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PlaEndo

The Remote Control of Maternal Metabolism by the Placenta

Total Cost €

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EC-Contrib. €

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Partnership

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Project "PlaEndo" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.pdn.cam.ac.uk/other-pages/sferruzzi-perri/amanda-sferruzzi-perri-lab-members
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-09-25

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 195˙454.00

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 Project objective

During pregnancy many physiological changes occur in the mother that are designed to support fetal growth. These include changes in the cardiovascular, pulmonary, immune and metabolic systems. In particular, the mother becomes less reactive to insulin, leading to increased glucose availability to the fetus in late pregnancy. These adaptations are thought to be signaled, in part by changes in placental hormone production. Whilst studies have shown that the placenta has the capacity to produce different hormones, their specific role in adapting maternal metabolism during pregnancy relies principally on association studies. Moreover, there are likely to be more protein mediators secreted by the placenta with systemic actions in the mother. Failure to adjust the mother's body to the pregnant state may result in pregnancy complications, including abnormal birth weight and maternal diabetes, which can further lead to a range of medical complications for the mother and baby. The overall goal of this study will be to identify the nature and wider biological significance of placental endocrine function in adapting the mother's body during pregnancy to support fetal growth, with a focus on maternal metabolism. This work will primarily use the mouse as an experimental model as the placental signaling/secreting cells are conveniently organized into a distinct region and are under unique genetic control. Therefore placental signaling cells can be isolated, cultured and genetically-modified independent of other cells in the mouse placenta. The secreted placental candidates will be identified using the latest sequencing technologies, and their metabolic effects will be tested on cell lines and in the whole organism using unique genetic tools available at the University of Cambridge. Knowledge gained from this study will be the first step in the development of targeted interventions for optimizing fetal growth and preventing pregnancy complications.

 Publications

year authors and title journal last update
List of publications.
2018 Tina Napso, Hannah E. J. Yong, Jorge Lopez-Tello, Amanda N. Sferruzzi-Perri
The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.01091
Frontiers in Physiology 9 2019-05-30

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