vaughan, Bjoern Peters, Alessandro Sette, Tom H M Ottenhoff, Krista E Meijgaarden, Natalie Nieuwenhuizen, Stefan H E Kaufmann, Ralph Schlapbach, John C Castle, Alexey I Nesvizhskii, Morten Nielsen, Eric W Deutsch, David S Campbell, Robert L Moritz, Roman A Zubarev, Anders Jimmy Ytterberg, Anthony W Purcell, Miguel Marcilla, Alberto Paradela, Qi Wang, Catherine E Costello, Nicola Ternette, Peter A van Veelen, Cécile A C M van Els, Albert J R Heck, Gustavo A de Souza, Ludvig M Sollid, Arie Admon, Stefan Stevanovic, Hans-Georg Rammensee, Pierre Thibault, Claude Perreault, Michal Bassani-Sternberg, Ruedi Aebersold, Etienne Caron
The SysteMHC Atlas project
published pages: D1237-D1247, ISSN: 0305-1048, DOI: 10.1093/nar/gkx664
Nucleic Acids Research 46/D1 2020-02-26
2016 Nacho Aguilo, Santiago Uranga, Dessislava Marinova, Marta Monzon, Juan Badiola, Carlos Martin
MTBVAC vaccine is safe, immunogenic and confers protective efficacy against Mycobacterium tuberculosis in newborn mice
published pages: 71-74, ISSN: 1472-9792, DOI: 10.1016/j.tube.2015.10.010
Tuberculosis 96 2020-02-26
2017 Catherine Riou, Natacha Berkowitz, Rene Goliath, Wendy A. Burgers, Robert J. Wilkinson
Analysis of the Phenotype of Mycobacterium tuberculosis-Specific CD4+ T Cells to Discriminate Latent from Active Tuberculosis in HIV-Uninfected and HIV-Infected Individuals
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.00968
Frontiers in Immunology 8 2020-02-26
2017 Raj Badhan, Swapnil Khadke, Yvonne Perrie
Application of Pharmacokinetics Modelling to Predict Human Exposure of a Cationic Liposomal Subunit Antigen Vaccine System
published pages: 57, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics9040057
Pharmaceutics 9/4 2020-02-26
2018 Teresa Prezzemolo, Krista E. van Meijgaarden, Kees L.M.C. Franken, Nadia Caccamo, Francesco Dieli, Tom H.M. Ottenhoff, Simone A. Joosten
Detailed characterization of human Mycobacterium tuberculosis specific HLA-E restricted CD8 + T cells
published pages: 293-305, ISSN: 0014-2980, DOI: 10.1002/eji.201747184
European Journal of Immunology 48/2 2020-02-26
2016 Andrea Zelmer, Rachel Tanner, Elena Stylianou, Timon Damelang, Sheldon Morris, Angelo Izzo, Ann Williams, Sally Sharpe, Ilaria Pepponi, Barry Walker, David A. Hokey, Helen McShane, Michael Brennan, Helen Fletcher
A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis
published pages: , ISSN: 1471-2334, DOI: 10.1186/s12879-016-1751-4
BMC Infectious Diseases 16/1 2020-02-26
2017 Etienne Caron, Ruedi Aebersold, Amir Banaei-Esfahani, Chloe Chong, Michal Bassani-Sternberg
A Case for a Human Immuno-Peptidome Project Consortium
published pages: 203-208, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2017.07.010
Immunity 47/2 2020-02-26
2017 Ans De Beuckelaer, Johan Grooten, Stefaan De Koker
Type I Interferons Modulate CD8+ T Cell Immunity to mRNA Vaccines
published pages: 216-226, ISSN: 1471-4914, DOI: 10.1016/j.molmed.2017.01.006
Trends in Molecular Medicine 23/3 2020-02-26
2016 Nadia Caccamo, Francesco Dieli
Inflammation and the coagulation system in tuberculosis: Tissue Factor leads the dance
published pages: 303-306, ISSN: 0014-2980, DOI: 10.1002/eji.201546225
European Journal of Immunology 46/2 2020-02-26
2016 Stefan H.E. Kaufmann, Anca Dorhoi
Molecular Determinants in Phagocyte-Bacteria Interactions
published pages: 476-491, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2016.02.014
Immunity 44/3 2020-02-26
2016 Mariateresa Coppola, Krista E. van Meijgaarden, Kees L. M. C. Franken, Susanna Commandeur, Gregory Dolganov, Igor Kramnik, Gary K. Schoolnik, Inaki Comas, Ole Lund, Corine Prins, Susan J. F. van den Eeden, Gro E. Korsvold, Fredrik Oftung, Annemieke Geluk, Tom H. M. Ottenhoff
New Genome-Wide Algorithm Identifies Novel In-Vivo Expressed Mycobacterium Tuberculosis Antigens Inducing Human T-Cell Responses with Classical and Unconventional Cytokine Profiles
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep37793
Scientific Reports 6/1 2020-02-26
2015 January Weiner, Stefan H.E. Kaufmann, Jeroen Maertzdorf
High-throughput data analysis and data integration for vaccine trials
published pages: 5249-5255, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2015.04.096
Vaccine 33/40 2020-02-26
2016 Elodie Mohr, Claire-Anne Siegrist
Vaccination in early life: standing up to the challenges
published pages: 1-8, ISSN: 0952-7915, DOI: 10.1016/j.coi.2016.04.004
Current Opinion in Immunology 41 2020-02-26
2017 Sabrina Mariotti, Manuela Pardini, Raffaela Teloni, Maria Cristina Gagliardi, Maurizio Fraziano, Roberto Nisini
A method permissive to fixation and permeabilization for the multiparametric analysis of apoptotic and necrotic cell phenotype by flow cytometry
published pages: 1115-1124, ISSN: 1552-4922, DOI: 10.1002/cyto.a.23268
Cytometry Part A 91/11 2020-02-26
2017 Michael J. Brennan, Rachel Tanner, Sheldon Morris, Thomas J. Scriba, Jacqueline M. Achkar, Andrea Zelmer, David A. Hokey, Angelo Izzo, Sally Sharpe, Ann Williams, Adam Penn-Nicholson, Mzwandile Erasmus, Elena Stylianou, Daniel F. Hoft, Helen McShane, Helen A. Fletcher
The Cross-Species Mycobacterial Growth Inhibition Assay (MGIA) Project, 2010–2014
published pages: e00142-17, ISSN: 1556-6811, DOI: 10.1128/CVI.00142-17
Clinical and Vaccine Immunology 24/9 2020-02-26
2016 Carla Roces, Elisabeth Kastner, Peter Stone, Deborah Lowry, Yvonne Perrie
Rapid Quantification and Validation of Lipid Concentrations within Liposomes
published pages: 29, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics8030029
Pharmaceutics 8/4 2020-02-26
2017 Hazel M. Dockrell, Steven G. Smith
What Have We Learnt about BCG Vaccination in the Last 20 Years?
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.01134
Frontiers in Immunology 8 2020-02-26
2016 Sergio Arregui, Joaquín Sanz, Dessislava Marinova, Carlos Martín, Yamir Moreno
On the impact of masking and blocking hypotheses for measuring the efficacy of new tuberculosis vaccines
published pages: e1513, ISSN: 2167-8359, DOI: 10.7717/peerj.1513
PeerJ 4 2020-02-26
2018 Nadia Caccamo, Simone A. Joosten, Tom H. M. Ottenhoff, Francesco Dieli
Atypical Human Effector/Memory CD4+ T Cells With a Naive-Like Phenotype
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02832
Frontiers in Immunology 9 2020-02-26
2019 Diana Mendes Freire, Claude Gutierrez, Acely Garza-Garcia, Anna D. Grabowska, Ambre J. Sala, Kanchiyaphat Ariyachaokun, Terezie Panikova, Katherine S.H. Beckham, André Colom, Vivian Pogenberg, Michele Cianci, Anne Tuukkanen, Yves-Marie Boudehen, Antonio Peixoto, Laure Botella, Dmitri I. Svergun, Dirk Schnappinger, Thomas R. Schneider, Pierre Genevaux, Luiz Pedro Sorio de Carvalho, Matthias Wilman
An NAD+ Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death
published pages: 1282-1291.e8, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2019.01.028
Molecular Cell 73/6 2020-02-26
2019 Karin Dijkman, Claudia C. Sombroek, Richard A. W. Vervenne, Sam O. Hofman, Charelle Boot, Edmond J. Remarque, Clemens H. M. Kocken, Tom H. M. Ottenhoff, Ivanela Kondova, Mohammed A. Khayum, Krista G. Haanstra, Michel P. M. Vierboom, Frank A. W. Verreck
Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques
published pages: 255-262, ISSN: 1078-8956, DOI: 10.1038/s41591-018-0319-9
Nature Medicine 25/2 2020-02-26
2018 Rosalie Lubbers, Jayne S. Sutherland, Delia Goletti, Roelof A. de Paus, Coline H. M. van Moorsel, Marcel Veltkamp, Stefan M. T. Vestjens, Willem J. W. Bos, Linda Petrone, Franca Del Nonno, Ingeborg M. Bajema, Karin Dijkman, Frank A. W. Verreck, Gerhard Walzl, Kyra A. Gelderman, Geert H. Groeneveld, Annemieke Geluk, Tom H. M. Ottenhoff, Simone A. Joosten, Leendert A. Trouw
Complement Component C1q as Serum Biomarker to Detect Active Tuberculosis
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02427
Frontiers in Immunology 9 2020-02-26
2019 Frida Arrey, Delia Löwe, Stefanie Kuhlmann, Peggy Kaiser, Pedro Moura-Alves, Gopinath Krishnamoorthy, Laura Lozza, Jeroen Maertzdorf, Tatsiana Skrahina, Alena Skrahina, Martin Gengenbacher, Geraldine Nouailles, Stefan H. E. Kaufmann
Humanized Mouse Model Mimicking Pathology of Human Tuberculosis for in vivo Evaluation of Drug Regimens
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00089
Frontiers in Immunology 10 2020-02-26
2019 January Weiner, Teresa Domaszewska, Simon Donkor, Stefan H E Kaufmann, Philip C Hill, Jayne S Sutherland
Changes in transcript, metabolite and antibody reactivity during the early protective immune response in humans to Mycobacterium tuberculosis infection
published pages: , ISSN: 1058-4838, DOI: 10.1093/cid/ciz785
Clinical Infectious Diseases 2020-02-26

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TBVAC2020" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TBVAC2020" are provided by the European Opendata Portal: CORDIS opendata.

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