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MOMENDO SIGNED

Molecular Mechanisms of Endometriosis

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MOMENDO project word cloud

Explore the words cloud of the MOMENDO project. It provides you a very rough idea of what is the project "MOMENDO" about.

painful    50    menstruation    molecular    efficient    micrornas    translate    repeated    limited    employing    considerable    utilizes    inflammatory    socioeconomic    reproductive    diagnostics    world    lymphovascular    metaplasia    tissue    rest    endometrial    stem    productivity    coelomic    iron    invasive    treatment    underlying    free    age    successfully    etiology    reported    embryonic    uterus    hormonal    combining    deeper    premature    suppression    worldwide    tissues    models    menopause    substantially    lesions    analogous    disease    interdisciplinary    marker    animal    surgeries    patient    pain    incompletely    force    periods    endocrine    51    experimental    innovative    academic    endometriosis    biomarker    theory    adult    retrograde    subfertility    hampering    proprietary    strengths    intercourse    atomic    microscopy    therapies    impacts    pelvic    women    illness    sexual    progression    endocost    options    cells    clinical    experts    persistent    chronic    outside    metastasis    epigenetic    therapeutic    negatively    werf    momendo    respective    conceptual    mechanisms    relationships    10   

Project "MOMENDO" data sheet

The following table provides information about the project.

Coordinator
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER 

Organization address
address: SCHLOSSPLATZ 2
city: MUENSTER
postcode: 48149
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.medizin.uni-muenster.de/momendo/the-project/
 Project website https://campus.uni-muenster.de/momendo/forschung/
 Total cost 346˙500 €
 EC max contribution 346˙500 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2015
 Funding Scheme MSCA-RISE
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER DE (MUENSTER) coordinator 63˙000.00
2    TERVISETEHNOLOOGIATE ARENDUSKESKUS AS EE (TARTU) participant 94˙500.00
3    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 81˙000.00
4    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) participant 54˙000.00
5    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) participant 40˙500.00
6    SEREND-IP GMBH DE (MUENSTER) participant 13˙500.00
7    AQUILA BIOMEDICAL LIMITED UK (EDINBURGH) participant 0.00
8    CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET) AR (BUENOS AIRES) partner 0.00
9    UNIVERSIDAD DE CHILE CL (SANTIAGO) partner 0.00

Map

 Project objective

Endometriosis (the presence of endometrial-like tissue or ‘lesions’ outside the uterus) is a chronic inflammatory disease affecting 6-10% of reproductive age women. It is associated with pelvic pain, painful periods, pain with sexual intercourse, and subfertility. The socioeconomic impacts of endometriosis are considerable. The recent WERF EndoCost study (a worldwide cost-of-illness study) reported that endometriosis reduced work productivity in 51% and negatively affected relationships in 50% of women with endometriosis. Current treatment options include invasive and repeated surgeries, or hormonal suppression with significant side effects analogous to a premature menopause. While several general concepts of the etiology of the disease such as retrograde menstruation, coelomic metaplasia, lymphovascular metastasis or the embryonic rest theory have been developed, the molecular mechanisms underlying the disease are currently still incompletely understood, hampering the development of efficient targeted therapies with limited side effects. MOMENDO utilizes the potential of an interdisciplinary consortium of leading world endometriosis experts to provide a deeper understanding of key molecular processes contributing to disease etiology and progression. By employing a wide range of experimental methods (biomarker and epigenetic studies on patient tissues, advanced animal models of the disease, proprietary atomic force microscopy for marker-free diagnostics) and novel and innovative conceptual approaches (adult stem cells, microRNAs, iron-induced inflammatory responses, novel endocrine concepts), MOMENDO will substantially contribute to a deeper understanding of the molecular mechanisms that explain the inflammatory pain associated with endometriosis and the persistent growth of endometriosis lesions. By combining the respective strengths of non-academic and clinical partners, MOMENDO expect to successfully translate these findings into novel therapeutic approaches.

 Deliverables

List of deliverables.
Effect and molecular mechanism of Syndecan-1 inhibition on endometriosis Documents, reports 2020-04-06 12:09:09
Evaluation of anti-endocrine therapy in vitro and in vivo Documents, reports 2020-04-06 12:09:09
In vivo and in vitro models of inflammation-associated pain Documents, reports 2020-04-06 12:09:09
Molecular role and therapeutic potential of HA in endometriosis Documents, reports 2020-04-06 12:09:09
Effect of herbal medicine on inflammation, angiogenesis and apoptotic resistance Documents, reports 2020-04-06 12:09:09
Therapeutic effect of SARMS Documents, reports 2020-04-06 12:09:09
CSC marker analysis and Nanostic analysis in patient tissues Documents, reports 2020-04-06 12:09:09
Nocireceptive neuronal marker study Documents, reports 2020-04-06 12:09:09
Impact of HA-CD44 inhibition on an endometriotic stem cell phenotype Documents, reports 2020-04-06 12:09:09
Project meetings and workshops Documents, reports 2020-04-06 12:09:09
Impact of miRNA expression on an invasive phenotype Documents, reports 2020-04-06 12:09:09
Pathogenetic role of the NFkB pathway following iron overload Documents, reports 2020-04-06 12:09:09
NFkB pathway analysis Documents, reports 2020-04-06 12:09:09
Induced differentiation of ESCs and CSCs as a therapeutic approach Documents, reports 2020-04-06 12:09:09
Identification and functional analysis of pain-related microRNAs Documents, reports 2020-04-06 12:09:09
Role of NFkB-dependent microRNAs in endometriotic cell behaviour Documents, reports 2020-04-06 12:09:09
Atomic force microscopy Documents, reports 2020-04-06 12:09:08
Webpage and Social Media Websites, patent fillings, videos etc. 2020-04-06 12:09:08
Therapeutic effects of DCA Documents, reports 2020-04-06 12:09:08

Take a look to the deliverables list in detail:  detailed list of MOMENDO deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Heidi Marjonen, Pauliina Auvinen, Hanna Kahila, Olga Tšuiko, Sulev Kõks, Airi Tiirats, Triin Viltrop, Timo Tuuri, Viveca Söderström-Anttila, Anne-Maria Suikkari, Andres Salumets, Aila Tiitinen, Nina Kaminen-Ahola
rs10732516 polymorphism at the IGF2/H19 locus associates with genotype-specific effects on placental DNA methylation and birth weight of newborns conceived by assisted reproductive technology
published pages: , ISSN: 1868-7075, DOI: 10.1186/s13148-018-0511-2
Clinical Epigenetics 10/1 2020-04-06
2018 Merli Saare, Kertu Liis Krigul, Triin Laisk-Podar, Sakthi Vignesh-Srinivasan, Nilufer Rahmioglu, Parameswaran Grace Lalit Kumar, Krina Zondervan, Andres Salumets, Maire Peters
DNA methylation alterations - potential cause of endometriosis pathogenesis or a reflection of tissue heterogeneity?
published pages: , ISSN: 0006-3363, DOI: 10.1093/biolre/ioy067
Biology of Reproduction 2020-04-06
2018 Kadri Rekker, Tõnis Tasa, Merli Saare, Külli Samuel, Ülle Kadastik, Helle Karro, Martin Götte, Andres Salumets, Maire Peters
Differentially-Expressed miRNAs in Ectopic Stromal Cells Contribute to Endometriosis Development: The Plausible Role of miR-139-5p and miR-375
published pages: 3789, ISSN: 1422-0067, DOI: 10.3390/ijms19123789
International Journal of Molecular Sciences 19/12 2020-04-06
2018 Deniss Sõritsa, Hindrek Teder, Retlav Roosipuu, Hannes Tamm, Triin Laisk-Podar, Pille Soplepmann, Alan Altraja, Andres Salumets, Maire Peters
Whole exome sequencing of benign pulmonary metastasizing leiomyoma reveals mutation in the BMP8B gene
published pages: , ISSN: 1471-2350, DOI: 10.1186/s12881-018-0537-5
BMC Medical Genetics 19/1 2020-04-06
2018 Marina Suhorutshenko, Viktorija Kukushkina, Agne Velthut-Meikas, Signe Altmäe, Maire Peters, Reedik Mägi, Kaarel Krjutškov, Mariann Koel, Francisco M Codoñer, Juan Fco Martinez-Blanch, Felipe Vilella, Carlos Simón, Andres Salumets, Triin Laisk
Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity
published pages: 2074-2086, ISSN: 0268-1161, DOI: 10.1093/humrep/dey301
Human Reproduction 33/11 2020-04-06
2019 Hannu Koistinen, Mariann Koel, Maire Peters, Ago Rinken, Karolina Lundin, Timo Tuuri, Juha S. Tapanainen, Henrik Alfthan, Andres Salumets, Ulf-HÃ¥kan Stenman, Darja Lavogina
Hyperglycosylated hCG activates LH/hCG-receptor with lower activity than hCG
published pages: 103-109, ISSN: 0303-7207, DOI: 10.1016/j.mce.2018.09.006
Molecular and Cellular Endocrinology 479 2020-04-06
2018 Sakthivignesh Ponandai-Srinivasan, Karin L Andersson, Monica Nister, Merli Saare, Halima A Hassan, Suby J Varghese, Maire Peters, Andres Salumets, Kristina Gemzell-Danielsson, Parameswaran Grace Luther Lalitkumar
Aberrant expression of genes associated with stemness and cancer in endometria and endometrioma in a subset of women with endometriosis
published pages: 1924-1938, ISSN: 0268-1161, DOI: 10.1093/humrep/dey241
Human Reproduction 33/10 2020-04-06
2017 Andreas N. Schüring, Beatrice Dahlhues, Anna Korte, Ludwig Kiesel, Ulf Titze, Birthe Heitkötter, Christian Ruckert, Martin Götte
The endometrial stem cell markers notch-1 and numb are associated with endometriosis
published pages: 294-301, ISSN: 1472-6483, DOI: 10.1016/j.rbmo.2017.11.010
Reproductive BioMedicine Online 36 2020-04-06
2017 Merli Saare, Kadri Rekker, Triin Laisk-Podar, Nilufer Rahmioglu, Krina Zondervan, Andres Salumets, Martin G?tte, Maire Peters
Challenges in endometriosis miRNA studies - from tissue heterogeneity to disease specific miRNAs
published pages: 2282-2292, ISSN: 0925-4439, DOI: 10.1016/j.bbadis.2017.06.018
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1863 2020-04-06
2019 Laura Ramirez Williams, Kathrin Brüggemann, Marina Hubert, Nurjannah Achmad, Ludwig Kiesel, Sebastian D. Schäfer, Burkhard Greve, Martin Götte
Gamma‐Secretase inhibition affects viability, apoptosis and the stem cell phenotype of endometriotic cells
published pages: , ISSN: 0001-6349, DOI: 10.1111/aogs.13707
Acta Obstetricia et Gynecologica Scandinavica 2020-04-06

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