Explore the words cloud of the MOMENDO project. It provides you a very rough idea of what is the project "MOMENDO" about.
The following table provides information about the project.
Coordinator |
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Organization address contact info |
Coordinator Country | Germany [DE] |
Project website | https://www.medizin.uni-muenster.de/momendo/the-project/ |
Project website | https://campus.uni-muenster.de/momendo/forschung/ |
Total cost | 346˙500 € |
EC max contribution | 346˙500 € (100%) |
Programme |
1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge) |
Code Call | H2020-MSCA-RISE-2015 |
Funding Scheme | MSCA-RISE |
Starting year | 2016 |
Duration (year-month-day) | from 2016-01-01 to 2019-12-31 |
Take a look of project's partnership.
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1 | WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER | DE (MUENSTER) | coordinator | 63˙000.00 |
2 | TERVISETEHNOLOOGIATE ARENDUSKESKUS AS | EE (TARTU) | participant | 94˙500.00 |
3 | KAROLINSKA INSTITUTET | SE (STOCKHOLM) | participant | 81˙000.00 |
4 | CHARITE - UNIVERSITAETSMEDIZIN BERLIN | DE (BERLIN) | participant | 54˙000.00 |
5 | THE UNIVERSITY OF EDINBURGH | UK (EDINBURGH) | participant | 40˙500.00 |
6 | SEREND-IP GMBH | DE (MUENSTER) | participant | 13˙500.00 |
7 | AQUILA BIOMEDICAL LIMITED | UK (EDINBURGH) | participant | 0.00 |
8 | CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) | AR (BUENOS AIRES) | partner | 0.00 |
9 | UNIVERSIDAD DE CHILE | CL (SANTIAGO) | partner | 0.00 |
Endometriosis (the presence of endometrial-like tissue or ‘lesions’ outside the uterus) is a chronic inflammatory disease affecting 6-10% of reproductive age women. It is associated with pelvic pain, painful periods, pain with sexual intercourse, and subfertility. The socioeconomic impacts of endometriosis are considerable. The recent WERF EndoCost study (a worldwide cost-of-illness study) reported that endometriosis reduced work productivity in 51% and negatively affected relationships in 50% of women with endometriosis. Current treatment options include invasive and repeated surgeries, or hormonal suppression with significant side effects analogous to a premature menopause. While several general concepts of the etiology of the disease such as retrograde menstruation, coelomic metaplasia, lymphovascular metastasis or the embryonic rest theory have been developed, the molecular mechanisms underlying the disease are currently still incompletely understood, hampering the development of efficient targeted therapies with limited side effects. MOMENDO utilizes the potential of an interdisciplinary consortium of leading world endometriosis experts to provide a deeper understanding of key molecular processes contributing to disease etiology and progression. By employing a wide range of experimental methods (biomarker and epigenetic studies on patient tissues, advanced animal models of the disease, proprietary atomic force microscopy for marker-free diagnostics) and novel and innovative conceptual approaches (adult stem cells, microRNAs, iron-induced inflammatory responses, novel endocrine concepts), MOMENDO will substantially contribute to a deeper understanding of the molecular mechanisms that explain the inflammatory pain associated with endometriosis and the persistent growth of endometriosis lesions. By combining the respective strengths of non-academic and clinical partners, MOMENDO expect to successfully translate these findings into novel therapeutic approaches.
Effect and molecular mechanism of Syndecan-1 inhibition on endometriosis | Documents, reports | 2020-04-06 12:09:09 |
Evaluation of anti-endocrine therapy in vitro and in vivo | Documents, reports | 2020-04-06 12:09:09 |
In vivo and in vitro models of inflammation-associated pain | Documents, reports | 2020-04-06 12:09:09 |
Molecular role and therapeutic potential of HA in endometriosis | Documents, reports | 2020-04-06 12:09:09 |
Effect of herbal medicine on inflammation, angiogenesis and apoptotic resistance | Documents, reports | 2020-04-06 12:09:09 |
Therapeutic effect of SARMS | Documents, reports | 2020-04-06 12:09:09 |
CSC marker analysis and Nanostic analysis in patient tissues | Documents, reports | 2020-04-06 12:09:09 |
Nocireceptive neuronal marker study | Documents, reports | 2020-04-06 12:09:09 |
Impact of HA-CD44 inhibition on an endometriotic stem cell phenotype | Documents, reports | 2020-04-06 12:09:09 |
Project meetings and workshops | Documents, reports | 2020-04-06 12:09:09 |
Impact of miRNA expression on an invasive phenotype | Documents, reports | 2020-04-06 12:09:09 |
Pathogenetic role of the NFkB pathway following iron overload | Documents, reports | 2020-04-06 12:09:09 |
NFkB pathway analysis | Documents, reports | 2020-04-06 12:09:09 |
Induced differentiation of ESCs and CSCs as a therapeutic approach | Documents, reports | 2020-04-06 12:09:09 |
Identification and functional analysis of pain-related microRNAs | Documents, reports | 2020-04-06 12:09:09 |
Role of NFkB-dependent microRNAs in endometriotic cell behaviour | Documents, reports | 2020-04-06 12:09:09 |
Atomic force microscopy | Documents, reports | 2020-04-06 12:09:08 |
Webpage and Social Media | Websites, patent fillings, videos etc. | 2020-04-06 12:09:08 |
Therapeutic effects of DCA | Documents, reports | 2020-04-06 12:09:08 |
Take a look to the deliverables list in detail: detailed list of MOMENDO deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2018 |
Heidi Marjonen, Pauliina Auvinen, Hanna Kahila, Olga Tšuiko, Sulev Kõks, Airi Tiirats, Triin Viltrop, Timo Tuuri, Viveca Söderström-Anttila, Anne-Maria Suikkari, Andres Salumets, Aila Tiitinen, Nina Kaminen-Ahola rs10732516 polymorphism at the IGF2/H19 locus associates with genotype-specific effects on placental DNA methylation and birth weight of newborns conceived by assisted reproductive technology published pages: , ISSN: 1868-7075, DOI: 10.1186/s13148-018-0511-2 |
Clinical Epigenetics 10/1 | 2020-04-06 |
2018 |
Merli Saare, Kertu Liis Krigul, Triin Laisk-Podar, Sakthi Vignesh-Srinivasan, Nilufer Rahmioglu, Parameswaran Grace Lalit Kumar, Krina Zondervan, Andres Salumets, Maire Peters DNA methylation alterations - potential cause of endometriosis pathogenesis or a reflection of tissue heterogeneity? published pages: , ISSN: 0006-3363, DOI: 10.1093/biolre/ioy067 |
Biology of Reproduction | 2020-04-06 |
2018 |
Kadri Rekker, Tõnis Tasa, Merli Saare, Külli Samuel, Ülle Kadastik, Helle Karro, Martin Götte, Andres Salumets, Maire Peters Differentially-Expressed miRNAs in Ectopic Stromal Cells Contribute to Endometriosis Development: The Plausible Role of miR-139-5p and miR-375 published pages: 3789, ISSN: 1422-0067, DOI: 10.3390/ijms19123789 |
International Journal of Molecular Sciences 19/12 | 2020-04-06 |
2018 |
Deniss Sõritsa, Hindrek Teder, Retlav Roosipuu, Hannes Tamm, Triin Laisk-Podar, Pille Soplepmann, Alan Altraja, Andres Salumets, Maire Peters Whole exome sequencing of benign pulmonary metastasizing leiomyoma reveals mutation in the BMP8B gene published pages: , ISSN: 1471-2350, DOI: 10.1186/s12881-018-0537-5 |
BMC Medical Genetics 19/1 | 2020-04-06 |
2018 |
Marina Suhorutshenko, Viktorija Kukushkina, Agne Velthut-Meikas, Signe Altmäe, Maire Peters, Reedik Mägi, Kaarel Krjutškov, Mariann Koel, Francisco M Codoñer, Juan Fco Martinez-Blanch, Felipe Vilella, Carlos Simón, Andres Salumets, Triin Laisk Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity published pages: 2074-2086, ISSN: 0268-1161, DOI: 10.1093/humrep/dey301 |
Human Reproduction 33/11 | 2020-04-06 |
2019 |
Hannu Koistinen, Mariann Koel, Maire Peters, Ago Rinken, Karolina Lundin, Timo Tuuri, Juha S. Tapanainen, Henrik Alfthan, Andres Salumets, Ulf-HÃ¥kan Stenman, Darja Lavogina Hyperglycosylated hCG activates LH/hCG-receptor with lower activity than hCG published pages: 103-109, ISSN: 0303-7207, DOI: 10.1016/j.mce.2018.09.006 |
Molecular and Cellular Endocrinology 479 | 2020-04-06 |
2018 |
Sakthivignesh Ponandai-Srinivasan, Karin L Andersson, Monica Nister, Merli Saare, Halima A Hassan, Suby J Varghese, Maire Peters, Andres Salumets, Kristina Gemzell-Danielsson, Parameswaran Grace Luther Lalitkumar Aberrant expression of genes associated with stemness and cancer in endometria and endometrioma in a subset of women with endometriosis published pages: 1924-1938, ISSN: 0268-1161, DOI: 10.1093/humrep/dey241 |
Human Reproduction 33/10 | 2020-04-06 |
2017 |
Andreas N. Schüring, Beatrice Dahlhues, Anna Korte, Ludwig Kiesel, Ulf Titze, Birthe Heitkötter, Christian Ruckert, Martin Götte The endometrial stem cell markers notch-1 and numb are associated with endometriosis published pages: 294-301, ISSN: 1472-6483, DOI: 10.1016/j.rbmo.2017.11.010 |
Reproductive BioMedicine Online 36 | 2020-04-06 |
2017 |
Merli Saare, Kadri Rekker, Triin Laisk-Podar, Nilufer Rahmioglu, Krina Zondervan, Andres Salumets, Martin G?tte, Maire Peters Challenges in endometriosis miRNA studies - from tissue heterogeneity to disease specific miRNAs published pages: 2282-2292, ISSN: 0925-4439, DOI: 10.1016/j.bbadis.2017.06.018 |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1863 | 2020-04-06 |
2019 |
Laura Ramirez Williams, Kathrin Brüggemann, Marina Hubert, Nurjannah Achmad, Ludwig Kiesel, Sebastian D. Schäfer, Burkhard Greve, Martin Götte Gammaâ€Secretase inhibition affects viability, apoptosis and the stem cell phenotype of endometriotic cells published pages: , ISSN: 0001-6349, DOI: 10.1111/aogs.13707 |
Acta Obstetricia et Gynecologica Scandinavica | 2020-04-06 |
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